Incidental Mutation 'R9189:Dock7'
| ID |
697582 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock7
|
| Ensembl Gene |
ENSMUSG00000028556 |
| Gene Name |
dedicator of cytokinesis 7 |
| Synonyms |
m, LOC242555, 3110056M06Rik |
| MMRRC Submission |
068951-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9189 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
98824908-99009152 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 98877350 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Proline
at position 1063
(T1063P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000117797
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030286]
[ENSMUST00000075836]
[ENSMUST00000127417]
[ENSMUST00000127946]
[ENSMUST00000205650]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000030286
AA Change: T1063P
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000030286
Gene: ENSMUSG00000028556
AA Change: T1063P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3398
|
67 |
159 |
6.5e-30 |
PFAM |
|
coiled coil region
|
367 |
394 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
504 |
N/A |
INTRINSIC |
|
Pfam:DOCK-C2
|
557 |
736 |
1.8e-51 |
PFAM |
|
low complexity region
|
789 |
799 |
N/A |
INTRINSIC |
|
low complexity region
|
862 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
888 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
1135 |
1163 |
N/A |
INTRINSIC |
|
low complexity region
|
1350 |
1364 |
N/A |
INTRINSIC |
|
low complexity region
|
1543 |
1565 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1571 |
2095 |
1.4e-217 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000075233
Gene: ENSMUSG00000028556
AA Change: T1033P
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF3398
|
65 |
159 |
5.8e-34 |
PFAM |
|
coiled coil region
|
367 |
394 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
504 |
N/A |
INTRINSIC |
|
Pfam:DOCK-C2
|
556 |
737 |
3.3e-58 |
PFAM |
|
low complexity region
|
789 |
799 |
N/A |
INTRINSIC |
|
low complexity region
|
862 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
888 |
901 |
N/A |
INTRINSIC |
|
low complexity region
|
1105 |
1133 |
N/A |
INTRINSIC |
|
low complexity region
|
1320 |
1334 |
N/A |
INTRINSIC |
|
low complexity region
|
1513 |
1535 |
N/A |
INTRINSIC |
|
Pfam:Ded_cyto
|
1888 |
2065 |
6.5e-80 |
PFAM |
|
| Predicted Effect |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000127417
AA Change: T1063P
|
| SMART Domains |
Protein: ENSMUSP00000117797
Gene: ENSMUSG00000028556
AA Change: T1063P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
140 |
162 |
N/A |
INTRINSIC |
|
Pfam:Ded_cyto
|
517 |
694 |
3e-80 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000127946
|
| SMART Domains |
Protein: ENSMUSP00000119103
Gene: ENSMUSG00000028556
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
56 |
66 |
N/A |
INTRINSIC |
|
low complexity region
|
129 |
140 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
168 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150254
|
| SMART Domains |
Protein: ENSMUSP00000114204
Gene: ENSMUSG00000028556
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
74 |
84 |
N/A |
INTRINSIC |
|
