Mutagenetix > Incidental Mutation

Incidental Mutation 'R9200:Dnah6'

698162

Institutional Source

Beutler Lab

Gene Symbol

Dnah6

Ensembl Gene

ENSMUSG00000052861

Gene Name

dynein, axonemal, heavy chain 6

Synonyms

A730004I20Rik, Dnahc6

MMRRC Submission

068957-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.116) question?

Stock #

R9200 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

73017606-73221651 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 73027514 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 3822 (T3822I)

Ref Sequence

ENSEMBL: ENSMUSP00000068758 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000064948] [ENSMUST00000114040] [ENSMUST00000204053]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000064948
AA Change: T3822I

PolyPhen 2 Score 0.058 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000068758
Gene: ENSMUSG00000052861
AA Change: T3822I

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000114040
AA Change: T3770I

PolyPhen 2 Score 0.013 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000109674
Gene: ENSMUSG00000052861
AA Change: T3770I

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	873	1300	2.2e-135	PFAM
AAA	1407	1510	2.76e-1	SMART
AAA	1688	1829	5.25e-1	SMART
low complexity region	1905	1915	N/A	INTRINSIC
AAA	2031	2184	1.01e-3	SMART
AAA	2382	2540	3.08e0	SMART
low complexity region	2555	2566	N/A	INTRINSIC
low complexity region	2593	2604	N/A	INTRINSIC
Pfam:MT	2633	2967	1.1e-53	PFAM
Pfam:AAA_9	2984	3214	1e-58	PFAM
Pfam:Dynein_heavy	3344	4089	2.2e-213	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000204053
AA Change: T3822I

PolyPhen 2 Score 0.058 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000144791
Gene: ENSMUSG00000052861
AA Change: T3822I

Domain	Start	End	E-Value	Type
coiled coil region	732	759	N/A	INTRINSIC
low complexity region	841	852	N/A	INTRINSIC
Pfam:DHC_N2	875	1298	4.3e-144	PFAM
AAA	1459	1562	2.76e-1	SMART
AAA	1740	1881	5.25e-1	SMART
low complexity region	1957	1967	N/A	INTRINSIC
AAA	2083	2236	1.01e-3	SMART
AAA	2434	2592	3.08e0	SMART
low complexity region	2607	2618	N/A	INTRINSIC
low complexity region	2645	2656	N/A	INTRINSIC
Pfam:MT	2685	3019	3.1e-53	PFAM
Pfam:AAA_9	3040	3265	3.6e-94	PFAM
Pfam:Dynein_heavy	3402	4140	1.2e-250	PFAM

