Incidental Mutation 'R9176:Tpp2'
| ID |
696649 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tpp2
|
| Ensembl Gene |
ENSMUSG00000041763 |
| Gene Name |
tripeptidyl peptidase II |
| Synonyms |
TppII |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.589)
|
| Stock # |
R9176 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
43973130-44042160 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 44031553 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Aspartic acid
at position 1124
(N1124D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000085244
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087933]
[ENSMUST00000188302]
[ENSMUST00000188313]
[ENSMUST00000189388]
[ENSMUST00000190207]
|
| AlphaFold |
Q64514 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000087933
AA Change: N1124D
PolyPhen 2
Score 0.294 (Sensitivity: 0.91; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000085244
Gene: ENSMUSG00000041763
AA Change: N1124D
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
35 |
500 |
1.4e-96 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
777 |
964 |
2.4e-80 |
PFAM |
|
low complexity region
|
1017 |
1033 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1034 |
1262 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000188302
|
| SMART Domains |
Protein: ENSMUSP00000140474
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
4.3e-84 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000188313
AA Change: N1111D
PolyPhen 2
Score 0.686 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000139918
Gene: ENSMUSG00000041763
AA Change: N1111D
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
5.1e-83 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
966 |
2.7e-93 |
PFAM |
|
low complexity region
|
1004 |
1020 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
1021 |
1249 |
1e-20 |
PDB |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000189388
|
| SMART Domains |
Protein: ENSMUSP00000140562
Gene: ENSMUSG00000041763
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Peptidase_S8
|
39 |
509 |
2.3e-81 |
PFAM |
|
low complexity region
|
674 |
685 |
N/A |
INTRINSIC |
|
Pfam:TPPII
|
773 |
880 |
7.8e-49 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000190207
AA Change: N177D
PolyPhen 2
Score 0.916 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000140313
Gene: ENSMUSG00000041763
AA Change: N177D
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
70 |
86 |
N/A |
INTRINSIC |
|
PDB:3LXU|X
|
87 |
281 |
3e-19 |
PDB |
|
| Meta Mutation Damage Score |
0.0715 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
100% (70/70) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
PHENOTYPE: Engineered mutations of this gene result in decreased lifespan and symptoms of immunohematopoietic senescence. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700001J03Rik |
T |
C |
5: 146,121,004 (GRCm39) |
D119G |
probably damaging |
Het |
| 1700123K08Rik |
T |
C |
5: 138,561,155 (GRCm39) |
D169G |
probably damaging |
Het |
| Abcd2 |
T |
G |
15: 91,075,623 (GRCm39) |
R63S |
probably benign |
Het |
| Ankrd55 |
T |
C |
13: 112,459,610 (GRCm39) |
V68A |
possibly damaging |
Het |
| Avil |
T |
C |
10: 126,852,248 (GRCm39) |
Y678H |
probably damaging |
Het |
| Bltp1 |
T |
A |
3: 37,010,852 (GRCm39) |
V1750E |
possibly damaging |
Het |
| Cd300ld2 |
C |
A |
11: 114,904,772 (GRCm39) |
E32* |
probably null |
Het |
| Chuk |
A |
T |
19: 44,076,442 (GRCm39) |
L423Q |
probably damaging |
Het |
| Cisd3 |
A |
G |
11: 97,579,127 (GRCm39) |
T90A |
probably damaging |
Het |
| Cmpk2 |
T |
A |
12: 26,524,027 (GRCm39) |
S275T |
probably benign |
Het |
| Cntnap5c |
T |
A |
17: 58,620,730 (GRCm39) |
N936K |
probably damaging |
Het |
| Col15a1 |
G |
C |
4: 47,288,200 (GRCm39) |
|
probably benign |
Het |
| Col4a4 |
G |
T |
1: 82,463,349 (GRCm39) |
P1047Q |
unknown |
Het |
| Col6a4 |
A |
G |
9: 105,938,755 (GRCm39) |
L1321P |
probably damaging |
Het |
| Crat |
A |
G |
2: 30,297,892 (GRCm39) |