low complexity region
|
147 |
158 |
N/A |
INTRINSIC |
|
low complexity region
|
173 |
186 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000205650
AA Change: T1033P
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that plays a role in axon formation and neuronal polarization. The encoded protein displays GEF activity toward RAC1 and RAC3 Rho small GTPases but not toward CDC42. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Mice homozygous for mutations of this gene exhibit coat color dilution, white tail tip, and on some genetic backgrounds a white belly spot. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acox1 |
T |
A |
11: 116,065,231 (GRCm39) |
D608V |
probably damaging |
Het |
| Actg1 |
A |
T |
11: 120,239,013 (GRCm39) |
C26S |
unknown |
Het |
| Ahnak |
T |
A |
19: 8,988,247 (GRCm39) |
V3177E |
possibly damaging |
Het |
| Akap11 |
G |
A |
14: 78,750,938 (GRCm39) |
T483I |
|
Het |
| Akr1cl |
A |
G |
1: 65,063,830 (GRCm39) |
S120P |
probably benign |
Het |
| Ankle2 |
G |
A |
5: 110,400,610 (GRCm39) |
V649M |
possibly damaging |
Het |
| Ankrd55 |
A |
T |
13: 112,504,570 (GRCm39) |
I439F |
probably damaging |
Het |
| Asb8 |
A |
G |
15: 98,040,635 (GRCm39) |
M9T |
possibly damaging |
Het |
| Ascc1 |
A |
T |
10: 59,843,645 (GRCm39) |
Y69F |
probably benign |
Het |
| Atp9a |
A |
T |
2: 168,518,060 (GRCm39) |
|
probably null |
Het |
| Cd8b1 |
T |
C |
6: 71,306,752 (GRCm39) |
F160L |
probably benign |
Het |
| Cdh23 |
G |
A |
10: 60,143,306 (GRCm39) |
A3005V |
possibly damaging |
Het |
| Cep250 |
A |
G |
2: 155,818,350 (GRCm39) |
T842A |
probably benign |
Het |
| Cgnl1 |
T |
A |
9: 71,630,847 (GRCm39) |
K552* |
probably null |
Het |
| Cntnap4 |
C |
T |
8: 113,602,600 (GRCm39) |
T1227M |
possibly damaging |
Het |
| Cobll1 |
C |
A |
2: 64,981,333 (GRCm39) |
V86F |
probably damaging |
Het |
| Dchs2 |
A |
G |
3: 83,255,561 (GRCm39) |
N2419S |
probably damaging |
Het |
| Dhx30 |
A |
T |
9: 109,914,494 (GRCm39) |
L1001* |
probably null |
Het |
| Diaph1 |
C |
T |
18: 38,024,162 (GRCm39) |
V559M |
unknown |
Het |
| Dis3l |
A |
T |
9: 64,217,731 (GRCm39) |
H783Q |
probably benign |
Het |
| Dsc1 |
T |
C |
18: 20,232,214 (GRCm39) |
T265A |
possibly damaging |
Het |
| Eif2ak4 |
A |
T |
2: 118,258,393 (GRCm39) |
Q581L |
probably damaging |
Het |
| Eprs1 |
A |
T |
1: 185,106,334 (GRCm39) |
D183V |
possibly damaging |
Het |
| Fads2 |
G |
C |
19: 10,069,183 (GRCm39) |
D80E |
probably benign |
Het |
| Fam167b |
G |
A |
4: 129,470,875 (GRCm39) |
R158C |
probably damaging |
Het |
| Flnb |
T |
A |
14: 7,892,976 (GRCm38) |
I682K |
possibly damaging |
Het |
| Garin4 |
G |
A |
1: 190,894,900 (GRCm39) |
T581I |
possibly damaging |
Het |
| Gpatch2l |
C |
T |
12: 86,291,152 (GRCm39) |
P112S |
probably benign |
Het |
| Gpn1 |
T |
A |
5: 31,654,710 (GRCm39) |
H87Q |
unknown |
Het |
| Greb1l |
T |
C |
18: 10,499,983 (GRCm39) |
V350A |
probably benign |
Het |
| Grm5 |
A |
T |
7: 87,724,024 (GRCm39) |
K771N |
probably damaging |
Het |
| Gucy2c |
C |
T |
6: 136,728,045 (GRCm39) |
S319N |
probably benign |
Het |
| H2bc8 |
A |
G |
13: 23,755,761 (GRCm39) |
D52G |
probably damaging |
Het |
| Hcfc2 |
G |
T |
10: 82,535,041 (GRCm39) |
