Mutagenetix > Incidental Mutation

Incidental Mutation 'R9204:Flnc'

698374

Institutional Source

Beutler Lab

Gene Symbol

Flnc

Ensembl Gene

ENSMUSG00000068699

Gene Name

filamin C, gamma

Synonyms

1110055E19Rik, actin binding protein 280, Fln2

MMRRC Submission

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R9204 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

29433256-29461883 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 29452354 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 1726 (I1726L)

Ref Sequence

ENSEMBL: ENSMUSP00000064163 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000065090] [ENSMUST00000101617]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000065090
AA Change: I1726L

PolyPhen 2 Score 0.925 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000064163
Gene: ENSMUSG00000068699
AA Change: I1726L

Domain	Start	End	E-Value	Type
CH	39	141	1.17e-25	SMART
CH	162	258	2.09e-22	SMART
IG_FLMN	275	372	3.84e-38	SMART
IG_FLMN	375	472	3.73e-36	SMART
IG_FLMN	474	569	4.41e-38	SMART
IG_FLMN	571	662	3.61e-34	SMART
IG_FLMN	667	762	2.48e-41	SMART
IG_FLMN	764	865	6.7e-29	SMART
IG_FLMN	867	964	3.42e-35	SMART
IG_FLMN	966	1060	2.92e-29	SMART
IG_FLMN	1062	1153	3.69e-40	SMART
IG_FLMN	1155	1248	6.53e-41	SMART
IG_FLMN	1250	1348	7.23e-34	SMART
IG_FLMN	1350	1441	2.04e-42	SMART
IG_FLMN	1443	1537	1.75e-41	SMART
IG_FLMN	1539	1634	1.31e-40	SMART
IG_FLMN	1636	1738	1.05e-30	SMART
IG_FLMN	1777	1858	2.93e-11	SMART
IG_FLMN	1859	1950	2.55e-43	SMART
IG_FLMN	1951	2037	2.43e-17	SMART
IG_FLMN	2041	2132	1.52e-41	SMART
PDB:2E9I\|A	2133	2162	3e-7	PDB
IG_FLMN	2217	2310	2.93e-11	SMART
IG_FLMN	2314	2405	1.67e-38	SMART
IG_FLMN	2408	2500	2.56e-25	SMART
IG_FLMN	2505	2596	9.54e-34	SMART
low complexity region	2618	2628	N/A	INTRINSIC
IG_FLMN	2635	2737	2.11e-26	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000101617
AA Change: I1726L

PolyPhen 2 Score 0.182 (Sensitivity: 0.92; Specificity: 0.87)

SMART Domains

Protein: ENSMUSP00000099139
Gene: ENSMUSG00000068699
AA Change: I1726L

Domain	Start	End	E-Value	Type
CH	39	141	1.17e-25	SMART
CH	162	258	2.09e-22	SMART
IG_FLMN	275	372	3.84e-38	SMART
IG_FLMN	375	472	3.73e-36	SMART
IG_FLMN	474	569	4.41e-38	SMART
IG_FLMN	571	662	3.61e-34	SMART
IG_FLMN	667	762	2.48e-41	SMART
IG_FLMN	764	865	6.7e-29	SMART
IG_FLMN	867	964	3.42e-35	SMART
IG_FLMN	966	1060	2.92e-29	SMART
IG_FLMN	1062	1153	3.69e-40	SMART
IG_FLMN	1155	1248	6.53e-41	SMART
IG_FLMN	1250	1348	7.23e-34	SMART
IG_FLMN	1350	1441	2.04e-42	SMART
IG_FLMN	1443	1537	1.75e-41	SMART
IG_FLMN	1539	1634	1.31e-40	SMART
IG_FLMN	1636	1738	6.11e-32	SMART
IG_FLMN	1744	1825	2.93e-11	SMART
IG_FLMN	1826	1917	2.55e-43	SMART
IG_FLMN	1918	2004	2.43e-17	SMART
IG_FLMN	2008	2099	1.52e-41	SMART
PDB:2E9I\|A	2100	2129	3e-7	PDB
IG_FLMN	2184	2277	2.93e-11	SMART
IG_FLMN	2281	2372	1.67e-38	SMART
IG_FLMN	2375	2467	2.56e-25	SMART
IG_FLMN	2472	2563	9.54e-34	SMART
low complexity region	2585	2595	N/A	INTRINSIC
IG_FLMN	2602	2704	2.11e-26	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 98.8%

