Incidental Mutation 'IGL00508:Svs5'
ID 6975
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Svs5
Ensembl Gene ENSMUSG00000017004
Gene Name seminal vesicle secretory protein 5
Synonyms seminal vesicle protein F, Svp-1, Svp1, SVS V, Svp5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # IGL00508
Quality Score
Status
Chromosome 2
Chromosomal Location 164174685-164176314 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 164078962 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Lysine at position 315 (T315K)
Ref Sequence ENSEMBL: ENSMUSP00000104999 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044953] [ENSMUST00000109374]
AlphaFold P30933
Predicted Effect possibly damaging
Transcript: ENSMUST00000044953
AA Change: T315K

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000042389
Gene: ENSMUSG00000040132
AA Change: T315K

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:SVS_QK 110 121 1.2e-6 PFAM
Pfam:SVS_QK 122 137 3.9e-3 PFAM
Pfam:SVS_QK 139 149 1.3e-5 PFAM
Pfam:SVS_QK 151 166 8.4e-4 PFAM
Pfam:SVS_QK 168 179 5.3e-6 PFAM
Pfam:SVS_QK 180 195 3.9e-3 PFAM
Pfam:SVS_QK 197 207 1.3e-5 PFAM
Pfam:SVS_QK 210 221 8.8e-5 PFAM
Pfam:SVS_QK 225 236 7.7e-6 PFAM
Pfam:SVS_QK 238 249 6.1e-6 PFAM
Pfam:SVS_QK 249 260 5.2e-4 PFAM
Pfam:SVS_QK 262 272 3.1e-5 PFAM
Pfam:SVS_QK 323 334 6.7e-5 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000109374
AA Change: T315K

PolyPhen 2 Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000104999
Gene: ENSMUSG00000040132
AA Change: T315K

