Incidental Mutation 'R9172:Vmn2r3'
ID |
696452 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r3
|
Ensembl Gene |
ENSMUSG00000091572 |
Gene Name |
vomeronasal 2, receptor 3 |
Synonyms |
EG637004 |
MMRRC Submission |
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R9172 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
3 |
Chromosomal Location |
64166225-64197130 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 64186403 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Methionine to Lysine
at position 94
(M94K)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000134891
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170244]
[ENSMUST00000176328]
|
AlphaFold |
H3BJ88 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170244
AA Change: M66K
PolyPhen 2
Score 0.788 (Sensitivity: 0.85; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000126165 Gene: ENSMUSG00000091572 AA Change: M66K
Domain | Start | End | E-Value | Type |
Pfam:ANF_receptor
|
64 |
479 |
4e-64 |
PFAM |
Pfam:NCD3G
|
521 |
574 |
1.1e-17 |
PFAM |
Pfam:7tm_3
|
605 |
842 |
2.9e-75 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000176328
AA Change: M94K
PolyPhen 2
Score 0.788 (Sensitivity: 0.85; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000134891 Gene: ENSMUSG00000091572 AA Change: M94K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
92 |
507 |
9.5e-66 |
PFAM |
Pfam:NCD3G
|
549 |
602 |
8.8e-17 |
PFAM |
Pfam:7tm_3
|
635 |
869 |
8.5e-48 |
PFAM |
|
Meta Mutation Damage Score |
0.1712 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
Validation Efficiency |
100% (63/63) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 66 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Accsl |
A |
T |
2: 93,691,833 (GRCm39) |
L332Q |
probably damaging |
Het |
Adcy1 |
A |
G |
11: 7,110,317 (GRCm39) |
N855D |
probably damaging |
Het |
Adgrl3 |
T |
A |
5: 81,922,251 (GRCm39) |
C1199S |
probably benign |
Het |
Alyref |
G |
A |
11: 120,486,842 (GRCm39) |
R140C |
probably benign |
Het |
Arhgap26 |
A |
T |
18: 39,378,382 (GRCm39) |
I92F |
probably damaging |
Het |
Atp9b |
G |
A |
18: 80,960,993 (GRCm39) |
R73* |
probably null |
Het |
Btaf1 |
G |
A |
19: 36,977,630 (GRCm39) |
A1483T |
probably damaging |
Het |
Cmtr2 |
T |
C |
8: 110,948,761 (GRCm39) |
L357P |
probably damaging |
Het |
Commd7 |
A |
T |
2: 153,470,474 (GRCm39) |
L51Q |
possibly damaging |
Het |
Cpd |
T |
A |
11: 76,675,252 (GRCm39) |
I1290L |
probably benign |
Het |
Cry2 |
C |
A |
2: 92,243,993 (GRCm39) |
E393D |
probably damaging |
Het |
Ctsm |
A |
T |
13: 61,685,643 (GRCm39) |
M74K |
|
Het |
Dnai7 |
A |
G |
6: 145,123,175 (GRCm39) |
F564L |
probably benign |
Het |
Dync2h1 |
T |
C |
9: 7,031,771 (GRCm39) |
Y3491C |
probably damaging |
Het |
Erc1 |
A |
C |
6: 119,801,842 (GRCm39) |
N58K |
possibly damaging |
Het |
Fbxw21 |
T |
C |
9: 108,975,764 (GRCm39) |
T211A |
probably benign |
Het |
Fcsk |
A |
G |
8: 111,610,557 (GRCm39) |
W949R |
probably damaging |
Het |
Fry |
T |
C |
5: 150,336,793 (GRCm39) |
V1388A |
probably benign |
Het |
Gca |
T |
G |
2: 62,520,368 (GRCm39) |
I176S |
probably damaging |
Het |
Gimap7 |
A |
T |
6: 48,700,761 (GRCm39) |
K116* |
probably null |
Het |
Gm40460 |
ACAACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
ACAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG |
7: 141,794,447 (GRCm39) |
|
probably benign |
Het |
Gm9195 |
A |
C |
14: 72,711,154 (GRCm39) |
L428R |
probably damaging |
Het |
Grin2b |
A |
G |
6: 135,756,255 (GRCm39) |
I490T |
possibly damaging |
Het |
Kif24 |
T |
C |
4: 41,400,442 (GRCm39) |
T499A |
probably benign |
Het |
Mbtps1 |
G |
A |
8: 120,260,108 (GRCm39) |
T413I |
probably damaging |
Het |
Med4 |
A |
T |
14: 73,751,365 (GRCm39) |
S105C |
probably benign |
Het |
Mgat1 |
G |
A |
11: 49,151,910 (GRCm39) |
R131Q |
probably damaging |
Het |
Mroh4 |
T |
C |
15: 74,477,961 (GRCm39) |
*984W |
probably null |
Het |
Mybpc1 |
T |
C |
10: 88,379,615 (GRCm39) |
E628G |
possibly damaging |
Het |
Myh8 |
C |
T |
11: 67,183,260 (GRCm39) |
P713L |
possibly damaging |
Het |
Myo7a |
T |
C |
7: 97,732,369 (GRCm39) |
D706G |
probably benign |
Het |
Nbas |
T |
A |
12: 13,424,751 (GRCm39) |
C997S |
possibly damaging |
Het |
Nkx2-1 |
C |
A |
12: 56,581,752 (GRCm39) |
G32C |
probably damaging |
Het |
Npas3 |
A |
G |
12: 54,112,653 (GRCm39) |
T466A |
probably benign |
Het |
Opa1 |
C |
T |
16: 29,439,232 (GRCm39) |
R683C |
probably benign |
Het |
Opa3 |
C |
T |
7: 18,989,466 (GRCm39) |
R110C |
probably damaging |
Het |
Or5p63 |
T |
C |
7: 107,811,169 (GRCm39) |
E189G |
probably benign |
Het |
Or8k38 |
T |
A |
2: 86,487,879 (GRCm39) |
I308L |
probably benign |
Het |
Ppfibp2 |
T |
A |
7: 107,337,525 (GRCm39) |
L609* |
probably null |
Het |
Pygo2 |
T |
A |
3: 89,340,617 (GRCm39) |
D338E |
possibly damaging |
Het |
Pzp |
A |
T |
6: 128,502,172 (GRCm39) |
M59K |
probably benign |
Het |
Reln |
A |
G |
5: 22,155,815 (GRCm39) |
|
probably null |
Het |
Ripor1 |
A |
G |
8: 106,347,833 (GRCm39) |
D1097G |
unknown |
Het |
Rmdn3 |
T |
C |
2: 118,968,863 (GRCm39) |
K443E |
probably benign |
Het |
Rnf145 |
A |
G |
11: 44,448,262 (GRCm39) |
D373G |
possibly damaging |
Het |
Sec23b |
A |
T |
2: 144,401,179 (GRCm39) |
E13D |
probably benign |
Het |
Semp2l1 |
G |
T |
1: 32,585,165 (GRCm39) |
H248Q |
probably benign |
Het |
Slc39a6 |
A |
G |
18: 24,715,399 (GRCm39) |
F707S |
probably damaging |
Het |
Sox11 |
G |
A |
12: 27,391,536 (GRCm39) |
A291V |
possibly damaging |
Het |
Spart |
T |
A |
3: 55,032,267 (GRCm39) |
V367D |
possibly damaging |
Het |
Spata31e3 |
A |
G |
13: 50,401,417 (GRCm39) |
F303S |
probably benign |
Het |
Strap |
A |
T |
6: 137,718,365 (GRCm39) |
K156N |
probably benign |
Het |
Stxbp5 |
T |
A |
10: 9,645,152 (GRCm39) |
I951F |
possibly damaging |
Het |
Taar7a |
T |
C |
10: 23,868,677 (GRCm39) |
I235V |
probably benign |
Het |
Tek |
T |
A |
4: 94,692,583 (GRCm39) |
N230K |
probably benign |
Het |
Tyw1 |
T |
A |
5: 130,325,520 (GRCm39) |
C469* |
probably null |
Het |
Vcan |
T |
C |
13: 89,828,050 (GRCm39) |
H3132R |
probably damaging |
Het |
Vmn2r24 |
A |
G |
6: 123,783,432 (GRCm39) |
D544G |
probably damaging |
Het |
Vps33a |
T |
C |
5: 123,674,604 (GRCm39) |
T388A |
probably benign |
Het |
Vta1 |
A |
G |
10: 14,551,743 (GRCm39) |
I152T |
probably damaging |
Het |
Vtcn1 |
A |
G |
3: 100,799,865 (GRCm39) |
D242G |
probably benign |
Het |
Zfp12 |
T |
A |
5: 143,231,220 (GRCm39) |
C548S |
probably damaging |
