Mutagenetix > Incidental Mutations

Incidental Mutation 'R9187:Olfr855'

697451

Institutional Source

Beutler Lab

Gene Symbol

Olfr855

Ensembl Gene

ENSMUSG00000043087

Gene Name

olfactory receptor 855

Synonyms

MOR148-1, GA_x6K02T2PVTD-13330461-13331399

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.157) question?

Stock #

R9187 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

19582617-19586030 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 19584654 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 39 (I39T)

Ref Sequence

ENSEMBL: ENSMUSP00000150218 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061693] [ENSMUST00000215587]

AlphaFold

Q7TRF8

Predicted Effect

probably benign
Transcript: ENSMUST00000061693
AA Change: I39T

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000054790
Gene: ENSMUSG00000043087
AA Change: I39T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	310	1.7e-54	PFAM
Pfam:7TM_GPCR_Srsx	37	182	5.2e-8	PFAM
Pfam:7tm_1	43	292	2.5e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215587
AA Change: I39T

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.5%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 74 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca5	A	G	11: 110,310,135		probably null	Het
Abcb1a	T	A	5: 8,715,016	C669S	probably benign	Het
Abcc3	A	G	11: 94,365,087	L524P	probably damaging	Het
Akap5	A	T	12: 76,329,971	K726*	probably null	Het
Aldh16a1	T	C	7: 45,142,017	E778G	probably damaging	Het
Ankle2	G	A	5: 110,252,744	V649M	possibly damaging	Het
Apon	A	G	10: 128,254,963	N170S	probably benign	Het
Baiap2l1	T	C	5: 144,280,954	Y274C	probably benign	Het
Bub1	A	T	2: 127,814,936	N425K	possibly damaging	Het
Camsap1	A	G	2: 25,930,016	C1487R	probably damaging	Het
Cd4	A	C	6: 124,867,688	V378G	probably damaging	Het
Cenpa	C	A	5: 30,667,036	P3Q	unknown	Het
Cfap65	T	A	1: 74,917,358	M1021L	probably benign	Het
Ddx39	G	T	8: 83,722,484	M300I	probably benign	Het
Dgkh	T	C	14: 78,595,161	R819G	probably damaging	Het
Dlc1	A	T	8: 36,938,632	M1K	probably null	Het
Dnah9	A	G	11: 66,005,146	W2468R	probably benign	Het
Ebag9	A	T	15: 44,640,310	K177I	probably damaging	Het
Ehbp1	T	C	11: 22,151,184	I249V	probably damaging	Het
Fam171b	T	C	2: 83,880,021	V679A	probably damaging	Het
Gabbr2	G	A	4: 46,674,533	T818I	probably damaging	Het
Gcn1l1	T	C	5: 115,614,118	S2098P	probably damaging	Het
Glb1	T	C	9: 114,473,923	I609T	probably damaging	Het
Gm12355	A	G	11: 98,625,361	V62A	possibly damaging	Het
Gm5916	T	G	9: 36,120,724	H88P	probably benign	Het
Gm6205	T	C	5: 94,683,896	V254A	probably benign	Het
Gon4l	T	C	3: 88,879,311	S586P	probably benign	Het
Gzmg	T	A	14: 56,157,257	T185S	probably benign	Het
Hipk3	T	A	2: 104,446,591	D381V	probably damaging	Het
Hnrnpul2	C	A	19: 8,830,955	N681K	probably benign	Het
Hpdl	C	A	4: 116,821,175	G30C	probably damaging	Het
Iws1	G	A	18: 32,080,160	E214K	possibly damaging	Het
Krt82	C	A	15: 101,541,825	V479L	probably benign	Het
Lama4	G	A	10: 39,048,128		probably null	Het
Lamc1	C	A	1: 153,221,688	E1537*	probably null	Het
Mab21l3	G	A	3: 101,823,278	T215M	probably benign	Het
Magi3	C	A	3: 104,015,757	V1215F	possibly damaging	Het
Mical2	T	A	7: 112,303,590	C89*	probably null	Het
Mitf	T	A	6: 98,017,874	V427D	probably benign	Het
Muc4	T	C	16: 32,768,728	V753A		Het
Myo16	G	A	8: 10,442,233	R725H	unknown	Het
Ncapg2	T	A	12: 116,438,667	D706E	probably damaging	Het
Ndst1	T	C	18: 60,691,196	D803G	probably benign	Het
Neb	A	T	2: 52,206,103	V5065D	probably damaging	Het
Npm3	G	A	19: 45,749,502	R19*	probably null	Het
Ntrk3	A	C	7: 78,247,218	N690K	possibly damaging	Het
Olfr850	T	C	9: 19,477,870	I127V	probably benign	Het
Olfr985	C	A	9: 40,127,590	V124L	possibly damaging	Het
P3h2	G	A	16: 26,105,436	A83V	probably benign	Het
Pdia2	A	G	17: 26,196,936	S362P	probably damaging	Het
Pmp22	C	T	11: 63,134,442	H34Y	probably benign	Het
Pmp22	T	C	11: 63,134,491	V50A	probably benign	Het
Ppfia4	T	C	1: 134,327,268	D283G	probably damaging	Het
Prss55	T	A	14: 64,077,082	Q213L	probably null	Het
Rgsl1	C	T	1: 153,793,867	E258K	possibly damaging	Het
Ripor2	T	C	13: 24,713,649	F777L	probably benign	Het
Rsf1	GGC	GGCGGCGGCCGC	7: 97,579,933		probably benign	Het
Sgce	G	A	6: 4,711,362	R173C	probably benign	Het
Sncaip	T	G	18: 52,906,939	M735R	probably benign	Het
Snrpd2	T	A	7: 19,152,580	I96N	probably damaging	Het
Spryd3	T	G	15: 102,130,675	D121A	probably damaging	Het
Sspo	T	C	6: 48,495,289	C149R	probably damaging	Het
Tbc1d10b	A	T	7: 127,207,933	M144K	probably benign	Het
Tbc1d31	T	A	15: 57,916,089	I66N	probably damaging	Het
Tssk1	A	G	16: 17,894,593	T81A	possibly damaging	Het
Ttc28	A	G	5: 111,102,036	Y284C	probably damaging	Het
Ttn	T	C	2: 76,743,411	T25713A	probably benign	Het
Vmn2r125	T	C	4: 156,351,259	W311R	probably damaging	Het
Vmn2r80	A	T	10: 79,194,604	T755S	probably benign	Het
Vmn2r98	T	C	17: 19,081,219	C828R	probably damaging	Het
Wwox	T	C	8: 114,712,238	F348S	probably damaging	Het
Zeb2	T	A	2: 45,110,028	R65W	possibly damaging	Het
Zfp712	T	A	13: 67,040,573	H630L	probably damaging	Het
Zfp764	G	T	7: 127,405,436	H174Q	probably damaging	Het

