Mutagenetix > Incidental Mutation

Incidental Mutation 'R9168:Olfr670'

696184

Institutional Source

Beutler Lab

Gene Symbol

Olfr670

Ensembl Gene

ENSMUSG00000044705

Gene Name

olfactory receptor 670

Synonyms

MOR32-8, GA_x6K02T2PBJ9-7589577-7588639

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.055) question?

Stock #

R9168 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

104957114-104962620 bp(-) (GRCm38)

Type of Mutation

makesense

DNA Base Change (assembly)

A to G at 104959794 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Arginine at position 313 (*313R)

Ref Sequence

ENSEMBL: ENSMUSP00000151138 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000050482] [ENSMUST00000214216]

AlphaFold

Q7TRP3

Predicted Effect

probably null
Transcript: ENSMUST00000050482
AA Change: *313R

SMART Domains

Protein: ENSMUSP00000060289
Gene: ENSMUSG00000044705
AA Change: *313R

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	311	3.7e-121	PFAM
Pfam:7TM_GPCR_Srsx	37	211	4.5e-7	PFAM
Pfam:7tm_1	43	293	3.9e-17	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000214216
AA Change: *313R

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.9%
20x: 99.6%

Validation Efficiency

97% (67/69)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alppl2	T	C	1: 87,087,328	Y437C	probably damaging	Het
Arhgef11	T	G	3: 87,726,483	L808R	probably damaging	Het
Armc7	G	A	11: 115,475,898		probably benign	Het
Ascl1	T	C	10: 87,492,499	N197S	probably benign	Het
Cdc42bpb	T	G	12: 111,320,083	E630D	possibly damaging	Het
Cep128	T	C	12: 91,267,020	I425V	probably damaging	Het
Ces4a	T	A	8: 105,149,418	D530E	probably benign	Het
Ch25h	T	C	19: 34,474,505	I208V	probably benign	Het
Cnpy3	A	C	17: 46,752,093	C11G	unknown	Het
Col12a1	A	C	9: 79,641,501	Y2187*	probably null	Het
Cyp2c40	C	T	19: 39,767,375	M498I	probably benign	Het
D630039A03Rik	T	A	4: 57,910,113	Y233F	probably damaging	Het
Dffa	A	T	4: 149,107,769	D100V	probably damaging	Het
Dock7	A	T	4: 99,065,406	M363K		Het
Dscam	A	G	16: 96,619,568	V1706A	possibly damaging	Het
En1	A	G	1: 120,603,163	D44G	unknown	Het
Enpp4	T	A	17: 44,102,250	N131I	probably damaging	Het
Ezh1	T	C	11: 101,195,607	D587G	probably damaging	Het
Gm10424	T	A	5: 95,270,274	M288L	probably benign	Het
Gm12394	T	C	4: 42,793,380	T251A	probably benign	Het
Gm21149	G	T	5: 15,472,134	H241N	possibly damaging	Het
Gna15	T	C	10: 81,514,358	Y70C	probably damaging	Het
Gucy1a1	T	G	3: 82,102,046	M552L	probably damaging	Het
Herc2	G	A	7: 56,152,460	V2017M	probably damaging	Het
Hsf4	C	T	8: 105,272,741	A297V	probably benign	Het
Ighd	T	A	12: 113,415,583	T122S		Het
Iqca	C	T	1: 90,138,215	R218Q	probably damaging	Het
Isl2	C	A	9: 55,544,943	S266R	probably benign	Het
Itpkb	A	C	1: 180,332,463	R51S	probably benign	Het
Jup	A	T	11: 100,383,393		probably null	Het
Kbtbd6	T	C	14: 79,453,113	V416A	possibly damaging	Het
Klhl22	T	A	16: 17,784,204	Y372N	probably damaging	Het
Klrc3	T	C	6: 129,639,179	E191G	probably damaging	Het
Lhx5	A	G	5: 120,432,345	D22G	probably benign	Het
March9	GGGCGGCGGCGGCGGCG	GGGCGGCGGCGGCG	10: 127,059,491		probably benign	Het
Mbtps1	A	G	8: 119,521,863	I707T	probably benign	Het
Nbeal1	T	A	1: 60,291,888	Y2219N	probably damaging	Het
Neb	A	G	2: 52,195,684	I5513T	probably damaging	Het
Nkx1-1	C	T	5: 33,433,787	V64M	unknown	Het
Nme4	G	T	17: 26,095,415	A13E	probably benign	Het
Olfr117	T	C	17: 37,660,156	Y59C	probably damaging	Het
Olfr866	T	C	9: 20,027,522	M139V	probably benign	Het
Osbpl3	A	T	6: 50,352,782		probably null	Het
Phc3	T	A	3: 30,907,395	M963L	probably benign	Het
Phf20	C	T	2: 156,267,314	P194S	probably benign	Het
Pou1f1	C	T	16: 65,520,541		probably benign	Het
Prdm13	C	G	4: 21,679,659	R277P	unknown	Het
Prelid1	A	G	13: 55,322,197	K3R	possibly damaging	Het
Psd	C	A	19: 46,320,794	D575Y	probably damaging	Het
Ptger3	C	A	3: 157,567,787	T257K	probably damaging	Het
Pth1r	T	C	9: 110,727,136	H223R	probably benign	Het
Ptk2b	C	T	14: 66,187,450	E182K	probably damaging	Het
Ptprj	T	C	2: 90,464,572	T431A	possibly damaging	Het
Rbbp5	T	A	1: 132,489,726	D119E	probably benign	Het
Rest	GGGGGCCTGCCCCTCCCACGGGGCCTGCCCCTCCCACGGGGCCTGCCCCTCCCACGGAGCCTGCCCCTCCCACGGGGC	GGGGGCCTGCCCCTCCCACGGGGCCTGCCCCTCCCACGGAGCCTGCCCCTCCCACGGGGC	5: 77,281,804		probably benign	Het
Rinl	T	G	7: 28,790,659	L41R	possibly damaging	Het
Rrp12	A	G	19: 41,877,164	V730A	probably benign	Het
Saraf	G	T	8: 34,165,189	V141L	possibly damaging	Het
Slc6a13	T	C	6: 121,325,083	L208P	probably damaging	Het
Slc9a9	C	A	9: 94,712,947	T170K	probably damaging	Het
Stk33	T	C	7: 109,329,540	N255S	probably damaging	Het
Tenm2	C	T	11: 36,039,895	V1769M	probably damaging	Het
Themis	C	A	10: 28,782,237	T420N	probably benign	Het
Tmem116	T	C	5: 121,467,912	V109A		Het
Tnfaip2	T	A	12: 111,444,948	L2Q	probably damaging	Het
Trub1	T	C	19: 57,464,427		probably null	Het
Ttn	C	T	2: 76,848,916	V10821I	unknown	Het
Ube2j1	C	A	4: 33,045,111	A197D	probably benign	Het
Vmn2r101	T	A	17: 19,588,876	I89N	probably damaging	Het
Wfikkn1	T	C	17: 25,878,171	Y393C	probably damaging	Het
Zfp729b	C	A	13: 67,593,823	E108*	probably null	Het
Zfp976	A	T	7: 42,613,587	C276*	probably null	Het