Het |
Zfp263 |
A |
G |
16: 3,567,323 (GRCm39) |
D546G |
probably benign |
Het |
Zfp324 |
T |
A |
7: 12,704,689 (GRCm39) |
C293S |
probably damaging |
Het |
Zfp747l1 |
T |
C |
7: 126,984,626 (GRCm39) |
K159E |
probably benign |
Het |
Zscan4c |
A |
T |
7: 10,743,819 (GRCm39) |
I473F |
possibly damaging |
Het |
|
Other mutations in Vmn2r3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01019:Vmn2r3
|
APN |
3 |
64,167,304 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01468:Vmn2r3
|
APN |
3 |
64,182,382 (GRCm39) |
missense |
possibly damaging |
0.57 |
IGL02032:Vmn2r3
|
APN |
3 |
64,182,476 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL02405:Vmn2r3
|
APN |
3 |
64,178,620 (GRCm39) |
splice site |
probably benign |
|
IGL02640:Vmn2r3
|
APN |
3 |
64,194,816 (GRCm39) |
missense |
probably benign |
|
IGL02719:Vmn2r3
|
APN |
3 |
64,183,031 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02746:Vmn2r3
|
APN |
3 |
64,167,239 (GRCm39) |
missense |
possibly damaging |
0.74 |
IGL02952:Vmn2r3
|
APN |
3 |
64,186,256 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03390:Vmn2r3
|
APN |
3 |
64,182,767 (GRCm39) |
missense |
possibly damaging |
0.55 |
G1citation:Vmn2r3
|
UTSW |
3 |
64,194,876 (GRCm39) |
missense |
probably benign |
0.30 |
R0023:Vmn2r3
|
UTSW |
3 |
64,182,787 (GRCm39) |
missense |
probably damaging |
0.99 |
R0433:Vmn2r3
|
UTSW |
3 |
64,183,054 (GRCm39) |
missense |
possibly damaging |
0.51 |
R0647:Vmn2r3
|
UTSW |
3 |
64,183,046 (GRCm39) |
missense |
probably damaging |
1.00 |
R1071:Vmn2r3
|
UTSW |
3 |
64,182,697 (GRCm39) |
missense |
possibly damaging |
0.79 |
R1536:Vmn2r3
|
UTSW |
3 |
64,182,538 (GRCm39) |
missense |
probably damaging |
1.00 |
R1806:Vmn2r3
|
UTSW |
3 |
64,194,810 (GRCm39) |
missense |
possibly damaging |
0.73 |
R1806:Vmn2r3
|
UTSW |
3 |
64,182,893 (GRCm39) |
missense |
probably benign |
0.03 |
R1852:Vmn2r3
|
UTSW |
3 |
64,166,815 (GRCm39) |
missense |
probably damaging |
1.00 |
R1868:Vmn2r3
|
UTSW |
3 |
64,166,537 (GRCm39) |
missense |
probably damaging |
1.00 |
R2072:Vmn2r3
|
UTSW |
3 |
64,182,493 (GRCm39) |
missense |
possibly damaging |
0.87 |
R2240:Vmn2r3
|
UTSW |
3 |
64,166,483 (GRCm39) |
missense |
probably benign |
0.44 |
R2446:Vmn2r3
|
UTSW |
3 |
64,182,733 (GRCm39) |
missense |
probably damaging |
0.98 |
R4133:Vmn2r3
|
UTSW |
3 |
64,183,138 (GRCm39) |
missense |
probably damaging |
0.99 |
R4159:Vmn2r3
|
UTSW |
3 |
64,194,850 (GRCm39) |
nonsense |
probably null |
|
R4494:Vmn2r3
|
UTSW |
3 |
64,182,692 (GRCm39) |
missense |
probably damaging |
1.00 |
R4860:Vmn2r3
|
UTSW |
3 |
64,183,022 (GRCm39) |
missense |
probably benign |
0.00 |
R4895:Vmn2r3
|
UTSW |
3 |
64,167,182 (GRCm39) |
missense |
probably benign |
0.00 |
R4912:Vmn2r3
|
UTSW |
3 |
64,166,618 (GRCm39) |
missense |
probably damaging |
1.00 |
R5018:Vmn2r3
|
UTSW |
3 |
64,178,774 (GRCm39) |
missense |
probably benign |
|
R5033:Vmn2r3
|
UTSW |
3 |
64,167,220 (GRCm39) |
missense |
probably benign |
0.09 |
R5126:Vmn2r3
|
UTSW |
3 |
64,166,740 (GRCm39) |
missense |
probably damaging |
1.00 |
R5148:Vmn2r3
|
UTSW |
3 |
64,186,247 (GRCm39) |
missense |
probably damaging |
1.00 |
R5414:Vmn2r3
|
UTSW |
3 |
64,166,978 (GRCm39) |
nonsense |
probably null |
