Incidental Mutation 'R9184:Kcnk15'
ID 697233
Institutional Source Beutler Lab
Gene Symbol Kcnk15
Ensembl Gene ENSMUSG00000035238
Gene Name potassium channel, subfamily K, member 15
Synonyms KCNK11, KT3.3, TASK5, KCNK14
MMRRC Submission 068979-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.097) question?
Stock # R9184 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 163695670-163700794 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 163700606 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 282 (V282M)
Ref Sequence ENSEMBL: ENSMUSP00000048326 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044734] [ENSMUST00000044798] [ENSMUST00000109396]
AlphaFold B2RVL1
Predicted Effect probably benign
Transcript: ENSMUST00000044734
SMART Domains Protein: ENSMUSP00000045637
Gene: ENSMUSG00000035226

DomainStartEndE-ValueType
C2 129 232 1.42e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000044798
AA Change: V282M

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000048326
Gene: ENSMUSG00000035238
AA Change: V282M

DomainStartEndE-ValueType
Pfam:Ion_trans_2 78 153 1.2e-20 PFAM
Pfam:Ion_trans_2 184 267 1.2e-19 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000109396
AA Change: V263M

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000105023
Gene: ENSMUSG00000035238
AA Change: V263M

DomainStartEndE-ValueType
Pfam:Ion_trans_2 62 134 5.2e-21 PFAM
Pfam:Ion_trans_2 165 248 1.6e-17 PFAM
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 97% (60/62)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030452D12Rik T C 8: 107,233,901 (GRCm39) V199A unknown Het
Abca7 A G 10: 79,838,690 (GRCm39) H621R probably damaging Het
Adam18 T A 8: 25,137,847 (GRCm39) N331I probably benign Het
Akt1 A G 12: 112,621,152 (GRCm39) S475P possibly damaging Het
Arc A G 15: 74,543,779 (GRCm39) V148A probably damaging Het
Atg2a T C 19: 6,291,887 (GRCm39) L21P probably damaging Het
Bltp2 T C 11: 78,162,214 (GRCm39) L692S probably damaging Het
C1qtnf2 T C 11: 43,365,180 (GRCm39) V25A probably benign Het
Cald1 G T 6: 34,730,512 (GRCm39) E244D unknown Het
Cdc42bpa T A 1: 179,972,301 (GRCm39) F1368I probably benign Het
Cfap61 G A 2: 145,919,308 (GRCm39) C680Y probably null Het
Chd1 T A 17: 15,962,551 (GRCm39) N769K possibly damaging Het
Clasp1 T A 1: 118,470,908 (GRCm39) V848E probably benign Het
Col15a1 G C 4: 47,288,200 (GRCm39) probably benign Het
Ctsb G T 14: 63,375,544 (GRCm39) G170V probably damaging Het
Dnah5 A G 15: 28,340,552 (GRCm39) K2320E probably benign Het
Fat4 A T 3: 39,036,592 (GRCm39) I3415F probably damaging Het
Fibcd1 A G 2: 31,706,488 (GRCm39) S448P probably damaging Het
Filip1 T C 9: 79,805,542 (GRCm39) K71E probably benign Het
Gad2 G A 2: 22,558,331 (GRCm39) V350I probably benign Het
Gigyf2 T A 1: 87,368,311 (GRCm39) S1032T possibly damaging Het
Glis3 T C 19: 28,509,007 (GRCm39) T326A probably damaging Het
Hspa9 C T 18: 35,082,168 (GRCm39) R146H possibly damaging Het
Jakmip2 A G 18: 43,715,352 (GRCm39) I58T probably benign Het
Klk1b8 A G 7: 43,602,158 (GRCm39) N30S probably benign Het
Lpin2 T A 17: 71,540,911 (GRCm39) Y454* probably null Het
Mcam T C 9: 44,046,545 (GRCm39) probably benign Het
Mms22l T C 4: 24,596,182 (GRCm39) L1047S probably damaging Het