F211L |
probably damaging |
Het |
| Csmd3 |
T |
C |
15: 47,864,937 (GRCm39) |
Q27R |
|
Het |
| Dapk1 |
T |
C |
13: 60,866,262 (GRCm39) |
V205A |
probably damaging |
Het |
| Ddx20 |
T |
C |
3: 105,586,158 (GRCm39) |
N729S |
probably benign |
Het |
| Derl2 |
A |
G |
11: 70,904,376 (GRCm39) |
V139A |
possibly damaging |
Het |
| Dscam |
C |
T |
16: 96,486,553 (GRCm39) |
D1041N |
probably benign |
Het |
| Fbxo2 |
A |
T |
4: 148,250,147 (GRCm39) |
R226W |
probably damaging |
Het |
| Fhip1b |
A |
C |
7: 105,030,585 (GRCm39) |
H180Q |
probably benign |
Het |
| Fhip2b |
T |
C |
14: 70,826,540 (GRCm39) |
K183E |
probably benign |
Het |
| Gpr19 |
A |
G |
6: 134,846,718 (GRCm39) |
S322P |
probably damaging |
Het |
| Gvin2 |
T |
C |
7: 105,551,262 (GRCm39) |
K597E |
possibly damaging |
Het |
| Herc6 |
A |
G |
6: 57,636,663 (GRCm39) |
N793S |
probably benign |
Het |
| Ikbke |
A |
T |
1: 131,191,025 (GRCm39) |
S563T |
probably benign |
Het |
| Il1r2 |
T |
C |
1: 40,144,478 (GRCm39) |
L55P |
probably damaging |
Het |
| Klhl8 |
C |
A |
5: 104,012,111 (GRCm39) |
A575S |
probably benign |
Het |
| Lims1 |
T |
G |
10: 58,254,265 (GRCm39) |
C340G |
probably damaging |
Het |
| Loxl3 |
G |
A |
6: 83,026,292 (GRCm39) |
C460Y |
probably damaging |
Het |
| Mapk9 |
T |
A |
11: 49,763,565 (GRCm39) |
L152* |
probably null |
Het |
| Mef2d |
T |
C |
3: 88,066,463 (GRCm39) |
V144A |
possibly damaging |
Het |
| Mertk |
A |
G |
2: 128,620,892 (GRCm39) |
D578G |
possibly damaging |
Het |
| Mettl1 |
C |
A |
10: 126,881,250 (GRCm39) |
Q254K |
probably benign |
Het |
| Naip2 |
T |
C |
13: 100,298,707 (GRCm39) |
E443G |
probably damaging |
Het |
| Ndor1 |
A |
G |
2: 25,138,241 (GRCm39) |
F484L |
probably damaging |
Het |
| Neurl1b |
C |
T |
17: 26,660,055 (GRCm39) |
T425I |
possibly damaging |
Het |
| Nomo1 |
G |
A |
7: 45,730,828 (GRCm39) |
V1104M |
possibly damaging |
Het |
| Or13a19 |
G |
T |
7: 139,903,121 (GRCm39) |
G170C |
probably damaging |
Het |
| Or13p8 |
T |
A |
4: 118,583,850 (GRCm39) |
Y135* |
probably null |
Het |
| Or4c10b |
T |
C |
2: 89,711,515 (GRCm39) |
V115A |
probably benign |
Het |
| Or5b95 |
A |
G |
19: 12,657,600 (GRCm39) |
M43V |
probably benign |
Het |
| Or5p57 |
A |
G |
7: 107,665,246 (GRCm39) |
V223A |
probably benign |
Het |
| Or8g20 |
T |
A |
9: 39,396,247 (GRCm39) |
M98L |
probably benign |
Het |
| Or9i2 |
A |
G |
19: 13,815,796 (GRCm39) |
V247A |
probably damaging |
Het |
| Parp4 |
A |
G |
14: 56,873,274 (GRCm39) |
K1173E |
possibly damaging |
Het |
| Phkb |
T |
A |
8: 86,697,623 (GRCm39) |
N477K |
probably damaging |
Het |
| Plekha7 |
T |
G |
7: 115,739,926 (GRCm39) |
I812L |
possibly damaging |
Het |
| Plxnb1 |
A |
G |
9: 108,941,651 (GRCm39) |
T1711A |
probably damaging |
Het |
| Polg |
A |
G |
7: 79,109,857 (GRCm39) |
V382A |
probably benign |
Het |
| Pomt2 |
T |
A |
12: 87,194,451 (GRCm39) |
|
probably benign |
Het |
| Prdm1 |
T |
C |
10: 44,316,123 (GRCm39) |
H671R |
probably damaging |
Het |
| Prkca |
G |
A |
11: 107,870,244 (GRCm39) |
R15C |
possibly damaging |
Het |
| Prkch |
T |
A |
12: 73,746,968 (GRCm39) |
N282K |
probably damaging |
Het |
| Ptpn6 |
T |
C |
6: 124,702,249 (GRCm39) |
R385G |
probably benign |
Het |
| Rad21 |
A |
T |
15: 51,841,455 (GRCm39) |
M87K |
probably damaging |
Het |
| Safb2 |
ACTTCTTCT |
ACTTCT |
17: 56,878,292 (GRCm39) |
|
probably benign |
Het |
| Scn1a |
A |
T |
2: 66,103,689 (GRCm39) |
V1857E |
probably damaging |
Het |
| Shprh |
A |
G |
10: 11,036,320 (GRCm39) |
T386A |
probably benign |
Het |
| Slco1b2 |
T |
C |
6: 141,598,229 (GRCm39) |
L94P |
probably damaging |
Het |
| Snx29 |
A |
G |
16: 11,236,728 (GRCm39) |
N90D |
probably benign |
Het |
| Stt3a |
A |
T |
9: 36,662,592 (GRCm39) |
H222Q |
probably damaging |
Het |
| Tbc1d5 |
T |
C |
17: 51,089,363 (GRCm39) |
T584A |
probably benign |
Het |
| Tktl2 |
T |
C |
8: 66,964,664 (GRCm39) |
V74A |
probably damaging |
Het |
| Trpv1 |
A |
T |
11: 73,130,481 (GRCm39) |
T196S |
probably benign |
Het |
| Ulk4 |
T |
C |
9: 120,974,128 (GRCm39) |
