Incidental Mutation 'R9188:Olfr569'
ID 697521
Institutional Source Beutler Lab
Gene Symbol Olfr569
Ensembl Gene ENSMUSG00000062142
Gene Name olfactory receptor 569
Synonyms MOR30-1, GA_x6K02T2PBJ9-5599295-5598351
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R9188 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 102883709-102890882 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 102887389 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 255 (I255F)
Ref Sequence ENSEMBL: ENSMUSP00000149088 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078191] [ENSMUST00000217024]
AlphaFold Q8VGZ2
Predicted Effect possibly damaging
Transcript: ENSMUST00000078191
AA Change: I255F

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000077321
Gene: ENSMUSG00000062142
AA Change: I255F

DomainStartEndE-ValueType
Pfam:7tm_4 33 312 1.2e-113 PFAM
Pfam:7TM_GPCR_Srsx 37 229 1.3e-9 PFAM
Pfam:7tm_1 43 294 1.9e-18 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000217024
AA Change: I255F

PolyPhen 2 Score 0.951 (Sensitivity: 0.79; Specificity: 0.95)
Meta Mutation Damage Score 0.3235 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (71/71)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700003E16Rik G T 6: 83,162,248 R385L probably benign Het
Abca8b A T 11: 109,981,735 C13* probably null Het
Actc1 T C 2: 114,050,498 D82G probably damaging Het
Adamts1 G A 16: 85,802,683 R10C probably damaging Het
Ankle2 G A 5: 110,252,744 V649M possibly damaging Het
Arhgap23 A G 11: 97,500,157 I4V possibly damaging Het
Asic2 A G 11: 81,151,912 F185S probably benign Het
Asmt G A X: 170,677,850 E322K probably damaging Het
Caprin2 T C 6: 148,865,924 D512G probably benign Het
Cltc A C 11: 86,737,166 I52S probably damaging Het
Cntn2 A G 1: 132,515,538 L1040P probably damaging Het
Col12a1 T C 9: 79,602,332 T3019A probably benign Het
Crisp4 A T 1: 18,122,766 C242* probably null Het
Crocc G T 4: 141,019,840 N1716K probably benign Het
Cstf3 A G 2: 104,608,878 E12G possibly damaging Het
Drc3 G T 11: 60,358,789 V45F probably damaging Het
Etv4 A G 11: 101,775,376 S108P probably damaging Het
Exosc10 T A 4: 148,558,560 D31E probably damaging Het
F11 A T 8: 45,245,699 D469E probably benign Het
Fzd7 A G 1: 59,484,638 H560R probably benign Het
Gabrp A G 11: 33,567,252 I140T possibly damaging Het
Gna15 T C 10: 81,507,964 T288A probably benign Het
Gucy2c T C 6: 136,723,758 D586G probably benign Het
H2-D1 T C 17: 35,265,802 V213A probably damaging Het
Hsd3b1 A T 3: 98,852,900 D258E probably damaging Het
Ier3 G T 17: 35,821,887 G57W probably damaging Het
Ifnlr1 T A 4: 135,698,860 C85S probably damaging Het
Ivd G T 2: 118,880,461 G384C probably damaging Het
Iws1 G A 18: 32,080,160 E214K possibly damaging Het
Jak2 A C 19: 29,310,953 D1068A probably damaging Het
Klk4 T C 7: 43,885,373 I252T probably damaging Het
Klra17 A T 6: 129,831,560 C237S probably damaging Het
Krtap1-3 T C 11: 99,591,061 T87A unknown Het
Lbhd1 A T 19: 8,887,033 probably null Het
Lrig3 A G 10: 126,003,066 R481G possibly damaging Het
Lrrc1 T C 9: 77,455,205 Y247C probably benign Het