Neb A G 2: 52,218,767 (GRCm39) I81T possibly damaging Het
Neurod4 A T 10: 130,106,958 (GRCm39) D105E probably damaging Het
Nlrp1b A G 11: 71,072,067 (GRCm39) L592P probably damaging Het
Nnt C A 13: 119,518,270 (GRCm39) K302N probably damaging Het
Notch4 T C 17: 34,806,364 (GRCm39) F1767S probably damaging Het
Or4c103 C A 2: 88,513,519 (GRCm39) A186S possibly damaging Het
Or4c58 T A 2: 89,675,294 (GRCm39) I8F probably benign Het
Or7g16 T C 9: 18,727,138 (GRCm39) I151V probably benign Het
Pcdhga4 A T 18: 37,820,460 (GRCm39) I670F possibly damaging Het
Pdp1 T C 4: 11,962,143 (GRCm39) E75G possibly damaging Het
Pds5b T A 5: 150,724,249 (GRCm39) N1275K probably benign Het
Pink1 G T 4: 138,048,321 (GRCm39) Q134K probably benign Het
Poli T A 18: 70,642,250 (GRCm39) H650L probably damaging Het
Prickle2 G A 6: 92,388,505 (GRCm39) P355L possibly damaging Het
Prkaca G A 8: 84,717,305 (GRCm39) G194D probably benign Het
Ptgs2 A T 1: 149,980,175 (GRCm39) Y371F probably damaging Het
Rarb T A 14: 16,818,882 (GRCm38) probably benign Het
Rarb C T 14: 16,818,881 (GRCm38) probably benign Het
Safb2 ACTTCTTCT ACTTCT 17: 56,878,292 (GRCm39) probably benign Het
Serpinb1b T G 13: 33,269,393 (GRCm39) V42G probably damaging Het
Sgsm2 T A 11: 74,782,834 (GRCm39) I41F possibly damaging Het
Slc26a5 T A 5: 22,018,880 (GRCm39) D653V probably damaging Het
Slc26a7 C T 4: 14,506,630 (GRCm39) V602M possibly damaging Het
Slu7 T C 11: 43,334,224 (GRCm39) S417P probably damaging Het
Smad2 T A 18: 76,422,171 (GRCm39) D194E probably benign Het
Sntg1 A T 1: 8,748,056 (GRCm39) V112E probably damaging Het
Strip1 A T 3: 107,521,979 (GRCm39) M733K probably benign Het
Szt2 G A 4: 118,241,726 (GRCm39) S1655L possibly damaging Het
Ttn A T 2: 76,599,949 (GRCm39) I19075N probably benign Het
Urb2 C T 8: 124,771,890 (GRCm39) T1437I probably benign Het
Vmn2r111 T A 17: 22,790,822 (GRCm39) I159F probably benign Het
Zfp78 T C 7: 6,382,300 (GRCm39) V450A probably damaging Het
Zmynd11 T A 13: 9,743,475 (GRCm39) H314L probably benign Het
Other mutations in Kcnk15
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0389:Kcnk15 UTSW 2 163,700,243 (GRCm39) missense probably benign 0.00
R0443:Kcnk15 UTSW 2 163,700,243 (GRCm39) missense probably benign 0.00
R1472:Kcnk15 UTSW 2 163,700,127 (GRCm39) missense probably damaging 1.00
R3722:Kcnk15 UTSW 2 163,700,214 (GRCm39) missense probably damaging 1.00
R3732:Kcnk15 UTSW 2 163,695,733 (GRCm39) missense probably benign 0.08
R3732:Kcnk15 UTSW 2 163,695,733 (GRCm39) missense probably benign 0.08
R4403:Kcnk15 UTSW 2 163,700,538 (GRCm39) missense probably damaging 1.00
R7090:Kcnk15 UTSW 2 163,700,637 (GRCm39) missense probably benign
R7588:Kcnk15 UTSW 2 163,700,226 (GRCm39) missense probably damaging 1.00
R8318:Kcnk15 UTSW 2 163,700,189 (GRCm39) missense probably damaging 1.00
R8987:Kcnk15 UTSW 2 163,700,217 (GRCm39) missense probably damaging 1.00
R9144:Kcnk15 UTSW 2 163,700,451 (GRCm39) missense probably benign 0.01
R9589:Kcnk15 UTSW 2 163,700,127 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCTCACCACCATAGGCTTCG -3'
(R):5'- TTGCTAACAGGAGGAGCTAGAC -3'

Sequencing Primer
(F):5'- ACCATAGGCTTCGGCGACTTC -3'
(R):5'- GAAGGACTATCAGATGGACTTCCTC -3'
Posted On 2022-02-07