Incidental Mutation 'R9180:Vmn2r104'
| ID |
696992 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r104
|
| Ensembl Gene |
ENSMUSG00000090315 |
| Gene Name |
vomeronasal 2, receptor 104 |
| Synonyms |
V2r7 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.108)
|
| Stock # |
R9180 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
20249687-20268467 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 20263087 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 125
(T125A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129895
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168050]
|
| AlphaFold |
E9Q2J5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168050
AA Change: T125A
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000129895
Gene: ENSMUSG00000090315
AA Change: T125A
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
85 |
457 |
4e-38 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
2.1e-20 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
1.7e-52 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 77 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930579F01Rik |
G |
A |
3: 137,889,470 (GRCm39) |
P49L |
probably benign |
Het |
| Adam34l |
T |
A |
8: 44,079,970 (GRCm39) |
R85* |
probably null |
Het |
| Anapc2 |
C |
T |
2: 25,163,303 (GRCm39) |
T180I |
probably benign |
Het |
| Ankib1 |
A |
T |
5: 3,756,276 (GRCm39) |
H556Q |
probably damaging |
Het |
| Aox1 |
A |
T |
1: 58,378,777 (GRCm39) |
K1009* |
probably null |
Het |
| Apob |
C |
T |
12: 8,047,925 (GRCm39) |
P968L |
probably damaging |
Het |
| Bpi |
T |
A |
2: 158,116,608 (GRCm39) |
F335Y |
probably benign |
Het |
| Cabcoco1 |
T |
C |
10: 68,272,719 (GRCm39) |
Y222C |
probably damaging |
Het |
| Camk2b |
G |
T |
11: 5,939,332 (GRCm39) |
C273* |
probably null |
Het |
| Catsperd |
G |
A |
17: 56,968,252 (GRCm39) |
D546N |
probably benign |
Het |
| Cenpb |
C |
T |
2: 131,021,463 (GRCm39) |
G112S |
probably damaging |
Het |
| Col6a5 |
A |
G |
9: 105,739,178 (GRCm39) |
L2585P |
probably damaging |
Het |
| Cop1 |
A |
G |
1: 159,147,339 (GRCm39) |
E555G |
probably damaging |
Het |
| Coro1b |
T |
C |
19: 4,203,392 (GRCm39) |
V411A |
probably benign |
Het |
| Cyfip2 |
G |
A |
11: 46,176,920 (GRCm39) |
R87C |
probably damaging |
Het |
| Dthd1 |
A |
C |
5: 63,045,410 (GRCm39) |
I725L |
probably benign |
Het |
| Dydc1 |
A |
C |
14: 40,800,054 (GRCm39) |
E20A |
probably damaging |
Het |
| Ermp1 |
T |
C |
19: 29,609,845 (GRCm39) |
I317V |
probably benign |
Het |
| Fat4 |
A |
G |
3: 38,942,556 (GRCm39) |
N483S |
possibly damaging |
Het |
| Fbxo33 |
A |
G |
12: 59,251,095 (GRCm39) |
|
probably null |
Het |
| Fcgbp |
G |
T |
7: 27,803,198 (GRCm39) |
E1601* |
probably null |
Het |
| Fer1l5 |
A |
T |
1: 36,449,999 (GRCm39) |
S1118C |
probably null |
Het |
| Fer1l6 |
T |
C |
15: 58,494,230 (GRCm39) |
V1141A |
probably benign |
Het |
| Flnb |
C |
T |
14: 7,818,219 (GRCm38) |
T23M |
probably damaging |
Het |
| Fsip2 |
T |
C |
2: 82,815,574 (GRCm39) |
L3769P |
possibly damaging |
Het |
| Gna11 |
T |
C |
10: 81,370,942 (GRCm39) |
K98R |
|
Het |
| Gpat3 |
A |
T |
5: 101,032,230 (GRCm39) |
T176S |
probably benign |
Het |
| Gprc5b |
A |
G |
7: 118,583,542 (GRCm39) |
L109P |
probably damaging |
Het |
| Hadha |
A |
T |
5: 30,340,038 (GRCm39) |
N246K |
probably benign |
Het |
| Haus3 |
G |
A |
5: 34,324,835 (GRCm39) |
Q275* |
probably null |
Het |
| Higd1b |
A |
G |
11: 102,728,090 (GRCm39) |
Y44C |
possibly damaging |
Het |
| Igkv1-131 |
