Mutagenetix > Incidental Mutation

Incidental Mutation 'R9187:Olfr855'

697451

Institutional Source

Beutler Lab

Gene Symbol

Olfr855

Ensembl Gene

ENSMUSG00000043087

Gene Name

olfactory receptor 855

Synonyms

MOR148-1, GA_x6K02T2PVTD-13330461-13331399

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.147) question?

Stock #

R9187 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

19582617-19586030 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 19584654 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 39 (I39T)

Ref Sequence

ENSEMBL: ENSMUSP00000150218 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061693] [ENSMUST00000215587]

AlphaFold

Q7TRF8

Predicted Effect

probably benign
Transcript: ENSMUST00000061693
AA Change: I39T

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000054790
Gene: ENSMUSG00000043087
AA Change: I39T

Domain	Start	End	E-Value	Type
Pfam:7tm_4	33	310	1.7e-54	PFAM
Pfam:7TM_GPCR_Srsx	37	182	5.2e-8	PFAM
Pfam:7tm_1	43	292	2.5e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215587
AA Change: I39T

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.5%

Validation Efficiency

97% (70/72)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 75 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca5	A	G	11: 110,310,135 (GRCm38)		probably null	Het
Abcb1a	T	A	5: 8,715,016 (GRCm38)	C669S	probably benign	Het
Abcc3	A	G	11: 94,365,087 (GRCm38)	L524P	probably damaging	Het
Akap5	A	T	12: 76,329,971 (GRCm38)	K726*	probably null	Het
Aldh16a1	T	C	7: 45,142,017 (GRCm38)	E778G	probably damaging	Het
Ankle2	G	A	5: 110,252,744 (GRCm38)	V649M	possibly damaging	Het
Apon	A	G	10: 128,254,963 (GRCm38)	N170S	probably benign	Het
Baiap2l1	T	C	5: 144,280,954 (GRCm38)	Y274C	probably benign	Het
Bub1	A	T	2: 127,814,936 (GRCm38)	N425K	possibly damaging	Het
Camsap1	A	G	2: 25,930,016 (GRCm38)	C1487R	probably damaging	Het
Cd4	A	C	6: 124,867,688 (GRCm38)	V378G	probably damaging	Het
Cenpa	C	A	5: 30,667,036 (GRCm38)	P3Q	unknown	Het
Cfap44	T	C	16: 44,404,781 (GRCm38)		probably benign	Het
Cfap65	T	A	1: 74,917,358 (GRCm38)	M1021L	probably benign	Het
Ddx39	G	T	8: 83,722,484 (GRCm38)	M300I	probably benign	Het
Dgkh	T	C	14: 78,595,161 (GRCm38)	R819G	probably damaging	Het
Dlc1	A	T	8: 36,938,632 (GRCm38)	M1K	probably null	Het
Dnah9	A	G	11: 66,005,146 (GRCm38)	W2468R	probably benign	Het
Ebag9	A	T	15: 44,640,310 (GRCm38)	K177I	probably damaging	Het
Ehbp1	T	C	11: 22,151,184 (GRCm38)	I249V	probably damaging	Het
Fam171b	T	C	2: 83,880,021 (GRCm38)	V679A	probably damaging	Het
Gabbr2	G	A	4: 46,674,533 (GRCm38)	T818I	probably damaging	Het
Gcn1l1	T	C	5: 115,614,118 (GRCm38)	S2098P	probably damaging	Het
Glb1	T	C	9: 114,473,923 (GRCm38)	I609T	probably damaging	Het
Gm12355	A	G	11: 98,625,361 (GRCm38)	V62A	possibly damaging	Het
Gm5916	T	G	9: 36,120,724 (GRCm38)	H88P	probably benign	Het
Gm6205	T	C	5: 94,683,896 (GRCm38)	V254A	probably benign	Het
