Incidental Mutation 'R9172:Kif24'
ID 696455
Institutional Source Beutler Lab
Gene Symbol Kif24
Ensembl Gene ENSMUSG00000028438
Gene Name kinesin family member 24
Synonyms 4933425J19Rik
MMRRC Submission
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9172 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 41390745-41464887 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 41400442 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 499 (T499A)
Ref Sequence ENSEMBL: ENSMUSP00000103690 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000030148] [ENSMUST00000108055]
AlphaFold Q6NWW5
Predicted Effect probably benign
Transcript: ENSMUST00000030148
AA Change: T365A

PolyPhen 2 Score 0.215 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000030148
Gene: ENSMUSG00000028438
AA Change: T365A

DomainStartEndE-ValueType
KISc 216 413 2.51e-29 SMART
low complexity region 481 499 N/A INTRINSIC
low complexity region 563 574 N/A INTRINSIC
low complexity region 626 644 N/A INTRINSIC
low complexity region 678 695 N/A INTRINSIC
low complexity region 1119 1130 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108055
AA Change: T499A

PolyPhen 2 Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000103690
Gene: ENSMUSG00000028438
AA Change: T499A

DomainStartEndE-ValueType
Blast:KISc 82 205 1e-47 BLAST
KISc 216 547 3.09e-134 SMART
low complexity region 615 633 N/A INTRINSIC
low complexity region 697 708 N/A INTRINSIC
low complexity region 760 778 N/A INTRINSIC
low complexity region 812 829 N/A INTRINSIC
low complexity region 1253 1264 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (63/63)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Kinesins, such as KIF24, are microtubule-dependent ATPases that function as molecular motors. They play important roles in intracellular vesicle transport and cell division (summary by Venturelli et al., 2010 [PubMed 20670673]).[supplied by OMIM, Feb 2011]
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Accsl A T 2: 93,691,833 (GRCm39) L332Q probably damaging Het
Adcy1 A G 11: 7,110,317 (GRCm39) N855D probably damaging Het
Adgrl3 T A 5: 81,922,251 (GRCm39) C1199S probably benign Het
Alyref G A 11: 120,486,842 (GRCm39) R140C probably benign Het
Arhgap26 A T 18: 39,378,382 (GRCm39) I92F probably damaging Het
Atp9b G A 18: 80,960,993 (GRCm39) R73* probably null Het
Btaf1 G A 19: 36,977,630 (GRCm39) A1483T probably damaging Het
Cmtr2 T C 8: 110,948,761 (GRCm39) L357P probably damaging Het
Commd7 A T 2: 153,470,474 (GRCm39) L51Q possibly damaging Het
Cpd T A 11: 76,675,252 (GRCm39) I1290L probably benign Het
Cry2 C A 2: 92,243,993 (GRCm39) E393D probably damaging Het
Ctsm A T 13: 61,685,643 (GRCm39) M74K Het
Dnai7 A G 6: 145,123,175 (GRCm39) F564L probably benign Het
Dync2h1 T C 9: 7,031,771 (GRCm39) Y3491C probably damaging Het
Erc1 A C 6: 119,801,842 (GRCm39) N58K possibly damaging Het
Fbxw21 T C 9: 108,975,764 (GRCm39) T211A probably benign Het
Fcsk A G 8: 111,610,557 (GRCm39) W949R probably damaging Het
Fry T C 5: 150,336,793 (GRCm39) V1388A probably benign Het
Gca T G 2: 62,520,368 (GRCm39) I176S probably damaging Het
Gimap7 A T 6: 48,700,761 (GRCm39) K116* probably null Het
Gm40460 ACAACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG ACAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG 7: 141,794,447 (GRCm39) probably benign Het
