Incidental Mutation 'R9199:Cyp2c66'
| ID |
698133 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cyp2c66
|
| Ensembl Gene |
ENSMUSG00000067229 |
| Gene Name |
cytochrome P450, family 2, subfamily c, polypeptide 66 |
| Synonyms |
2010301M18Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.150)
|
| Stock # |
R9199 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
19 |
| Chromosomal Location |
39102342-39175200 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 39130800 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Lysine to Arginine
at position 138
(K138R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000084487
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000087234]
[ENSMUST00000146494]
|
| AlphaFold |
Q5GLZ0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000087234
AA Change: K138R
PolyPhen 2
Score 0.164 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000084487
Gene: ENSMUSG00000067229
AA Change: K138R
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
Pfam:p450
|
30 |
487 |
1e-157 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000146494
|
| SMART Domains |
Protein: ENSMUSP00000120397
Gene: ENSMUSG00000067229
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
25 |
N/A |
INTRINSIC |
|
SCOP:d1cpt__
|
26 |
55 |
4e-9 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (51/51) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1110057P08Rik |
A |
T |
16: 88,971,654 (GRCm39) |
|
probably benign |
Het |
| Abca9 |
A |
T |
11: 110,056,770 (GRCm39) |
C17S |
possibly damaging |
Het |
| Acan |
T |
G |
7: 78,736,057 (GRCm39) |
F168V |
probably damaging |
Het |
| Acp7 |
A |
G |
7: 28,316,591 (GRCm39) |
L128P |
probably benign |
Het |
| Agtpbp1 |
C |
A |
13: 59,613,808 (GRCm39) |
M1044I |
probably benign |
Het |
| Arhgef3 |
A |
G |
14: 27,122,244 (GRCm39) |
Q361R |
possibly damaging |
Het |
| Brdt |
A |
T |
5: 107,498,029 (GRCm39) |
R235* |
probably null |
Het |
| Cacna1d |
A |
G |
14: 29,764,893 (GRCm39) |
S2013P |
probably benign |
Het |
| Cacna2d4 |
T |
A |
6: 119,244,787 (GRCm39) |
D274E |
probably benign |
Het |
| Ccdc24 |
T |
A |
4: 117,728,313 (GRCm39) |
I144F |
probably null |
Het |
| Ceacam5 |
C |
G |
7: 17,479,350 (GRCm39) |
L156V |
probably benign |
Het |
| Cenpn |
G |
A |
8: 117,664,014 (GRCm39) |
|
probably null |
Het |
| Cfap69 |
A |
T |
5: 5,668,952 (GRCm39) |
V385E |
possibly damaging |
Het |
| Cldnd1 |
A |
G |
16: 58,553,070 (GRCm39) |
H177R |
probably damaging |
Het |
| Cr1l |
A |
T |
1: 194,786,177 (GRCm39) |
V439D |
probably benign |
Het |
| Cul2 |
A |
G |
18: 3,423,577 (GRCm39) |
N329S |
probably benign |
Het |
| Ddx46 |
G |
A |
13: 55,825,342 (GRCm39) |
E996K |
probably damaging |
Het |
| Dnah14 |
A |
G |
1: 181,478,566 (GRCm39) |
K1444E |
possibly damaging |
Het |
| Evl |
G |
A |
12: 108,647,814 (GRCm39) |
|
probably null |
Het |
| Flnc |
C |
T |
6: 29,441,490 (GRCm39) |
T424I |
probably benign |
Het |
| Gadd45gip1 |
T |
A |
8: 85,559,128 (GRCm39) |
V70E |
probably damaging |
Het |
| Garem2 |
A |
G |
5: 30,319,471 (GRCm39) |
H311R |
probably damaging |
Het |
| Gm32742 |
G |
C |
9: 51,060,607 (GRCm39) |
H899D |
possibly damaging |
Het |
| Gm5148 |
C |
T |
3: 37,768,989 (GRCm39) |
C77Y |
probably benign |
Het |
| Gm5460 |
A |
G |
14: 33,758,393 (GRCm39) |
D141G |
possibly damaging |
Het |
| Kcnj8 |
T |
C |
6: 142,512,118 (GRCm39) |
N163S |
probably damaging |
Het |