A22S |
probably benign |
Het |
| Hnf4a |
A |
G |
2: 163,393,497 (GRCm39) |
D39G |
probably benign |
Het |
| Il6st |
C |
T |
13: 112,635,340 (GRCm39) |
T584M |
probably damaging |
Het |
| Irf3 |
T |
A |
7: 44,650,246 (GRCm39) |
V254E |
possibly damaging |
Het |
| Iws1 |
G |
A |
18: 32,213,213 (GRCm39) |
E214K |
possibly damaging |
Het |
| Kank4 |
T |
A |
4: 98,668,289 (GRCm39) |
K53* |
probably null |
Het |
| Kcnj11 |
A |
T |
7: 45,748,176 (GRCm39) |
F382L |
possibly damaging |
Het |
| Kcnq3 |
T |
C |
15: 65,867,510 (GRCm39) |
Y711C |
probably damaging |
Het |
| Kctd3 |
A |
G |
1: 188,704,636 (GRCm39) |
S712P |
possibly damaging |
Het |
| Krt20 |
A |
G |
11: 99,323,087 (GRCm39) |
I245T |
possibly damaging |
Het |
| Larp1b |
T |
C |
3: 40,925,039 (GRCm39) |
I219T |
probably damaging |
Het |
| Lman2l |
A |
G |
1: 36,478,771 (GRCm39) |
F114L |
probably damaging |
Het |
| Loxl2 |
T |
A |
14: 69,929,859 (GRCm39) |
Y746N |
possibly damaging |
Het |
| Lrrc43 |
T |
C |
5: 123,646,109 (GRCm39) |
S628P |
probably benign |
Het |
| Mroh8 |
A |
C |
2: 157,111,545 (GRCm39) |
D136E |
probably damaging |
Het |
| Nek8 |
T |
A |
11: 78,063,342 (GRCm39) |
M141L |
probably benign |
Het |
| Nr2e1 |
C |
A |
10: 42,454,268 (GRCm39) |
R22L |
probably damaging |
Het |
| Nr6a1 |
C |
T |
2: 38,816,129 (GRCm39) |
|
probably null |
Het |
| Onecut2 |
A |
G |
18: 64,473,890 (GRCm39) |
Y147C |
probably damaging |
Het |
| Or1ad1 |
T |
A |
11: 50,876,166 (GRCm39) |
C213S |
probably damaging |
Het |
| Or1j1 |
T |
A |
2: 36,702,214 (GRCm39) |
M297L |
possibly damaging |
Het |
| Or5d37 |
A |
G |
2: 87,924,194 (GRCm39) |
F29L |
probably damaging |
Het |
| Or5d39 |
T |
C |
2: 87,979,908 (GRCm39) |
M152V |
probably benign |
Het |
| Pcdhac2 |
T |
C |
18: 37,277,316 (GRCm39) |
F99L |
probably benign |
Het |
| Pcdhga2 |
T |
G |
18: 37,802,795 (GRCm39) |
V213G |
possibly damaging |
Het |
| Pgap1 |
A |
T |
1: 54,519,908 (GRCm39) |
V909E |
probably benign |
Het |
| Pik3r4 |
A |
T |
9: 105,547,038 (GRCm39) |
T939S |
probably benign |
Het |
| Pip4k2c |
T |
C |
10: 127,035,246 (GRCm39) |
D374G |
possibly damaging |
Het |
| Plxdc1 |
A |
T |
11: 97,844,788 (GRCm39) |
D252E |
probably benign |
Het |
| Pm20d1 |
A |
C |
1: 131,730,115 (GRCm39) |
D218A |
probably damaging |
Het |
| Polq |
C |
A |
16: 36,865,265 (GRCm39) |
Q706K |
probably damaging |
Het |
| Pram1 |
A |
T |
17: 33,860,131 (GRCm39) |
I233F |
probably benign |
Het |
| Prr27 |
C |
A |
5: 87,990,994 (GRCm39) |
P202Q |
probably benign |
Het |
| Prss41 |
A |
T |
17: 24,061,361 (GRCm39) |
H143Q |
probably damaging |
Het |
| Ptpn21 |
A |
G |
12: 98,655,261 (GRCm39) |
Y569H |
probably damaging |
Het |
| Rad17 |
T |
C |
13: 100,773,564 (GRCm39) |
K142E |
probably damaging |
Het |
| Rcan3 |
T |
C |
4: 135,152,607 (GRCm39) |
E38G |
probably benign |
Het |
| Rgl3 |
C |
A |
9: 21,885,356 (GRCm39) |
R658L |
possibly damaging |
Het |
| Rnf125 |
T |
A |
18: 21,116,240 (GRCm39) |
*141K |
probably null |
Het |
| Ros1 |
G |
T |
10: 52,019,502 (GRCm39) |
N711K |
probably damaging |
Het |
| Rsph10b |
T |
A |
5: 143,896,504 (GRCm39) |
Y421N |
probably benign |
Het |
| Ryr1 |
C |
T |
7: 28,776,471 (GRCm39) |
V2222I |