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.4%

Validation Efficiency

99% (71/72)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the dynein family, whose members encode large proteins that are constituents of the microtubule-associated motor protein complex. This complex is composed of dynein heavy, intermediate and light chains, which can be axonemal or cytoplasmic. This protein is an axonemal dynein heavy chain. It is involved in producing force for ciliary beating by using energy from ATP hydrolysis. Mutations in this gene may cause primary ciliary dyskinesia (PCD) as well as heterotaxy. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810013L24Rik	T	C	16: 8,856,034 (GRCm38)	L275P	possibly damaging	Het
Acsm2	C	A	7: 119,580,616 (GRCm38)	Y352*	probably null	Het
Adh7	C	T	3: 138,221,806 (GRCm38)	R38C	probably benign	Het
Ankrd2	A	T	19: 42,040,432 (GRCm38)	T145S		Het
Anpep	T	C	7: 79,841,122 (GRCm38)	N241D	probably benign	Het
Apaf1	G	A	10: 91,009,240 (GRCm38)	L990F	probably benign	Het
Arsi	A	G	18: 60,916,764 (GRCm38)	T240A	possibly damaging	Het
Ascc3	A	G	10: 50,645,691 (GRCm38)	E434G	possibly damaging	Het
Atp2c2	A	T	8: 119,748,260 (GRCm38)	K535*	probably null	Het
B3galt4	A	G	17: 33,951,410 (GRCm38)		probably benign	Het
Brwd1	C	G	16: 96,037,954 (GRCm38)	C839S	probably benign	Het
Cars	C	T	7: 143,575,917 (GRCm38)		probably null	Het
Catsperd	T	A	17: 56,628,229 (GRCm38)	V14D	unknown	Het
Ccdc150	A	C	1: 54,260,038 (GRCm38)	T58P	probably damaging	Het
Cdon	A	G	9: 35,503,321 (GRCm38)	D1164G	probably benign	Het
Celsr1	G	T	15: 86,033,085 (GRCm38)	S229*	probably null	Het
Cic	A	C	7: 25,272,515 (GRCm38)	D557A	probably damaging	Het
Clip4	G	A	17: 71,810,889 (GRCm38)	G310R	probably damaging	Het
Dach1	G	T	14: 97,828,307 (GRCm38)	R695S	probably damaging	Het
Ddc	T	C	11: 11,815,388 (GRCm38)	N428S	possibly damaging	Het
Dnmt1	T	A	9: 20,908,600 (GRCm38)	M1535L	probably benign	Het
Edc4	T	C	8: 105,890,419 (GRCm38)		probably null	Het
Emilin2	A	G	17: 71,274,234 (GRCm38)	I499T	possibly damaging	Het
Etl4	A	G	2: 20,781,891 (GRCm38)	D766G	probably damaging	Het
Fes	T	C	7: 80,382,392 (GRCm38)	Q414R	probably benign	Het
Fhod1	A	G	8: 105,331,440 (GRCm38)	V844A	probably benign	Het
Fshr	A	T	17: 89,046,675 (GRCm38)	V85E	probably benign	Het
Gc	T	C	5: 89,445,377 (GRCm38)	N61S	probably benign	Het
Gm13089	G	A	4: 143,697,286 (GRCm38)	P311L	possibly damaging	Het
Gm28710	T	C	5: 16,801,661 (GRCm38)		probably null	Het
Il18rap	C	T	1: 40,543,017 (GRCm38)	T366M	probably benign	Het
Itga1	A	T	13: 114,968,461 (GRCm38)	I1059N	possibly damaging	Het
Itpr3	T	A	17: 27,107,662 (GRCm38)	V1426E	probably damaging	Het
Jag1	T	A	2: 137,087,124 (GRCm38)	Y804F	probably benign	Het
Lama3	A	G	18: 12,472,240 (GRCm38)	T1084A	probably benign	Het
Mdn1	A	G	4: 32,760,791 (GRCm38)	D4952G	probably benign	Het
Mmrn1	A	G	6: 60,976,876 (GRCm38)	T714A	probably damaging	Het
Nab1	T	A	1: 52,490,366 (GRCm38)	H124L	possibly damaging	Het
Nacc2	A	G	2: 26,090,106 (GRCm38)	F106S	probably damaging	Het
Nbeal1	T	C	1: 60,281,266 (GRCm38)	I2006T	probably damaging	Het
Nkpd1	C	A	7: 19,523,758 (GRCm38)	H487Q	probably benign	Het
Nop2	G	A	6: 125,140,880 (GRCm38)		probably null	Het
Olfr1116	T	A	2: 87,269,711 (GRCm38)	M310K	probably benign	Het
Olfr1489	A	G	19: 13,633,231 (GRCm38)	N40S	probably damaging	Het
Otud6b	A	T	4: 14,811,712 (GRCm38)	Y310*	probably null	Het
Phyh	A	T	2: 4,927,436 (GRCm38)	Y111F	probably benign	Het
Pon3	A	G	6: 5,240,863 (GRCm38)	L106P	probably benign	Het
Ppp6r3	T	C	19: 3,469,748 (GRCm38)	D615G	probably damaging	Het
Prdm10	G	A	9: 31,357,142 (GRCm38)	V796I	probably damaging	Het
Prkdc	G	T	16: 15,705,289 (GRCm38)	V1192F	probably damaging	Het
R3hdm2	T	G	10: 127,457,652 (GRCm38)	S142A	probably damaging	Het
Rab39	T	C	9: 53,686,365 (GRCm38)	N200S	probably benign	Het
Rcc2	A	G	4: 140,718,353 (GRCm38)	I441V	probably benign	Het
Rxra	G	A	2: 27,737,484 (GRCm38)	V72I	possibly damaging	Het
Ryr1	T	G	7: 29,095,099 (GRCm38)	Q1252P	probably benign	Het
Sectm1a	T	C	11: 121,069,647 (GRCm38)	Y114C	probably damaging	Het
Smim1	T	C	4: 154,023,819 (GRCm38)		probably null	Het
Smpd2	C	T	10: 41,487,565 (GRCm38)	D301N	probably benign	Het
Smyd3	T	C	1: 179,405,398 (GRCm38)	D139G	probably benign	Het
Sox13	C	T	1: 133,386,005 (GRCm38)	C399Y	probably damaging	Het
Tarsl2	A	G	7: 65,652,265 (GRCm38)	E179G	probably benign	Het
Tas2r138	A	G	6: 40,612,560 (GRCm38)	F251L	probably damaging	Het
Tesk1	A	G	4: 43,447,307 (GRCm38)	E565G	probably damaging	Het
Tm2d1	A	T	4: 98,357,963 (GRCm38)	F201I	possibly damaging	Het
Tom1l2	C	A	11: 60,230,116 (GRCm38)	D501Y	probably benign	Het
Trim39	G	T	17: 36,268,775 (GRCm38)	T96K	probably benign	Het
Ubash3a	A	G	17: 31,217,997 (GRCm38)	H196R	probably damaging	Het
Unc13b	A	G	4: 43,257,352 (GRCm38)	E1206G	possibly damaging	Het
Usp17lc	A	T	7: 103,418,898 (GRCm38)	T467S	probably benign	Het
Vmn1r128	T	C	7: 21,349,391 (GRCm38)	S7P	possibly damaging	Het
Vmn1r185	T	A	7: 26,611,648 (GRCm38)	H144L	possibly damaging	Het
Wfdc6b	A	T	2: 164,613,788 (GRCm38)	R12S	possibly damaging	Het
Zmynd8	A	T	2: 165,840,085 (GRCm38)	D175E	probably benign	Het

