Incidental Mutation 'R9178:Zfp580'
ID 696815
Institutional Source Beutler Lab
Gene Symbol Zfp580
Ensembl Gene ENSMUSG00000055633
Gene Name zinc finger protein 580
Synonyms 1500015O20Rik
MMRRC Submission 068978-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9178 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 5054537-5056722 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 5056152 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Alanine at position 171 (S171A)
Ref Sequence ENSEMBL: ENSMUSP00000147223 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045543] [ENSMUST00000069324] [ENSMUST00000108571] [ENSMUST00000207215] [ENSMUST00000207974] [ENSMUST00000208042] [ENSMUST00000208570] [ENSMUST00000208161] [ENSMUST00000208728]
AlphaFold Q9DB38
Predicted Effect probably benign
Transcript: ENSMUST00000045543
SMART Domains Protein: ENSMUSP00000041033
Gene: ENSMUSG00000035228

DomainStartEndE-ValueType
coiled coil region 62 101 N/A INTRINSIC
Predicted Effect possibly damaging
Transcript: ENSMUST00000069324
AA Change: S113A

PolyPhen 2 Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000065861
Gene: ENSMUSG00000055633
AA Change: S113A

DomainStartEndE-ValueType
low complexity region 2 30 N/A INTRINSIC
ZnF_C2H2 92 114 3.39e-3 SMART
ZnF_C2H2 120 142 1.18e-2 SMART
ZnF_C2H2 150 172 1.04e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108571
SMART Domains Protein: ENSMUSP00000104211
Gene: ENSMUSG00000035228

DomainStartEndE-ValueType
Pfam:CCDC106 117 337 1.4e-100 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207215
Predicted Effect probably benign
Transcript: ENSMUST00000207974
Predicted Effect probably benign
Transcript: ENSMUST00000208042
Predicted Effect possibly damaging
Transcript: ENSMUST00000208570
AA Change: S171A