| Klri1 |
A |
T |
6: 129,674,264 (GRCm39) |
*249R |
probably null |
Het |
| Kmt5b |
A |
G |
19: 3,865,525 (GRCm39) |
D863G |
probably damaging |
Het |
| Ltbp2 |
G |
T |
12: 84,832,750 (GRCm39) |
T1538K |
probably benign |
Het |
| Or51ah3 |
G |
A |
7: 103,210,143 (GRCm39) |
G153D |
probably damaging |
Het |
| Or5b120 |
A |
G |
19: 13,480,436 (GRCm39) |
H243R |
probably damaging |
Het |
| Pheta2 |
A |
T |
15: 82,227,877 (GRCm39) |
E132V |
probably damaging |
Het |
| Pramel16 |
A |
G |
4: 143,675,656 (GRCm39) |
L390P |
probably damaging |
Het |
| Ptchd3 |
A |
G |
11: 121,721,741 (GRCm39) |
I205V |
probably benign |
Het |
| Rab8b |
G |
A |
9: 66,758,641 (GRCm39) |
A152V |
probably damaging |
Het |
| Rasef |
T |
C |
4: 73,658,625 (GRCm39) |
D343G |
possibly damaging |
Het |
| Rcan2 |
G |
A |
17: 44,264,423 (GRCm39) |
V28I |
probably benign |
Het |
| Sec1 |
G |
A |
7: 45,328,009 (GRCm39) |
T346M |
probably benign |
Het |
| Sgk1 |
T |
A |
10: 21,758,558 (GRCm39) |
N7K |
probably damaging |
Het |
| Slc39a12 |
A |
T |
2: 14,394,321 (GRCm39) |
I64F |
possibly damaging |
Het |
| Spock3 |
A |
G |
8: 63,798,764 (GRCm39) |
T259A |
probably damaging |
Het |
| Sypl1 |
A |
T |
12: 33,016,463 (GRCm39) |
|
probably benign |
Het |
| Teddm2 |
G |
T |
1: 153,726,767 (GRCm39) |
Q36K |
probably damaging |
Het |
| Tlr1 |
A |
G |
5: 65,083,534 (GRCm39) |
S348P |
possibly damaging |
Het |
| Ttll12 |
A |
G |
15: 83,466,559 (GRCm39) |
F336S |
probably damaging |
Het |
| Ttll8 |
G |
A |
15: 88,798,818 (GRCm39) |
P639L |
probably benign |
Het |
| Usp24 |
T |
C |
4: 106,244,681 (GRCm39) |
V1212A |
probably damaging |
Het |
| Vcan |
C |
A |
13: 89,838,615 (GRCm39) |
G2310* |
probably null |
Het |
| Vmn2r104 |
A |
T |
17: 20,262,097 (GRCm39) |
N344K |
probably damaging |
Het |
| Zfp281 |
A |
G |
1: 136,553,643 (GRCm39) |
N207S |
probably benign |
Het |
| Zfp534 |
T |
A |
4: 147,760,439 (GRCm39) |
M77L |
probably benign |
Het |
| Zfp819 |
G |
A |
7: 43,267,203 (GRCm39) |
S562N |
probably benign |
Het |
| Zmym1 |
C |
T |
4: 126,944,623 (GRCm39) |
C188Y |
possibly damaging |
Het |
|
| Other mutations in Cyp2c66 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01145:Cyp2c66
|
APN |
19 |
39,159,405 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01589:Cyp2c66
|
APN |
19 |
39,172,379 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02098:Cyp2c66
|
APN |
19 |
39,159,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02114:Cyp2c66
|
APN |
19 |
39,159,519 (GRCm39) |
splice site |
probably benign |
|
|
IGL02567:Cyp2c66
|
APN |
19 |
39,175,084 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL03181:Cyp2c66
|
APN |
19 |
39,130,483 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03230:Cyp2c66
|
APN |
19 |
39,172,302 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0007:Cyp2c66
|
UTSW |
19 |
39,159,402 (GRCm39) |
nonsense |
probably null |
|
|
R0092:Cyp2c66
|
UTSW |
19 |
39,172,224 (GRCm39) |
splice site |
probably benign |
|
|
R0242:Cyp2c66
|
UTSW |
19 |
39,130,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0242:Cyp2c66
|
UTSW |
19 |
39,130,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0324:Cyp2c66
|
UTSW |
19 |
39,165,135 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0675:Cyp2c66
|
UTSW |
19 |
39,175,060 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1127:Cyp2c66
|
UTSW |
19 |
39,151,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1871:Cyp2c66