Other mutations in Dnah6

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00264:Dnah6	APN	6	73,195,737 (GRCm38)	missense	probably benign	0.00
IGL00488:Dnah6	APN	6	73,086,207 (GRCm38)	missense	possibly damaging	0.95
IGL00497:Dnah6	APN	6	73,195,761 (GRCm38)	missense	probably damaging	1.00
IGL00557:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00561:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00563:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00755:Dnah6	APN	6	73,212,434 (GRCm38)	critical splice donor site	probably null
IGL00756:Dnah6	APN	6	73,123,771 (GRCm38)	missense	possibly damaging	0.76
IGL00764:Dnah6	APN	6	73,195,620 (GRCm38)	missense	possibly damaging	0.47
IGL00895:Dnah6	APN	6	73,156,350 (GRCm38)	missense	possibly damaging	0.67
IGL00922:Dnah6	APN	6	73,033,526 (GRCm38)	splice site	probably benign
IGL00972:Dnah6	APN	6	73,083,157 (GRCm38)	splice site	probably benign
IGL00975:Dnah6	APN	6	73,173,390 (GRCm38)	missense	possibly damaging	0.94
IGL01014:Dnah6	APN	6	73,074,781 (GRCm38)	splice site	probably benign
IGL01307:Dnah6	APN	6	73,065,725 (GRCm38)	missense	probably damaging	1.00
IGL01353:Dnah6	APN	6	73,173,456 (GRCm38)	missense	probably benign	0.01
IGL01362:Dnah6	APN	6	73,092,178 (GRCm38)	missense	probably damaging	1.00
IGL01373:Dnah6	APN	6	73,074,748 (GRCm38)	missense	probably benign	0.10
IGL01559:Dnah6	APN	6	73,024,252 (GRCm38)	critical splice donor site	probably null
IGL01622:Dnah6	APN	6	73,144,718 (GRCm38)	missense	probably damaging	1.00
IGL01623:Dnah6	APN	6	73,144,718 (GRCm38)	missense	probably damaging	1.00
IGL01682:Dnah6	APN	6	73,075,802 (GRCm38)	missense	probably damaging	1.00
IGL01735:Dnah6	APN	6	73,076,660 (GRCm38)	nonsense	probably null
IGL01736:Dnah6	APN	6	73,188,377 (GRCm38)	missense	probably benign	0.06
IGL01825:Dnah6	APN	6	73,065,776 (GRCm38)	missense	probably damaging	1.00
IGL01835:Dnah6	APN	6	73,135,801 (GRCm38)	missense	probably damaging	1.00
IGL01870:Dnah6	APN	6	73,032,569 (GRCm38)	missense	probably benign	0.04
IGL01935:Dnah6	APN	6	73,060,143 (GRCm38)	missense	probably benign
IGL02126:Dnah6	APN	6	73,103,166 (GRCm38)	missense	probably benign	0.01
IGL02191:Dnah6	APN	6	73,017,797 (GRCm38)	missense	probably benign	0.00
IGL02293:Dnah6	APN	6	73,133,650 (GRCm38)	splice site	probably benign
IGL02316:Dnah6	APN	6	73,168,911 (GRCm38)	missense	probably benign	0.19
IGL02339:Dnah6	APN	6	73,101,898 (GRCm38)	missense	probably benign	0.00
IGL02380:Dnah6	APN	6	73,076,640 (GRCm38)	missense	probably benign	0.12
IGL02458:Dnah6	APN	6	73,027,448 (GRCm38)	missense	probably benign	0.43
IGL02499:Dnah6	APN	6	73,021,227 (GRCm38)	missense	probably benign	0.12
IGL02652:Dnah6	APN	6	73,095,104 (GRCm38)	missense	probably damaging	1.00
IGL02668:Dnah6	APN	6	73,121,823 (GRCm38)	missense	possibly damaging	0.61
IGL02858:Dnah6	APN	6	73,208,599 (GRCm38)	missense	probably benign	0.03
IGL02875:Dnah6	APN	6	73,138,715 (GRCm38)	missense	probably damaging	0.99
IGL02878:Dnah6	APN	6	73,032,587 (GRCm38)	missense	probably benign	0.01
IGL02989:Dnah6	APN	6	73,069,420 (GRCm38)	missense	probably damaging	1.00
IGL03001:Dnah6	APN	6	73,149,140 (GRCm38)	missense	probably benign	0.19
IGL03135:Dnah6	APN	6	73,145,004 (GRCm38)	missense	probably benign	0.00
IGL03145:Dnah6	APN	6	73,041,054 (GRCm38)	missense	probably damaging	1.00
IGL03202:Dnah6	APN	6	73,144,700 (GRCm38)	missense	probably damaging	1.00
IGL03282:Dnah6	APN	6	73,053,647 (GRCm38)	splice site	probably benign