T |
C |
6: 67,743,218 (GRCm39) |
K55R |
probably benign |
Het |
| Igtp |
G |
T |
11: 58,098,091 (GRCm39) |
E421* |
probably null |
Het |
| Kcnk3 |
G |
T |
5: 30,745,532 (GRCm39) |
|
probably benign |
Het |
| Krtap4-13 |
A |
T |
11: 99,700,165 (GRCm39) |
C165S |
unknown |
Het |
| Lrfn4 |
T |
C |
19: 4,663,353 (GRCm39) |
R394G |
probably benign |
Het |
| Lrrc7 |
A |
C |
3: 157,867,011 (GRCm39) |
L910R |
possibly damaging |
Het |
| Mbtd1 |
A |
G |
11: 93,823,218 (GRCm39) |
D568G |
probably damaging |
Het |
| Mettl16 |
T |
A |
11: 74,693,826 (GRCm39) |
I279N |
probably benign |
Het |
| Mmrn2 |
A |
G |
14: 34,121,158 (GRCm39) |
H676R |
probably benign |
Het |
| Mrgprg |
T |
C |
7: 143,318,350 (GRCm39) |
K254R |
probably benign |
Het |
| Muc16 |
A |
C |
9: 18,554,038 (GRCm39) |
V4085G |
unknown |
Het |
| Mvp |
T |
C |
7: 126,591,822 (GRCm39) |
Q456R |
probably benign |
Het |
| Myf6 |
T |
C |
10: 107,329,318 (GRCm39) |
D209G |
probably benign |
Het |
| Ociad1 |
A |
G |
5: 73,467,725 (GRCm39) |
D167G |
probably benign |
Het |
| Or11l3 |
A |
G |
11: 58,516,062 (GRCm39) |
L270P |
probably benign |
Het |
| Or1l4 |
A |
G |
2: 37,091,292 (GRCm39) |
D13G |
probably benign |
Het |
| Or51f23b |
T |
A |
7: 102,402,734 (GRCm39) |
Y134F |
probably damaging |
Het |
| Or5m3 |
T |
G |
2: 85,838,325 (GRCm39) |
D68E |
probably damaging |
Het |
| Or6c1b |
T |
C |
10: 129,272,858 (GRCm39) |
F59S |
probably damaging |
Het |
| Phf20 |
A |
G |
2: 156,114,537 (GRCm39) |
D295G |
probably benign |
Het |
| Pkd1l3 |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
GACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCAACAAACATGACATCAGACACACCTGCATCCAGCAGCCCA |
8: 110,350,827 (GRCm39) |
|
probably benign |
Het |
| Ppp1r13b |
A |
T |
12: 111,811,416 (GRCm39) |
H157Q |
probably benign |
Het |
| Prss3b |
A |
G |
6: 41,008,681 (GRCm39) |
L211P |
probably damaging |
Het |
| Rbm26 |
C |
T |
14: 105,391,039 (GRCm39) |
R149H |
unknown |
Het |
| Reg3d |
C |
T |
6: 78,355,443 (GRCm39) |
C16Y |
possibly damaging |
Het |
| Rrp36 |
A |
G |
17: 46,978,980 (GRCm39) |
F193L |
possibly damaging |
Het |
| Rtca |
A |
T |
3: 116,282,905 (GRCm39) |
M361K |
probably benign |
Het |
| Ryr3 |
T |
G |
2: 112,491,981 (GRCm39) |
D3790A |
probably damaging |
Het |
| Serpina3n |
C |
A |
12: 104,377,440 (GRCm39) |
A231E |
probably benign |
Het |
| Sh2d2a |
A |
G |
3: 87,759,070 (GRCm39) |
D224G |
possibly damaging |
Het |
| Sh3bp2 |
A |
T |
5: 34,718,377 (GRCm39) |
K526* |
probably null |
Het |
| Slc12a2 |
A |
G |
18: 58,069,469 (GRCm39) |
T1017A |
possibly damaging |
Het |
| Slc12a8 |
T |
C |
16: 33,361,397 (GRCm39) |
L93P |
probably damaging |
Het |
| Slc5a6 |
A |
G |
5: 31,195,190 (GRCm39) |
I469T |
probably damaging |
Het |
| Smarcc1 |
T |
A |
9: 109,964,728 (GRCm39) |
V95D |
probably damaging |
Het |
| Snap29 |
T |
A |
16: 17,224,163 (GRCm39) |
S59R |
probably damaging |
Het |
| Tmem121b |
T |
A |
6: 120,469,784 (GRCm39) |
Y311F |
probably damaging |
Het |
| Tpcn1 |
C |
A |
5: 120,694,000 (GRCm39) |
V199L |
probably benign |
Het |
| Ttn |
T |
C |
2: 76,618,721 (GRCm39) |
I16188V |
probably benign |
Het |
| Usp24 |
T |
C |
4: 106,216,247 (GRCm39) |
I366T |
possibly damaging |
Het |
| Utrn |
T |
A |
10: 12,545,463 (GRCm39) |
E1727D |
probably damaging |
Het |
| Vav2 |
T |
C |
2: 27,182,701 (GRCm39) |
D301G |
probably damaging |
Het |
| Vmn2r73 |
T |
G |
7: 85,507,123 (GRCm39) |
I730L |
probably benign |
Het |
| Zfp352 |
A |
T |
4: 90,113,118 (GRCm39) |
K419N |
