Incidental Mutation 'R9175:Vmn2r107'
| ID |
696644 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r107
|
| Ensembl Gene |
ENSMUSG00000056910 |
| Gene Name |
vomeronasal 2, receptor 107 |
| Synonyms |
V2r6 |
| MMRRC Submission |
068948-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.117)
|
| Stock # |
R9175 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
20565687-20596034 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 20577051 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 350
(I350F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000048706
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000042090]
|
| AlphaFold |
E9PZJ7 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000042090
AA Change: I350F
PolyPhen 2
Score 0.793 (Sensitivity: 0.85; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000048706
Gene: ENSMUSG00000056910
AA Change: I350F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
466 |
3.6e-40 |
PFAM |
|
Pfam:NCD3G
|
509 |
562 |
5.1e-21 |
PFAM |
|
Pfam:7tm_3
|
593 |
830 |
8e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 48 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2900092C05Rik |
G |
A |
7: 12,249,412 (GRCm39) |
D82N |
probably benign |
Het |
| Abca13 |
A |
G |
11: 9,531,593 (GRCm39) |
K4607E |
probably damaging |
Het |
| Agpat4 |
G |
C |
17: 12,417,669 (GRCm39) |
G70A |
probably damaging |
Het |
| Ank2 |
G |
A |
3: 126,722,402 (GRCm39) |
T1017I |
possibly damaging |
Het |
| C2cd2 |
T |
C |
16: 97,678,421 (GRCm39) |
I339V |
probably benign |
Het |
| Cacna1a |
A |
T |
8: 85,296,644 (GRCm39) |
N1221Y |
probably damaging |
Het |
| Cacna1e |
A |
G |
1: 154,274,314 (GRCm39) |
V2197A |
probably damaging |
Het |
| Ccdc74a |
T |
C |
16: 17,468,042 (GRCm39) |
S101P |
probably benign |
Het |
| Cdh13 |
A |
T |
8: 119,968,968 (GRCm39) |
I442F |
probably damaging |
Het |
| Cnot2 |
A |
T |
10: 116,334,051 (GRCm39) |
M373K |
possibly damaging |
Het |
| Coch |
C |
A |
12: 51,645,060 (GRCm39) |
H205N |
possibly damaging |
Het |
| Col6a4 |
A |
G |
9: 105,957,560 (GRCm39) |
V88A |
probably benign |
Het |
| Erich3 |
A |
G |
3: 154,419,601 (GRCm39) |
T35A |
probably benign |
Het |
| Gm28360 |
A |
T |
1: 117,781,328 (GRCm39) |
K106N |
possibly damaging |
Het |
| Hps4 |
G |
A |
5: 112,525,905 (GRCm39) |
S642N |
possibly damaging |
Het |
| Hspg2 |
T |
C |
4: 137,256,657 (GRCm39) |
F1467L |
probably damaging |
Het |
| Ighg2c |
T |
C |
12: 113,252,499 (GRCm39) |
T18A |
|
Het |
| Iqcm |
A |
G |
8: 76,710,867 (GRCm39) |
K472E |
possibly damaging |
Het |
| Kcnk5 |
A |
T |
14: 20,192,117 (GRCm39) |
V348D |
probably benign |
Het |
| Kcns3 |
C |
T |
12: 11,169,801 (GRCm39) |
|
probably benign |
Het |
| Klk15 |
C |
T |
7: 43,587,790 (GRCm39) |
H73Y |
possibly damaging |
Het |
| Muc5ac |
A |
G |
7: 141,366,093 (GRCm39) |
D2787G |
possibly damaging |
Het |
| Nasp |
A |
G |
4: 116,471,576 (GRCm39) |
C84R |
probably damaging |
Het |
| Nfia |
G |
A |
4: 97,671,362 (GRCm39) |
R24H |
probably damaging |
Het |
| Opa3 |
C |
T |
7: 18,989,466 (GRCm39) |
R110C |
probably damaging |
Het |
| Or2t48 |
T |
C |
11: 58,420,590 (GRCm39) |
D74G |
probably damaging |
Het |
| Or8k25 |
A |
G |
2: 86,244,099 (GRCm39) |
I99T |
probably benign |
Het |
| Pdia4 |
A |
C |
6: 47,775,417 (GRCm39) |
S464R |
possibly damaging |
Het |
| Rab3gap2 |
A |
G |
1: 185,009,360 (GRCm39) |
D1092G |
probably damaging |
Het |
| Rev3l |
A |
G |
10: 39,730,764 (GRCm39) |
K2763E |
possibly damaging |
Het |
| Sanbr |
A |
T |
11: 23,534,518 (GRCm39) |
|
probably null |
Het |
| Sorbs1 |
A |
T |
19: 40,315,018 (GRCm39) |
L598Q |
probably damaging |