IGL03286:Dnah6	APN	6	73,083,085 (GRCm38)	missense	probably damaging	1.00
IGL03372:Dnah6	APN	6	73,075,850 (GRCm38)	missense	probably benign	0.15
P0025:Dnah6	UTSW	6	73,163,504 (GRCm38)	missense	probably benign	0.00
PIT4305001:Dnah6	UTSW	6	73,065,755 (GRCm38)	missense	probably benign	0.03
PIT4466001:Dnah6	UTSW	6	73,208,641 (GRCm38)	missense	probably benign	0.00
PIT4480001:Dnah6	UTSW	6	73,101,880 (GRCm38)	missense	probably benign	0.00
PIT4515001:Dnah6	UTSW	6	73,114,582 (GRCm38)	missense	probably damaging	1.00
PIT4651001:Dnah6	UTSW	6	73,060,260 (GRCm38)	missense	probably benign	0.02
R0103:Dnah6	UTSW	6	73,092,172 (GRCm38)	missense	probably damaging	1.00
R0103:Dnah6	UTSW	6	73,092,172 (GRCm38)	missense	probably damaging	1.00
R0105:Dnah6	UTSW	6	73,155,279 (GRCm38)	missense	probably damaging	0.99
R0105:Dnah6	UTSW	6	73,155,279 (GRCm38)	missense	probably damaging	0.99
R0127:Dnah6	UTSW	6	73,038,734 (GRCm38)	splice site	probably benign
R0164:Dnah6	UTSW	6	73,188,535 (GRCm38)	splice site	probably benign
R0165:Dnah6	UTSW	6	73,021,323 (GRCm38)	missense	probably benign	0.01
R0183:Dnah6	UTSW	6	73,082,923 (GRCm38)	missense	probably damaging	1.00
R0200:Dnah6	UTSW	6	73,069,420 (GRCm38)	missense	probably damaging	1.00
R0304:Dnah6	UTSW	6	73,159,115 (GRCm38)	missense	probably damaging	1.00
R0324:Dnah6	UTSW	6	73,173,558 (GRCm38)	missense	possibly damaging	0.86
R0335:Dnah6	UTSW	6	73,069,399 (GRCm38)	splice site	probably benign
R0345:Dnah6	UTSW	6	73,021,257 (GRCm38)	missense	probably benign	0.12
R0357:Dnah6	UTSW	6	73,188,359 (GRCm38)	missense	probably benign
R0362:Dnah6	UTSW	6	73,208,609 (GRCm38)	missense	probably benign	0.06
R0377:Dnah6	UTSW	6	73,121,992 (GRCm38)	missense	possibly damaging	0.93
R0386:Dnah6	UTSW	6	73,083,124 (GRCm38)	missense	probably damaging	0.99
R0547:Dnah6	UTSW	6	73,044,774 (GRCm38)	missense	probably benign	0.15
R0639:Dnah6	UTSW	6	73,022,412 (GRCm38)	missense	probably benign	0.02
R0673:Dnah6	UTSW	6	73,123,811 (GRCm38)	missense	probably benign	0.01
R0690:Dnah6	UTSW	6	73,129,474 (GRCm38)	missense	probably benign	0.01
R0708:Dnah6	UTSW	6	73,212,622 (GRCm38)	missense	probably benign	0.05
R0711:Dnah6	UTSW	6	73,087,602 (GRCm38)	missense	probably damaging	0.99
R0718:Dnah6	UTSW	6	73,035,293 (GRCm38)	missense	possibly damaging	0.80
R0894:Dnah6	UTSW	6	73,124,757 (GRCm38)	missense	probably benign	0.00
R0972:Dnah6	UTSW	6	73,159,193 (GRCm38)	missense	possibly damaging	0.94
R1263:Dnah6	UTSW	6	73,144,965 (GRCm38)	missense	probably damaging	0.99
R1298:Dnah6	UTSW	6	73,159,135 (GRCm38)	missense	probably damaging	1.00
R1300:Dnah6	UTSW	6	73,124,709 (GRCm38)	missense	probably benign	0.22
R1301:Dnah6	UTSW	6	73,208,545 (GRCm38)	critical splice donor site	probably null
R1341:Dnah6	UTSW	6	73,191,619 (GRCm38)	missense	probably benign	0.09
R1509:Dnah6	UTSW	6	73,027,442 (GRCm38)	missense	probably damaging	1.00
R1519:Dnah6	UTSW	6	73,049,048 (GRCm38)	missense	probably damaging	0.97
R1533:Dnah6	UTSW	6	73,151,553 (GRCm38)	missense	probably benign
R1557:Dnah6	UTSW	6	73,049,131 (GRCm38)	nonsense	probably null
R1591:Dnah6	UTSW	6	73,076,600 (GRCm38)	missense	probably benign	0.01
R1602:Dnah6	UTSW	6	73,067,469 (GRCm38)	missense	probably damaging	1.00
R1610:Dnah6	UTSW	6	73,144,963 (GRCm38)	missense	probably benign	0.09
R1616:Dnah6	UTSW	6	73,100,112 (GRCm38)	missense	probably benign	0.10
R1643:Dnah6	UTSW	6	73,044,752 (GRCm38)	missense	possibly damaging	0.85
R1644:Dnah6	UTSW	6	73,155,296 (GRCm38)	missense	probably benign	0.18