E968G |
probably benign |
Het |
| Zbtb8a |
G |
T |
4: 129,254,221 (GRCm39) |
T91K |
probably damaging |
Het |
| Zfp317 |
T |
A |
9: 19,559,163 (GRCm39) |
V459E |
probably damaging |
Het |
| Zfp790 |
A |
G |
7: 29,529,387 (GRCm39) |
T691A |
probably benign |
Het |
|
| Other mutations in Tpp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00977:Tpp2
|
APN |
1 |
44,022,451 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01021:Tpp2
|
APN |
1 |
43,973,347 (GRCm39) |
nonsense |
probably null |
|
|
IGL01096:Tpp2
|
APN |
1 |
44,000,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01344:Tpp2
|
APN |
1 |
44,022,422 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01642:Tpp2
|
APN |
1 |
43,993,813 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02719:Tpp2
|
APN |
1 |
43,979,391 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02890:Tpp2
|
APN |
1 |
44,038,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03102:Tpp2
|
APN |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03175:Tpp2
|
APN |
1 |
44,012,671 (GRCm39) |
missense |
probably benign |
0.35 |
|
beaver
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
billingsly
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
cleaver
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
dow
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
Eddie
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
jerry
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
June
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
landers
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
mathers
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
recurrentis
|
UTSW |
1 |
44,031,553 (GRCm39) |
missense |
probably null |
0.29 |
|
state
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
wally
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
Ward
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
wilson
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
BB010:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB020:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0001:Tpp2
|
UTSW |
1 |
44,010,886 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0003:Tpp2
|
UTSW |
1 |
43,999,299 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Tpp2
|
UTSW |
1 |
44,020,908 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R0110:Tpp2
|
UTSW |
1 |
44,017,664 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0110:Tpp2
|
UTSW |
1 |
44,038,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0167:Tpp2
|
UTSW |
1 |
44,009,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0441:Tpp2
|
UTSW |
1 |
44,029,722 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0520:Tpp2
|
UTSW |
1 |
44,029,690 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0639:Tpp2
|
UTSW |
1 |
44,014,607 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1118:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1119:Tpp2
|
UTSW |
1 |
44,031,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1593:Tpp2
|
UTSW |
1 |
44,014,593 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1702:Tpp2
|
UTSW |
1 |
44,029,708 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1756:Tpp2
|
UTSW |
1 |
44,017,885 (GRCm39) |
splice site |
probably null |
|
|
R2066:Tpp2
|
UTSW |
1 |
44,017,598 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R2171:Tpp2
|
UTSW |
1 |
43,996,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2378:Tpp2
|
UTSW |
1 |
44,038,925 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2394:Tpp2
|
UTSW |
1 |
44,022,346 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2507:Tpp2
|
UTSW |
1 |
44,040,609 (GRCm39) |
missense |
probably benign |
0.31 |
|
R2879:Tpp2
|
UTSW |
1 |
44,010,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3436:Tpp2
|
UTSW |
1 |
43,979,304 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4106:Tpp2
|
UTSW |
1 |
44,040,617 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4658:Tpp2
|
UTSW |
1 |
43,993,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4760:Tpp2