probably benign |
Het |
| Zfp84 |
C |
A |
7: 29,474,873 (GRCm39) |
S48R |
probably damaging |
Het |
| Zfp947 |
A |
T |
17: 22,364,386 (GRCm39) |
H429Q |
probably damaging |
Het |
|
| Other mutations in Vmn2r104 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00427:Vmn2r104
|
APN |
17 |
20,258,501 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01098:Vmn2r104
|
APN |
17 |
20,268,358 (GRCm39) |
missense |
probably benign |
0.27 |
|
IGL01333:Vmn2r104
|
APN |
17 |
20,263,055 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01527:Vmn2r104
|
APN |
17 |
20,263,158 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01773:Vmn2r104
|
APN |
17 |
20,260,930 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01939:Vmn2r104
|
APN |
17 |
20,250,187 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02121:Vmn2r104
|
APN |
17 |
20,262,056 (GRCm39) |
nonsense |
probably null |
|
|
IGL02305:Vmn2r104
|
APN |
17 |
20,263,118 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02374:Vmn2r104
|
APN |
17 |
20,263,048 (GRCm39) |
missense |
probably benign |
0.34 |
|
IGL03260:Vmn2r104
|
APN |
17 |
20,263,083 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03366:Vmn2r104
|
APN |
17 |
20,249,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0091:Vmn2r104
|
UTSW |
17 |
20,262,075 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0125:Vmn2r104
|
UTSW |
17 |
20,250,069 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0257:Vmn2r104
|
UTSW |
17 |
20,249,889 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0381:Vmn2r104
|
UTSW |
17 |
20,268,264 (GRCm39) |
nonsense |
probably null |
|
|
R0709:Vmn2r104
|
UTSW |
17 |
20,263,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0786:Vmn2r104
|
UTSW |
17 |
20,262,987 (GRCm39) |
missense |
probably benign |
|
|
R1575:Vmn2r104
|
UTSW |
17 |
20,262,477 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1827:Vmn2r104
|
UTSW |
17 |
20,262,497 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1932:Vmn2r104
|
UTSW |
17 |
20,261,031 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1956:Vmn2r104
|
UTSW |
17 |
20,262,313 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2203:Vmn2r104
|
UTSW |
17 |
20,250,083 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2205:Vmn2r104
|
UTSW |
17 |
20,250,083 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2859:Vmn2r104
|
UTSW |
17 |
20,268,455 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3701:Vmn2r104
|
UTSW |
17 |
20,249,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3834:Vmn2r104
|
UTSW |
17 |
20,250,183 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4151:Vmn2r104
|
UTSW |
17 |
20,250,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4470:Vmn2r104
|
UTSW |
17 |
20,262,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4625:Vmn2r104
|
UTSW |
17 |
20,268,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4754:Vmn2r104
|
UTSW |
17 |
20,261,030 (GRCm39) |
nonsense |
probably null |
|
|
R4911:Vmn2r104
|
UTSW |
17 |
20,250,288 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5270:Vmn2r104
|
UTSW |
17 |
20,258,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5279:Vmn2r104
|
UTSW |
17 |
20,262,146 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5311:Vmn2r104
|
UTSW |
17 |
20,250,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5370:Vmn2r104
|
UTSW |
17 |
20,250,450 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5461:Vmn2r104
|
UTSW |
17 |
20,250,343 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5683:Vmn2r104