Gm9195 A C 14: 72,711,154 (GRCm39) L428R probably damaging Het
Grin2b A G 6: 135,756,255 (GRCm39) I490T possibly damaging Het
Mbtps1 G A 8: 120,260,108 (GRCm39) T413I probably damaging Het
Med4 A T 14: 73,751,365 (GRCm39) S105C probably benign Het
Mgat1 G A 11: 49,151,910 (GRCm39) R131Q probably damaging Het
Mroh4 T C 15: 74,477,961 (GRCm39) *984W probably null Het
Mybpc1 T C 10: 88,379,615 (GRCm39) E628G possibly damaging Het
Myh8 C T 11: 67,183,260 (GRCm39) P713L possibly damaging Het
Myo7a T C 7: 97,732,369 (GRCm39) D706G probably benign Het
Nbas T A 12: 13,424,751 (GRCm39) C997S possibly damaging Het
Nkx2-1 C A 12: 56,581,752 (GRCm39) G32C probably damaging Het
Npas3 A G 12: 54,112,653 (GRCm39) T466A probably benign Het
Opa1 C T 16: 29,439,232 (GRCm39) R683C probably benign Het
Opa3 C T 7: 18,989,466 (GRCm39) R110C probably damaging Het
Or5p63 T C 7: 107,811,169 (GRCm39) E189G probably benign Het
Or8k38 T A 2: 86,487,879 (GRCm39) I308L probably benign Het
Ppfibp2 T A 7: 107,337,525 (GRCm39) L609* probably null Het
Pygo2 T A 3: 89,340,617 (GRCm39) D338E possibly damaging Het
Pzp A T 6: 128,502,172 (GRCm39) M59K probably benign Het
Reln A G 5: 22,155,815 (GRCm39) probably null Het
Ripor1 A G 8: 106,347,833 (GRCm39) D1097G unknown Het
Rmdn3 T C 2: 118,968,863 (GRCm39) K443E probably benign Het
Rnf145 A G 11: 44,448,262 (GRCm39) D373G possibly damaging Het
Sec23b A T 2: 144,401,179 (GRCm39) E13D probably benign Het
Semp2l1 G T 1: 32,585,165 (GRCm39) H248Q probably benign Het
Slc39a6 A G 18: 24,715,399 (GRCm39) F707S probably damaging Het
Sox11 G A 12: 27,391,536 (GRCm39) A291V possibly damaging Het
Spart T A 3: 55,032,267 (GRCm39) V367D possibly damaging Het
Spata31e3 A G 13: 50,401,417 (GRCm39) F303S probably benign Het
Strap A T 6: 137,718,365 (GRCm39) K156N probably benign Het
Stxbp5 T A 10: 9,645,152 (GRCm39) I951F possibly damaging Het
Taar7a T C 10: 23,868,677 (GRCm39) I235V probably benign Het
Tek T A 4: 94,692,583 (GRCm39) N230K probably benign Het
Tyw1 T A 5: 130,325,520 (GRCm39) C469* probably null Het
Vcan T C 13: 89,828,050 (GRCm39) H3132R probably damaging Het
Vmn2r24 A G 6: 123,783,432 (GRCm39) D544G probably damaging Het
Vmn2r3 A T 3: 64,186,403 (GRCm39) M94K possibly damaging Het
Vps33a T C 5: 123,674,604 (GRCm39) T388A probably benign Het
Vta1 A G 10: 14,551,743 (GRCm39) I152T probably damaging Het
Vtcn1 A G 3: 100,799,865 (GRCm39) D242G probably benign Het
Zfp12 T A 5: 143,231,220 (GRCm39) C548S probably damaging Het
Zfp263 A G 16: 3,567,323 (GRCm39) D546G probably benign Het
Zfp324 T A 7: 12,704,689 (GRCm39) C293S probably damaging Het
Zfp747l1 T C 7: 126,984,626 (GRCm39) K159E probably benign Het
Zscan4c A T 7: 10,743,819 (GRCm39) I473F possibly damaging Het
Other mutations in Kif24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00509:Kif24 APN 4 41,413,826 (GRCm39) splice site probably null
IGL00787:Kif24 APN 4 41,397,583 (GRCm39) missense probably damaging 1.00
IGL01065:Kif24 APN 4 41,423,639 (GRCm39) unclassified probably benign
IGL01716:Kif24 APN 4 41,393,454 (GRCm39) missense probably benign 0.40
IGL01796:Kif24 APN 4 41,392,978 (GRCm39) unclassified probably benign
IGL02307:Kif24 APN 4 41,395,274 (GRCm39) missense probably benign 0.02
IGL03061:Kif24 APN 4 41,394,323 (GRCm39) missense possibly damaging 0.86