Gon4l	T	C	3: 88,879,311 (GRCm38)	S586P	probably benign	Het
Gzmg	T	A	14: 56,157,257 (GRCm38)	T185S	probably benign	Het
Hipk3	T	A	2: 104,446,591 (GRCm38)	D381V	probably damaging	Het
Hnrnpul2	C	A	19: 8,830,955 (GRCm38)	N681K	probably benign	Het
Hpdl	C	A	4: 116,821,175 (GRCm38)	G30C	probably damaging	Het
Iws1	G	A	18: 32,080,160 (GRCm38)	E214K	possibly damaging	Het
Krt82	C	A	15: 101,541,825 (GRCm38)	V479L	probably benign	Het
Lama4	G	A	10: 39,048,128 (GRCm38)		probably null	Het
Lamc1	C	A	1: 153,221,688 (GRCm38)	E1537*	probably null	Het
Mab21l3	G	A	3: 101,823,278 (GRCm38)	T215M	probably benign	Het
Magi3	C	A	3: 104,015,757 (GRCm38)	V1215F	possibly damaging	Het
Mical2	T	A	7: 112,303,590 (GRCm38)	C89*	probably null	Het
Mitf	T	A	6: 98,017,874 (GRCm38)	V427D	probably benign	Het
Muc4	T	C	16: 32,768,728 (GRCm38)	V753A		Het
Myo16	G	A	8: 10,442,233 (GRCm38)	R725H	unknown	Het
Ncapg2	T	A	12: 116,438,667 (GRCm38)	D706E	probably damaging	Het
Ndst1	T	C	18: 60,691,196 (GRCm38)	D803G	probably benign	Het
Neb	A	T	2: 52,206,103 (GRCm38)	V5065D	probably damaging	Het
Npm3	G	A	19: 45,749,502 (GRCm38)	R19*	probably null	Het
Ntrk3	A	C	7: 78,247,218 (GRCm38)	N690K	possibly damaging	Het
Olfr850	T	C	9: 19,477,870 (GRCm38)	I127V	probably benign	Het
Olfr985	C	A	9: 40,127,590 (GRCm38)	V124L	possibly damaging	Het
P3h2	G	A	16: 26,105,436 (GRCm38)	A83V	probably benign	Het
Pdia2	A	G	17: 26,196,936 (GRCm38)	S362P	probably damaging	Het
Pmp22	T	C	11: 63,134,491 (GRCm38)	V50A	probably benign	Het
Pmp22	C	T	11: 63,134,442 (GRCm38)	H34Y	probably benign	Het
Ppfia4	T	C	1: 134,327,268 (GRCm38)	D283G	probably damaging	Het
Prss55	T	A	14: 64,077,082 (GRCm38)	Q213L	probably null	Het
Rgsl1	C	T	1: 153,793,867 (GRCm38)	E258K	possibly damaging	Het
Ripor2	T	C	13: 24,713,649 (GRCm38)	F777L	probably benign	Het
Rsf1	GGC	GGCGGCGGCCGC	7: 97,579,933 (GRCm38)		probably benign	Het
Sgce	G	A	6: 4,711,362 (GRCm38)	R173C	probably benign	Het
Sncaip	T	G	18: 52,906,939 (GRCm38)	M735R	probably benign	Het
Snrpd2	T	A	7: 19,152,580 (GRCm38)	I96N	probably damaging	Het
Spryd3	T	G	15: 102,130,675 (GRCm38)	D121A	probably damaging	Het
Sspo	T	C	6: 48,495,289 (GRCm38)	C149R	probably damaging	Het
Tbc1d10b	A	T	7: 127,207,933 (GRCm38)	M144K	probably benign	Het
Tbc1d31	T	A	15: 57,916,089 (GRCm38)	I66N	probably damaging	Het
Tssk1	A	G	16: 17,894,593 (GRCm38)	T81A	possibly damaging	Het
Ttc28	A	G	5: 111,102,036 (GRCm38)	Y284C	probably damaging	Het
Ttn	T	C	2: 76,743,411 (GRCm38)	T25713A	probably benign	Het
Vmn2r125	T	C	4: 156,351,259 (GRCm38)	W311R	probably damaging	Het
Vmn2r80	A	T	10: 79,194,604 (GRCm38)	T755S	probably benign	Het
Vmn2r98	T	C	17: 19,081,219 (GRCm38)	C828R	probably damaging	Het
Wwox	T	C	8: 114,712,238 (GRCm38)	F348S	probably damaging	Het
Zeb2	T	A	2: 45,110,028 (GRCm38)	R65W	possibly damaging	Het
Zfp712	T	A	13: 67,040,573 (GRCm38)	H630L	probably damaging	Het
Zfp764	G	T	7: 127,405,436 (GRCm38)	H174Q	probably damaging	Het

