Incidental Mutation 'R9202:Or5m5'
ID 698260
Institutional Source Beutler Lab
Gene Symbol Or5m5
Ensembl Gene ENSMUSG00000044923
Gene Name olfactory receptor family 5 subfamily M member 5
Synonyms MOR196-2, Olfr1030, GA_x6K02T2Q125-47462755-47463693
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.057) question?
Stock # R9202 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 85809656-85815142 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 85814801 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 206 (F206I)
Ref Sequence ENSEMBL: ENSMUSP00000053309 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056849]
AlphaFold Q8VFL5
Predicted Effect probably damaging
Transcript: ENSMUST00000056849
AA Change: F206I

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000053309
Gene: ENSMUSG00000044923
AA Change: F206I

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 2.4e-58 PFAM
Pfam:7tm_1 47 296 3.2e-27 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 95% (41/43)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk1 A T 3: 127,479,938 (GRCm39) I17K Het
Ampd3 T C 7: 110,402,346 (GRCm39) I441T probably damaging Het
Ankrd31 C T 13: 97,015,383 (GRCm39) Q1551* probably null Het
Asphd1 T A 7: 126,547,934 (GRCm39) Y123F probably damaging Het
Atf2 A G 2: 73,649,472 (GRCm39) S380P probably damaging Het
Bltp1 A G 3: 36,944,970 (GRCm39) S310G probably benign Het
Ccdc88b T C 19: 6,833,213 (GRCm39) E278G probably damaging Het
Celsr1 G T 15: 85,917,286 (GRCm39) S229* probably null Het
Cep72 G T 13: 74,198,420 (GRCm39) T320K probably benign Het
Clip4 G A 17: 72,117,884 (GRCm39) G310R probably damaging Het
Ctnna3 T G 10: 64,708,947 (GRCm39) M662R probably damaging Het
Cyp2r1 T G 7: 114,152,047 (GRCm39) probably benign Het
Flvcr1 T A 1: 190,744,351 (GRCm39) Y399F probably benign Het
Gimap8 T A 6: 48,633,403 (GRCm39) F407L probably benign Het
Insrr C T 3: 87,720,427 (GRCm39) R1022W probably damaging Het
Ipo4 A T 14: 55,868,597 (GRCm39) probably null Het
Klhl35 A G 7: 99,120,212 (GRCm39) N363S probably benign Het
Loxl4 T C 19: 42,593,452 (GRCm39) T240A probably benign Het
Med23 T C 10: 24,780,202 (GRCm39) V950A probably benign Het
Nceh1 A G 3: 27,333,428 (GRCm39) I175V probably benign Het
Ndst4 C T 3: 125,518,385 (GRCm39) S354L probably benign Het
Or3a10 A G 11: 73,935,441 (GRCm39) S220P probably damaging Het
Or5ac24 T C 16: 59,165,618 (GRCm39) I149V probably benign Het
Osbpl5 T C 7: 143,254,498 (GRCm39) D515G probably benign Het
Pafah2 T C 4: 134,131,440 (GRCm39) S68P probably benign Het
Pcnx2 T A 8: 126,616,416 (GRCm39) probably null Het
Pde11a G T 2: 75,853,077 (GRCm39) S847* probably null Het
Pramel11 T A 4: 143,623,646 (GRCm39) N176I probably benign Het
Pramel19 A G 4: 101,797,860 (GRCm39) D86G probably damaging Het
Ptprq C T 10: 107,522,416 (GRCm39) V546I probably damaging Het
R3hdm2 T G 10: 127,293,521 (GRCm39) S142A probably damaging Het
Ripk2 C A 4: 16,124,502 (GRCm39) G402V probably benign Het
Speg T C 1: 75,367,637 (GRCm39) S715P probably damaging Het
Ttll12 A G 15: 83,466,264 (GRCm39) F399S probably damaging Het
Ugt1a2 G T 1: 88,128,375 (GRCm39) C6F probably benign Het
Vars2 T C 17: 35,974,444 (GRCm39) probably null Het
Vars2 T C 17: 35,977,551 (GRCm39) Y127C probably damaging Het
Vmn2r95 T C 17: 18,644,394 (GRCm39) F10S probably benign Het
Wdr12 T C 1: 60,121,205 (GRCm39) D371G possibly damaging Het
Wdr89 C T 12: 75,679,943 (GRCm39) E104K probably benign Het
Zbtb1 G T 12: 76,433,784 (GRCm39) R590L probably damaging Het
Zfhx3 A G 8: 109,677,920 (GRCm39) D2990G possibly damaging Het
Zfp710 G A 7: 79,731,609 (GRCm39) G262D probably damaging Het
Other mutations in Or5m5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01775:Or5m5 APN 2 85,815,014 (GRCm39) missense probably damaging 0.99
IGL01795:Or5m5 APN 2 85,814,478 (GRCm39) missense probably damaging 1.00
IGL02395:Or5m5 APN 2 85,814,426 (GRCm39) missense possibly damaging 0.76
IGL03277:Or5m5 APN 2 85,814,517 (GRCm39) missense probably damaging 0.99
PIT4468001:Or5m5 UTSW 2 85,814,792 (GRCm39) missense probably benign 0.10
R0458:Or5m5 UTSW 2 85,814,600 (GRCm39) missense probably benign 0.00
R1114:Or5m5 UTSW 2 85,814,651 (GRCm39) missense probably benign
R1642:Or5m5 UTSW 2 85,814,201 (GRCm39) missense probably benign 0.00
R2189:Or5m5 UTSW 2 85,814,412 (GRCm39) missense probably damaging 1.00
R4094:Or5m5 UTSW 2 85,814,562 (GRCm39) missense probably damaging 1.00
R4246:Or5m5 UTSW 2 85,814,624 (GRCm39) missense possibly damaging 0.90
R4677:Or5m5 UTSW 2 85,814,315 (GRCm39) missense possibly damaging 0.61
R5537:Or5m5 UTSW 2 85,814,570 (GRCm39) missense possibly damaging 0.83
R6018:Or5m5 UTSW 2 85,815,148 (GRCm39) utr 3 prime probably benign
R6531:Or5m5 UTSW 2 85,814,651 (GRCm39) missense probably benign
R7367:Or5m5 UTSW 2 85,814,687 (GRCm39) missense possibly damaging 0.68
R7611:Or5m5 UTSW 2 85,814,407 (GRCm39) nonsense probably null
R7693:Or5m5 UTSW 2 85,814,979 (GRCm39) missense probably damaging 1.00
R7753:Or5m5 UTSW 2 85,815,060 (GRCm39) missense possibly damaging 0.75
R8940:Or5m5 UTSW 2 85,814,543 (GRCm39) missense probably benign
R8961:Or5m5 UTSW 2 85,814,610 (GRCm39) missense probably damaging 1.00
R9049:Or5m5 UTSW 2 85,814,235 (GRCm39) missense possibly damaging 0.49
Predicted Primers PCR Primer
(F):5'- CAAAGGTGTATGTGTGCGTC -3'
(R):5'- GGACTGCTCCACTGATTTATCTG -3'

Sequencing Primer
(F):5'- CTGATTGCTGGTCCCTATATCTATGG -3'
(R):5'- ATCTGTGGGAGGTCTAACATACATGC -3'
Posted On 2022-02-07