Incidental Mutation 'R9193:Chil3'
ID 697791
Institutional Source Beutler Lab
Gene Symbol Chil3
Ensembl Gene ENSMUSG00000040809
Gene Name chitinase-like 3
Synonyms Ym1, Chi3l3
MMRRC Submission
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.489) question?
Stock # R9193 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 106054870-106074852 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106063081 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 170 (S170P)
Ref Sequence ENSEMBL: ENSMUSP00000053923 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000063062]
AlphaFold O35744
PDB Structure THE CRYSTAL STRUCTURE OF NOVEL MAMMALIAN LECTIN YM1 SUGGESTS A SACCHARIDE BINDING SITE [X-RAY DIFFRACTION]
The Crystal Structure of Ym1 at 1.31 A Resolution [X-RAY DIFFRACTION]
Predicted Effect possibly damaging
Transcript: ENSMUST00000063062
AA Change: S170P

PolyPhen 2 Score 0.896 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000053923
Gene: ENSMUSG00000040809
AA Change: S170P

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Glyco_18 22 365 5.17e-134 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is thought to function as a lectin and may be involved in inflammation and allergy. [provided by RefSeq, Sep 2015]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ak1 A T 2: 32,520,391 (GRCm39) K79M probably benign Het
Amy1 T C 3: 113,356,278 (GRCm39) K293E probably benign Het
Bcl2l10 A G 9: 75,255,333 (GRCm39) Q50R probably benign Het
Bpifa6 G A 2: 153,826,740 (GRCm39) G35D probably benign Het
Cachd1 C A 4: 100,634,339 (GRCm39) P5Q unknown Het
Capn13 A T 17: 73,652,191 (GRCm39) I266N probably damaging Het
Ckap4 A G 10: 84,363,350 (GRCm39) I571T probably damaging Het
Col14a1 A G 15: 55,242,964 (GRCm39) M371V unknown Het
Dag1 A G 9: 108,085,467 (GRCm39) L558P possibly damaging Het
Edem3 G A 1: 151,694,270 (GRCm39) E868K probably benign Het
Eif3k T C 7: 28,673,624 (GRCm39) Y150C probably damaging Het
Farp1 T C 14: 121,518,281 (GRCm39) I988T probably benign Het
Fat3 A G 9: 15,910,248 (GRCm39) M1918T probably benign Het
Gba2 A G 4: 43,578,112 (GRCm39) I79T probably benign Het
Gbp8 T C 5: 105,179,169 (GRCm39) D110G probably damaging Het
Gm57858 G T 3: 36,089,428 (GRCm39) N165K probably benign Het
H2-M2 T A 17: 37,793,428 (GRCm39) M193L probably benign Het
H2-T13 A G 17: 36,391,956 (GRCm39) V39A possibly damaging Het
Ighv7-1 T A 12: 113,860,110 (GRCm39) D94V probably damaging Het
Il2ra T C 2: 11,689,202 (GRCm39) F244L possibly damaging Het
Jag1 A T 2: 136,931,764 (GRCm39) H602Q probably null Het
Kidins220 A T 12: 25,036,966 (GRCm39) I16F possibly damaging Het
Klb A G 5: 65,529,368 (GRCm39) T299A possibly damaging Het
Lama4 A G 10: 38,951,444 (GRCm39) K1063R probably benign Het
Lrit2 A G 14: 36,794,550 (GRCm39) E538G possibly damaging Het
Lrrc7 A T 3: 158,059,011 (GRCm39) L32* probably null Het
Lrrtm3 A T 10: 63,765,883 (GRCm39) I568N probably damaging Het
Myom1 A G 17: 71,343,295 (GRCm39) D164G probably damaging Het
Naaladl2 T C 3: 23,900,742 (GRCm39) D696G probably damaging Het
Nalcn A T 14: 123,545,792 (GRCm39) L1073* probably null Het
Nid2 T C 14: 19,853,278 (GRCm39) S1166P probably damaging Het
Nlrp4c T C 7: 6,095,621 (GRCm39) V833A probably benign Het
Nyap2 T C 1: 81,275,712 (GRCm39) S619P probably damaging Het
Or10d5j T C 9: 39,867,878 (GRCm39) M118V probably damaging Het
Or2a20 A T 6: 43,194,086 (GRCm39) T80S probably benign Het
Or4a71 A G 2: 89,357,987 (GRCm39) Y256H probably damaging Het
Or8k16 C A 2: 85,520,644 (GRCm39) Y290* probably null Het
P3h2 T C 16: 25,923,991 (GRCm39) N148S probably benign Het
P4htm A G 9: 108,460,081 (GRCm39) M231T probably damaging Het
Pank1 T A 19: 34,804,634 (GRCm39) K349I possibly damaging Het
Pgam5 A G 5: 110,413,466 (GRCm39) Y210H probably benign Het
Prb1b T C 6: 132,288,996 (GRCm39) H276R unknown Het
Prl2a1 T A 13: 27,992,535 (GRCm39) C220S probably damaging Het
Psca C T 15: 74,587,932 (GRCm39) Q39* probably null Het
Rgs20 A T 1: 5,091,067 (GRCm39) M121K possibly damaging Het
S100z C T 13: 95,613,883 (GRCm39) V76M possibly damaging Het
Slc30a10 T C 1: 185,195,034 (GRCm39) I282T probably damaging Het
Slc30a3 T C 5: 31,246,088 (GRCm39) Y214C probably damaging Het
Sox5 C T 6: 143,790,570 (GRCm39) E497K probably benign Het