Other mutations in Olfr855

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01020:Olfr855	APN	9	19,585,320 (GRCm38)	missense	possibly damaging	0.74
IGL01405:Olfr855	APN	9	19,585,205 (GRCm38)	missense	probably benign	0.23
IGL01775:Olfr855	APN	9	19,584,705 (GRCm38)	missense	probably benign	0.04
IGL01920:Olfr855	APN	9	19,585,022 (GRCm38)	missense	probably benign	0.01
R0501:Olfr855	UTSW	9	19,584,618 (GRCm38)	missense	probably damaging	1.00
R0600:Olfr855	UTSW	9	19,585,304 (GRCm38)	missense	possibly damaging	0.47
R0667:Olfr855	UTSW	9	19,585,447 (GRCm38)	missense	probably benign
R1769:Olfr855	UTSW	9	19,585,386 (GRCm38)	missense	probably damaging	0.98
R3117:Olfr855	UTSW	9	19,584,941 (GRCm38)	missense	probably damaging	0.99
R4002:Olfr855	UTSW	9	19,584,714 (GRCm38)	missense	probably damaging	1.00
R4003:Olfr855	UTSW	9	19,584,714 (GRCm38)	missense	probably damaging	1.00
R4043:Olfr855	UTSW	9	19,584,995 (GRCm38)	missense	probably benign	0.16
R4243:Olfr855	UTSW	9	19,584,558 (GRCm38)	missense	probably damaging	1.00
R4672:Olfr855	UTSW	9	19,585,430 (GRCm38)	missense	possibly damaging	0.74
R4673:Olfr855	UTSW	9	19,585,430 (GRCm38)	missense	possibly damaging	0.74
R4959:Olfr855	UTSW	9	19,585,208 (GRCm38)	missense	probably benign
R4973:Olfr855	UTSW	9	19,585,208 (GRCm38)	missense	probably benign
R5223:Olfr855	UTSW	9	19,585,026 (GRCm38)	missense	probably benign	0.16
R5681:Olfr855	UTSW	9	19,584,899 (GRCm38)	missense	probably damaging	1.00
R6005:Olfr855	UTSW	9	19,584,885 (GRCm38)	missense	probably benign	0.45
R6017:Olfr855	UTSW	9	19,585,434 (GRCm38)	missense	probably benign	0.00
R6145:Olfr855	UTSW	9	19,584,888 (GRCm38)	missense	probably benign	0.02
R6615:Olfr855	UTSW	9	19,584,989 (GRCm38)	missense	probably benign	0.05
R6771:Olfr855	UTSW	9	19,585,379 (GRCm38)	missense	probably benign	0.16
R6969:Olfr855	UTSW	9	19,584,590 (GRCm38)	missense	possibly damaging	0.77
R7239:Olfr855	UTSW	9	19,585,191 (GRCm38)	missense	probably damaging	1.00
R7313:Olfr855	UTSW	9	19,584,642 (GRCm38)	missense	probably damaging	1.00
R7361:Olfr855	UTSW	9	19,584,560 (GRCm38)	missense	probably benign	0.00
R8112:Olfr855	UTSW	9	19,584,724 (GRCm38)	missense	probably benign	0.44
R8470:Olfr855	UTSW	9	19,584,969 (GRCm38)	missense	probably damaging	0.99
R9155:Olfr855	UTSW	9	19,585,083 (GRCm38)	missense	probably benign	0.00
R9422:Olfr855	UTSW	9	19,584,672 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ACTTGAGCATGGCATGGAAG -3'
(R):5'- GCAGTCTGTGTAAGTGATGCTC -3'

Sequencing Primer
(F):5'- CTTGAGCATGGCATGGAAGTAGTTAG -3'
(R):5'- AAGTGATGCTCTGGTCATTTGC -3'

Posted On

2022-02-07