Other mutations in Olfr670

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00978:Olfr670	APN	7	104960716	missense	probably damaging	0.96
IGL01100:Olfr670	APN	7	104959995	missense	probably benign	0.07
IGL01351:Olfr670	APN	7	104960739	start gained	probably benign
IGL01478:Olfr670	APN	7	104960348	missense	probably damaging	0.97
IGL01835:Olfr670	APN	7	104960462	missense	probably benign	0.01
IGL02326:Olfr670	APN	7	104960646	missense	probably benign	0.12
IGL02434:Olfr670	APN	7	104960072	missense	probably benign	0.05
IGL02434:Olfr670	APN	7	104960074	nonsense	probably null
IGL02968:Olfr670	APN	7	104960244	missense	possibly damaging	0.90
R0055:Olfr670	UTSW	7	104960496	missense	possibly damaging	0.46
R0055:Olfr670	UTSW	7	104960496	missense	possibly damaging	0.46
R0345:Olfr670	UTSW	7	104960181	missense	probably damaging	1.00
R0401:Olfr670	UTSW	7	104959943	missense	probably damaging	1.00
R0646:Olfr670	UTSW	7	104959811	missense	probably benign	0.02
R1493:Olfr670	UTSW	7	104960502	missense	probably damaging	0.97
R1532:Olfr670	UTSW	7	104960265	missense	probably benign
R1557:Olfr670	UTSW	7	104960540	missense	probably damaging	0.99
R4072:Olfr670	UTSW	7	104960716	missense	probably damaging	0.96
R4074:Olfr670	UTSW	7	104960716	missense	probably damaging	0.96
R4075:Olfr670	UTSW	7	104960716	missense	probably damaging	0.96
R4076:Olfr670	UTSW	7	104960716	missense	probably damaging	0.96
R4229:Olfr670	UTSW	7	104960594	missense	probably benign	0.18
R4230:Olfr670	UTSW	7	104960594	missense	probably benign	0.18
R5374:Olfr670	UTSW	7	104959996	missense	probably damaging	1.00
R6006:Olfr670	UTSW	7	104960663	missense	probably damaging	0.99
R6891:Olfr670	UTSW	7	104959985	missense	probably damaging	1.00
R7465:Olfr670	UTSW	7	104959917	missense	probably benign	0.23
R8105:Olfr670	UTSW	7	104960422	missense	probably benign	0.15
R8117:Olfr670	UTSW	7	104960149	missense	probably damaging	1.00
R8356:Olfr670	UTSW	7	104960727	missense	probably benign	0.00
R8510:Olfr670	UTSW	7	104960114	nonsense	probably null
R9145:Olfr670	UTSW	7	104959997	missense	probably damaging	1.00
R9234:Olfr670	UTSW	7	104960444	missense	probably damaging	1.00
R9706:Olfr670	UTSW	7	104959988	missense	probably damaging	0.99
R9789:Olfr670	UTSW	7	104960450	missense	probably damaging	0.97

Predicted Primers

PCR Primer
(F):5'- GTCCTTAGGAATTCCACACATTC -3'
(R):5'- CACATCTGTGTCATCCTGGC -3'

Sequencing Primer
(F):5'- CGAAGCAGGTTCCTGTCATTGAAC -3'
(R):5'- GGCCTTCTTCACTCCAGC -3'

Posted On

2022-02-07