Spata31g1 A G 4: 42,971,519 (GRCm39) D284G probably benign Het
Sptbn1 C T 11: 30,087,551 (GRCm39) E963K possibly damaging Het
Srl T C 16: 4,311,723 (GRCm39) E465G possibly damaging Het
Tacc2 T C 7: 130,228,304 (GRCm39) M1663T probably benign Het
Tas2r119 T G 15: 32,177,932 (GRCm39) V166G probably benign Het
Tcf7l1 A G 6: 72,611,205 (GRCm39) V191A probably damaging Het
Thap7 A T 16: 17,346,901 (GRCm39) I92K probably damaging Het
Tnfsf10 A G 3: 27,371,407 (GRCm39) T38A possibly damaging Het
Trav7-5 C G 14: 53,768,615 (GRCm39) A61G probably benign Het
Trim30c C T 7: 104,031,553 (GRCm39) V421I probably benign Het
Ugt2b38 A T 5: 87,571,729 (GRCm39) M101K probably benign Het
Vmn1r44 T A 6: 89,870,565 (GRCm39) C104S probably damaging Het
Wdr74 T A 19: 8,715,240 (GRCm39) V133E probably damaging Het
Zfp735 A T 11: 73,580,600 (GRCm39) Y33F possibly damaging Het
Other mutations in Chil3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00332:Chil3 APN 3 106,056,017 (GRCm39) missense probably damaging 1.00
IGL01552:Chil3 APN 3 106,056,164 (GRCm39) missense probably damaging 0.98
IGL02538:Chil3 APN 3 106,071,445 (GRCm39) missense probably damaging 1.00
PIT4382001:Chil3 UTSW 3 106,055,975 (GRCm39) missense probably damaging 1.00
R0145:Chil3 UTSW 3 106,067,794 (GRCm39) missense probably damaging 1.00
R0269:Chil3 UTSW 3 106,063,072 (GRCm39) missense probably benign 0.00
R0310:Chil3 UTSW 3 106,067,839 (GRCm39) missense possibly damaging 0.75
R0453:Chil3 UTSW 3 106,056,221 (GRCm39) missense probably benign 0.26
R0541:Chil3 UTSW 3 106,068,548 (GRCm39) critical splice acceptor site probably null
R0617:Chil3 UTSW 3 106,063,072 (GRCm39) missense probably benign 0.00
R0831:Chil3 UTSW 3 106,057,063 (GRCm39) missense probably benign 0.19
R1699:Chil3 UTSW 3 106,067,682 (GRCm39) critical splice donor site probably null
R1851:Chil3 UTSW 3 106,056,117 (GRCm39) critical splice donor site probably null
R1852:Chil3 UTSW 3 106,056,117 (GRCm39) critical splice donor site probably null
R2105:Chil3 UTSW 3 106,067,794 (GRCm39) missense possibly damaging 0.73
R2202:Chil3 UTSW 3 106,071,562 (GRCm39) missense probably benign 0.11
R2204:Chil3 UTSW 3 106,071,562 (GRCm39) missense probably benign 0.11
R2205:Chil3 UTSW 3 106,071,562 (GRCm39) missense probably benign 0.11
R4358:Chil3 UTSW 3 106,067,815 (GRCm39) nonsense probably null
R4492:Chil3 UTSW 3 106,063,017 (GRCm39) missense probably damaging 1.00
R4543:Chil3 UTSW 3 106,067,686 (GRCm39) missense probably benign
R4554:Chil3 UTSW 3 106,067,686 (GRCm39) missense probably benign
R4930:Chil3 UTSW 3 106,071,524 (GRCm39) missense possibly damaging 0.67
R5011:Chil3 UTSW 3 106,057,477 (GRCm39) missense possibly damaging 0.46
R5083:Chil3 UTSW 3 106,071,405 (GRCm39) critical splice donor site probably null
R5231:Chil3 UTSW 3 106,063,045 (GRCm39) missense probably damaging 0.96
R5423:Chil3 UTSW 3 106,055,978 (GRCm39) missense probably damaging 1.00
R6804:Chil3 UTSW 3 106,071,495 (GRCm39) nonsense probably null
R6859:Chil3 UTSW 3 106,067,730 (GRCm39) missense probably benign 0.14
R7218:Chil3 UTSW 3 106,067,853 (GRCm39) splice site probably null
R7391:Chil3 UTSW 3 106,071,496 (GRCm39) missense probably damaging 1.00
R7426:Chil3 UTSW 3 106,063,022 (GRCm39) missense probably benign 0.05
R7582:Chil3 UTSW 3 106,071,572 (GRCm39) missense probably damaging 1.00
R7620:Chil3 UTSW 3 106,067,751 (GRCm39) missense probably damaging 1.00
R7647:Chil3 UTSW 3 106,056,122 (GRCm39) missense possibly damaging 0.73
R7749:Chil3 UTSW 3 106,056,161 (GRCm39) missense probably benign 0.22
R7944:Chil3 UTSW 3 106,057,464 (GRCm39) nonsense probably null
R8099:Chil3 UTSW 3 106,055,984 (GRCm39) missense probably damaging 1.00
R8181:Chil3 UTSW 3 106,057,203 (GRCm39) missense probably damaging 0.98
R8859:Chil3 UTSW 3 106,071,440 (GRCm39) missense possibly damaging 0.86
R9011:Chil3 UTSW 3 106,057,031 (GRCm39) nonsense probably null
R9352:Chil3 UTSW 3 106,067,787 (GRCm39) missense probably damaging 1.00
R9607:Chil3 UTSW 3 106,067,685 (GRCm39) missense probably null 0.01
Predicted Primers PCR Primer
(F):5'- TAACAGTGCCTTGAAGCAACC -3'
(R):5'- GAACAGACATTGGAGTTCCTAAAAC -3'

Sequencing Primer
(F):5'- GTGCCTTGAAGCAACCAATAAG -3'
(R):5'- CTGAAATGACATGTAAGTACAT -3'
Posted On 2022-02-07