probably damaging |
Het |
| Samsn1 |
C |
T |
16: 75,656,449 (GRCm39) |
C333Y |
probably damaging |
Het |
| Slc9a2 |
G |
A |
1: 40,794,944 (GRCm39) |
E502K |
probably benign |
Het |
| Stard9 |
A |
T |
2: 120,533,500 (GRCm39) |
E3252D |
possibly damaging |
Het |
| Syne1 |
C |
A |
10: 5,123,008 (GRCm39) |
R309S |
probably damaging |
Het |
| Syne1 |
T |
C |
10: 5,172,289 (GRCm39) |
I5051V |
probably benign |
Het |
| Syngap1 |
A |
G |
17: 27,183,948 (GRCm39) |
S1241G |
probably damaging |
Het |
| Tbpl2 |
T |
C |
2: 23,966,030 (GRCm39) |
K321R |
probably damaging |
Het |
| Tnrc18 |
C |
T |
5: 142,717,107 (GRCm39) |
G2449E |
probably damaging |
Het |
| Trim25 |
A |
G |
11: 88,901,731 (GRCm39) |
D342G |
probably benign |
Het |
| Tssk4 |
T |
A |
14: 55,887,904 (GRCm39) |
H33Q |
probably benign |
Het |
| Ttc3 |
G |
A |
16: 94,268,831 (GRCm39) |
G1971D |
possibly damaging |
Het |
| Tufm |
C |
T |
7: 126,088,849 (GRCm39) |
Q347* |
probably null |
Het |
| Ubxn10 |
G |
A |
4: 138,448,133 (GRCm39) |
S181F |
possibly damaging |
Het |
| Ushbp1 |
T |
C |
8: 71,841,539 (GRCm39) |
E430G |
probably benign |
Het |
| Vmn1r33 |
T |
C |
6: 66,588,716 (GRCm39) |
I279M |
possibly damaging |
Het |
| Vmn2r115 |
T |
C |
17: 23,564,784 (GRCm39) |
F224L |
probably damaging |
Het |
| Vmn2r23 |
A |
T |
6: 123,681,323 (GRCm39) |
H77L |
probably benign |
Het |
| Vps13a |
T |
C |
19: 16,663,961 (GRCm39) |
I1481V |
probably benign |
Het |
| Vps35 |
T |
C |
8: 86,007,898 (GRCm39) |
N294S |
possibly damaging |
Het |
| Washc3 |
A |
T |
10: 88,051,916 (GRCm39) |
T102S |
probably benign |
Het |
| Zfp27 |
T |
A |
7: 29,595,359 (GRCm39) |
E202V |
possibly damaging |
Het |
| Zfp58 |
T |
C |
13: 67,640,035 (GRCm39) |
H152R |
possibly damaging |
Het |
| Zfr2 |
T |
C |
10: 81,080,496 (GRCm39) |
V390A |
probably damaging |
Het |
|
| Other mutations in Dock7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Dock7
|
APN |
4 |
98,952,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01126:Dock7
|
APN |
4 |
98,861,789 (GRCm39) |
splice site |
probably benign |
|
|
IGL01490:Dock7
|
APN |
4 |
98,833,355 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01553:Dock7
|
APN |
4 |
98,833,803 (GRCm39) |
nonsense |
probably null |
|
|
IGL01728:Dock7
|
APN |
4 |
98,850,568 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01776:Dock7
|
APN |
4 |
98,829,178 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL01954:Dock7
|
APN |
4 |
98,971,388 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01985:Dock7
|
APN |
4 |
98,911,614 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL02054:Dock7
|
APN |
4 |
98,861,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02150:Dock7
|
APN |
4 |
98,968,089 (GRCm39) |
splice site |
probably benign |
|
|
IGL02153:Dock7
|
APN |
4 |
98,846,304 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02183:Dock7
|
APN |
4 |
98,847,228 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02494:Dock7
|
APN |
4 |
98,877,471 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL02618:Dock7
|
APN |
4 |
98,971,265 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02634:Dock7
|
APN |
4 |
98,877,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02670:Dock7
