Incidental Mutation 'R9200:Zmynd8'
| ID |
698147 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zmynd8
|
| Ensembl Gene |
ENSMUSG00000039671 |
| Gene Name |
zinc finger, MYND-type containing 8 |
| Synonyms |
ZMYND8, RACK7, 1110013E22Rik, 2010005I16Rik, Prkcbp1, 3632413B07Rik |
| MMRRC Submission |
068957-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9200 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
165626072-165740896 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 165682005 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 175
(D175E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000104892
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018050]
[ENSMUST00000088113]
[ENSMUST00000099084]
[ENSMUST00000109262]
[ENSMUST00000109266]
[ENSMUST00000109269]
[ENSMUST00000136842]
[ENSMUST00000153655]
[ENSMUST00000170272]
[ENSMUST00000177633]
|
| AlphaFold |
A2A484 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000018050
AA Change: D171E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000018050
Gene: ENSMUSG00000039671
AA Change: D171E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
90 |
131 |
2.23e-11 |
SMART |
|
BROMO
|
147 |
254 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
275 |
349 |
4e-12 |
PFAM |
|
Pfam:DUF3544
|
412 |
624 |
9.8e-112 |
PFAM |
|
internal_repeat_2
|
640 |
701 |
9.06e-5 |
PROSPERO |
|
low complexity region
|
770 |
805 |
N/A |
INTRINSIC |
|
low complexity region
|
853 |
868 |
N/A |
INTRINSIC |
|
low complexity region
|
875 |
887 |
N/A |
INTRINSIC |
|
coiled coil region
|
916 |
978 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
988 |
1022 |
2.2e-7 |
PFAM |
|
low complexity region
|
1055 |
1075 |
N/A |
INTRINSIC |
|
low complexity region
|
1142 |
1156 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000088113
AA Change: D166E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000085436
Gene: ENSMUSG00000039671
AA Change: D166E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
85 |
126 |
2.23e-11 |
SMART |
|
BROMO
|
142 |
249 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
271 |
346 |
2.7e-11 |
PFAM |
|
Pfam:DUF3544
|
408 |
617 |
2.1e-102 |
PFAM |
|
internal_repeat_2
|
635 |
696 |
4.2e-5 |
PROSPERO |
|
low complexity region
|
765 |
800 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
863 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
882 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
973 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1070 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099084
AA Change: D146E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000096683
Gene: ENSMUSG00000039671
AA Change: D146E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
65 |
106 |
2.23e-11 |
SMART |
|
BROMO
|
122 |
229 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
250 |
324 |
4.1e-12 |
PFAM |
|
Pfam:DUF3544
|
387 |
599 |
1e-111 |
PFAM |
|
internal_repeat_2
|
615 |
676 |
4.95e-5 |
PROSPERO |
|
low complexity region
|
745 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
819 |
844 |
N/A |
INTRINSIC |
|
low complexity region
|
880 |
895 |
N/A |
INTRINSIC |
|
low complexity region
|
902 |
914 |
N/A |
INTRINSIC |
|
coiled coil region
|
943 |
1005 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
1015 |
1049 |
2.3e-7 |
PFAM |
|
low complexity region
|
1082 |
1102 |
N/A |
INTRINSIC |
|
low complexity region
|
1169 |
1183 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109262
AA Change: D146E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000104885
Gene: ENSMUSG00000039671
AA Change: D146E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
65 |
106 |
2.23e-11 |
SMART |
|
BROMO
|
122 |
229 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
250 |
324 |
1.2e-12 |
PFAM |
|
Pfam:DUF3544
|
387 |
460 |