|
R5785:Vmn2r3
|
UTSW |
3 |
64,166,444 (GRCm39) |
missense |
possibly damaging |
0.89 |
R5905:Vmn2r3
|
UTSW |
3 |
64,182,698 (GRCm39) |
missense |
probably benign |
0.19 |
R5992:Vmn2r3
|
UTSW |
3 |
64,167,068 (GRCm39) |
missense |
probably damaging |
1.00 |
R6028:Vmn2r3
|
UTSW |
3 |
64,182,698 (GRCm39) |
missense |
probably benign |
0.19 |
R6331:Vmn2r3
|
UTSW |
3 |
64,186,182 (GRCm39) |
missense |
probably damaging |
1.00 |
R6378:Vmn2r3
|
UTSW |
3 |
64,182,517 (GRCm39) |
missense |
probably damaging |
1.00 |
R6775:Vmn2r3
|
UTSW |
3 |
64,183,039 (GRCm39) |
missense |
possibly damaging |
0.88 |
R6822:Vmn2r3
|
UTSW |
3 |
64,194,876 (GRCm39) |
missense |
probably benign |
0.30 |
R6826:Vmn2r3
|
UTSW |
3 |
64,182,327 (GRCm39) |
nonsense |
probably null |
|
R6886:Vmn2r3
|
UTSW |
3 |
64,166,927 (GRCm39) |
missense |
probably damaging |
1.00 |
R6971:Vmn2r3
|
UTSW |
3 |
64,166,668 (GRCm39) |
missense |
probably damaging |
0.99 |
R7154:Vmn2r3
|
UTSW |
3 |
64,194,732 (GRCm39) |
missense |
probably benign |
0.02 |
R7192:Vmn2r3
|
UTSW |
3 |
64,167,364 (GRCm39) |
missense |
probably benign |
0.24 |
R7282:Vmn2r3
|
UTSW |
3 |
64,168,825 (GRCm39) |
missense |
possibly damaging |
0.90 |
R7472:Vmn2r3
|
UTSW |
3 |
64,182,953 (GRCm39) |
missense |
probably benign |
0.00 |
R7563:Vmn2r3
|
UTSW |
3 |
64,182,770 (GRCm39) |
missense |
possibly damaging |
0.60 |
R7726:Vmn2r3
|
UTSW |
3 |
64,182,939 (GRCm39) |
nonsense |
probably null |
|
R7966:Vmn2r3
|
UTSW |
3 |
64,186,235 (GRCm39) |
missense |
probably damaging |
0.99 |
R8025:Vmn2r3
|
UTSW |
3 |
64,182,871 (GRCm39) |
missense |
possibly damaging |
0.91 |
R8050:Vmn2r3
|
UTSW |
3 |
64,178,714 (GRCm39) |
missense |
probably damaging |
0.99 |
R8300:Vmn2r3
|
UTSW |
3 |
64,182,347 (GRCm39) |
missense |
probably benign |
0.00 |
R8402:Vmn2r3
|
UTSW |
3 |
64,178,617 (GRCm39) |
splice site |
probably benign |
|
R8486:Vmn2r3
|
UTSW |
3 |
64,186,370 (GRCm39) |
missense |
probably damaging |
1.00 |
R8523:Vmn2r3
|
UTSW |
3 |
64,182,311 (GRCm39) |
missense |
probably benign |
0.03 |
R8678:Vmn2r3
|
UTSW |
3 |
64,166,896 (GRCm39) |
missense |
possibly damaging |
0.76 |
R8885:Vmn2r3
|
UTSW |
3 |
64,182,383 (GRCm39) |
missense |
probably benign |
0.00 |
R8886:Vmn2r3
|
UTSW |
3 |
64,194,892 (GRCm39) |
missense |
possibly damaging |
0.47 |
R8905:Vmn2r3
|
UTSW |
3 |
64,166,695 (GRCm39) |
missense |
probably damaging |
0.99 |
R8937:Vmn2r3
|
UTSW |
3 |
64,166,673 (GRCm39) |
missense |
probably damaging |
1.00 |
R8955:Vmn2r3
|
UTSW |
3 |
64,168,803 (GRCm39) |
missense |
possibly damaging |
0.56 |
R9485:Vmn2r3
|
UTSW |
3 |
64,183,046 (GRCm39) |
missense |
probably damaging |
1.00 |
R9575:Vmn2r3
|
UTSW |
3 |
64,178,735 (GRCm39) |
missense |
probably benign |
0.01 |
R9618:Vmn2r3
|
UTSW |
3 |
64,178,724 (GRCm39) |
missense |
probably damaging |
0.98 |
X0022:Vmn2r3
|
UTSW |
3 |
64,182,389 (GRCm39) |
missense |
probably damaging |
1.00 |
X0022:Vmn2r3
|
UTSW |
3 |
64,178,669 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
Predicted Primers |
PCR Primer
(F):5'- AGTGACATAGTTGATCCTCCTGCTC -3'
(R):5'- CCAAATGTAGTAGCATAAAACTGAGGC -3'
Sequencing Primer
(F):5'- CTCCTGCTCCAATAATTCCAATTAG -3'
(R):5'- AAAACTGAGGCACCTGTTGTTCC -3'
|
Posted On |
2022-02-07 |