|
APN |
4 |
98,854,523 (GRCm39) |
splice site |
probably null |
|
|
IGL02690:Dock7
|
APN |
4 |
98,857,872 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02692:Dock7
|
APN |
4 |
98,875,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02833:Dock7
|
APN |
4 |
98,833,732 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02858:Dock7
|
APN |
4 |
98,833,442 (GRCm39) |
nonsense |
probably null |
|
|
IGL02875:Dock7
|
APN |
4 |
98,864,231 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03027:Dock7
|
APN |
4 |
98,958,450 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
IGL03027:Dock7
|
APN |
4 |
98,866,164 (GRCm39) |
missense |
probably benign |
|
|
IGL03032:Dock7
|
APN |
4 |
98,854,585 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03104:Dock7
|
APN |
4 |
98,847,260 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
IGL03136:Dock7
|
APN |
4 |
98,892,028 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03345:Dock7
|
APN |
4 |
98,873,056 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Beaming
|
UTSW |
4 |
98,967,992 (GRCm39) |
nonsense |
probably null |
|
|
moonlight
|
UTSW |
4 |
0 () |
large deletion |
|
|
|
Nocturn
|
UTSW |
4 |
98,952,199 (GRCm39) |
missense |
probably benign |
0.00 |
|
sonata
|
UTSW |
4 |
98,889,364 (GRCm39) |
nonsense |
probably null |
|
|
BB005:Dock7
|
UTSW |
4 |
98,889,335 (GRCm39) |
missense |
|
|
|
BB015:Dock7
|
UTSW |
4 |
98,889,335 (GRCm39) |
missense |
|
|
|
PIT4810001:Dock7
|
UTSW |
4 |
98,833,796 (GRCm39) |
nonsense |
probably null |
|
|
R0086:Dock7
|
UTSW |
4 |
98,833,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0242:Dock7
|
UTSW |
4 |
98,850,517 (GRCm39) |
missense |
probably benign |
|
|
R0242:Dock7
|
UTSW |
4 |
98,850,517 (GRCm39) |
missense |
probably benign |
|
|
R0245:Dock7
|
UTSW |
4 |
98,943,586 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0308:Dock7
|
UTSW |
4 |
98,873,051 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0556:Dock7
|
UTSW |
4 |
98,833,426 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0612:Dock7
|
UTSW |
4 |
98,877,470 (GRCm39) |
missense |
probably benign |
0.31 |
|
R0652:Dock7
|
UTSW |
4 |
98,943,586 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R0669:Dock7
|
UTSW |
4 |
98,875,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0681:Dock7
|
UTSW |
4 |
98,904,941 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0725:Dock7
|
UTSW |
4 |
98,833,528 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0828:Dock7
|
UTSW |
4 |
98,903,982 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0837:Dock7
|
UTSW |
4 |
98,877,495 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0962:Dock7
|
UTSW |
4 |
98,833,432 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R1140:Dock7
|
UTSW |
4 |
98,953,643 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1476:Dock7
|
UTSW |
4 |
98,967,672 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1614:Dock7
|
UTSW |
4 |
98,949,517 (GRCm39) |
missense |
probably benign |
0.12 |
|
R1625:Dock7
|
UTSW |
4 |
98,850,433 (GRCm39) |
splice site |
probably null |
|
|
R1640:Dock7
|
UTSW |
4 |
98,833,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1752:Dock7