3.1e-29 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109266
AA Change: D191E
PolyPhen 2
Score 0.107 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000104889
Gene: ENSMUSG00000039671
AA Change: D191E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
11 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
110 |
151 |
2.23e-11 |
SMART |
|
BROMO
|
167 |
274 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
295 |
369 |
4.1e-12 |
PFAM |
|
Pfam:DUF3544
|
432 |
644 |
1e-111 |
PFAM |
|
internal_repeat_2
|
660 |
721 |
8.36e-5 |
PROSPERO |
|
low complexity region
|
790 |
825 |
N/A |
INTRINSIC |
|
low complexity region
|
873 |
888 |
N/A |
INTRINSIC |
|
low complexity region
|
895 |
907 |
N/A |
INTRINSIC |
|
coiled coil region
|
936 |
998 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
1008 |
1042 |
2.3e-7 |
PFAM |
|
low complexity region
|
1075 |
1095 |
N/A |
INTRINSIC |
|
low complexity region
|
1162 |
1176 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109269
AA Change: D175E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000104892
Gene: ENSMUSG00000039671
AA Change: D175E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
27 |
38 |
N/A |
INTRINSIC |
|
low complexity region
|
41 |
60 |
N/A |
INTRINSIC |
|
PHD
|
94 |
135 |
2.23e-11 |
SMART |
|
BROMO
|
151 |
258 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
280 |
355 |
6.6e-11 |
PFAM |
|
Pfam:DUF3544
|
417 |
626 |
2.6e-102 |
PFAM |
|
internal_repeat_2
|
644 |
705 |
6.15e-5 |
PROSPERO |
|
low complexity region
|
774 |
809 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
909 |
924 |
N/A |
INTRINSIC |
|
low complexity region
|
931 |
943 |
N/A |
INTRINSIC |
|
coiled coil region
|
972 |
1034 |
N/A |
INTRINSIC |
|
low complexity region
|
1111 |
1131 |
N/A |
INTRINSIC |
|
low complexity region
|
1198 |
1212 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000136842
AA Change: D177E
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000120631
Gene: ENSMUSG00000039671
AA Change: D177E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
19 |
30 |
N/A |
INTRINSIC |
|
low complexity region
|
54 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
68 |
87 |
N/A |
INTRINSIC |
|
PHD
|
96 |
137 |
2.23e-11 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153655
AA Change: D166E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000120932
Gene: ENSMUSG00000039671
AA Change: D166E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
15 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
85 |
126 |
2.23e-11 |
SMART |
|
BROMO
|
142 |
249 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
270 |
344 |
3.5e-12 |
PFAM |
|
Pfam:DUF3544
|
407 |
480 |
6.7e-29 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000170272
AA Change: D146E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000128680
Gene: ENSMUSG00000039671
AA Change: D146E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
34 |
N/A |
INTRINSIC |
|
low complexity region
|
37 |
56 |
N/A |
INTRINSIC |
|
PHD
|
65 |
106 |
2.23e-11 |
SMART |
|
BROMO
|
122 |
229 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
250 |
324 |
1.1e-11 |
PFAM |
|
Pfam:DUF3544
|
387 |
599 |
1.9e-111 |
PFAM |
|
internal_repeat_2
|
615 |
676 |
7.92e-5 |
PROSPERO |
|
low complexity region
|
745 |
780 |
N/A |
INTRINSIC |
|
low complexity region
|
828 |
843 |
N/A |
INTRINSIC |
|
low complexity region
|
850 |
862 |
N/A |
INTRINSIC |
|
coiled coil region
|
891 |
953 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
963 |
997 |
1.1e-6 |
PFAM |
|
low complexity region
|
1030 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1117 |
1131 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177633
AA Change: D166E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000136211
Gene: ENSMUSG00000039671
AA Change: D166E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