March1 T A 8: 66,456,151 Y174* probably null Het
Mlxip A T 5: 123,445,579 T402S probably benign Het
Mmd2 T C 5: 142,575,202 K93E probably damaging Het
Mmp27 A G 9: 7,579,791 D422G possibly damaging Het
Mroh7 T C 4: 106,709,592 I487V probably benign Het
Nectin2 A G 7: 19,719,194 probably null Het
Nfkbia A T 12: 55,490,473 L277H probably damaging Het
Olfr722 T C 14: 49,894,909 M298V probably benign Het
Otof C T 5: 30,376,751 V1410M probably damaging Het
Pcdhb11 A G 18: 37,423,135 N506S probably damaging Het
Pik3c2g A C 6: 139,622,403 E172D possibly damaging Het
Plch1 T C 3: 63,731,654 D466G probably null Het
Plekha6 C T 1: 133,292,433 R955W probably damaging Het
Ppm1d T A 11: 85,345,921 S509T possibly damaging Het
Prmt7 A G 8: 106,234,854 D133G probably damaging Het
Prr27 C A 5: 87,843,135 P202Q probably benign Het
Rfx6 A G 10: 51,718,167 I394M probably benign Het
Rgl1 G T 1: 152,519,171 N715K probably damaging Het
Rnf212 G T 5: 108,774,945 S13* probably null Het
Rpgrip1l T C 8: 91,305,010 T80A probably damaging Het
Rsl1 G T 13: 67,182,121 S211I probably benign Het
Serpinb9d A G 13: 33,202,860 M304V probably damaging Het
Sh3rf1 G T 8: 61,361,773 probably null Het
Snx16 C A 3: 10,420,775 K261N possibly damaging Het
Srebf2 G A 15: 82,182,156 R635Q probably benign Het
Styxl1 T C 5: 135,765,818 probably null Het
Tarbp2 A G 15: 102,522,511 D233G probably benign Het
Tenm4 A T 7: 96,772,027 N633Y probably damaging Het
Tgs1 T C 4: 3,585,693 L190P probably benign Het
Tmem87a C T 2: 120,402,763 G55D probably benign Het
Ttn A T 2: 76,903,124 Y4602* probably null Het
Unc5b A T 10: 60,773,771 L582Q probably damaging Het
Wdpcp A G 11: 21,660,025 D31G probably damaging Het
Wdr78 T C 4: 103,082,135 T77A Het
Wrb A G 16: 96,154,163 D140G probably benign Het
Zbtb32 C T 7: 30,591,895 probably benign Het
Zfp936 C T 7: 43,190,344 L412F probably benign Het
Other mutations in Olfr569
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01965:Olfr569 APN 7 102887607 missense probably damaging 1.00
IGL02505:Olfr569 APN 7 102887607 missense probably damaging 1.00
IGL02885:Olfr569 APN 7 102888036 missense possibly damaging 0.83
IGL03339:Olfr569 APN 7 102887782 missense probably benign 0.02
R0383:Olfr569 UTSW 7 102887251 missense possibly damaging 0.91
R1767:Olfr569 UTSW 7 102887626 missense probably damaging 1.00
R1793:Olfr569 UTSW 7 102888043 missense probably benign 0.44
R1812:Olfr569 UTSW 7 102888078 missense probably benign 0.32
R6061:Olfr569 UTSW 7 102887951 missense probably benign 0.31
R7855:Olfr569 UTSW 7 102887628 missense probably benign 0.01
R8155:Olfr569 UTSW 7 102887245 missense probably benign 0.00
R8890:Olfr569 UTSW 7 102887492 nonsense probably null
R9131:Olfr569 UTSW 7 102887979 missense probably benign 0.07
R9398:Olfr569 UTSW 7 102887793 missense probably damaging 1.00
Z1177:Olfr569 UTSW 7 102887761 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCTCCTGAATCCTCGGATGAC -3'
(R):5'- TCCTACTGTGAGCACATGGC -3'

Sequencing Primer
(F):5'- GAATCCTCGGATGACCCTGTC -3'
(R):5'- TGTGCTGATACCAGAGTCAATCG -3'
Posted On 2022-02-07