Incidental Mutation 'R9207:Mpped2'
ID 698565
Institutional Source Beutler Lab
Gene Symbol Mpped2
Ensembl Gene ENSMUSG00000016386
Gene Name metallophosphoesterase domain containing 2
Synonyms 239Fb, 2700082O15Rik
MMRRC Submission 068981-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9207 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 106523614-106698701 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 106697319 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 265 (T265A)
Ref Sequence ENSEMBL: ENSMUSP00000016530 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000016530] [ENSMUST00000111063] [ENSMUST00000125023]
AlphaFold Q9CZJ0
Predicted Effect probably benign
Transcript: ENSMUST00000016530
AA Change: T265A

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000016530
Gene: ENSMUSG00000016386
AA Change: T265A

DomainStartEndE-ValueType
Pfam:Metallophos 58 256 3e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000111063
AA Change: T265A

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000106692
Gene: ENSMUSG00000016386
AA Change: T265A

DomainStartEndE-ValueType
Pfam:Metallophos 58 256 1.5e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000125023
AA Change: T265A

PolyPhen 2 Score 0.150 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000123267
Gene: ENSMUSG00000016386
AA Change: T265A

DomainStartEndE-ValueType
Pfam:Metallophos 58 256 1.7e-10 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (43/43)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene likely encodes a metallophosphoesterase. The encoded protein may play a role a brain development. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadat T G 8: 60,979,657 (GRCm39) I173S probably damaging Het
Actrt2 T A 4: 154,751,920 (GRCm39) H72L probably benign Het
Adgrf1 A G 17: 43,621,164 (GRCm39) D467G probably benign Het
Axdnd1 A G 1: 156,215,616 (GRCm39) L226P Het
Begain T C 12: 108,999,250 (GRCm39) D507G probably damaging Het
Bsdc1 A G 4: 129,362,830 (GRCm39) N134S probably benign Het
Ccdc39 C A 3: 33,886,706 (GRCm39) E301* probably null Het
Cdh23 A G 10: 60,243,210 (GRCm39) V1055A probably damaging Het
Efcab8 A G 2: 153,656,339 (GRCm39) D591G unknown Het
Fibcd1 G A 2: 31,706,455 (GRCm39) R459C probably damaging Het
Frem3 T G 8: 81,340,071 (GRCm39) V788G possibly damaging Het
Ftcd A T 10: 76,422,973 (GRCm39) I423L probably benign Het
Gad1 G A 2: 70,409,546 (GRCm39) probably null Het
Gm8229 T C 14: 44,606,238 (GRCm39) L156P Het
Grm7 T C 6: 111,335,874 (GRCm39) Y762H probably damaging Het
Hectd4 T A 5: 121,433,496 (GRCm39) V937D possibly damaging Het
Ifnz T C 4: 88,701,525 (GRCm39) V168A probably benign Het
Irx4 C G 13: 73,416,649 (GRCm39) C348W probably damaging Het
Itgb4 G T 11: 115,897,923 (GRCm39) G1603V probably damaging Het
Krt32 A G 11: 99,977,580 (GRCm39) V162A possibly damaging Het
Npas3 T C 12: 54,114,818 (GRCm39) L580P possibly damaging Het
Or4f47 G A 2: 111,972,397 (GRCm39) V36M probably benign Het
Or5b109 A T 19: 13,212,400 (GRCm39) Q262L possibly damaging Het
Or8b54 G A 9: 38,686,960 (GRCm39) M136I possibly damaging Het
Plec A G 15: 76,058,117 (GRCm39) L3940P probably damaging Het
Pum2 T C 12: 8,763,904 (GRCm39) Y283H probably damaging Het