Het |
| Sppl2b |
A |
T |
10: 80,698,807 (GRCm39) |
M154L |
probably benign |
Het |
| Stk33 |
A |
G |
7: 108,920,724 (GRCm39) |
I331T |
probably damaging |
Het |
| Strip2 |
A |
G |
6: 29,933,035 (GRCm39) |
E494G |
probably benign |
Het |
| Supt6 |
C |
T |
11: 78,112,052 (GRCm39) |
R1010Q |
possibly damaging |
Het |
| Tada1 |
G |
A |
1: 166,210,005 (GRCm39) |
R69H |
probably damaging |
Het |
| Tent4a |
A |
G |
13: 69,663,915 (GRCm39) |
L268P |
probably damaging |
Het |
| Tmco1 |
C |
T |
1: 167,136,132 (GRCm39) |
|
probably benign |
Het |
| Tomm34 |
A |
G |
2: 163,912,385 (GRCm39) |
|
probably null |
Het |
| Tpi1 |
T |
C |
6: 124,788,871 (GRCm39) |
T223A |
probably damaging |
Het |
| Trpc3 |
T |
A |
3: 36,709,279 (GRCm39) |
N399I |
probably benign |
Het |
| Vgll2 |
A |
G |
10: 51,903,635 (GRCm39) |
H166R |
probably damaging |
Het |
| Vmn2r114 |
T |
A |
17: 23,527,212 (GRCm39) |
K440M |
probably damaging |
Het |
| Vmn2r55 |
T |
C |
7: 12,385,793 (GRCm39) |
Y729C |
possibly damaging |
Het |
| Zfp106 |
G |
T |
2: 120,353,197 (GRCm39) |
A1554E |
probably damaging |
Het |
| Zfyve27 |
A |
G |
19: 42,169,997 (GRCm39) |
Y176C |
probably damaging |
Het |
| Zswim5 |
T |
A |
4: 116,822,941 (GRCm39) |
N470K |
probably benign |
Het |
|
| Other mutations in Vmn2r107 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01402:Vmn2r107
|
APN |
17 |
20,596,009 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01768:Vmn2r107
|
APN |
17 |
20,565,868 (GRCm39) |
missense |
probably benign |
0.32 |
|
IGL02086:Vmn2r107
|
APN |
17 |
20,578,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02136:Vmn2r107
|
APN |
17 |
20,595,168 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02266:Vmn2r107
|
APN |
17 |
20,577,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02285:Vmn2r107
|
APN |
17 |
20,595,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02724:Vmn2r107
|
APN |
17 |
20,577,006 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02998:Vmn2r107
|
APN |
17 |
20,578,017 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03089:Vmn2r107
|
APN |
17 |
20,595,974 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03284:Vmn2r107
|
APN |
17 |
20,577,173 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL03307:Vmn2r107
|
APN |
17 |
20,577,038 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03399:Vmn2r107
|
APN |
17 |
20,578,220 (GRCm39) |
splice site |
probably benign |
|
|
3-1:Vmn2r107
|
UTSW |
17 |
20,565,766 (GRCm39) |
missense |
probably benign |
|
|
BB006:Vmn2r107
|
UTSW |
17 |
20,565,706 (GRCm39) |
missense |
probably null |
0.96 |
|
BB016:Vmn2r107
|
UTSW |
17 |
20,565,706 (GRCm39) |
missense |
probably null |
0.96 |
|
R0285:Vmn2r107
|
UTSW |
17 |
20,565,873 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0455:Vmn2r107
|
UTSW |
17 |
20,595,085 (GRCm39) |
splice site |
probably benign |
|
|
R0497:Vmn2r107
|
UTSW |
17 |
20,595,394 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0506:Vmn2r107
|
UTSW |
17 |
20,578,021 (GRCm39) |
missense |
probably benign |
|
|
R0621:Vmn2r107
|
UTSW |
17 |
20,595,252 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0667:Vmn2r107
|
UTSW |
17 |
20,575,916 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1118:Vmn2r107
|
UTSW |
17 |
20,576,860 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1204:Vmn2r107
|
UTSW |
17 |
20,578,031 (GRCm39) |
missense |
probably benign |
|
|
R1237:Vmn2r107
|
UTSW |
17 |
20,576,947 (GRCm39) |
nonsense |
probably null |
|
|
R1485:Vmn2r107
|
UTSW |
17 |
20,595,109 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1783:Vmn2r107
|
UTSW |
17 |