|
UTSW |
19 |
39,151,858 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R3404:Cyp2c66
|
UTSW |
19 |
39,151,771 (GRCm39) |
missense |
probably benign |
|
|
R3429:Cyp2c66
|
UTSW |
19 |
39,151,892 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3896:Cyp2c66
|
UTSW |
19 |
39,130,722 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4115:Cyp2c66
|
UTSW |
19 |
39,165,003 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4116:Cyp2c66
|
UTSW |
19 |
39,165,003 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R4667:Cyp2c66
|
UTSW |
19 |
39,165,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4668:Cyp2c66
|
UTSW |
19 |
39,165,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4711:Cyp2c66
|
UTSW |
19 |
39,151,843 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R4960:Cyp2c66
|
UTSW |
19 |
39,151,766 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5070:Cyp2c66
|
UTSW |
19 |
39,151,914 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5113:Cyp2c66
|
UTSW |
19 |
39,151,882 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5125:Cyp2c66
|
UTSW |
19 |
39,159,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5178:Cyp2c66
|
UTSW |
19 |
39,159,473 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5588:Cyp2c66
|
UTSW |
19 |
39,151,858 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6011:Cyp2c66
|
UTSW |
19 |
39,130,380 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6497:Cyp2c66
|
UTSW |
19 |
39,151,821 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6707:Cyp2c66
|
UTSW |
19 |
39,174,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7173:Cyp2c66
|
UTSW |
19 |
39,159,401 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7202:Cyp2c66
|
UTSW |
19 |
39,130,348 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7469:Cyp2c66
|
UTSW |
19 |
39,172,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7614:Cyp2c66
|
UTSW |
19 |
39,159,472 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7985:Cyp2c66
|
UTSW |
19 |
39,102,430 (GRCm39) |
missense |
probably null |
1.00 |
|
R8012:Cyp2c66
|
UTSW |
19 |
39,172,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8056:Cyp2c66
|
UTSW |
19 |
39,130,485 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8302:Cyp2c66
|
UTSW |
19 |
39,165,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8329:Cyp2c66
|
UTSW |
19 |
39,174,906 (GRCm39) |
nonsense |
probably null |
|
|
R8365:Cyp2c66
|
UTSW |
19 |
39,165,048 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8472:Cyp2c66
|
UTSW |
19 |
39,165,021 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8502:Cyp2c66
|
UTSW |
19 |
39,130,773 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8688:Cyp2c66
|
UTSW |
19 |
39,151,884 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8715:Cyp2c66
|
UTSW |
19 |
39,159,388 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9551:Cyp2c66
|
UTSW |
19 |
39,172,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9552:Cyp2c66
|
UTSW |
19 |
39,172,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9601:Cyp2c66
|
UTSW |
19 |
39,175,054 (GRCm39) |
missense |
probably benign |
|
|
R9777:Cyp2c66
|
UTSW |
19 |
39,102,520 (GRCm39) |
missense |
probably benign |
0.15 |
|
Z1177:Cyp2c66
|
UTSW |
19 |
39,175,070 (GRCm39) |
missense |
probably damaging |
0.96 |
|
| Predicted Primers |
|
| Posted On |
2022-02-07 |
Incidental Mutation