Validation Efficiency

100% (52/52)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of three related filamin genes, specifically gamma filamin. These filamin proteins crosslink actin filaments into orthogonal networks in cortical cytoplasm and participate in the anchoring of membrane proteins for the actin cytoskeleton. Three functional domains exist in filamin: an N-terminal filamentous actin-binding domain, a C-terminal self-association domain, and a membrane glycoprotein-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a hypomorphic allele display neonatal lethality, respiratory failure, reduced skeletal muscle mass, and abnormal skeletal muscle fiber morphology. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadat	T	C	8: 60,543,532 (GRCm38)	V389A	possibly damaging	Het
Adgrl1	T	C	8: 83,933,890 (GRCm38)	F792S	probably benign	Het
Angptl2	A	T	2: 33,228,330 (GRCm38)	I39F	probably benign	Het
Aprt	A	G	8: 122,576,616 (GRCm38)	I29T	probably damaging	Het
Arhgap21	A	T	2: 20,881,005 (GRCm38)	S464T	probably damaging	Het
Atic	T	C	1: 71,564,477 (GRCm38)	Y151H	probably damaging	Het
BB014433	T	C	8: 15,042,623 (GRCm38)	T77A	unknown	Het
Boc	C	A	16: 44,487,714 (GRCm38)	C926F		Het
Brd10	A	G	19: 29,719,538 (GRCm38)	S852P	possibly damaging	Het
Cabin1	C	T	10: 75,694,716 (GRCm38)	R1544Q	probably benign	Het
Ccdc33	A	G	9: 58,031,105 (GRCm38)	V861A	probably benign	Het
Ccdc88c	T	C	12: 100,938,063 (GRCm38)	T230A	unknown	Het
Cdc42bpa	T	A	1: 180,111,895 (GRCm38)		probably null	Het
Chrnb2	T	C	3: 89,760,821 (GRCm38)	M396V	probably benign	Het
Chst2	A	G	9: 95,405,102 (GRCm38)	V397A	probably damaging	Het
Cit	T	A	5: 115,988,439 (GRCm38)	N1643K	probably damaging	Het
Ckb	T	A	12: 111,671,435 (GRCm38)	D113V	probably benign	Het
Cyp2c68	A	T	19: 39,739,127 (GRCm38)	M136K	probably damaging	Het
Epas1	G	T	17: 86,809,445 (GRCm38)	R181L	probably damaging	Het
Fras1	G	A	5: 96,735,163 (GRCm38)	R2518H	probably damaging	Het
Gid4	T	C	11: 60,417,828 (GRCm38)	V58A	probably benign	Het
Hmcn1	T	A	1: 150,734,511 (GRCm38)	N1469I	probably benign	Het
Hmcn2	A	G	2: 31,388,365 (GRCm38)	E1693G	probably damaging	Het
Irx4	C	G	13: 73,268,530 (GRCm38)	C348W	probably damaging	Het
Lrig2	A	G	3: 104,480,122 (GRCm38)	S410P	possibly damaging	Het
Lsm11	A	G	11: 45,933,962 (GRCm38)	V246A	probably benign	Het
Ltbp1	G	T	17: 75,363,430 (GRCm38)	V1489F	probably damaging	Het
Mc2r	T	C	18: 68,407,596 (GRCm38)	T209A	probably benign	Het
Mms22l	T	C	4: 24,581,153 (GRCm38)	L821P	probably damaging	Het
Mtus2	A	T	5: 148,301,483 (GRCm38)	E1206V	probably damaging	Het
Muc5b	T	A	7: 141,856,392 (GRCm38)	H1234Q	unknown	Het
Naip5	A	T	13: 100,222,500 (GRCm38)	F743I	probably damaging	Het
Nphp3	G	A	9: 104,042,106 (GRCm38)	V1318I	probably benign	Het
Or4c10b	T	G	2: 89,881,138 (GRCm38)	L104W	probably damaging	Het
Or52a24	A	G	7: 103,732,849 (GRCm38)	K308E	possibly damaging	Het
Or5p60	A	T	7: 108,124,728 (GRCm38)	N178K	possibly damaging	Het
Or7g26	T	C	9: 19,318,699 (GRCm38)	L61P	probably damaging	Het
Or8b4	C	A	9: 37,919,374 (GRCm38)	T239K	probably damaging	Het
Or9k2b	G	C	10: 130,180,697 (GRCm38)	P61R	probably damaging	Het
Paqr5	G	A	9: 61,961,544 (GRCm38)	R246C	probably benign	Het
Pdgfb	T	C	15: 80,001,755 (GRCm38)	Q128R	probably damaging	Het
Prr3	T	A	17: 35,974,727 (GRCm38)	I88F	possibly damaging	Het
Ptprd	C	G	4: 75,954,078 (GRCm38)	A1134P	possibly damaging	Het
R3hcc1l	G	A	19: 42,563,862 (GRCm38)	D433N	probably benign	Het
Scnn1b	A	T	7: 121,899,299 (GRCm38)	T21S	probably benign	Het
Smcr8	A	G	11: 60,778,031 (GRCm38)	I2V	probably damaging	Het
Stk33	T	C	7: 109,341,479 (GRCm38)	D8G	probably benign	Het
Tbc1d22a	T	C	15: 86,214,602 (GRCm38)	F10L	probably benign	Het
Tmem126a	T	A	7: 90,452,818 (GRCm38)	I58F	possibly damaging	Het
Ttf2	T	C	3: 100,962,564 (GRCm38)	K398E	probably benign	Het
Tyw1	G	A	5: 130,269,224 (GRCm38)	R202Q	probably damaging	Het
Usp53	G	T	3: 122,947,419 (GRCm38)	N727K	probably benign	Het
Vmn2r25	T	G	6: 123,853,133 (GRCm38)	I20L	probably benign	Het
Zfp747l1	T	A	7: 127,385,160 (GRCm38)	I257L	unknown	Het