|
UTSW |
4 |
98,854,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1941:Dock7
|
UTSW |
4 |
98,872,952 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2020:Dock7
|
UTSW |
4 |
98,847,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2092:Dock7
|
UTSW |
4 |
98,897,545 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2293:Dock7
|
UTSW |
4 |
98,854,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2424:Dock7
|
UTSW |
4 |
98,833,544 (GRCm39) |
nonsense |
probably null |
|
|
R3767:Dock7
|
UTSW |
4 |
98,859,066 (GRCm39) |
missense |
probably benign |
|
|
R3768:Dock7
|
UTSW |
4 |
98,859,066 (GRCm39) |
missense |
probably benign |
|
|
R3769:Dock7
|
UTSW |
4 |
98,859,066 (GRCm39) |
missense |
probably benign |
|
|
R3770:Dock7
|
UTSW |
4 |
98,859,066 (GRCm39) |
missense |
probably benign |
|
|
R3917:Dock7
|
UTSW |
4 |
98,904,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3943:Dock7
|
UTSW |
4 |
98,880,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4021:Dock7
|
UTSW |
4 |
98,892,157 (GRCm39) |
splice site |
probably null |
|
|
R4073:Dock7
|
UTSW |
4 |
98,896,296 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4170:Dock7
|
UTSW |
4 |
98,854,638 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4180:Dock7
|
UTSW |
4 |
98,904,973 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4261:Dock7
|
UTSW |
4 |
98,892,123 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R4321:Dock7
|
UTSW |
4 |
98,960,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4522:Dock7
|
UTSW |
4 |
98,850,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4582:Dock7
|
UTSW |
4 |
98,892,153 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4648:Dock7
|
UTSW |
4 |
98,857,881 (GRCm39) |
nonsense |
probably null |
|
|
R4940:Dock7
|
UTSW |
4 |
98,908,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5090:Dock7
|
UTSW |
4 |
98,879,648 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5374:Dock7
|
UTSW |
4 |
98,877,275 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5392:Dock7
|
UTSW |
4 |
98,896,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5527:Dock7
|
UTSW |
4 |
98,842,105 (GRCm39) |
intron |
probably benign |
|
|
R5544:Dock7
|
UTSW |
4 |
98,855,494 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5556:Dock7
|
UTSW |
4 |
98,832,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5870:Dock7
|
UTSW |
4 |
98,952,199 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5899:Dock7
|
UTSW |
4 |
98,879,660 (GRCm39) |
missense |
probably benign |
|
|
R6360:Dock7
|
UTSW |
4 |
98,857,899 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6415:Dock7
|
UTSW |
4 |
98,880,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6468:Dock7
|
UTSW |
4 |
98,855,464 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6562:Dock7
|
UTSW |
4 |
98,879,647 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6613:Dock7
|
UTSW |
4 |
98,866,197 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6703:Dock7
|
UTSW |
4 |
98,834,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6723:Dock7
|
UTSW |
4 |
98,892,153 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6786:Dock7