R1655:Dnah6	UTSW	6	73,205,732 (GRCm38)	missense	possibly damaging	0.88
R1661:Dnah6	UTSW	6	73,124,778 (GRCm38)	missense	probably benign	0.00
R1665:Dnah6	UTSW	6	73,124,778 (GRCm38)	missense	probably benign	0.00
R1675:Dnah6	UTSW	6	73,129,540 (GRCm38)	missense	probably damaging	1.00
R1734:Dnah6	UTSW	6	73,044,761 (GRCm38)	missense	probably damaging	0.98
R1757:Dnah6	UTSW	6	73,160,982 (GRCm38)	missense	probably damaging	1.00
R1794:Dnah6	UTSW	6	73,024,958 (GRCm38)	missense	probably damaging	0.99
R1831:Dnah6	UTSW	6	73,181,797 (GRCm38)	missense	possibly damaging	0.76
R1866:Dnah6	UTSW	6	73,100,088 (GRCm38)	missense	probably benign	0.00
R1897:Dnah6	UTSW	6	73,181,762 (GRCm38)	missense	probably benign	0.30
R1951:Dnah6	UTSW	6	73,084,721 (GRCm38)	nonsense	probably null
R1978:Dnah6	UTSW	6	73,121,970 (GRCm38)	missense	possibly damaging	0.51
R1987:Dnah6	UTSW	6	73,095,044 (GRCm38)	missense	probably damaging	0.96
R1988:Dnah6	UTSW	6	73,092,192 (GRCm38)	missense	probably damaging	1.00
R2012:Dnah6	UTSW	6	73,067,466 (GRCm38)	missense	probably damaging	1.00
R2014:Dnah6	UTSW	6	73,173,419 (GRCm38)	missense	probably damaging	0.98
R2022:Dnah6	UTSW	6	73,027,422 (GRCm38)	missense	probably benign
R2041:Dnah6	UTSW	6	73,073,439 (GRCm38)	missense	probably damaging	1.00
R2068:Dnah6	UTSW	6	73,021,182 (GRCm38)	missense	probably benign	0.23
R2114:Dnah6	UTSW	6	73,144,035 (GRCm38)	missense	probably damaging	1.00
R2152:Dnah6	UTSW	6	73,049,166 (GRCm38)	missense	probably benign	0.32
R2163:Dnah6	UTSW	6	73,089,746 (GRCm38)	splice site	probably null
R2193:Dnah6	UTSW	6	73,138,640 (GRCm38)	missense	probably damaging	1.00
R2235:Dnah6	UTSW	6	73,100,085 (GRCm38)	missense	probably damaging	0.96
R2276:Dnah6	UTSW	6	73,113,581 (GRCm38)	missense	probably benign	0.15
R2292:Dnah6	UTSW	6	73,021,109 (GRCm38)	missense	probably damaging	1.00
R2355:Dnah6	UTSW	6	73,156,421 (GRCm38)	missense	possibly damaging	0.95
R2395:Dnah6	UTSW	6	73,091,967 (GRCm38)	splice site	probably null
R2436:Dnah6	UTSW	6	73,149,173 (GRCm38)	missense	probably benign	0.05
R2847:Dnah6	UTSW	6	73,129,331 (GRCm38)	missense	probably benign	0.41
R2848:Dnah6	UTSW	6	73,129,331 (GRCm38)	missense	probably benign	0.41
R3033:Dnah6	UTSW	6	73,173,350 (GRCm38)	missense	probably benign	0.03
R3429:Dnah6	UTSW	6	73,121,814 (GRCm38)	missense	possibly damaging	0.95
R3430:Dnah6	UTSW	6	73,121,814 (GRCm38)	missense	possibly damaging	0.95
R3499:Dnah6	UTSW	6	73,032,633 (GRCm38)	missense	probably benign	0.21
R3811:Dnah6	UTSW	6	73,191,498 (GRCm38)	missense	probably benign	0.00
R3852:Dnah6	UTSW	6	73,127,927 (GRCm38)	missense	possibly damaging	0.82
R3975:Dnah6	UTSW	6	73,121,992 (GRCm38)	missense	possibly damaging	0.93
R4164:Dnah6	UTSW	6	73,089,592 (GRCm38)	nonsense	probably null
R4246:Dnah6	UTSW	6	73,129,448 (GRCm38)	missense	probably benign	0.00
R4367:Dnah6	UTSW	6	73,149,484 (GRCm38)	missense	possibly damaging	0.95
R4378:Dnah6	UTSW	6	73,118,026 (GRCm38)	missense	probably benign	0.01
R4405:Dnah6	UTSW	6	73,129,291 (GRCm38)	missense	probably benign	0.00
R4420:Dnah6	UTSW	6	73,191,479 (GRCm38)	missense	probably benign
R4486:Dnah6	UTSW	6	73,038,746 (GRCm38)	missense	probably damaging	1.00
R4512:Dnah6	UTSW	6	73,178,416 (GRCm38)	missense	probably damaging	1.00
R4547:Dnah6	UTSW	6	73,192,405 (GRCm38)	missense	probably benign
R4573:Dnah6	UTSW	6	73,086,181 (GRCm38)	missense	probably damaging	1.00
R4574:Dnah6	UTSW	6	73,086,181 (GRCm38)	missense	probably damaging	1.00
R4590:Dnah6	UTSW	6	73,152,712 (GRCm38)	missense	probably damaging	0.99