Other mutations in Flnc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00952:Flnc	APN	6	29,459,547 (GRCm38)	nonsense	probably null
IGL01099:Flnc	APN	6	29,433,618 (GRCm38)	missense	probably damaging	0.99
IGL01656:Flnc	APN	6	29,443,508 (GRCm38)	splice site	probably benign
IGL01659:Flnc	APN	6	29,448,671 (GRCm38)	missense	probably damaging	0.98
IGL01780:Flnc	APN	6	29,438,493 (GRCm38)	nonsense	probably null
IGL01935:Flnc	APN	6	29,454,280 (GRCm38)	missense	probably damaging	1.00
IGL02039:Flnc	APN	6	29,450,719 (GRCm38)	missense	probably benign	0.05
IGL02119:Flnc	APN	6	29,447,512 (GRCm38)	missense	probably damaging	0.98
IGL02122:Flnc	APN	6	29,444,336 (GRCm38)	missense	possibly damaging	0.70
IGL02236:Flnc	APN	6	29,454,376 (GRCm38)	missense	probably damaging	1.00
IGL02350:Flnc	APN	6	29,438,493 (GRCm38)	nonsense	probably null
IGL02357:Flnc	APN	6	29,438,493 (GRCm38)	nonsense	probably null
IGL02428:Flnc	APN	6	29,451,485 (GRCm38)	missense	probably damaging	1.00
IGL02496:Flnc	APN	6	29,440,685 (GRCm38)	missense	probably damaging	0.98
IGL02516:Flnc	APN	6	29,450,841 (GRCm38)	missense	probably damaging	0.99
IGL02696:Flnc	APN	6	29,446,698 (GRCm38)	missense	probably damaging	0.98
IGL03165:Flnc	APN	6	29,449,378 (GRCm38)	missense	probably damaging	1.00
IGL03190:Flnc	APN	6	29,445,637 (GRCm38)	splice site	probably benign
I1329:Flnc	UTSW	6	29,451,415 (GRCm38)	missense	probably damaging	1.00
R0111:Flnc	UTSW	6	29,454,340 (GRCm38)	missense	probably damaging	0.99
R0665:Flnc	UTSW	6	29,455,531 (GRCm38)	missense	probably damaging	1.00
R0748:Flnc	UTSW	6	29,446,344 (GRCm38)	missense	probably damaging	0.99
R0960:Flnc	UTSW	6	29,441,512 (GRCm38)	missense	probably damaging	1.00
R1328:Flnc	UTSW	6	29,438,613 (GRCm38)	missense	probably damaging	1.00
R1502:Flnc	UTSW	6	29,438,694 (GRCm38)	missense	probably benign	0.45
R1544:Flnc	UTSW	6	29,444,080 (GRCm38)	missense	probably benign	0.00
R1565:Flnc	UTSW	6	29,455,171 (GRCm38)	missense	probably damaging	1.00
R1640:Flnc	UTSW	6	29,433,807 (GRCm38)	missense	possibly damaging	0.78
R1691:Flnc	UTSW	6	29,441,214 (GRCm38)	missense	probably benign	0.09
R1818:Flnc	UTSW	6	29,457,448 (GRCm38)	missense	probably damaging	1.00
R1826:Flnc	UTSW	6	29,455,185 (GRCm38)	missense	probably damaging	0.99
R1851:Flnc	UTSW	6	29,443,479 (GRCm38)	missense	probably damaging	1.00
R1898:Flnc	UTSW	6	29,438,666 (GRCm38)	nonsense	probably null
R1905:Flnc	UTSW	6	29,459,460 (GRCm38)	missense	probably damaging	1.00
R1985:Flnc	UTSW	6	29,444,416 (GRCm38)	splice site	probably benign
R2016:Flnc	UTSW	6	29,443,797 (GRCm38)	critical splice donor site	probably null
R2017:Flnc	UTSW	6	29,443,797 (GRCm38)	critical splice donor site	probably null