PolyPhen 2 Score 0.705 (Sensitivity: 0.86; Specificity: 0.92)
Predicted Effect probably benign
Transcript: ENSMUST00000208161
Predicted Effect probably benign
Transcript: ENSMUST00000208728
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (74/74)
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930563M21Rik T A 9: 55,880,992 (GRCm39) T146S unknown Het
Abca8b A T 11: 109,840,937 (GRCm39) F1079I probably benign Het
Adcy10 A T 1: 165,403,218 (GRCm39) Q1572L possibly damaging Het
Akna T C 4: 63,312,846 (GRCm39) T426A possibly damaging Het
Alkbh8 A G 9: 3,338,448 (GRCm39) probably benign Het
Apc2 G A 10: 80,150,235 (GRCm39) G1763E probably benign Het
Bmp1 G T 14: 70,727,613 (GRCm39) R657S possibly damaging Het
Calm1 G A 12: 100,171,979 (GRCm39) probably null Het
Ccdc150 C A 1: 54,311,644 (GRCm39) A210E probably damaging Het
Cdc42bpa T C 1: 179,958,401 (GRCm39) I275T Het
Cfap54 G T 10: 92,830,579 (GRCm39) Q1186K probably benign Het
Col6a6 A G 9: 105,659,169 (GRCm39) V592A probably benign Het
Colec11 A T 12: 28,644,854 (GRCm39) N213K possibly damaging Het
Dennd2b C T 7: 109,156,291 (GRCm39) G153D probably benign Het
Dennd5b G A 6: 148,934,844 (GRCm39) R676* probably null Het
Dnaaf5 T G 5: 139,138,652 (GRCm39) Y278D probably damaging Het
Dop1a T A 9: 86,371,796 (GRCm39) Y162* probably null Het
Dync1li2 A G 8: 105,150,255 (GRCm39) L369P possibly damaging Het
Ebf1 A G 11: 44,883,276 (GRCm39) T505A probably benign Het
Ebf1 A G 11: 44,895,548 (GRCm39) I584M probably benign Het
Eif1ad17 A G 12: 87,978,786 (GRCm39) R57G probably damaging Het
Frmpd1 T C 4: 45,285,367 (GRCm39) L1396P probably damaging Het
Gart A T 16: 91,430,904 (GRCm39) V386D possibly damaging Het
Gprin1 C T 13: 54,885,601 (GRCm39) R891H probably damaging Het
Gsap G A 5: 21,422,471 (GRCm39) V147I probably damaging Het
Gsc G T 12: 104,439,120 (GRCm39) Y85* probably null Het
Gtf2a1l A G 17: 88,976,152 (GRCm39) N5S Het
Hmcn2 T C 2: 31,281,521 (GRCm39) V1912A possibly damaging Het
Icos G T 1: 61,034,714 (GRCm39) S179I probably damaging Het
Ifi209 T C 1: 173,464,969 (GRCm39) L33P probably damaging Het
Igsf10 A G 3: 59,233,480 (GRCm39) I1751T possibly damaging Het
Il31ra T C 13: 112,677,780 (GRCm39) Y252C probably damaging Het
Ints6 A T 14: 62,947,036 (GRCm39) S310T probably damaging Het
Kcng1 A T 2: 168,111,105 (GRCm39) S20T possibly damaging Het
Klf15 T C 6: 90,444,091 (GRCm39) I222T probably damaging Het
Lmo7 A T 14: 102,044,906 (GRCm39) K53* probably null Het
Map10 C A 8: 126,397,649 (GRCm39) N347K probably damaging Het
Mrps11 C A 7: 78,440,444 (GRCm39) T111K probably damaging Het
Myom3 T G 4: 135,506,710 (GRCm39) D494E probably benign Het
Naalad2 T A 9: 18,242,152 (GRCm39) Y584F probably damaging Het
Ndufa9 A G 6: 126,826,050 (GRCm39) V9A probably benign Het
Nrcam G T 12: 44,615,329 (GRCm39) V640F possibly damaging Het
Or10x4 C T 1: 174,219,229 (GRCm39) T198I probably benign Het
Or2t48 C A 11: 58,420,473 (GRCm39) G113V probably damaging Het
Or52d1 T C 7: 103,755,720 (GRCm39) M78T probably benign Het
Or5ak23 G A 2: 85,244,848 (GRCm39) A125V probably damaging Het
Pcdhga8 T A 18: 37,860,892 (GRCm39) H649Q probably benign Het
Pdk1 C A 2: 71,730,402 (GRCm39) H413Q probably benign Het
Pfkm T A 15: 98,027,161 (GRCm39) H611Q probably damaging Het
Polr3g T C 13: 81,842,535 (GRCm39) Y160C unknown Het
Ppargc1b A T 18: 61,443,993 (GRCm39) M406K probably benign Het
Ptf1a C T 2: 19,450,536 (GRCm39) probably benign Het
Rc3h2 A T 2: 37,295,264 (GRCm39) C251S possibly damaging Het
Rnf32 A G 5: 29,411,211 (GRCm39) T166A possibly damaging Het
Sav1 A T 12: 70,022,790 (GRCm39) V254E probably damaging Het
Sel1l T C 12: 91,797,526 (GRCm39) N234D probably benign Het
Setd1a C T 7: 127,385,590 (GRCm39) P766S possibly damaging Het
Skida1 T A 2: 18,050,489 (GRCm39) K801* probably null Het
Slc22a5 G A 11: 53,774,547 (GRCm39) T146I probably benign Het
Slc25a24 G T 3: 109,064,268 (GRCm39) A206S possibly damaging Het
Slc39a6 G A 18: 24,733,970 (GRCm39) R240W probably damaging Het
Ssc5d T A 7: 4,930,058 (GRCm39) D46E probably damaging Het
Tekt4 C T 17: 25,690,901 (GRCm39) A69V possibly damaging Het
Tmigd1 T A 11: 76,804,878 (GRCm39) F239Y probably benign Het
Tpp1 T A 7: 105,400,846 (GRCm39) R60S probably benign Het
Trank1 A T 9: 111,196,268 (GRCm39) I1431F probably damaging Het
Trav15-1-dv6-1 G T 14: 53,797,519 (GRCm39) W56L probably damaging Het
Ugt2b38 A G 5: 87,568,396 (GRCm39) S300P probably damaging Het
Urah T A 7: 140,417,587 (GRCm39) L119Q unknown Het
Uspl1 T A 5: 149,141,148 (GRCm39) F382L probably damaging Het
Vps9d1 T A 8: 123,975,574 (GRCm39) Q157L probably damaging Het
Wbp1l G A 19: 46,640,933 (GRCm39) V88I probably benign Het
Zfp444 T C 7: 6,191,157 (GRCm39) S113P probably damaging Het
Zfp607a A G 7: 27,577,382 (GRCm39) I151V probably benign Het
Zfp827 T C 8: 79,818,564 (GRCm39) F614S probably damaging Het
Zic4 A T 9: 91,260,913 (GRCm39) Q56L possibly damaging Het
Other mutations in Zfp580
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01154:Zfp580 APN 7 5,056,267 (GRCm39) missense possibly damaging 0.64
R1580:Zfp580 UTSW 7 5,056,284 (GRCm39) missense probably damaging 1.00
R2120:Zfp580 UTSW 7 5,056,008 (GRCm39) missense probably damaging 0.99
R2167:Zfp580 UTSW 7 5,056,063 (GRCm39) missense possibly damaging 0.79
R5793:Zfp580 UTSW 7 5,055,891 (GRCm39) intron probably benign
R8192:Zfp580 UTSW 7 5,056,114 (GRCm39) missense probably benign 0.41
R8872:Zfp580 UTSW 7 5,056,216 (GRCm39) missense possibly damaging 0.93
R9226:Zfp580 UTSW 7 5,056,137 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- ATCTGCTCATCGACGCCAAC -3'
(R):5'- CCTAGGGTAAGGCAGTAACCTCAG -3'

Sequencing Primer
(F):5'- AACGGGGTCCCCTACAC -3'
(R):5'- AGGGCTGAGCTCAGTGCAG -3'
Posted On 2022-02-07