Incidental Mutation 'R9198:Usp35'
ID 698047
Institutional Source Beutler Lab
Gene Symbol Usp35
Ensembl Gene ENSMUSG00000035713
Gene Name ubiquitin specific peptidase 35
Synonyms LOC244144, LOC381901
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R9198 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 96958587-96981227 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 96962276 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 527 (Y527H)
Ref Sequence ENSEMBL: ENSMUSP00000137726 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004622] [ENSMUST00000139582] [ENSMUST00000168435]
AlphaFold M0QWN7
Predicted Effect probably benign
Transcript: ENSMUST00000004622
SMART Domains Protein: ENSMUSP00000004622
Gene: ENSMUSG00000004508

DomainStartEndE-ValueType
PH 9 121 1.07e-22 SMART
Blast:PH 268 314 4e-11 BLAST
low complexity region 348 355 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000139582
AA Change: Y527H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000137726
Gene: ENSMUSG00000035713
AA Change: Y527H

DomainStartEndE-ValueType
low complexity region 86 102 N/A INTRINSIC
Pfam:UCH 440 915 5.2e-50 PFAM
Pfam:UCH_1 441 890 1.5e-29 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000168435
AA Change: Y527H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000137927
Gene: ENSMUSG00000035713
AA Change: Y527H

DomainStartEndE-ValueType
low complexity region 86 102 N/A INTRINSIC
Pfam:UCH 440 915 7.1e-48 PFAM
Pfam:UCH_1 441 890 7.4e-26 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.5%
Validation Efficiency 97% (61/63)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam22 A G 5: 8,167,583 (GRCm39) probably null Het
Adamts9 A T 6: 92,837,170 (GRCm39) S1164T probably benign Het
Bcat1 A T 6: 144,985,222 (GRCm39) I140N probably damaging Het
Bod1l T C 5: 41,957,129 (GRCm39) T2832A probably benign Het
Brca2 A T 5: 150,459,977 (GRCm39) E417D possibly damaging Het
Ccdc88b T C 19: 6,831,268 (GRCm39) D558G possibly damaging Het
Ccdc88b T C 19: 6,833,213 (GRCm39) E278G probably damaging Het
Celsr1 G T 15: 85,917,286 (GRCm39) S229* probably null Het
Cenpf G T 1: 189,388,987 (GRCm39) T1615K probably damaging Het
Cep250 T C 2: 155,830,354 (GRCm39) probably null Het
Clec4d T C 6: 123,251,757 (GRCm39) F213S probably damaging Het
Clip4 G A 17: 72,117,884 (GRCm39) G310R probably damaging Het
Csmd1 G A 8: 15,962,430 (GRCm39) R3255W probably damaging Het
Ctsm T C 13: 61,687,612 (GRCm39) D82G probably damaging Het
Cyp26a1 A G 19: 37,686,790 (GRCm39) T81A probably damaging Het
Dld A G 12: 31,390,885 (GRCm39) V187A probably benign Het
Dmrt2 T A 19: 25,655,477 (GRCm39) Y359N probably benign Het
Dnah9 T C 11: 65,846,570 (GRCm39) N2914S probably benign Het
Dpyd A T 3: 118,553,303 (GRCm39) probably null Het
Fgl2 A C 5: 21,577,920 (GRCm39) Q69P probably damaging Het
Gadd45gip1 A T 8: 85,560,780 (GRCm39) I132F probably damaging Het
Gm15446 T C 5: 110,090,743 (GRCm39) C332R probably damaging Het
Gm15737 A T 6: 92,856,640 (GRCm39) E23V unknown Het
Gm5111 A G 6: 48,567,037 (GRCm39) H84R unknown Het
Golga3 G A 5: 110,355,619 (GRCm39) S991N probably benign Het
H2-M10.3 A G 17: 36,678,919 (GRCm39) Y50H probably damaging Het
Hivep2 C T 10: 14,005,621 (GRCm39) H740Y probably benign Het
Il18rap C T 1: 40,582,177 (GRCm39) T366M probably benign Het
Ints7 T A 1: 191,351,872 (GRCm39) S860R probably benign Het
Lipi T A 16: 75,362,461 (GRCm39) T217S possibly damaging Het
Lrrc2 G T 9: 110,791,722 (GRCm39) C158F probably benign Het
Lrrc30 T C 17: 67,938,854 (GRCm39) D242G probably benign Het
Map1a A T 2: 121,133,854 (GRCm39) M1557L probably benign Het
Matn2 A G 15: 34,423,924 (GRCm39) E594G probably damaging Het