R2020:Flnc	UTSW	6	29,444,363 (GRCm38)	missense	probably damaging	0.97
R2104:Flnc	UTSW	6	29,450,735 (GRCm38)	critical splice donor site	probably null
R2132:Flnc	UTSW	6	29,443,676 (GRCm38)	missense	probably damaging	1.00
R2141:Flnc	UTSW	6	29,448,675 (GRCm38)	missense	probably damaging	1.00
R2197:Flnc	UTSW	6	29,459,135 (GRCm38)	missense	probably damaging	1.00
R2202:Flnc	UTSW	6	29,459,508 (GRCm38)	missense	probably damaging	1.00
R2203:Flnc	UTSW	6	29,459,508 (GRCm38)	missense	probably damaging	1.00
R2204:Flnc	UTSW	6	29,459,508 (GRCm38)	missense	probably damaging	1.00
R2205:Flnc	UTSW	6	29,459,508 (GRCm38)	missense	probably damaging	1.00
R2209:Flnc	UTSW	6	29,455,845 (GRCm38)	missense	possibly damaging	0.91
R2248:Flnc	UTSW	6	29,451,401 (GRCm38)	missense	probably damaging	0.99
R2258:Flnc	UTSW	6	29,438,666 (GRCm38)	nonsense	probably null
R2259:Flnc	UTSW	6	29,438,666 (GRCm38)	nonsense	probably null
R2280:Flnc	UTSW	6	29,438,666 (GRCm38)	nonsense	probably null
R2281:Flnc	UTSW	6	29,438,666 (GRCm38)	nonsense	probably null
R2873:Flnc	UTSW	6	29,447,543 (GRCm38)	missense	probably damaging	0.96
R2900:Flnc	UTSW	6	29,448,585 (GRCm38)	missense	probably damaging	0.98
R3788:Flnc	UTSW	6	29,454,057 (GRCm38)	missense	probably damaging	0.99
R3799:Flnc	UTSW	6	29,443,739 (GRCm38)	missense	probably damaging	1.00
R3801:Flnc	UTSW	6	29,447,404 (GRCm38)	missense	probably damaging	0.98
R3851:Flnc	UTSW	6	29,453,719 (GRCm38)	missense	probably damaging	1.00
R3910:Flnc	UTSW	6	29,459,427 (GRCm38)	missense	probably damaging	1.00
R3982:Flnc	UTSW	6	29,442,941 (GRCm38)	missense	probably damaging	1.00
R3983:Flnc	UTSW	6	29,442,941 (GRCm38)	missense	probably damaging	1.00
R4023:Flnc	UTSW	6	29,451,635 (GRCm38)	missense	possibly damaging	0.95
R4676:Flnc	UTSW	6	29,445,154 (GRCm38)	splice site	probably null
R4694:Flnc	UTSW	6	29,443,448 (GRCm38)	missense	probably damaging	1.00
R4695:Flnc	UTSW	6	29,440,429 (GRCm38)	missense	probably damaging	0.99
R4735:Flnc	UTSW	6	29,455,813 (GRCm38)	missense	probably damaging	1.00
R4773:Flnc	UTSW	6	29,445,039 (GRCm38)	missense	possibly damaging	0.96
R4828:Flnc	UTSW	6	29,455,167 (GRCm38)	missense	probably damaging	1.00
R4856:Flnc	UTSW	6	29,447,890 (GRCm38)	missense	probably damaging	1.00
R4879:Flnc	UTSW	6	29,460,806 (GRCm38)	missense	probably damaging	0.99
R4899:Flnc	UTSW	6	29,446,843 (GRCm38)	missense	probably benign	0.17
R4906:Flnc	UTSW	6	29,447,525 (GRCm38)	missense	probably damaging	0.99
R5089:Flnc	UTSW	6	29,447,813 (GRCm38)	missense	probably damaging	0.96
R5173:Flnc	UTSW	6	29,455,538 (GRCm38)	missense	probably damaging	1.00
R5174:Flnc	UTSW	6	29,448,894 (GRCm38)	missense	possibly damaging	0.91
R5290:Flnc	UTSW	6	29,457,554 (GRCm38)	missense	probably damaging	1.00
