Mutagenetix > Incidental Mutations

Incidental Mutation 'R9197:Lilra6'

697983

Institutional Source

Beutler Lab

Gene Symbol

Lilra6

Ensembl Gene

ENSMUSG00000030427

Gene Name

leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6

Synonyms

Pira3, 7M1

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.079) question?

Stock #

R9197 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

3908280-3915503 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 3912717 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 340 (T340A)

Ref Sequence

ENSEMBL: ENSMUSP00000042636 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000038176] [ENSMUST00000090689] [ENSMUST00000206077]

AlphaFold

A0A0B4J1F3

Predicted Effect

possibly damaging
Transcript: ENSMUST00000038176
AA Change: T340A

PolyPhen 2 Score 0.944 (Sensitivity: 0.80; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000042636
Gene: ENSMUSG00000030427
AA Change: T340A

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	40	105	3.11e0	SMART
IG	129	315	4.53e-2	SMART
IG_like	237	302	1.54e-1	SMART
IG_like	328	415	1.79e1	SMART
IG_like	429	517	2.66e1	SMART
IG	529	618	8.59e-3	SMART
low complexity region	637	646	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000090689
AA Change: T302A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000088188
Gene: ENSMUSG00000030427
AA Change: T302A

Domain	Start	End	E-Value	Type
low complexity region	8	17	N/A	INTRINSIC
IG_like	34	118	7.25e0	SMART
IG_like	129	220	1.62e2	SMART
IG_like	290	377	1.79e1	SMART
IG_like	391	479	2.66e1	SMART
IG	491	580	8.59e-3	SMART
low complexity region	599	608	N/A	INTRINSIC

Predicted Effect

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410089E03Rik	A	T	15: 8,251,052	I2820F	unknown	Het
4932415D10Rik	C	A	10: 82,284,567	C4203F	possibly damaging	Het
BC048679	C	T	7: 81,495,218	V126M	probably benign	Het
Brd2	T	C	17: 34,114,396	Y427C	probably damaging	Het
Btbd1	T	A	7: 81,793,615	T474S	probably damaging	Het
Cacna1c	T	C	6: 118,613,989	T1524A		Het
Capn9	T	A	8: 124,613,861	V588D	probably damaging	Het
Ccdc88b	T	C	19: 6,855,845	E278G	probably damaging	Het
Ccr3	T	C	9: 124,029,695	S356P	probably damaging	Het
Cyfip1	C	T	7: 55,904,474	H754Y	probably null	Het
Dolk	A	G	2: 30,284,681	S451P	probably damaging	Het
Elac2	G	A	11: 65,001,856	A829T	probably benign	Het
Fahd2a	T	C	2: 127,436,364	I308V	possibly damaging	Het
Gm7168	T	A	17: 13,949,227	N285K	probably benign	Het
Hgf	T	A	5: 16,561,061	V65E	probably benign	Het
Igsf21	A	T	4: 140,034,773	L198Q	probably benign	Het
Il18rap	C	T	1: 40,543,017	T366M	probably benign	Het
Ipo4	C	T	14: 55,633,383	R264H	probably damaging	Het
Jak2	C	T	19: 29,311,757	T1103I	probably benign	Het
Kdm4d	T	A	9: 14,464,241	Y107F	probably damaging	Het
Lad1	T	A	1: 135,831,892	S509T	probably benign	Het
Lhx5	C	A	5: 120,435,381	P143Q	possibly damaging	Het
Lrrc4	T	C	6: 28,831,319	H99R	probably benign	Het
Mmp11	T	A	10: 75,927,233	D175V	probably damaging	Het
Msh2	T	A	17: 87,719,515	M813K	possibly damaging	Het
Mvp	T	C	7: 126,989,787	N603D	probably damaging	Het
Olfr195	T	A	16: 59,149,126	I92N	probably damaging	Het
Olfr896-ps1	G	A	9: 38,292,784	V280M	possibly damaging	Het
Pcdha2	A	C	18: 36,939,826	Y170S	probably damaging	Het
Pcdhb19	G	A	18: 37,498,301	C383Y	probably damaging	Het
Pcdhga2	A	T	18: 37,671,500	D799V	probably benign	Het
Pias3	A	G	3: 96,703,748	Y430C	probably benign	Het
Pign	A	G	1: 105,589,093	F575L	probably benign	Het
Rin3	A	T	12: 102,369,047	I406F	probably benign	Het
Rpgrip1	A	T	14: 52,145,400	E674D	possibly damaging	Het
Snx13	T	C	12: 35,105,197	V420A	probably benign	Het
Spata31d1c	A	T	13: 65,035,876	M411L	probably benign	Het
Tmem150a	T	G	6: 72,356,739	M28R	probably benign	Het
Trp53	T	C	11: 69,589,174	Y233H	probably damaging	Het
Ufl1	A	G	4: 25,250,519	I778T	possibly damaging	Het
Vmn2r89	T	A	14: 51,456,139	H315Q	possibly damaging	Het
Wapl	T	A	14: 34,722,287	N565K	probably damaging	Het
Zfhx2	G	A	14: 55,074,722	Q172*	probably null	Het
Zfp592	T	A	7: 81,024,319	S344T	possibly damaging	Het
Zfp970	T	C	2: 177,476,085	I484T	probably benign	Het