|
UTSW |
1 |
44,010,875 (GRCm39) |
missense |
probably benign |
0.08 |
|
R4963:Tpp2
|
UTSW |
1 |
44,031,428 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5049:Tpp2
|
UTSW |
1 |
44,040,633 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5073:Tpp2
|
UTSW |
1 |
43,993,896 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6010:Tpp2
|
UTSW |
1 |
43,990,373 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6118:Tpp2
|
UTSW |
1 |
43,979,306 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6155:Tpp2
|
UTSW |
1 |
43,995,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Tpp2
|
UTSW |
1 |
44,022,739 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6236:Tpp2
|
UTSW |
1 |
44,016,477 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6695:Tpp2
|
UTSW |
1 |
44,022,436 (GRCm39) |
missense |
probably benign |
|
|
R6845:Tpp2
|
UTSW |
1 |
44,017,668 (GRCm39) |
nonsense |
probably null |
|
|
R7054:Tpp2
|
UTSW |
1 |
44,022,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7094:Tpp2
|
UTSW |
1 |
44,008,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7223:Tpp2
|
UTSW |
1 |
44,008,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7316:Tpp2
|
UTSW |
1 |
44,009,591 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7324:Tpp2
|
UTSW |
1 |
44,017,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7363:Tpp2
|
UTSW |
1 |
44,024,582 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7454:Tpp2
|
UTSW |
1 |
43,993,819 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7496:Tpp2
|
UTSW |
1 |
44,022,677 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7699:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7700:Tpp2
|
UTSW |
1 |
44,009,626 (GRCm39) |
missense |
probably benign |
|
|
R7804:Tpp2
|
UTSW |
1 |
44,022,441 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7933:Tpp2
|
UTSW |
1 |
44,000,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7979:Tpp2
|
UTSW |
1 |
43,979,297 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8032:Tpp2
|
UTSW |
1 |
44,014,628 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R8101:Tpp2
|
UTSW |
1 |
44,009,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tpp2
|
UTSW |
1 |
44,022,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8314:Tpp2
|
UTSW |
1 |
43,973,387 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8518:Tpp2
|
UTSW |
1 |
44,019,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Tpp2
|
UTSW |
1 |
44,016,365 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8529:Tpp2
|
UTSW |
1 |
44,022,300 (GRCm39) |
missense |
probably benign |
|
|
R8756:Tpp2
|
UTSW |
1 |
43,999,295 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Tpp2
|
UTSW |
1 |
44,011,849 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8773:Tpp2
|
UTSW |
1 |
44,009,552 (GRCm39) |
splice site |
probably benign |
|
|
R8915:Tpp2
|
UTSW |
1 |
44,016,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9049:Tpp2
|
UTSW |
1 |
43,992,502 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9090:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9214:Tpp2
|
UTSW |
1 |
44,031,514 (GRCm39) |
missense |
probably benign |
|
|
R9271:Tpp2
|
UTSW |
1 |
43,993,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9316:Tpp2
|
UTSW |
1 |
44,017,604 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9371:Tpp2
|
UTSW |
1 |
43,999,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9422:Tpp2
|
UTSW |
1 |
44,017,897 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9488:Tpp2
|
UTSW |
1 |
44,041,272 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9513:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9514:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9516:Tpp2
|
UTSW |
1 |
44,017,648 (GRCm39) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACATGCAGTTTCACGGCTGG -3'
(R):5'- CAAACTTTATATGCCCCAGTACAG -3'
Sequencing Primer
(F):5'- ATGCTGCCAATGCTGTT -3'
(R):5'- CCAGTACAGGGGAATGCC -3'
|
| Posted On |
2022-02-07 |
Incidental Mutation