Incidental Mutation 'R9190:Lrrc32'
ID 697680
Institutional Source Beutler Lab
Gene Symbol Lrrc32
Ensembl Gene ENSMUSG00000090958
Gene Name leucine rich repeat containing 32
Synonyms D7H11S833E, EG434215, D11S833Eh, Garp
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.295) question?
Stock # R9190 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 98138515-98151038 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 98148234 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Arginine at position 338 (H338R)
Ref Sequence ENSEMBL: ENSMUSP00000133205 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165205] [ENSMUST00000205937] [ENSMUST00000205956]
AlphaFold G3XA59
Predicted Effect probably benign
Transcript: ENSMUST00000165205
AA Change: H338R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000133205
Gene: ENSMUSG00000090958
AA Change: H338R

DomainStartEndE-ValueType
signal peptide 1 17 N/A INTRINSIC
Blast:LRRNT 22 54 3e-12 BLAST
LRR_TYP 73 96 9.44e-2 SMART
LRR 97 123 1.86e2 SMART
LRR 124 148 3.01e2 SMART
LRR 149 172 5.41e0 SMART
LRR 173 196 1.51e0 SMART
LRR_TYP 197 220 7.67e-2 SMART
LRR 265 287 1.49e2 SMART
LRR 315 338 4.97e0 SMART
LRR 339 362 8.01e0 SMART
LRR 363 384 5.57e1 SMART
LRR_TYP 386 409 3.44e-4 SMART
low complexity region 425 437 N/A INTRINSIC
LRR 443 466 2.33e2 SMART
LRR 514 536 2.03e1 SMART
LRR 537 559 2.61e1 SMART
Blast:LRR 561 588 6e-11 BLAST
transmembrane domain 630 652 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000205937
Predicted Effect probably benign
Transcript: ENSMUST00000205956
AA Change: H338R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a conditional allele activated in T cells exhibit reduced regulatory T cell ability to drive Th17 differentiation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930433I11Rik C T 7: 40,642,880 (GRCm39) T183I possibly damaging Het
Abca13 T A 11: 9,241,886 (GRCm39) S1250T probably damaging Het
Adamts12 T A 15: 11,336,446 (GRCm39) S1510R probably benign Het
Adcy5 T A 16: 35,089,364 (GRCm39) C520* probably null Het
Arhgap21 A T 2: 20,858,983 (GRCm39) M1237K probably null Het
Atp8b4 T A 2: 126,225,607 (GRCm39) N541I probably damaging Het
Bbs12 G T 3: 37,375,223 (GRCm39) R557L probably damaging Het
Bcl7c T C 7: 127,266,200 (GRCm39) T183A probably benign Het
Brd7 A G 8: 89,081,274 (GRCm39) S192P probably damaging Het
Calhm3 G A 19: 47,146,121 (GRCm39) A28V probably benign Het
Ccdc113 A G 8: 96,263,101 (GRCm39) N37S probably damaging Het
Cdh5 T G 8: 104,867,337 (GRCm39) V538G probably damaging Het
Cfap43 T C 19: 47,726,293 (GRCm39) E1639G possibly damaging Het
Clca3a2 C T 3: 144,796,599 (GRCm39) V203I probably benign Het
Clstn2 A G 9: 97,414,815 (GRCm39) F360L probably damaging Het
Cnst GTGACACGCTTG GTG 1: 179,407,039 (GRCm39) probably benign Het
Cog2 T C 8: 125,260,058 (GRCm39) Y234H probably damaging Het
Ddhd2 T C 8: 26,244,495 (GRCm39) S44G probably benign Het
Dync2i2 G T 2: 29,922,211 (GRCm39) H417N probably benign Het
Farp1 A G 14: 121,492,988 (GRCm39) E530G probably damaging Het
Fhad1 C T 4: 141,646,058 (GRCm39) probably null Het
Foxj3 T A 4: 119,477,538 (GRCm39) C449* probably null Het
Fsbp G C 4: 11,584,005 (GRCm39) V235L probably benign Het
Fuom T C 7: 139,681,252 (GRCm39) E73G probably benign Het
Gm5134 A G 10: 75,844,645 (GRCm39) H667R probably damaging Het
Igsf21 A G 4: 139,756,028 (GRCm39) I361T probably damaging Het
Iws1 G A 18: 32,213,213 (GRCm39) E214K possibly damaging Het
Kmt2d A T 15: 98,749,896 (GRCm39) V2599E unknown Het
Lama1 T A 17: 68,111,514 (GRCm39) M2255K Het
Litafd C A 16: 8,501,647 (GRCm39) P50T Het
Map1b C A 13: 99,571,914 (GRCm39) R269L probably damaging Het
Ms4a5 T A 19: 11,256,733 (GRCm39) I55F probably damaging Het
Muc5b G C 7: 141,411,939 (GRCm39) L1628F unknown Het
Myo6 A G 9: 80,195,384 (GRCm39) Q918R unknown Het
Or1e25 T A 11: 73,493,877 (GRCm39) M157K probably benign Het