R4604:Dnah6	UTSW	6	73,129,660 (GRCm38)	missense	possibly damaging	0.92
R4652:Dnah6	UTSW	6	73,070,597 (GRCm38)	missense	probably benign
R4653:Dnah6	UTSW	6	73,073,457 (GRCm38)	missense	possibly damaging	0.76
R4669:Dnah6	UTSW	6	73,037,688 (GRCm38)	missense	probably damaging	1.00
R4674:Dnah6	UTSW	6	73,192,422 (GRCm38)	missense	probably benign	0.04
R4712:Dnah6	UTSW	6	73,025,012 (GRCm38)	critical splice acceptor site	probably null
R4788:Dnah6	UTSW	6	73,129,530 (GRCm38)	missense	probably damaging	1.00
R4791:Dnah6	UTSW	6	73,095,074 (GRCm38)	missense	probably benign	0.11
R4792:Dnah6	UTSW	6	73,089,668 (GRCm38)	missense	probably damaging	0.99
R4801:Dnah6	UTSW	6	73,089,698 (GRCm38)	missense	probably damaging	1.00
R4802:Dnah6	UTSW	6	73,089,698 (GRCm38)	missense	probably damaging	1.00
R4817:Dnah6	UTSW	6	73,022,424 (GRCm38)	missense	probably benign	0.02
R4830:Dnah6	UTSW	6	73,044,762 (GRCm38)	missense	possibly damaging	0.85
R4862:Dnah6	UTSW	6	73,121,788 (GRCm38)	missense	probably damaging	0.99
R4916:Dnah6	UTSW	6	73,192,676 (GRCm38)	intron	probably benign
R4948:Dnah6	UTSW	6	73,053,689 (GRCm38)	missense	probably benign	0.00
R4953:Dnah6	UTSW	6	73,188,383 (GRCm38)	missense	probably benign	0.19
R5000:Dnah6	UTSW	6	73,144,815 (GRCm38)	missense	probably benign	0.26
R5036:Dnah6	UTSW	6	73,044,691 (GRCm38)	missense	probably benign
R5044:Dnah6	UTSW	6	73,037,622 (GRCm38)	missense	probably benign	0.41
R5143:Dnah6	UTSW	6	73,181,761 (GRCm38)	missense	possibly damaging	0.91
R5157:Dnah6	UTSW	6	73,195,634 (GRCm38)	missense	probably benign
R5186:Dnah6	UTSW	6	73,067,427 (GRCm38)	missense	probably damaging	1.00
R5201:Dnah6	UTSW	6	73,195,732 (GRCm38)	missense	possibly damaging	0.82
R5249:Dnah6	UTSW	6	73,113,488 (GRCm38)	missense	probably damaging	1.00
R5272:Dnah6	UTSW	6	73,127,861 (GRCm38)	critical splice donor site	probably null
R5330:Dnah6	UTSW	6	73,074,590 (GRCm38)	missense	probably damaging	1.00
R5331:Dnah6	UTSW	6	73,074,590 (GRCm38)	missense	probably damaging	1.00
R5340:Dnah6	UTSW	6	73,212,620 (GRCm38)	missense	probably benign
R5343:Dnah6	UTSW	6	73,212,616 (GRCm38)	missense	probably benign
R5375:Dnah6	UTSW	6	73,123,855 (GRCm38)	missense	probably damaging	1.00
R5380:Dnah6	UTSW	6	73,037,615 (GRCm38)	missense	probably damaging	1.00
R5435:Dnah6	UTSW	6	73,060,138 (GRCm38)	missense	probably benign	0.00
R5455:Dnah6	UTSW	6	73,075,734 (GRCm38)	missense	probably benign	0.00
R5458:Dnah6	UTSW	6	73,086,185 (GRCm38)	missense	probably damaging	1.00
R5463:Dnah6	UTSW	6	73,092,157 (GRCm38)	missense	probably benign	0.04
R5484:Dnah6	UTSW	6	73,092,116 (GRCm38)	missense	possibly damaging	0.95
R5513:Dnah6	UTSW	6	73,190,419 (GRCm38)	missense	probably null	0.00
R5527:Dnah6	UTSW	6	73,159,229 (GRCm38)	missense	probably benign
R5541:Dnah6	UTSW	6	73,192,988 (GRCm38)	missense	possibly damaging	0.91
R5548:Dnah6	UTSW	6	73,151,689 (GRCm38)	missense	probably damaging	1.00
R5680:Dnah6	UTSW	6	73,149,525 (GRCm38)	missense	probably damaging	1.00
R5689:Dnah6	UTSW	6	73,021,227 (GRCm38)	missense	probably benign	0.12
R5966:Dnah6	UTSW	6	73,060,279 (GRCm38)	missense	probably benign	0.00
R5980:Dnah6	UTSW	6	73,181,722 (GRCm38)	missense	probably benign	0.01
R6049:Dnah6	UTSW	6	73,086,166 (GRCm38)	missense	probably benign	0.38
R6092:Dnah6	UTSW	6	73,114,697 (GRCm38)	missense	possibly damaging	0.61
R6130:Dnah6	UTSW	6	73,188,494 (GRCm38)	missense	probably benign	0.16
R6279:Dnah6	UTSW	6	73,065,815 (GRCm38)	missense	probably damaging	1.00