IGL03080:Kif24 APN 4 41,394,417 (GRCm39) missense probably benign 0.12
IGL03100:Kif24 APN 4 41,394,446 (GRCm39) missense possibly damaging 0.59
R0226:Kif24 UTSW 4 41,414,939 (GRCm39) nonsense probably null
R0345:Kif24 UTSW 4 41,428,413 (GRCm39) missense probably benign 0.01
R0365:Kif24 UTSW 4 41,428,731 (GRCm39) missense probably benign 0.06
R0366:Kif24 UTSW 4 41,428,717 (GRCm39) missense possibly damaging 0.77
R0579:Kif24 UTSW 4 41,393,706 (GRCm39) missense probably damaging 0.97
R0682:Kif24 UTSW 4 41,428,620 (GRCm39) missense probably benign 0.01
R1611:Kif24 UTSW 4 41,423,552 (GRCm39) missense probably benign 0.02
R1634:Kif24 UTSW 4 41,393,529 (GRCm39) missense probably benign 0.02
R1772:Kif24 UTSW 4 41,409,787 (GRCm39) missense probably damaging 1.00
R1997:Kif24 UTSW 4 41,392,904 (GRCm39) missense possibly damaging 0.92
R3833:Kif24 UTSW 4 41,395,064 (GRCm39) missense probably damaging 1.00
R3849:Kif24 UTSW 4 41,404,734 (GRCm39) missense probably damaging 1.00
R4356:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4357:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4358:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4359:Kif24 UTSW 4 41,413,827 (GRCm39) critical splice donor site probably null
R4406:Kif24 UTSW 4 41,393,954 (GRCm39) missense probably damaging 1.00
R4580:Kif24 UTSW 4 41,395,287 (GRCm39) missense probably damaging 1.00
R4756:Kif24 UTSW 4 41,397,545 (GRCm39) critical splice donor site probably null
R4921:Kif24 UTSW 4 41,394,329 (GRCm39) missense probably damaging 0.99
R4935:Kif24 UTSW 4 41,394,939 (GRCm39) missense probably damaging 0.99
R5288:Kif24 UTSW 4 41,395,373 (GRCm39) missense probably benign 0.09
R5398:Kif24 UTSW 4 41,394,401 (GRCm39) missense possibly damaging 0.50
R5885:Kif24 UTSW 4 41,423,463 (GRCm39) missense probably damaging 1.00
R5901:Kif24 UTSW 4 41,428,604 (GRCm39) missense probably damaging 1.00
R5919:Kif24 UTSW 4 41,394,477 (GRCm39) missense possibly damaging 0.62
R5945:Kif24 UTSW 4 41,428,670 (GRCm39) nonsense probably null
R6278:Kif24 UTSW 4 41,423,498 (GRCm39) missense probably damaging 1.00
R6291:Kif24 UTSW 4 41,413,959 (GRCm39) missense probably damaging 1.00
R6891:Kif24 UTSW 4 41,394,168 (GRCm39) missense probably benign 0.33
R7178:Kif24 UTSW 4 41,395,085 (GRCm39) missense probably benign 0.00
R7437:Kif24 UTSW 4 41,404,687 (GRCm39) missense possibly damaging 0.70
R7453:Kif24 UTSW 4 41,394,673 (GRCm39) missense possibly damaging 0.91
R7543:Kif24 UTSW 4 41,413,993 (GRCm39) nonsense probably null
R7548:Kif24 UTSW 4 41,423,601 (GRCm39) missense possibly damaging 0.57
R8167:Kif24 UTSW 4 41,392,957 (GRCm39) missense possibly damaging 0.87
R8305:Kif24 UTSW 4 41,428,825 (GRCm39) missense probably damaging 1.00
R8407:Kif24 UTSW 4 41,394,488 (GRCm39) missense probably benign 0.05
R8722:Kif24 UTSW 4 41,394,233 (GRCm39) missense probably benign
R8916:Kif24 UTSW 4 41,394,963 (GRCm39) missense probably benign 0.23
R9093:Kif24 UTSW 4 41,428,691 (GRCm39) missense probably benign
R9468:Kif24 UTSW 4 41,404,794 (GRCm39) missense probably damaging 1.00
R9687:Kif24 UTSW 4 41,428,546 (GRCm39) missense probably damaging 0.99
Z1088:Kif24 UTSW 4 41,395,091 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ACACAGAGAGTTCCTGGAGG -3'
(R):5'- ACAGGGCAGTTGTCTTTCTC -3'

Sequencing Primer
(F):5'- TGGAGGGAAAATGACACCTACCTTC -3'
(R):5'- GGTGCTTGAAACTAAACTCTGGTCTC -3'
Posted On 2022-02-07