Or2t48 A G 11: 58,420,161 (GRCm39) V217A possibly damaging Het
Or5m11b T A 2: 85,805,884 (GRCm39) I99N possibly damaging Het
Or9i1b T G 19: 13,896,967 (GRCm39) N194K probably benign Het
Pals2 A G 6: 50,157,219 (GRCm39) R296G probably damaging Het
Plin5 A G 17: 56,419,462 (GRCm39) V320A probably damaging Het
Ptx4 A T 17: 25,342,257 (GRCm39) Q244L possibly damaging Het
Rab3gap1 A G 1: 127,858,495 (GRCm39) T535A probably benign Het
Ranbp2 T C 10: 58,313,117 (GRCm39) F1279S probably damaging Het
Rgl1 T C 1: 152,428,362 (GRCm39) H254R probably damaging Het
Rida C T 15: 34,487,909 (GRCm39) A69T probably damaging Het
Scn2a T C 2: 65,511,346 (GRCm39) F131L probably benign Het
Septin1 T C 7: 126,816,092 (GRCm39) I141V probably benign Het
Slc10a6 A G 5: 103,765,571 (GRCm39) S171P probably damaging Het
Slc18a1 A G 8: 69,519,790 (GRCm39) probably null Het
Slc38a6 T C 12: 73,388,526 (GRCm39) S247P possibly damaging Het
Tet2 A T 3: 133,187,147 (GRCm39) I1094K possibly damaging Het
Tmem234 C T 4: 129,501,333 (GRCm39) S138L probably benign Het
Trpv1 T A 11: 73,145,148 (GRCm39) probably null Het
Vmn2r60 T A 7: 41,844,935 (GRCm39) M766K probably damaging Het
Vmn2r84 T C 10: 130,226,843 (GRCm39) N332D probably benign Het
Zfp292 A T 4: 34,819,563 (GRCm39) I258N probably damaging Het
Zxdc A G 6: 90,375,773 (GRCm39) K750E probably damaging Het
Other mutations in Lrrc32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01447:Lrrc32 APN 7 98,147,583 (GRCm39) missense probably damaging 1.00
IGL01484:Lrrc32 APN 7 98,143,442 (GRCm39) missense probably damaging 0.99
IGL01608:Lrrc32 APN 7 98,148,564 (GRCm39) missense probably benign 0.01
IGL02025:Lrrc32 APN 7 98,148,767 (GRCm39) missense probably benign 0.00
IGL02026:Lrrc32 APN 7 98,148,767 (GRCm39) missense probably benign 0.00
IGL03061:Lrrc32 APN 7 98,148,629 (GRCm39) missense probably benign 0.04
IGL03191:Lrrc32 APN 7 98,147,454 (GRCm39) missense possibly damaging 0.66
R0706:Lrrc32 UTSW 7 98,148,917 (GRCm39) missense probably damaging 1.00
R0947:Lrrc32 UTSW 7 98,148,090 (GRCm39) missense probably benign
R1470:Lrrc32 UTSW 7 98,148,564 (GRCm39) missense probably benign
R1470:Lrrc32 UTSW 7 98,148,564 (GRCm39) missense probably benign
R2879:Lrrc32 UTSW 7 98,148,984 (GRCm39) missense probably benign 0.02
R3608:Lrrc32 UTSW 7 98,148,393 (GRCm39) missense probably benign 0.09
R4417:Lrrc32 UTSW 7 98,148,144 (GRCm39) missense probably benign 0.01
R4798:Lrrc32 UTSW 7 98,148,224 (GRCm39) missense probably damaging 1.00
R4872:Lrrc32 UTSW 7 98,147,727 (GRCm39) missense probably damaging 0.99
R5813:Lrrc32 UTSW 7 98,147,618 (GRCm39) missense probably damaging 1.00
R6062:Lrrc32 UTSW 7 98,147,748 (GRCm39) missense probably benign 0.00
R6742:Lrrc32 UTSW 7 98,148,039 (GRCm39) missense probably benign 0.00
R6930:Lrrc32 UTSW 7 98,148,471 (GRCm39) missense possibly damaging 0.89
R7265:Lrrc32 UTSW 7 98,148,644 (GRCm39) missense probably damaging 1.00
R7367:Lrrc32 UTSW 7 98,148,086 (GRCm39) nonsense probably null
R7372:Lrrc32 UTSW 7 98,149,014 (GRCm39) missense probably benign 0.28
R7414:Lrrc32 UTSW 7 98,149,201 (GRCm39) missense probably benign 0.01
R7485:Lrrc32 UTSW 7 98,147,414 (GRCm39) missense possibly damaging 0.94
R7679:Lrrc32 UTSW 7 98,148,894 (GRCm39) missense possibly damaging 0.91
R7713:Lrrc32 UTSW 7 98,148,545 (GRCm39) missense probably damaging 0.99
R8782:Lrrc32 UTSW 7 98,148,270 (GRCm39) missense probably damaging 1.00
R8815:Lrrc32 UTSW 7 98,148,242 (GRCm39) missense probably damaging 1.00
R9258:Lrrc32 UTSW 7 98,148,345 (GRCm39) missense probably benign 0.02
R9367:Lrrc32 UTSW 7 98,148,937 (GRCm39) missense probably damaging 1.00
Z1088:Lrrc32 UTSW 7 98,148,267 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TCCCGAGACTCATCTACCTG -3'
(R):5'- CAAGGCATTGTCCTGCAGAAG -3'

Sequencing Primer
(F):5'- CGAGACTCATCTACCTGAATGTG -3'
(R):5'- CACATTGTGGCTCAAGTC -3'
Posted On 2022-02-07