Mutagenetix > Incidental Mutation

Incidental Mutation 'R9203:Csnka2ip'

698347

Institutional Source

Beutler Lab

Gene Symbol

Csnka2ip

Ensembl Gene

ENSMUSG00000068167

Gene Name

casein kinase 2, alpha prime interacting protein

Synonyms

Ckt2

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.147) question?

Stock #

R9203 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

64298173-64422694 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 64298630 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 578 (D578V)

Ref Sequence

ENSEMBL: ENSMUSP00000147880 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000089279] [ENSMUST00000209382]

AlphaFold

Q8CH19

Predicted Effect

unknown
Transcript: ENSMUST00000089279
AA Change: D134V

SMART Domains

Protein: ENSMUSP00000086692
Gene: ENSMUSG00000068167
AA Change: D134V

Domain	Start	End	E-Value	Type
low complexity region	164	182	N/A	INTRINSIC
low complexity region	186	201	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000209382
AA Change: D578V

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 58 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Anapc1	T	C	2: 128,465,422 (GRCm39)	H1686R	possibly damaging	Het
Ankrd33b	A	G	15: 31,298,028 (GRCm39)	M243T	probably benign	Het
Appl1	G	T	14: 26,682,970 (GRCm39)	S104*	probably null	Het
Appl2	A	T	10: 83,476,879 (GRCm39)	Y48*	probably null	Het
Cacna1d	T	C	14: 29,773,669 (GRCm39)	N1694S	probably benign	Het
Cc2d2a	G	T	5: 43,891,179 (GRCm39)	D1372Y	probably benign	Het
Cdh4	C	T	2: 179,422,196 (GRCm39)	R107C	probably damaging	Het
Celsr1	G	T	15: 85,917,286 (GRCm39)	S229*	probably null	Het
Cfap54	T	G	10: 92,880,990 (GRCm39)	M358L	probably benign	Het
Ctns	T	C	11: 73,082,563 (GRCm39)	I56V	probably benign	Het
Dnah9	A	G	11: 65,746,113 (GRCm39)	I4000T	possibly damaging	Het
Dock2	A	G	11: 34,622,366 (GRCm39)	V91A	possibly damaging	Het
Dpep2	T	C	8: 106,712,885 (GRCm39)	H335R	probably damaging	Het
Eno1	C	T	4: 150,332,539 (GRCm39)	R400*	probably null	Het
Fam114a1	C	A	5: 65,137,300 (GRCm39)	P81H	probably damaging	Het
Gemin6	A	G	17: 80,535,237 (GRCm39)	T66A	probably benign	Het
Grm4	T	C	17: 27,653,980 (GRCm39)	I657V	probably benign	Het
H2ac22	T	C	13: 21,971,057 (GRCm39)	N111S	probably benign	Het
Has3	T	C	8: 107,600,852 (GRCm39)	C105R	probably damaging	Het
Hecw1	T	C	13: 14,491,243 (GRCm39)	E170G	probably benign	Het
Hoxd3	T	C	2: 74,576,744 (GRCm39)	V208A	probably damaging	Het
Hypk	C	T	2: 121,288,163 (GRCm39)	Q75*	probably null	Het
Itpkb	T	A	1: 180,161,004 (GRCm39)	W377R	probably benign	Het
Kbtbd2	A	T	6: 56,755,987 (GRCm39)	V583E	probably damaging	Het
Kdm5d	A	G	Y: 940,981 (GRCm39)	Y1122C	probably damaging	Het
Kif7	A	C	7: 79,354,472 (GRCm39)	L771R	probably damaging	Het
Krt9	C	G	11: 100,079,734 (GRCm39)	G553R	unknown	Het
Lama3	G	A	18: 12,595,869 (GRCm39)	A933T	probably benign	Het
Muc16	A	G	9: 18,462,984 (GRCm39)	I7406T	unknown	Het
Ndst4	C	T	3: 125,518,385 (GRCm39)	S354L	probably benign	Het
Ntng2	G	T	2: 29,084,998 (GRCm39)	C535*	probably null	Het
Omg	A	G	11: 79,393,051 (GRCm39)	M269T	probably benign	Het
Or1x6	A	T	11: 50,939,161 (GRCm39)	T76S	possibly damaging	Het
Or52e3	A	T	7: 102,869,862 (GRCm39)	*312C	probably null	Het
Parp2	T	C	14: 51,056,850 (GRCm39)	S325P	probably benign	Het
Pclo	C	T	5: 14,728,528 (GRCm39)	T2462M	unknown	Het
Pi4ka	G	T	16: 17,100,165 (GRCm39)	H1912N		Het
Piezo2	T	C	18: 63,290,302 (GRCm39)	I152M	probably benign	Het
Pigv	A	T	4: 133,392,990 (GRCm39)	L60Q	probably damaging	Het
Plcz1	T	A	6: 139,953,481 (GRCm39)	K379*	probably null	Het
Poll	T	C	19: 45,542,091 (GRCm39)	N405S	probably benign	Het
Pou6f2	T	A	13: 18,303,615 (GRCm39)	I467F		Het
Pramel11	T	A	4: 143,623,646 (GRCm39)	N176I	probably benign	Het
Psg26	T	C	7: 18,212,382 (GRCm39)	I324M	probably damaging	Het
Ptprh	T	A	7: 4,574,970 (GRCm39)	I350F	probably damaging	Het
Slpi	C	T	2: 164,196,817 (GRCm39)	V126I	probably benign	Het
Smarca5	C	T	8: 81,431,258 (GRCm39)	W986*	probably null	Het
Sorcs1	A	G	19: 50,250,733 (GRCm39)	I366T	probably damaging	Het
Sv2c	G	T	13: 96,224,745 (GRCm39)	S188*	probably null	Het
Sycp2	T	C	2: 177,996,906 (GRCm39)	K1099R	probably damaging	Het
Tdp2	C	A	13: 25,020,916 (GRCm39)	Y178*	probably null	Het
Trabd2b	A	G	4: 114,460,122 (GRCm39)	E420G	probably damaging	Het
Uggt2	A	T	14: 119,294,975 (GRCm39)	H550Q	probably benign	Het
Vmn2r66	T	C	7: 84,654,950 (GRCm39)	K453R	probably benign	Het
Vsig10l	A	G	7: 43,112,657 (GRCm39)	M1V	probably null	Het
Wdr70	G	A	15: 7,902,684 (GRCm39)	S646L	probably benign	Het
Zfp219	A	T	14: 52,246,405 (GRCm39)	S241T	probably damaging	Het
Zfp24	G	A	18: 24,147,326 (GRCm39)	H329Y	probably damaging	Het