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:SVS_QK 110 121 1.2e-6 PFAM
Pfam:SVS_QK 122 137 3.9e-3 PFAM
Pfam:SVS_QK 139 149 1.3e-5 PFAM
Pfam:SVS_QK 151 166 8.4e-4 PFAM
Pfam:SVS_QK 168 179 5.3e-6 PFAM
Pfam:SVS_QK 180 195 3.9e-3 PFAM
Pfam:SVS_QK 197 207 1.3e-5 PFAM
Pfam:SVS_QK 210 221 8.8e-5 PFAM
Pfam:SVS_QK 225 236 7.7e-6 PFAM
Pfam:SVS_QK 238 249 6.1e-6 PFAM
Pfam:SVS_QK 249 260 5.2e-4 PFAM
Pfam:SVS_QK 262 272 3.1e-5 PFAM
Pfam:SVS_QK 323 334 6.7e-5 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A C 13: 81,654,306 (GRCm39) D2188E probably damaging Het
Atrx A G X: 104,867,405 (GRCm39) S2026P probably damaging Het
Cacna1b A C 2: 24,547,301 (GRCm39) probably null Het
Cfap46 C T 7: 139,240,605 (GRCm39) S56N probably damaging Het
Cfap57 C T 4: 118,438,367 (GRCm39) probably null Het
Ckap5 T G 2: 91,436,601 (GRCm39) V1567G probably damaging Het
Cyp2c38 A T 19: 39,449,169 (GRCm39) Y61* probably null Het
D130052B06Rik A G 11: 33,549,402 (GRCm39) E7G unknown Het
Dhx38 A G 8: 110,283,566 (GRCm39) L527P possibly damaging Het
Dnaaf5 A G 5: 139,163,701 (GRCm39) N653D probably benign Het
Dnah8 T G 17: 31,074,904 (GRCm39) M4541R probably damaging Het
Dpyd A T 3: 118,858,636 (GRCm39) T617S probably benign Het
Fpr2 A T 17: 18,113,034 (GRCm39) N10I probably damaging Het
Frmd4a A T 2: 4,599,545 (GRCm39) K524* probably null Het
Gpr45 C T 1: 43,071,452 (GRCm39) P32S possibly damaging Het
H2-Eb2 A T 17: 34,553,341 (GRCm39) I176F probably damaging Het
Hcrtr1 T A 4: 130,031,062 (GRCm39) N74I probably damaging Het
Ifi47 C T 11: 48,986,241 (GRCm39) Q3* probably null Het
Krt8 T A 15: 101,906,460 (GRCm39) M350L probably benign Het
Lilra6 A G 7: 3,914,553 (GRCm39) S533P probably benign Het
Map1b A T 13: 99,565,741 (GRCm39) S2327T unknown Het
Mcoln3 T A 3: 145,839,683 (GRCm39) I345N probably damaging Het
Mettl3 C A 14: 52,532,436 (GRCm39) probably benign Het
Mgat4a G A 1: 37,488,204 (GRCm39) R472* probably null Het
Micall1 A G 15: 79,014,768 (GRCm39) K715E probably damaging Het
Pak1 G T 7: 97,503,775 (GRCm39) G37C probably benign Het
Pomt2 T G 12: 87,166,401 (GRCm39) H426P probably damaging Het
Pou2f3 G A 9: 43,051,258 (GRCm39) P155S probably benign Het
Psg25 A G 7: 18,263,656 (GRCm39) Y56H probably benign Het
Rab9 G T X: 165,240,860 (GRCm39) Y150* probably null Het
Rhox2g T A X: 36,824,463 (GRCm39) N152I probably damaging Het
Sema6d T C 2: 124,498,844 (GRCm39) probably benign Het
Simc1 C A 13: 54,672,989 (GRCm39) Q446K probably benign Het
Syt9 C T 7: 107,024,574 (GRCm39) R156* probably null Het
Tmem260 A T 14: 48,746,578 (GRCm39) Y618F probably damaging Het
Wdr44 A G X: 23,666,783 (GRCm39) I719V possibly damaging Het
Zfp518a T G 19: 40,901,914 (GRCm39) I614M probably damaging Het
Other mutations in Svs5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01722:Svs5 APN 2 164,079,446 (GRCm39) missense possibly damaging 0.71
IGL03189:Svs5 APN 2 164,079,032 (GRCm39) missense possibly damaging 0.73
IGL03378:Svs5 APN 2 164,175,260 (GRCm39) missense probably benign 0.00
R0781:Svs5 UTSW 2 164,175,507 (GRCm39) missense probably benign 0.16
R1110:Svs5 UTSW 2 164,175,507 (GRCm39) missense probably benign 0.16
R1276:Svs5 UTSW 2 164,079,168 (GRCm39) missense possibly damaging 0.95
R1541:Svs5 UTSW 2 164,078,929 (GRCm39) missense possibly damaging 0.71
R1590:Svs5 UTSW 2 164,079,578 (GRCm39) missense possibly damaging 0.86
R3103:Svs5 UTSW 2 164,175,313 (GRCm39) missense probably benign 0.00
R3946:Svs5 UTSW 2 164,079,047 (GRCm39) missense probably benign 0.01
R3965:Svs5 UTSW 2 164,079,662 (GRCm39) missense possibly damaging 0.53
R4075:Svs5 UTSW 2 164,079,238 (GRCm39) missense probably benign 0.01
R4632:Svs5 UTSW 2 164,079,667 (GRCm39) missense probably benign 0.40
R4732:Svs5 UTSW 2 164,079,043 (GRCm39) missense possibly damaging 0.87
R4733:Svs5 UTSW 2 164,079,043 (GRCm39) missense possibly damaging 0.87
R4839:Svs5 UTSW 2 164,078,806 (GRCm39) missense probably benign 0.40
R5706:Svs5 UTSW 2 164,079,589 (GRCm39) missense possibly damaging 0.53
R6936:Svs5 UTSW 2 164,079,548 (GRCm39) missense possibly damaging 0.86
R7052:Svs5 UTSW 2 164,080,126 (GRCm39) missense unknown
R7338:Svs5 UTSW 2 164,174,728 (GRCm39) missense possibly damaging 0.96
R7836:Svs5 UTSW 2 164,079,500 (GRCm39) missense possibly damaging 0.86
R8017:Svs5 UTSW 2 164,175,341 (GRCm39) missense possibly damaging 0.86
R8019:Svs5 UTSW 2 164,175,341 (GRCm39) missense possibly damaging 0.86
R8035:Svs5 UTSW 2 164,079,053 (GRCm39) missense probably benign 0.18
R8100:Svs5 UTSW 2 164,079,712 (GRCm39) missense probably benign 0.08
R8187:Svs5 UTSW 2 164,079,692 (GRCm39) missense possibly damaging 0.88
R8310:Svs5 UTSW 2 164,080,091 (GRCm39) missense probably damaging 1.00
R8312:Svs5 UTSW 2 164,080,091 (GRCm39) missense probably damaging 1.00
R9089:Svs5 UTSW 2 164,079,341 (GRCm39) missense probably benign 0.27
R9156:Svs5 UTSW 2 164,079,509 (GRCm39) missense probably benign 0.32
R9545:Svs5 UTSW 2 164,079,313 (GRCm39) missense possibly damaging 0.52
R9790:Svs5 UTSW 2 164,078,918 (GRCm39) nonsense probably null
R9791:Svs5 UTSW 2 164,078,918 (GRCm39) nonsense probably null
Z1176:Svs5 UTSW 2 164,174,711 (GRCm39) missense possibly damaging 0.73
Posted On 2012-04-20