Mfsd12 T C 10: 81,198,544 (GRCm39) L345P probably damaging Het
Mmp24 A G 2: 155,640,041 (GRCm39) R124G probably benign Het
Ngef T A 1: 87,406,797 (GRCm39) H240L unknown Het
Nmur1 T G 1: 86,315,256 (GRCm39) D203A probably benign Het
Nt5c3 T C 6: 56,859,955 (GRCm39) Q328R probably benign Het
Ogfr T C 2: 180,232,850 (GRCm39) probably null Het
Or4k1 A T 14: 50,377,990 (GRCm39) Y35* probably null Het
Or52ac1 T A 7: 104,245,635 (GRCm39) Y251F probably damaging Het
Or5h19 A G 16: 58,856,263 (GRCm39) V279A probably benign Het
Osbpl10 G A 9: 115,061,211 (GRCm39) W588* probably null Het
Pask A T 1: 93,265,205 (GRCm39) S17T possibly damaging Het
Pfkfb3 C T 2: 11,491,084 (GRCm39) R170K probably damaging Het
Plec A G 15: 76,069,937 (GRCm39) C960R unknown Het
Pramel11 T A 4: 143,623,646 (GRCm39) N176I probably benign Het
R3hdm2 T G 10: 127,293,521 (GRCm39) S142A probably damaging Het
Rfx7 T C 9: 72,524,163 (GRCm39) L451P probably damaging Het
Rimbp2 T A 5: 128,883,552 (GRCm39) E76V probably damaging Het
Rock2 A G 12: 17,015,557 (GRCm39) N818S probably benign Het
Ryk A T 9: 102,758,854 (GRCm39) I248F possibly damaging Het
Setd2 A G 9: 110,378,168 (GRCm39) Q661R possibly damaging Het
Siae T C 9: 37,539,105 (GRCm39) V172A probably benign Het
Slc35f4 A G 14: 49,556,377 (GRCm39) S9P unknown Het
Smg1 T C 7: 117,795,179 (GRCm39) E456G unknown Het
Srgap3 C T 6: 112,743,865 (GRCm39) A458T probably damaging Het
Tgfbrap1 T A 1: 43,093,799 (GRCm39) R564S probably damaging Het
Usp15 A G 10: 123,004,143 (GRCm39) Y204H probably damaging Het
Usp8 T A 2: 126,600,524 (GRCm39) *1092K probably null Het
Vmn2r73 A T 7: 85,518,987 (GRCm39) M545K probably benign Het
Ylpm1 A T 12: 85,080,689 (GRCm39) probably null Het
Zscan22 G T 7: 12,641,130 (GRCm39) R458L probably damaging Het
Other mutations in Usp35
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03239:Usp35 APN 7 96,970,799 (GRCm39) missense possibly damaging 0.62
R0046:Usp35 UTSW 7 96,962,804 (GRCm39) splice site probably null
R0046:Usp35 UTSW 7 96,962,804 (GRCm39) splice site probably null
R0739:Usp35 UTSW 7 96,960,874 (GRCm39) nonsense probably null
R2655:Usp35 UTSW 7 96,961,354 (GRCm39) missense probably benign
R3623:Usp35 UTSW 7 96,961,827 (GRCm39) missense probably damaging 1.00
R4750:Usp35 UTSW 7 96,959,546 (GRCm39) missense possibly damaging 0.85
R4967:Usp35 UTSW 7 96,962,782 (GRCm39) missense probably damaging 1.00
R5317:Usp35 UTSW 7 96,960,846 (GRCm39) missense probably damaging 0.99
R5341:Usp35 UTSW 7 96,975,134 (GRCm39) missense probably damaging 1.00
R5761:Usp35 UTSW 7 96,961,558 (GRCm39) missense probably benign 0.00
R5894:Usp35 UTSW 7 96,962,284 (GRCm39) missense probably damaging 1.00
R6113:Usp35 UTSW 7 96,973,533 (GRCm39) missense probably damaging 1.00
R6282:Usp35 UTSW 7 96,975,155 (GRCm39) missense probably damaging 1.00
R6454:Usp35 UTSW 7 96,960,851 (GRCm39) nonsense probably null
R6454:Usp35 UTSW 7 96,960,767 (GRCm39) missense probably damaging 0.98
R7142:Usp35 UTSW 7 96,960,754 (GRCm39) missense probably damaging 0.97
R7158:Usp35 UTSW 7 96,975,171 (GRCm39) start codon destroyed probably null 0.89
R7260:Usp35 UTSW 7 96,969,286 (GRCm39) missense probably damaging 0.98
R8270:Usp35 UTSW 7 96,961,551 (GRCm39) missense probably benign
R8275:Usp35 UTSW 7 96,964,026 (GRCm39) missense probably damaging 1.00
R8795:Usp35 UTSW 7 96,961,270 (GRCm39) missense probably benign
R8795:Usp35 UTSW 7 96,961,167 (GRCm39) missense possibly damaging 0.92
RF003:Usp35 UTSW 7 96,971,303 (GRCm39) missense possibly damaging 0.88
Predicted Primers PCR Primer
(F):5'- CCCAGGCTTCACATGTAGTTTAG -3'
(R):5'- TAGGCAGGCATGTTTGGAAC -3'

Sequencing Primer
(F):5'- CACATGTAGTTTAGAGTCTTTGGAG -3'
(R):5'- GAACAGTCTTAGACCCTCAGTGTG -3'
Posted On 2022-02-07