R6300:Dnah6	UTSW	6	73,065,815 (GRCm38)	missense	probably damaging	1.00
R6301:Dnah6	UTSW	6	73,086,217 (GRCm38)	missense	probably damaging	1.00
R6315:Dnah6	UTSW	6	73,191,605 (GRCm38)	missense	probably benign	0.02
R6394:Dnah6	UTSW	6	73,155,418 (GRCm38)	nonsense	probably null
R6470:Dnah6	UTSW	6	73,074,586 (GRCm38)	missense	probably damaging	1.00
R6526:Dnah6	UTSW	6	73,074,704 (GRCm38)	missense	probably benign	0.05
R6545:Dnah6	UTSW	6	73,044,732 (GRCm38)	missense	probably damaging	1.00
R6583:Dnah6	UTSW	6	73,173,533 (GRCm38)	missense	probably benign	0.02
R6609:Dnah6	UTSW	6	73,053,695 (GRCm38)	missense	possibly damaging	0.52
R6638:Dnah6	UTSW	6	73,035,280 (GRCm38)	splice site	probably null
R6640:Dnah6	UTSW	6	73,024,293 (GRCm38)	missense	probably damaging	1.00
R6647:Dnah6	UTSW	6	73,138,760 (GRCm38)	missense	probably damaging	1.00
R6744:Dnah6	UTSW	6	73,037,549 (GRCm38)	missense	probably damaging	0.97
R6767:Dnah6	UTSW	6	73,133,608 (GRCm38)	missense	probably benign	0.29
R6845:Dnah6	UTSW	6	73,133,542 (GRCm38)	missense	probably damaging	1.00
R6913:Dnah6	UTSW	6	73,212,522 (GRCm38)	missense	probably benign	0.00
R6918:Dnah6	UTSW	6	73,181,755 (GRCm38)	nonsense	probably null
R6929:Dnah6	UTSW	6	73,044,773 (GRCm38)	missense	probably damaging	0.96
R6981:Dnah6	UTSW	6	73,021,178 (GRCm38)	missense	probably benign	0.00
R7065:Dnah6	UTSW	6	73,087,562 (GRCm38)	missense	possibly damaging	0.87
R7139:Dnah6	UTSW	6	73,135,680 (GRCm38)	missense	probably damaging	1.00
R7169:Dnah6	UTSW	6	73,038,746 (GRCm38)	missense	probably damaging	1.00
R7202:Dnah6	UTSW	6	73,181,705 (GRCm38)	critical splice donor site	probably null
R7203:Dnah6	UTSW	6	73,173,545 (GRCm38)	missense	probably benign	0.00
R7315:Dnah6	UTSW	6	73,084,760 (GRCm38)	missense	probably damaging	1.00
R7329:Dnah6	UTSW	6	73,144,722 (GRCm38)	nonsense	probably null
R7387:Dnah6	UTSW	6	73,212,612 (GRCm38)	nonsense	probably null
R7388:Dnah6	UTSW	6	73,192,317 (GRCm38)	missense	possibly damaging	0.47
R7454:Dnah6	UTSW	6	73,212,492 (GRCm38)	missense	probably damaging	1.00
R7520:Dnah6	UTSW	6	73,127,904 (GRCm38)	missense	probably benign	0.04
R7524:Dnah6	UTSW	6	73,118,099 (GRCm38)	missense	probably damaging	1.00
R7548:Dnah6	UTSW	6	73,027,440 (GRCm38)	missense	probably damaging	1.00
R7570:Dnah6	UTSW	6	73,149,430 (GRCm38)	missense	probably benign	0.01
R7604:Dnah6	UTSW	6	73,092,168 (GRCm38)	missense	probably damaging	1.00
R7615:Dnah6	UTSW	6	73,095,206 (GRCm38)	missense	possibly damaging	0.85
R7622:Dnah6	UTSW	6	73,124,759 (GRCm38)	missense	possibly damaging	0.94
R7690:Dnah6	UTSW	6	73,169,080 (GRCm38)	splice site	probably null
R7735:Dnah6	UTSW	6	73,069,429 (GRCm38)	missense	probably damaging	1.00
R7754:Dnah6	UTSW	6	73,025,720 (GRCm38)	missense	probably benign	0.41
R7829:Dnah6	UTSW	6	73,127,919 (GRCm38)	nonsense	probably null
R7904:Dnah6	UTSW	6	73,135,467 (GRCm38)	splice site	probably null
R8034:Dnah6	UTSW	6	73,129,225 (GRCm38)	missense	probably damaging	1.00
R8093:Dnah6	UTSW	6	73,160,913 (GRCm38)	missense	probably damaging	1.00
R8120:Dnah6	UTSW	6	73,025,786 (GRCm38)	missense	probably damaging	1.00
R8178:Dnah6	UTSW	6	73,060,225 (GRCm38)	missense	probably benign	0.16
R8206:Dnah6	UTSW	6	73,037,566 (GRCm38)	nonsense	probably null
R8214:Dnah6	UTSW	6	73,044,728 (GRCm38)	missense	probably damaging	1.00
R8269:Dnah6	UTSW	6	73,168,827 (GRCm38)	critical splice donor site	probably null
R8273:Dnah6	UTSW	6	73,195,681 (GRCm38)	missense	probably benign	0.00