R5338:Flnc	UTSW	6	29,444,064 (GRCm38)	missense	possibly damaging	0.47
R5352:Flnc	UTSW	6	29,449,318 (GRCm38)	missense	possibly damaging	0.85
R5397:Flnc	UTSW	6	29,441,161 (GRCm38)	missense	possibly damaging	0.87
R5431:Flnc	UTSW	6	29,456,384 (GRCm38)	missense	possibly damaging	0.74
R5481:Flnc	UTSW	6	29,441,217 (GRCm38)	missense	probably damaging	1.00
R5511:Flnc	UTSW	6	29,458,898 (GRCm38)	missense	probably damaging	1.00
R5539:Flnc	UTSW	6	29,446,230 (GRCm38)	missense	probably damaging	1.00
R5549:Flnc	UTSW	6	29,453,691 (GRCm38)	missense	probably damaging	1.00
R5567:Flnc	UTSW	6	29,444,045 (GRCm38)	nonsense	probably null
R5584:Flnc	UTSW	6	29,446,628 (GRCm38)	missense	probably damaging	0.98
R5689:Flnc	UTSW	6	29,441,592 (GRCm38)	missense	probably benign	0.03
R5753:Flnc	UTSW	6	29,433,489 (GRCm38)	missense	probably benign
R5786:Flnc	UTSW	6	29,459,537 (GRCm38)	nonsense	probably null
R5822:Flnc	UTSW	6	29,459,430 (GRCm38)	missense	probably damaging	0.98
R5823:Flnc	UTSW	6	29,461,202 (GRCm38)	missense	probably damaging	0.99
R5933:Flnc	UTSW	6	29,441,106 (GRCm38)	missense	probably damaging	0.99
R6043:Flnc	UTSW	6	29,446,608 (GRCm38)	missense	probably damaging	1.00
R6320:Flnc	UTSW	6	29,459,063 (GRCm38)	missense	probably damaging	1.00
R6337:Flnc	UTSW	6	29,454,319 (GRCm38)	missense	probably damaging	0.99
R6399:Flnc	UTSW	6	29,458,883 (GRCm38)	missense	probably damaging	1.00
R6423:Flnc	UTSW	6	29,445,156 (GRCm38)	splice site	probably null
R6540:Flnc	UTSW	6	29,446,377 (GRCm38)	missense	possibly damaging	0.96
R6547:Flnc	UTSW	6	29,448,608 (GRCm38)	missense	probably damaging	0.98
R6717:Flnc	UTSW	6	29,450,902 (GRCm38)	small deletion	probably benign
R6875:Flnc	UTSW	6	29,445,749 (GRCm38)	missense	probably damaging	1.00
R7193:Flnc	UTSW	6	29,450,871 (GRCm38)	missense	probably damaging	1.00
R7255:Flnc	UTSW	6	29,445,766 (GRCm38)	missense	probably damaging	1.00
R7303:Flnc	UTSW	6	29,460,850 (GRCm38)	missense	probably benign	0.31
R7413:Flnc	UTSW	6	29,452,259 (GRCm38)	missense	probably damaging	1.00
R7422:Flnc	UTSW	6	29,455,471 (GRCm38)	missense	probably damaging	1.00
R7559:Flnc	UTSW	6	29,459,010 (GRCm38)	missense	probably damaging	1.00
R7632:Flnc	UTSW	6	29,446,985 (GRCm38)	missense	probably damaging	0.98
R7651:Flnc	UTSW	6	29,444,050 (GRCm38)	missense	probably benign	0.08
R7679:Flnc	UTSW	6	29,456,790 (GRCm38)	missense	probably benign	0.00
R7697:Flnc	UTSW	6	29,456,517 (GRCm38)	missense	probably damaging	0.98
R7788:Flnc	UTSW	6	29,456,444 (GRCm38)	missense	possibly damaging	0.67
R7852:Flnc	UTSW	6	29,440,898 (GRCm38)	missense	probably damaging	1.00
R7870:Flnc	UTSW	6	29,454,307 (GRCm38)	missense	probably damaging	1.00