8 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
43 |
54 |
N/A |
INTRINSIC |
|
low complexity region
|
57 |
76 |
N/A |
INTRINSIC |
|
PHD
|
85 |
126 |
2.23e-11 |
SMART |
|
BROMO
|
142 |
249 |
1.77e-17 |
SMART |
|
Pfam:PWWP
|
270 |
344 |
9.6e-12 |
PFAM |
|
Pfam:DUF3544
|
407 |
619 |
1.8e-111 |
PFAM |
|
internal_repeat_2
|
635 |
696 |
6.45e-5 |
PROSPERO |
|
low complexity region
|
765 |
800 |
N/A |
INTRINSIC |
|
low complexity region
|
848 |
863 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
882 |
N/A |
INTRINSIC |
|
coiled coil region
|
911 |
973 |
N/A |
INTRINSIC |
|
Pfam:zf-MYND
|
983 |
1017 |
6.7e-7 |
PFAM |
|
low complexity region
|
1050 |
1070 |
N/A |
INTRINSIC |
|
low complexity region
|
1137 |
1151 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
99% (71/72) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 73 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acsm2 |
C |
A |
7: 119,179,839 (GRCm39) |
Y352* |
probably null |
Het |
| Adh7 |
C |
T |
3: 137,927,567 (GRCm39) |
R38C |
probably benign |
Het |
| Ankrd2 |
A |
T |
19: 42,028,871 (GRCm39) |
T145S |
|
Het |
| Anpep |
T |
C |
7: 79,490,870 (GRCm39) |
N241D |
probably benign |
Het |
| Apaf1 |
G |
A |
10: 90,845,102 (GRCm39) |
L990F |
probably benign |
Het |
| Arsi |
A |
G |
18: 61,049,836 (GRCm39) |
T240A |
possibly damaging |
Het |
| Ascc3 |
A |
G |
10: 50,521,787 (GRCm39) |
E434G |
possibly damaging |
Het |
| Atp2c2 |
A |
T |
8: 120,474,999 (GRCm39) |
K535* |
probably null |
Het |
| B3galt4 |
A |
G |
17: 34,170,384 (GRCm39) |
|
probably benign |
Het |
| Brwd1 |
C |
G |
16: 95,839,154 (GRCm39) |
C839S |
probably benign |
Het |
| Cars1 |
C |
T |
7: 143,129,654 (GRCm39) |
|
probably null |
Het |
| Catsperd |
T |
A |
17: 56,935,229 (GRCm39) |
V14D |
unknown |
Het |
| Ccdc150 |
A |
C |
1: 54,299,197 (GRCm39) |
T58P |
probably damaging |
Het |
| Cdhr17 |
T |
C |
5: 17,006,659 (GRCm39) |
|
probably null |
Het |
| Cdon |
A |
G |
9: 35,414,617 (GRCm39) |
D1164G |
probably benign |
Het |
| Celsr1 |
G |
T |
15: 85,917,286 (GRCm39) |
S229* |
probably null |
Het |
| Cic |
A |
C |
7: 24,971,940 (GRCm39) |
D557A |
probably damaging |
Het |
| Clip4 |
G |
A |
17: 72,117,884 (GRCm39) |
G310R |
probably damaging |
Het |
| Dach1 |
G |
T |
14: 98,065,743 (GRCm39) |
R695S |
probably damaging |
Het |
| Ddc |
T |
C |
11: 11,765,388 (GRCm39) |
N428S |
possibly damaging |
Het |
| Dnah6 |
G |
A |
6: 73,004,497 (GRCm39) |
T3822I |
probably benign |
Het |
| Dnmt1 |
T |
A |
9: 20,819,896 (GRCm39) |
M1535L |
probably benign |
Het |
| Edc4 |
T |
C |
8: 106,617,051 (GRCm39) |
|
probably null |
Het |
| Emilin2 |
A |
G |
17: 71,581,229 (GRCm39) |
I499T |
possibly damaging |
Het |
| Etl4 |
A |
G |
2: 20,786,702 (GRCm39) |
D766G |
probably damaging |
Het |
| Fes |
T |
C |
7: 80,032,140 (GRCm39) |
Q414R |
probably benign |
Het |
| Fhod1 |
A |
G |
8: 106,058,072 (GRCm39) |
V844A |
probably benign |
Het |
| Fshr |
A |
T |
17: 89,354,103 (GRCm39) |
V85E |
probably benign |
Het |
| Gc |
T |
C |
5: 89,593,236 (GRCm39) |
N61S |
probably benign |
Het |
| Hapstr1 |
T |
C |
16: 8,673,898 (GRCm39) |
L275P |
possibly damaging |
Het |
| Il18rap |
C |
T |
1: 40,582,177 (GRCm39) |
T366M |
probably benign |
Het |
| Itga1 |
A |
T |
13: 115,104,997 (GRCm39) |
I1059N |
possibly damaging |
Het |
| Itpr3 |
T |
A |
17: 27,326,636 (GRCm39) |
V1426E |
probably damaging |
Het |
| Jag1 |
T |
A |
2: 136,929,044 (GRCm39) |
Y804F |
probably benign |
Het |
| Lama3 |
A |
G |
18: 12,605,297 (GRCm39) |
T1084A |
probably benign |
Het |
| Mdn1 |
A |
G |
4: 32,760,791 (GRCm39) |
D4952G |
probably benign |
Het |
| Mmrn1 |
A |
G |
6: 60,953,860 (GRCm39) |
T714A |
probably damaging |
Het |
| Nab1 |
T |
A |
1: 52,529,525 (GRCm39) |
H124L |
possibly damaging |
Het |
| Nacc2 |
A |
G |
2: 25,980,118 (GRCm39) |
F106S |
probably damaging |
Het |
| Nbeal1 |
T |