Other mutations in Olfr855

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01020:Olfr855	APN	9	19585320	missense	possibly damaging	0.74
IGL01405:Olfr855	APN	9	19585205	missense	probably benign	0.23
IGL01775:Olfr855	APN	9	19584705	missense	probably benign	0.04
IGL01920:Olfr855	APN	9	19585022	missense	probably benign	0.01
R0501:Olfr855	UTSW	9	19584618	missense	probably damaging	1.00
R0600:Olfr855	UTSW	9	19585304	missense	possibly damaging	0.47
R0667:Olfr855	UTSW	9	19585447	missense	probably benign
R1769:Olfr855	UTSW	9	19585386	missense	probably damaging	0.98
R3117:Olfr855	UTSW	9	19584941	missense	probably damaging	0.99
R4002:Olfr855	UTSW	9	19584714	missense	probably damaging	1.00
R4003:Olfr855	UTSW	9	19584714	missense	probably damaging	1.00
R4043:Olfr855	UTSW	9	19584995	missense	probably benign	0.16
R4243:Olfr855	UTSW	9	19584558	missense	probably damaging	1.00
R4672:Olfr855	UTSW	9	19585430	missense	possibly damaging	0.74
R4673:Olfr855	UTSW	9	19585430	missense	possibly damaging	0.74
R4959:Olfr855	UTSW	9	19585208	missense	probably benign
R4973:Olfr855	UTSW	9	19585208	missense	probably benign
R5223:Olfr855	UTSW	9	19585026	missense	probably benign	0.16
R5681:Olfr855	UTSW	9	19584899	missense	probably damaging	1.00
R6005:Olfr855	UTSW	9	19584885	missense	probably benign	0.45
R6017:Olfr855	UTSW	9	19585434	missense	probably benign	0.00
R6145:Olfr855	UTSW	9	19584888	missense	probably benign	0.02
R6615:Olfr855	UTSW	9	19584989	missense	probably benign	0.05
R6771:Olfr855	UTSW	9	19585379	missense	probably benign	0.16
R6969:Olfr855	UTSW	9	19584590	missense	possibly damaging	0.77
R7239:Olfr855	UTSW	9	19585191	missense	probably damaging	1.00
R7313:Olfr855	UTSW	9	19584642	missense	probably damaging	1.00
R7361:Olfr855	UTSW	9	19584560	missense	probably benign	0.00
R8112:Olfr855	UTSW	9	19584724	missense	probably benign	0.44
R8470:Olfr855	UTSW	9	19584969	missense	probably damaging	0.99
R9155:Olfr855	UTSW	9	19585083	missense	probably benign	0.00
R9422:Olfr855	UTSW	9	19584672	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACTTGAGCATGGCATGGAAG -3'
(R):5'- GCAGTCTGTGTAAGTGATGCTC -3'

Sequencing Primer
(F):5'- CTTGAGCATGGCATGGAAGTAGTTAG -3'
(R):5'- AAGTGATGCTCTGGTCATTTGC -3'

Posted On

2022-02-07