R7873:Flnc	UTSW	6	29,456,991 (GRCm38)	missense	possibly damaging	0.88
R7921:Flnc	UTSW	6	29,447,770 (GRCm38)	missense	possibly damaging	0.58
R7950:Flnc	UTSW	6	29,456,382 (GRCm38)	missense	possibly damaging	0.61
R7953:Flnc	UTSW	6	29,447,829 (GRCm38)	missense	probably damaging	0.99
R7970:Flnc	UTSW	6	29,447,526 (GRCm38)	missense	possibly damaging	0.96
R8071:Flnc	UTSW	6	29,457,446 (GRCm38)	missense	probably damaging	1.00
R8143:Flnc	UTSW	6	29,441,485 (GRCm38)	missense	probably benign	0.20
R8166:Flnc	UTSW	6	29,433,732 (GRCm38)	missense	probably damaging	0.99
R8167:Flnc	UTSW	6	29,455,922 (GRCm38)	missense	probably damaging	0.98
R8306:Flnc	UTSW	6	29,449,370 (GRCm38)	missense	probably benign	0.05
R8428:Flnc	UTSW	6	29,450,850 (GRCm38)	missense	probably benign	0.36
R8466:Flnc	UTSW	6	29,438,622 (GRCm38)	missense	probably damaging	0.98
R8671:Flnc	UTSW	6	29,443,502 (GRCm38)	critical splice donor site	probably null
R8885:Flnc	UTSW	6	29,455,411 (GRCm38)	missense	probably damaging	0.96
R8922:Flnc	UTSW	6	29,456,836 (GRCm38)	missense	probably damaging	0.99
R8923:Flnc	UTSW	6	29,452,237 (GRCm38)	missense	probably damaging	1.00
R8985:Flnc	UTSW	6	29,440,500 (GRCm38)	missense	probably benign	0.37
R9075:Flnc	UTSW	6	29,447,647 (GRCm38)	missense	probably damaging	0.96
R9098:Flnc	UTSW	6	29,455,519 (GRCm38)	nonsense	probably null
R9162:Flnc	UTSW	6	29,455,861 (GRCm38)	missense	probably damaging	1.00
R9199:Flnc	UTSW	6	29,441,491 (GRCm38)	missense	probably benign	0.31
R9273:Flnc	UTSW	6	29,447,816 (GRCm38)	missense	probably benign	0.08
R9411:Flnc	UTSW	6	29,441,485 (GRCm38)	missense	probably benign
R9412:Flnc	UTSW	6	29,441,485 (GRCm38)	missense	probably benign
R9413:Flnc	UTSW	6	29,441,485 (GRCm38)	missense	probably benign
R9451:Flnc	UTSW	6	29,445,463 (GRCm38)	missense	probably damaging	0.98
R9524:Flnc	UTSW	6	29,461,110 (GRCm38)	missense	probably damaging	1.00
R9575:Flnc	UTSW	6	29,454,400 (GRCm38)	missense	probably damaging	0.98
R9582:Flnc	UTSW	6	29,460,737 (GRCm38)	missense	probably damaging	0.99
R9595:Flnc	UTSW	6	29,433,721 (GRCm38)	missense	probably benign	0.05
R9664:Flnc	UTSW	6	29,457,215 (GRCm38)	missense	probably damaging	1.00
R9665:Flnc	UTSW	6	29,455,448 (GRCm38)	missense	probably damaging	1.00
R9686:Flnc	UTSW	6	29,456,435 (GRCm38)	missense	possibly damaging	0.84
Z1088:Flnc	UTSW	6	29,457,151 (GRCm38)	missense	probably damaging	1.00
Z1177:Flnc	UTSW	6	29,457,130 (GRCm38)	missense	probably damaging	1.00
Z1177:Flnc	UTSW	6	29,447,545 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGGGTCCCAGAATCCAGATC -3'
(R):5'- CCCAAGGGCTCATTCTAGAG -3'

Sequencing Primer
(F):5'- TGTGATCACAGTGGACGC -3'
(R):5'- CAAGGGCTCATTCTAGAGTACTCTG -3'

Posted On

2022-02-07