C |
1: 60,320,425 (GRCm39) |
I2006T |
probably damaging |
Het |
| Nkpd1 |
C |
A |
7: 19,257,683 (GRCm39) |
H487Q |
probably benign |
Het |
| Nop2 |
G |
A |
6: 125,117,843 (GRCm39) |
|
probably null |
Het |
| Or10ag54 |
T |
A |
2: 87,100,055 (GRCm39) |
M310K |
probably benign |
Het |
| Or5b124 |
A |
G |
19: 13,610,595 (GRCm39) |
N40S |
probably damaging |
Het |
| Otud6b |
A |
T |
4: 14,811,712 (GRCm39) |
Y310* |
probably null |
Het |
| Phyh |
A |
T |
2: 4,932,247 (GRCm39) |
Y111F |
probably benign |
Het |
| Pon3 |
A |
G |
6: 5,240,863 (GRCm39) |
L106P |
probably benign |
Het |
| Ppp6r3 |
T |
C |
19: 3,519,748 (GRCm39) |
D615G |
probably damaging |
Het |
| Pramel23 |
G |
A |
4: 143,423,856 (GRCm39) |
P311L |
possibly damaging |
Het |
| Prdm10 |
G |
A |
9: 31,268,438 (GRCm39) |
V796I |
probably damaging |
Het |
| Prkdc |
G |
T |
16: 15,523,153 (GRCm39) |
V1192F |
probably damaging |
Het |
| R3hdm2 |
T |
G |
10: 127,293,521 (GRCm39) |
S142A |
probably damaging |
Het |
| Rab39 |
T |
C |
9: 53,597,665 (GRCm39) |
N200S |
probably benign |
Het |
| Rcc2 |
A |
G |
4: 140,445,664 (GRCm39) |
I441V |
probably benign |
Het |
| Rxra |
G |
A |
2: 27,627,496 (GRCm39) |
V72I |
possibly damaging |
Het |
| Ryr1 |
T |
G |
7: 28,794,524 (GRCm39) |
Q1252P |
probably benign |
Het |
| Sectm1a |
T |
C |
11: 120,960,473 (GRCm39) |
Y114C |
probably damaging |
Het |
| Smim1 |
T |
C |
4: 154,108,276 (GRCm39) |
|
probably null |
Het |
| Smpd2 |
C |
T |
10: 41,363,561 (GRCm39) |
D301N |
probably benign |
Het |
| Smyd3 |
T |
C |
1: 179,232,963 (GRCm39) |
D139G |
probably benign |
Het |
| Sox13 |
C |
T |
1: 133,313,743 (GRCm39) |
C399Y |
probably damaging |
Het |
| Tars3 |
A |
G |
7: 65,302,013 (GRCm39) |
E179G |
probably benign |
Het |
| Tas2r138 |
A |
G |
6: 40,589,494 (GRCm39) |
F251L |
probably damaging |
Het |
| Tesk1 |
A |
G |
4: 43,447,307 (GRCm39) |
E565G |
probably damaging |
Het |
| Tm2d1 |
A |
T |
4: 98,246,200 (GRCm39) |
F201I |
possibly damaging |
Het |
| Tom1l2 |
C |
A |
11: 60,120,942 (GRCm39) |
D501Y |
probably benign |
Het |
| Trim39 |
G |
T |
17: 36,579,667 (GRCm39) |
T96K |
probably benign |
Het |
| Ubash3a |
A |
G |
17: 31,436,971 (GRCm39) |
H196R |
probably damaging |
Het |
| Unc13b |
A |
G |
4: 43,257,352 (GRCm39) |
E1206G |
possibly damaging |
Het |
| Usp17lc |
A |
T |
7: 103,068,105 (GRCm39) |
T467S |
probably benign |
Het |
| Vmn1r128 |
T |
C |
7: 21,083,316 (GRCm39) |
S7P |
possibly damaging |
Het |
| Vmn1r185 |
T |
A |
7: 26,311,073 (GRCm39) |
H144L |
possibly damaging |
Het |
| Wfdc6b |
A |
T |
2: 164,455,708 (GRCm39) |
R12S |
possibly damaging |
Het |
|
| Other mutations in Zmynd8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01288:Zmynd8
|
APN |
2 |
165,654,734 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01311:Zmynd8
|
APN |
2 |
165,647,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02317:Zmynd8
|
APN |
2 |
165,662,492 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02548:Zmynd8
|
APN |
2 |
165,675,325 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02798:Zmynd8
|
APN |
2 |
165,694,070 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL02933:Zmynd8
|
APN |
2 |
165,670,238 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
cain
|
UTSW |
2 |
165,699,973 (GRCm39) |
critical splice donor site |
probably null |
|
|
F5770:Zmynd8
|
UTSW |
2 |
165,654,314 (GRCm39) |
nonsense |
probably null |
|
|
I1329:Zmynd8
|
UTSW |
2 |
165,670,145 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0031:Zmynd8
|
UTSW |
2 |
165,662,618 (GRCm39) |
splice site |
probably benign |
|
|
R0267:Zmynd8
|
UTSW |
2 |
165,670,322 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0608:Zmynd8
|
UTSW |
2 |
165,629,078 (GRCm39) |
splice site |
probably null |
|
|
R1663:Zmynd8
|
UTSW |
2 |
165,649,805 (GRCm39) |
missense |
probably benign |
0.11 |
|
R2212:Zmynd8