|
UTSW |
17 |
20,260,981 (GRCm39) |
nonsense |
probably null |
|
|
R5795:Vmn2r104
|
UTSW |
17 |
20,250,544 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5795:Vmn2r104
|
UTSW |
17 |
20,250,372 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5970:Vmn2r104
|
UTSW |
17 |
20,249,733 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5983:Vmn2r104
|
UTSW |
17 |
20,261,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5992:Vmn2r104
|
UTSW |
17 |
20,249,747 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6066:Vmn2r104
|
UTSW |
17 |
20,258,573 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6156:Vmn2r104
|
UTSW |
17 |
20,261,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6182:Vmn2r104
|
UTSW |
17 |
20,250,507 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6245:Vmn2r104
|
UTSW |
17 |
20,261,829 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6333:Vmn2r104
|
UTSW |
17 |
20,249,848 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6573:Vmn2r104
|
UTSW |
17 |
20,262,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7101:Vmn2r104
|
UTSW |
17 |
20,250,358 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7123:Vmn2r104
|
UTSW |
17 |
20,261,088 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7485:Vmn2r104
|
UTSW |
17 |
20,249,737 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7514:Vmn2r104
|
UTSW |
17 |
20,249,791 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7634:Vmn2r104
|
UTSW |
17 |
20,261,971 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7958:Vmn2r104
|
UTSW |
17 |
20,262,988 (GRCm39) |
missense |
probably benign |
|
|
R8031:Vmn2r104
|
UTSW |
17 |
20,263,048 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8094:Vmn2r104
|
UTSW |
17 |
20,250,483 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8191:Vmn2r104
|
UTSW |
17 |
20,250,465 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8308:Vmn2r104
|
UTSW |
17 |
20,261,040 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R8691:Vmn2r104
|
UTSW |
17 |
20,262,110 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8795:Vmn2r104
|
UTSW |
17 |
20,262,988 (GRCm39) |
missense |
probably benign |
|
|
R8900:Vmn2r104
|
UTSW |
17 |
20,261,924 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8913:Vmn2r104
|
UTSW |
17 |
20,249,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9199:Vmn2r104
|
UTSW |
17 |
20,262,097 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9282:Vmn2r104
|
UTSW |
17 |
20,261,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9303:Vmn2r104
|
UTSW |
17 |
20,268,439 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9305:Vmn2r104
|
UTSW |
17 |
20,268,439 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9322:Vmn2r104
|
UTSW |
17 |
20,263,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9325:Vmn2r104
|
UTSW |
17 |
20,268,433 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9414:Vmn2r104
|
UTSW |
17 |
20,250,250 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9785:Vmn2r104
|
UTSW |
17 |
20,268,409 (GRCm39) |
missense |
probably benign |
|
|
RF007:Vmn2r104
|
UTSW |
17 |
20,268,302 (GRCm39) |
missense |
probably benign |
0.36 |
|
Z1177:Vmn2r104
|
UTSW |
17 |
20,250,051 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCTGAATTGATCTCCATGTGTCTG -3'
(R):5'- CTGCATACGTGTTTCTATGCG -3'
Sequencing Primer
(F):5'- TGACTGTCAGTAACCACAATCC -3'
(R):5'- ACGTGTTTCTATGCGATTTACACAGG -3'
|
| Posted On |
2022-02-07 |
Incidental Mutation