|
UTSW |
4 |
98,949,529 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7026:Dock7
|
UTSW |
4 |
98,967,156 (GRCm39) |
missense |
probably benign |
|
|
R7051:Dock7
|
UTSW |
4 |
98,834,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7074:Dock7
|
UTSW |
4 |
98,833,445 (GRCm39) |
missense |
unknown |
|
|
R7106:Dock7
|
UTSW |
4 |
98,855,563 (GRCm39) |
missense |
unknown |
|
|
R7147:Dock7
|
UTSW |
4 |
98,849,654 (GRCm39) |
missense |
unknown |
|
|
R7257:Dock7
|
UTSW |
4 |
98,861,649 (GRCm39) |
missense |
unknown |
|
|
R7334:Dock7
|
UTSW |
4 |
98,864,180 (GRCm39) |
missense |
unknown |
|
|
R7511:Dock7
|
UTSW |
4 |
98,967,992 (GRCm39) |
nonsense |
probably null |
|
|
R7511:Dock7
|
UTSW |
4 |
98,949,519 (GRCm39) |
missense |
|
|
|
R7729:Dock7
|
UTSW |
4 |
98,943,683 (GRCm39) |
missense |
|
|
|
R7928:Dock7
|
UTSW |
4 |
98,889,335 (GRCm39) |
missense |
|
|
|
R7984:Dock7
|
UTSW |
4 |
98,877,303 (GRCm39) |
missense |
unknown |
|
|
R8287:Dock7
|
UTSW |
4 |
98,866,157 (GRCm39) |
missense |
unknown |
|
|
R8439:Dock7
|
UTSW |
4 |
98,971,266 (GRCm39) |
missense |
|
|
|
R8466:Dock7
|
UTSW |
4 |
98,952,336 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8758:Dock7
|
UTSW |
4 |
98,949,555 (GRCm39) |
missense |
|
|
|
R8849:Dock7
|
UTSW |
4 |
98,904,986 (GRCm39) |
missense |
|
|
|
R8944:Dock7
|
UTSW |
4 |
98,829,243 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8964:Dock7
|
UTSW |
4 |
98,949,476 (GRCm39) |
missense |
|
|
|
R9008:Dock7
|
UTSW |
4 |
98,833,448 (GRCm39) |
nonsense |
probably null |
|
|
R9040:Dock7
|
UTSW |
4 |
98,889,364 (GRCm39) |
nonsense |
probably null |
|
|
R9160:Dock7
|
UTSW |
4 |
98,857,962 (GRCm39) |
missense |
unknown |
|
|
R9168:Dock7
|
UTSW |
4 |
98,953,643 (GRCm39) |
missense |
|
|
|
R9215:Dock7
|
UTSW |
4 |
98,859,088 (GRCm39) |
missense |
unknown |
|
|
R9243:Dock7
|
UTSW |
4 |
98,857,871 (GRCm39) |
missense |
unknown |
|
|
R9256:Dock7
|
UTSW |
4 |
98,971,272 (GRCm39) |
missense |
|
|
|
R9328:Dock7
|
UTSW |
4 |
98,968,064 (GRCm39) |
missense |
|
|
|
R9332:Dock7
|
UTSW |
4 |
98,896,280 (GRCm39) |
missense |
|
|
|
R9450:Dock7
|
UTSW |
4 |
98,861,426 (GRCm39) |
missense |
unknown |
|
|
R9584:Dock7
|
UTSW |
4 |
98,861,481 (GRCm39) |
nonsense |
probably null |
|
|
R9631:Dock7
|
UTSW |
4 |
98,854,560 (GRCm39) |
missense |
unknown |
|
|
R9676:Dock7
|
UTSW |
4 |
98,904,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9701:Dock7
|
UTSW |
4 |
98,846,384 (GRCm39) |
missense |
unknown |
|
|
R9723:Dock7
|
UTSW |
4 |
98,960,660 (GRCm39) |
missense |
|
|
|
R9723:Dock7
|
UTSW |
4 |
98,908,270 (GRCm39) |
missense |
|
|
|
R9727:Dock7
|
UTSW |
4 |
98,875,568 (GRCm39) |
missense |
unknown |
|
|
R9777:Dock7
|
UTSW |
4 |
98,877,464 (GRCm39) |
missense |
unknown |
|
|
R9802:Dock7
|
UTSW |
4 |
98,846,384 (GRCm39) |
missense |
unknown |
|
|
X0027:Dock7
|
UTSW |
4 |
98,892,090 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Dock7
|
UTSW |
4 |
98,833,462 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GTTAACAACACAGGACTCGGG -3'
(R):5'- ACGTTTTATGGATGATATTGCTGCC -3'
Sequencing Primer
(F):5'- GACTCGGGGCTGCTTCTTC -3'
(R):5'- GCTGCCCTGGTTAGCACAATTG -3'
|
| Posted On |
2022-02-07 |
Incidental Mutation