|
UTSW |
2 |
165,657,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3412:Zmynd8
|
UTSW |
2 |
165,657,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3413:Zmynd8
|
UTSW |
2 |
165,657,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3749:Zmynd8
|
UTSW |
2 |
165,647,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3820:Zmynd8
|
UTSW |
2 |
165,657,381 (GRCm39) |
nonsense |
probably null |
|
|
R3836:Zmynd8
|
UTSW |
2 |
165,700,019 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3957:Zmynd8
|
UTSW |
2 |
165,654,395 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4379:Zmynd8
|
UTSW |
2 |
165,649,858 (GRCm39) |
splice site |
probably null |
|
|
R4526:Zmynd8
|
UTSW |
2 |
165,649,527 (GRCm39) |
intron |
probably benign |
|
|
R4739:Zmynd8
|
UTSW |
2 |
165,647,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4838:Zmynd8
|
UTSW |
2 |
165,681,954 (GRCm39) |
nonsense |
probably null |
|
|
R4932:Zmynd8
|
UTSW |
2 |
165,676,871 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4933:Zmynd8
|
UTSW |
2 |
165,676,871 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4997:Zmynd8
|
UTSW |
2 |
165,634,736 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5652:Zmynd8
|
UTSW |
2 |
165,649,618 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5741:Zmynd8
|
UTSW |
2 |
165,681,937 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6008:Zmynd8
|
UTSW |
2 |
165,684,707 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R6242:Zmynd8
|
UTSW |
2 |
165,740,867 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6332:Zmynd8
|
UTSW |
2 |
165,680,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6394:Zmynd8
|
UTSW |
2 |
165,687,943 (GRCm39) |
nonsense |
probably null |
|
|
R6772:Zmynd8
|
UTSW |
2 |
165,649,521 (GRCm39) |
missense |
probably benign |
0.35 |
|
R6970:Zmynd8
|
UTSW |
2 |
165,717,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6986:Zmynd8
|
UTSW |
2 |
165,675,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7229:Zmynd8
|
UTSW |
2 |
165,699,973 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7266:Zmynd8
|
UTSW |
2 |
165,649,492 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7296:Zmynd8
|
UTSW |
2 |
165,681,929 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7642:Zmynd8
|
UTSW |
2 |
165,654,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7818:Zmynd8
|
UTSW |
2 |
165,684,751 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7821:Zmynd8
|
UTSW |
2 |
165,723,000 (GRCm39) |
intron |
probably benign |
|
|
R8135:Zmynd8
|
UTSW |
2 |
165,654,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8828:Zmynd8
|
UTSW |
2 |
165,654,466 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9128:Zmynd8
|
UTSW |
2 |
165,700,058 (GRCm39) |
start codon destroyed |
probably null |
|
|
R9345:Zmynd8
|
UTSW |
2 |
165,654,668 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9478:Zmynd8
|
UTSW |
2 |
165,649,569 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9626:Zmynd8
|
UTSW |
2 |
165,654,268 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9649:Zmynd8
|
UTSW |
2 |
165,680,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9759:Zmynd8
|
UTSW |
2 |
165,680,746 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
V7580:Zmynd8
|
UTSW |
2 |
165,654,314 (GRCm39) |
nonsense |
probably null |
|
|
V7581:Zmynd8
|
UTSW |
2 |
165,654,314 (GRCm39) |
nonsense |
probably null |
|
|
V7583:Zmynd8
|
UTSW |
2 |
165,654,314 (GRCm39) |
nonsense |
probably null |
|
|
Z1088:Zmynd8
|
UTSW |
2 |
165,670,091 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Zmynd8
|
UTSW |
2 |
165,670,108 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTCTATCTGACGATGTCCAG -3'
(R):5'- TAGAGGTCCAGAGTGGTCAG -3'
Sequencing Primer
(F):5'- GACGATGTCCAGATTAATCCACTTGG -3'
(R):5'- TCCAGAGTGGTCAGCAGTG -3'
|
| Posted On |
2022-02-07 |
Incidental Mutation