Other mutations in Csnka2ip

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02039:Csnka2ip	APN	16	64,298,957 (GRCm39)	missense	probably damaging	0.99
IGL02677:Csnka2ip	APN	16	64,298,675 (GRCm39)	missense	probably damaging	0.99
G1Funyon:Csnka2ip	UTSW	16	64,299,354 (GRCm39)	missense	unknown
R0593:Csnka2ip	UTSW	16	64,298,975 (GRCm39)	missense	probably damaging	0.99
R1075:Csnka2ip	UTSW	16	64,298,310 (GRCm39)	nonsense	probably null
R1698:Csnka2ip	UTSW	16	64,298,422 (GRCm39)	nonsense	probably null
R1815:Csnka2ip	UTSW	16	64,298,855 (GRCm39)	missense	probably benign
R6446:Csnka2ip	UTSW	16	64,299,744 (GRCm39)	nonsense	probably null
R6709:Csnka2ip	UTSW	16	64,298,932 (GRCm39)	missense	possibly damaging	0.92
R6937:Csnka2ip	UTSW	16	64,299,058 (GRCm39)	utr 5 prime	probably benign
R6999:Csnka2ip	UTSW	16	64,298,933 (GRCm39)	missense	unknown
R7013:Csnka2ip	UTSW	16	64,298,780 (GRCm39)	missense	unknown
R7103:Csnka2ip	UTSW	16	64,299,120 (GRCm39)	missense	unknown
R7395:Csnka2ip	UTSW	16	64,299,803 (GRCm39)	missense
R7816:Csnka2ip	UTSW	16	64,299,852 (GRCm39)	unclassified	probably benign
R8301:Csnka2ip	UTSW	16	64,299,354 (GRCm39)	missense	unknown
R8416:Csnka2ip	UTSW	16	64,300,295 (GRCm39)	missense
R8946:Csnka2ip	UTSW	16	64,300,667 (GRCm39)	splice site	probably benign
R9479:Csnka2ip	UTSW	16	64,298,262 (GRCm39)	missense	unknown
R9774:Csnka2ip	UTSW	16	64,299,093 (GRCm39)	missense	unknown
R9799:Csnka2ip	UTSW	16	64,298,672 (GRCm39)	missense	unknown

Predicted Primers

PCR Primer
(F):5'- ATATCCTGAAACCGGAACCG -3'
(R):5'- AGAGAAGCCTTCCTCAACCTG -3'

Sequencing Primer
(F):5'- AACCGGAGTGGGATCTACC -3'
(R):5'- ACCTGTTTCCAACTTCCTATGAAAG -3'

Posted On

2022-02-07