20,576,775 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1873:Vmn2r107
|
UTSW |
17 |
20,565,840 (GRCm39) |
missense |
probably benign |
0.10 |
|
R1974:Vmn2r107
|
UTSW |
17 |
20,575,879 (GRCm39) |
splice site |
probably null |
|
|
R2009:Vmn2r107
|
UTSW |
17 |
20,595,729 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2029:Vmn2r107
|
UTSW |
17 |
20,595,549 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2164:Vmn2r107
|
UTSW |
17 |
20,595,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Vmn2r107
|
UTSW |
17 |
20,595,817 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R3087:Vmn2r107
|
UTSW |
17 |
20,580,607 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3740:Vmn2r107
|
UTSW |
17 |
20,595,151 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3961:Vmn2r107
|
UTSW |
17 |
20,595,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4031:Vmn2r107
|
UTSW |
17 |
20,595,483 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4270:Vmn2r107
|
UTSW |
17 |
20,576,041 (GRCm39) |
missense |
probably benign |
|
|
R4963:Vmn2r107
|
UTSW |
17 |
20,595,403 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5121:Vmn2r107
|
UTSW |
17 |
20,576,015 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5640:Vmn2r107
|
UTSW |
17 |
20,595,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6007:Vmn2r107
|
UTSW |
17 |
20,595,316 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6238:Vmn2r107
|
UTSW |
17 |
20,565,849 (GRCm39) |
missense |
probably benign |
0.43 |
|
R6298:Vmn2r107
|
UTSW |
17 |
20,576,044 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6467:Vmn2r107
|
UTSW |
17 |
20,595,939 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6726:Vmn2r107
|
UTSW |
17 |
20,595,637 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6782:Vmn2r107
|
UTSW |
17 |
20,577,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7299:Vmn2r107
|
UTSW |
17 |
20,565,878 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7301:Vmn2r107
|
UTSW |
17 |
20,565,878 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7375:Vmn2r107
|
UTSW |
17 |
20,576,138 (GRCm39) |
missense |
probably benign |
|
|
R7448:Vmn2r107
|
UTSW |
17 |
20,595,994 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7495:Vmn2r107
|
UTSW |
17 |
20,595,271 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R7589:Vmn2r107
|
UTSW |
17 |
20,595,634 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7594:Vmn2r107
|
UTSW |
17 |
20,580,635 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7678:Vmn2r107
|
UTSW |
17 |
20,576,901 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7929:Vmn2r107
|
UTSW |
17 |
20,565,706 (GRCm39) |
missense |
probably null |
0.96 |
|
R7974:Vmn2r107
|
UTSW |
17 |
20,577,270 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8040:Vmn2r107
|
UTSW |
17 |
20,595,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8263:Vmn2r107
|
UTSW |
17 |
20,580,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8426:Vmn2r107
|
UTSW |
17 |
20,577,239 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9537:Vmn2r107
|
UTSW |
17 |
20,595,149 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9642:Vmn2r107
|
UTSW |
17 |
20,580,661 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9711:Vmn2r107
|
UTSW |
17 |
20,577,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0022:Vmn2r107
|
UTSW |
17 |
20,577,230 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTCTAATGCGAAATATTGGGC -3'
(R):5'- GTCTCATCTCATGGAGGCTG -3'
Sequencing Primer
(F):5'- ATTGGGCAAAGGTTATTGACATGGC -3'
(R):5'- CTCATCTCATGGAGGCTGTGAGC -3'
|
| Posted On |
2022-02-07 |
Incidental Mutation