R8273:Dnah6	UTSW	6	73,076,599 (GRCm38)	missense	probably benign	0.31
R8331:Dnah6	UTSW	6	73,025,000 (GRCm38)	missense	probably benign	0.10
R8350:Dnah6	UTSW	6	73,195,815 (GRCm38)	missense	probably benign	0.41
R8428:Dnah6	UTSW	6	73,074,651 (GRCm38)	missense	probably benign	0.15
R8447:Dnah6	UTSW	6	73,138,774 (GRCm38)	missense	probably damaging	0.99
R8450:Dnah6	UTSW	6	73,195,815 (GRCm38)	missense	probably benign	0.41
R8517:Dnah6	UTSW	6	73,178,457 (GRCm38)	missense	probably benign	0.16
R8523:Dnah6	UTSW	6	73,095,188 (GRCm38)	missense	probably damaging	1.00
R8691:Dnah6	UTSW	6	73,168,867 (GRCm38)	missense	probably damaging	1.00
R8700:Dnah6	UTSW	6	73,075,890 (GRCm38)	intron	probably benign
R8737:Dnah6	UTSW	6	73,067,445 (GRCm38)	missense	possibly damaging	0.83
R8762:Dnah6	UTSW	6	73,179,828 (GRCm38)	missense	possibly damaging	0.83
R8804:Dnah6	UTSW	6	73,065,773 (GRCm38)	missense	probably benign
R8809:Dnah6	UTSW	6	73,032,563 (GRCm38)	missense	possibly damaging	0.94
R8813:Dnah6	UTSW	6	73,127,954 (GRCm38)	missense	probably damaging	1.00
R8849:Dnah6	UTSW	6	73,144,173 (GRCm38)	critical splice acceptor site	probably null
R8867:Dnah6	UTSW	6	73,021,148 (GRCm38)	missense	probably damaging	1.00
R8882:Dnah6	UTSW	6	73,178,498 (GRCm38)	missense	probably benign	0.05
R8973:Dnah6	UTSW	6	73,144,751 (GRCm38)	missense	probably benign	0.39
R9049:Dnah6	UTSW	6	73,142,292 (GRCm38)	missense	probably damaging	1.00
R9053:Dnah6	UTSW	6	73,084,657 (GRCm38)	missense	possibly damaging	0.94
R9064:Dnah6	UTSW	6	73,149,173 (GRCm38)	missense	probably benign	0.00
R9077:Dnah6	UTSW	6	73,144,046 (GRCm38)	nonsense	probably null
R9102:Dnah6	UTSW	6	73,067,486 (GRCm38)	missense	probably benign
R9106:Dnah6	UTSW	6	73,144,769 (GRCm38)	missense	probably damaging	1.00
R9119:Dnah6	UTSW	6	73,060,203 (GRCm38)	missense	possibly damaging	0.95
R9124:Dnah6	UTSW	6	73,121,899 (GRCm38)	missense	possibly damaging	0.78
R9165:Dnah6	UTSW	6	73,144,941 (GRCm38)	missense	probably damaging	1.00
R9182:Dnah6	UTSW	6	73,144,705 (GRCm38)	nonsense	probably null
R9265:Dnah6	UTSW	6	73,083,057 (GRCm38)	missense	probably benign	0.02
R9368:Dnah6	UTSW	6	73,021,278 (GRCm38)	missense	probably benign	0.22
R9378:Dnah6	UTSW	6	73,212,530 (GRCm38)	missense	probably benign
R9439:Dnah6	UTSW	6	73,035,347 (GRCm38)	missense	possibly damaging	0.66
R9506:Dnah6	UTSW	6	73,142,316 (GRCm38)	missense	probably damaging	1.00
R9645:Dnah6	UTSW	6	73,138,767 (GRCm38)	missense	possibly damaging	0.82
R9731:Dnah6	UTSW	6	73,191,606 (GRCm38)	missense	probably benign	0.00
RF002:Dnah6	UTSW	6	73,101,889 (GRCm38)	missense	probably benign
RF020:Dnah6	UTSW	6	73,118,057 (GRCm38)	missense	probably benign	0.00
W0251:Dnah6	UTSW	6	73,178,518 (GRCm38)	missense	possibly damaging	0.95
X0025:Dnah6	UTSW	6	73,191,500 (GRCm38)	missense	probably benign	0.01
X0025:Dnah6	UTSW	6	73,037,673 (GRCm38)	missense	probably damaging	1.00
Z1176:Dnah6	UTSW	6	73,133,559 (GRCm38)	missense	probably benign
Z1176:Dnah6	UTSW	6	73,087,783 (GRCm38)	missense	possibly damaging	0.79
Z1177:Dnah6	UTSW	6	73,032,526 (GRCm38)	missense	probably damaging	0.99
Z1177:Dnah6	UTSW	6	73,021,237 (GRCm38)	missense	probably benign	0.13
Z1177:Dnah6	UTSW	6	73,155,272 (GRCm38)	missense	possibly damaging	0.92
Z1177:Dnah6	UTSW	6	73,041,138 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- CCTCAACATCTGCTTATGATTTAGC -3'
(R):5'- CTGATGAGGAAGAAGCCTTTGC -3'

Sequencing Primer
(F):5'- ACATCTGCTTATGATTTAGCTTTCTG -3'
(R):5'- GAAGAACTGACTCCTGCAAGTTGTC -3'

Posted On

2022-02-07