Other mutations in Lilra6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00508:Lilra6	APN	7	3911554	missense	probably benign	0.04
IGL00569:Lilra6	APN	7	3914589	missense	probably damaging	0.99
IGL00899:Lilra6	APN	7	3913057	missense	probably damaging	1.00
IGL00955:Lilra6	APN	7	3911404	splice site	probably benign
IGL01585:Lilra6	APN	7	3914499	missense	probably benign	0.01
IGL02195:Lilra6	APN	7	3914550	missense	probably benign	0.00
IGL02586:Lilra6	APN	7	3908820	missense	probably benign	0.36
IGL02719:Lilra6	APN	7	3912992	missense	possibly damaging	0.96
IGL03166:Lilra6	APN	7	3912627	missense	possibly damaging	0.69
IGL03329:Lilra6	APN	7	3914648	splice site	probably benign
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0233:Lilra6	UTSW	7	3914936	missense	possibly damaging	0.69
R0423:Lilra6	UTSW	7	3914775	splice site	probably benign
R0483:Lilra6	UTSW	7	3913139	missense	probably benign	0.02
R0511:Lilra6	UTSW	7	3912785	missense	possibly damaging	0.77
R1472:Lilra6	UTSW	7	3912719	missense	probably damaging	1.00
R1560:Lilra6	UTSW	7	3911408	critical splice donor site	probably null
R1584:Lilra6	UTSW	7	3912662	missense	probably damaging	1.00
R1781:Lilra6	UTSW	7	3915067	missense	probably benign	0.28
R2411:Lilra6	UTSW	7	3911454	missense	probably damaging	1.00
R2420:Lilra6	UTSW	7	3914858	missense	probably damaging	1.00
R4021:Lilra6	UTSW	7	3911418	missense	probably benign	0.20
R4074:Lilra6	UTSW	7	3914890	missense	probably benign	0.23
R4284:Lilra6	UTSW	7	3908804	missense	possibly damaging	0.76
R4508:Lilra6	UTSW	7	3912029	nonsense	probably null
R4894:Lilra6	UTSW	7	3912531	missense	probably benign	0.01
R4977:Lilra6	UTSW	7	3914383	missense	probably benign	0.01
R5048:Lilra6	UTSW	7	3915441	critical splice donor site	probably null
R5164:Lilra6	UTSW	7	3914881	missense	probably damaging	1.00
R5185:Lilra6	UTSW	7	3914636	missense	probably benign	0.00
R5527:Lilra6	UTSW	7	3914587	start gained	probably benign
R6281:Lilra6	UTSW	7	3911973	missense	probably damaging	1.00
R6480:Lilra6	UTSW	7	3912933	missense	probably damaging	1.00
R6512:Lilra6	UTSW	7	3914388	missense	probably benign	0.06
R6565:Lilra6	UTSW	7	3915020	missense	probably benign
R7017:Lilra6	UTSW	7	3908708	missense	possibly damaging	0.93
R7095:Lilra6	UTSW	7	3913197	missense	probably damaging	1.00
R7747:Lilra6	UTSW	7	3912996	missense	probably benign	0.16
R8056:Lilra6	UTSW	7	3912552	missense	probably damaging	1.00
R8280:Lilra6	UTSW	7	3913047	missense	probably benign	0.01
R9354:Lilra6	UTSW	7	3911629	missense	probably damaging	1.00
R9379:Lilra6	UTSW	7	3913167	missense	probably damaging	1.00
R9406:Lilra6	UTSW	7	3914854	missense	probably benign
R9462:Lilra6	UTSW	7	3911995	missense	probably damaging	0.97
Z1176:Lilra6	UTSW	7	3915074	critical splice acceptor site	probably null
Z1177:Lilra6	UTSW	7	3912581	missense	possibly damaging	0.48

Predicted Primers

PCR Primer
(F):5'- TGTTGGAGAGCACTAGGTACTGAC -3'
(R):5'- TCAGATTCTCAACCCCAGGC -3'

Sequencing Primer
(F):5'- ACCACAGTAATGGGGTATTCTTG -3'
(R):5'- GGCTCTGCTCTCAGGAGAACTTC -3'

Posted On

2022-02-07