Rad54l T C 4: 115,967,215 (GRCm39) H281R probably damaging Het
Rftn2 T A 1: 55,224,149 (GRCm39) Q397L probably damaging Het
Rnf166 C T 8: 123,195,068 (GRCm39) A151T probably benign Het
Setdb1 A T 3: 95,246,113 (GRCm39) I604N possibly damaging Het
Smr2 A G 5: 88,256,726 (GRCm39) T135A unknown Het
Snai2 C A 16: 14,524,946 (GRCm39) H151N possibly damaging Het
Spag6l A T 16: 16,598,492 (GRCm39) I333N probably benign Het
Spta1 A G 1: 174,039,139 (GRCm39) T1161A probably benign Het
Sult2a1 G T 7: 13,566,627 (GRCm39) A116E probably benign Het
Tas2r120 T A 6: 132,634,626 (GRCm39) L236* probably null Het
Tchhl1 T A 3: 93,377,819 (GRCm39) N174K possibly damaging Het
Tex15 T C 8: 34,065,784 (GRCm39) L1738P probably damaging Het
Timp4 T C 6: 115,224,270 (GRCm39) Y133C probably damaging Het
Tmem25 A G 9: 44,710,476 (GRCm39) probably null Het
Tubd1 A T 11: 86,456,537 (GRCm39) T399S probably benign Het
Tyw1 G A 5: 130,298,065 (GRCm39) R202Q probably damaging Het
Zfp110 A T 7: 12,582,485 (GRCm39) I378L probably benign Het
Other mutations in Mpped2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01068:Mpped2 APN 2 106,695,091 (GRCm39) missense probably damaging 1.00
IGL01734:Mpped2 APN 2 106,614,158 (GRCm39) missense probably damaging 1.00
IGL03031:Mpped2 APN 2 106,613,968 (GRCm39) splice site probably benign
LCD18:Mpped2 UTSW 2 106,551,773 (GRCm39) intron probably benign
R1446:Mpped2 UTSW 2 106,614,077 (GRCm39) missense possibly damaging 0.92
R1460:Mpped2 UTSW 2 106,575,237 (GRCm39) unclassified probably benign
R1857:Mpped2 UTSW 2 106,613,989 (GRCm39) missense probably damaging 1.00
R1888:Mpped2 UTSW 2 106,529,790 (GRCm39) missense probably benign 0.26
R1888:Mpped2 UTSW 2 106,529,790 (GRCm39) missense probably benign 0.26
R1919:Mpped2 UTSW 2 106,697,377 (GRCm39) missense probably damaging 1.00
R2073:Mpped2 UTSW 2 106,575,147 (GRCm39) nonsense probably null
R2074:Mpped2 UTSW 2 106,575,147 (GRCm39) nonsense probably null
R2075:Mpped2 UTSW 2 106,575,147 (GRCm39) nonsense probably null
R2295:Mpped2 UTSW 2 106,529,846 (GRCm39) missense possibly damaging 0.94
R4720:Mpped2 UTSW 2 106,614,091 (GRCm39) missense probably damaging 1.00
R4851:Mpped2 UTSW 2 106,529,724 (GRCm39) utr 5 prime probably benign
R5201:Mpped2 UTSW 2 106,529,847 (GRCm39) missense possibly damaging 0.94
R6500:Mpped2 UTSW 2 106,691,925 (GRCm39) missense probably damaging 1.00
R6603:Mpped2 UTSW 2 106,697,322 (GRCm39) missense probably benign 0.06
R6994:Mpped2 UTSW 2 106,529,878 (GRCm39) missense possibly damaging 0.83
R7807:Mpped2 UTSW 2 106,575,085 (GRCm39) missense possibly damaging 0.73
R8827:Mpped2 UTSW 2 106,691,928 (GRCm39) missense possibly damaging 0.94
R8878:Mpped2 UTSW 2 106,575,065 (GRCm39) missense probably damaging 0.97
R8932:Mpped2 UTSW 2 106,697,395 (GRCm39) missense possibly damaging 0.84
R9024:Mpped2 UTSW 2 106,614,043 (GRCm39) missense probably benign 0.12
Z1177:Mpped2 UTSW 2 106,691,937 (GRCm39) missense probably damaging 1.00
Z1177:Mpped2 UTSW 2 106,575,148 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGGTATCTGGAAAGGCCCAC -3'
(R):5'- GCCTTTGAGCAAACAGAAGTC -3'

Sequencing Primer
(F):5'- TCTGGAAAGGCCCACTGAATTTC -3'
(R):5'- TCACATTCCAACGGGATG -3'
Posted On 2022-02-07