Incidental Mutation 'R9208:Mslnl'
| ID |
698667 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mslnl
|
| Ensembl Gene |
ENSMUSG00000041062 |
| Gene Name |
mesothelin-like |
| Synonyms |
|
| MMRRC Submission |
068982-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R9208 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
25736040-25748330 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 25742720 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Serine
at position 117
(P117S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000049020
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047098]
|
| AlphaFold |
Q8C160 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000047098
AA Change: P117S
PolyPhen 2
Score 0.936 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000049020
Gene: ENSMUSG00000041062
AA Change: P117S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Mesothelin
|
29 |
589 |
2.8e-70 |
PFAM |
|
low complexity region
|
633 |
653 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.2293 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.4%
|
| Validation Efficiency |
98% (65/66) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 67 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810474O19Rik |
C |
T |
6: 149,326,529 (GRCm38) |
L358F |
probably damaging |
Het |
| Acot6 |
T |
A |
12: 84,106,584 (GRCm38) |
L200Q |
possibly damaging |
Het |
| AI314180 |
A |
T |
4: 58,875,444 (GRCm38) |
D173E |
probably damaging |
Het |
| Apbb1 |
A |
G |
7: 105,559,520 (GRCm38) |
S569P |
probably damaging |
Het |
| Atl3 |
A |
G |
19: 7,510,082 (GRCm38) |
I121V |
probably benign |
Het |
| C87436 |
A |
G |
6: 86,446,245 (GRCm38) |
D267G |
probably benign |
Het |
| Ccdc7a |
T |
A |
8: 128,746,001 (GRCm38) |
I1617F |
possibly damaging |
Het |
| Cic |
T |
C |
7: 25,288,077 (GRCm38) |
F1397L |
probably benign |
Het |
| Cln6 |
T |
A |
9: 62,849,183 (GRCm38) |
M203K |
probably benign |
Het |
| Clock |
A |
G |
5: 76,237,024 (GRCm38) |
S449P |
probably benign |
Het |
| Cse1l |
C |
A |
2: 166,941,265 (GRCm38) |
N743K |
probably damaging |
Het |
| Cyp1a2 |
A |
G |
9: 57,682,300 (GRCm38) |
I77T |
probably damaging |
Het |
| D6Wsu163e |
A |
G |
6: 126,966,969 (GRCm38) |
I443V |
probably benign |
Het |
| Dctn1 |
T |
C |
6: 83,199,702 (GRCm38) |
V1246A |
probably benign |
Het |
| Dennd5b |
T |
C |
6: 149,101,200 (GRCm38) |
E37G |
probably benign |
Het |
| Dnah11 |
C |
T |
12: 118,027,516 (GRCm38) |
E2372K |
probably damaging |
Het |
| Ercc5 |
T |
C |
1: 44,178,343 (GRCm38) |
W949R |
possibly damaging |
Het |
| Fam13c |
A |
G |
10: 70,553,039 (GRCm38) |
E465G |
probably damaging |
Het |
| Fam83d |
T |
A |
2: 158,768,546 (GRCm38) |
C145S |
probably damaging |
Het |
| Fbln7 |
T |
A |
2: 128,895,423 (GRCm38) |
V386E |
probably damaging |
Het |
| Fpr3 |
A |
T |
17: 17,970,869 (GRCm38) |
Q134L |
probably damaging |
Het |
| Gm3636 |
T |
A |
14: 6,741,416 (GRCm38) |
R5S |
possibly damaging |
Het |
| Gna15 |
A |
G |
10: 81,509,390 (GRCm38) |
S214P |
probably benign |
Het |
| Hdac9 |
A |
G |
12: 34,170,102 (GRCm38) |
M897T |
probably benign |
Het |
| Hdc |
T |
C |
2: 126,594,680 (GRCm38) |
N424D |
probably benign |
Het |
| Krtap27-1 |
A |
G |
16: 88,671,428 (GRCm38) |
V76A |
possibly damaging |
Het |
| Lrrd1 |
T |
A |
5: 3,850,995 (GRCm38) |
H433Q |
probably damaging |
Het |
| Ltn1 |
T |
C |
16: 87,400,410 (GRCm38) |
D1180G |
probably benign |
Het |
| Macf1 |
A |
G |
4: 123,684,132 (GRCm38) |
C20R |
unknown |
Het |
| Mphosph9 |
T |
C |
5: 124,312,791 (GRCm38) |
N306D |
probably damaging |
Het |
| Mpp7 |
T |
C |
18: 7,403,327 (GRCm38) |
R328G |
probably benign |
Het |
| Muc16 |
T |
A |
9: 18,508,537 (GRCm38) |
K117M |
probably damaging |
Het |
| Mycbp2 |
T |
C |
14: 103,295,228 (GRCm38) |
N430S |
probably benign |
Het |
| Myl1 |
T |
C |
1: 66,934,524 (GRCm38) |
I8V |
probably benign |
Het |
| Ncdn |
A |
T |
4: 126,750,248 (GRCm38) |
D260E |
probably benign |
Het |
| Nkx3-2 |
T |
A |
5: 41,761,771 (GRCm38) |
R291S |
probably damaging |
Het |
| Nr4a2 |
A |
G |
2: 57,109,081 (GRCm38) |
V448A |
probably damaging |
Het |
| Nrip1 |
T |
C |
16: 76,292,728 (GRCm38) |
E647G |
possibly damaging |
Het |
| Olfr1259 |
C |
A |
2: 89,943,381 (GRCm38) |
V245L |
possibly damaging |
Het |
| Olfr282 |
C |
A |
15: 98,437,733 (GRCm38) |
A88E |
probably benign |
Het |
| Olfr69 |
A |
G |
7: 103,768,271 (GRCm38) |
I42T |
probably benign |
Het |
| Olfr892-ps1 |
T |
C |
9: 38,189,824 (GRCm38) |
M33T |
possibly damaging |
Het |
| Patj |
A |
T |
4: 98,539,073 (GRCm38) |
I172F |
unknown |
Het |
| Per1 |
T |
C |
11: 69,104,810 (GRCm38) |
S739P |
possibly damaging |
Het |
| Plekhn1 |
A |
C |
4: 156,222,402 (GRCm38) |
V510G |
possibly damaging |
Het |
| Plxna4 |
A |
T |
6: 32,517,444 (GRCm38) |
V79D |
probably damaging |
Het |
| Pram1 |
A |
G |
17: 33,640,827 (GRCm38) |
T123A |
probably benign |
Het |
| Ptpn23 |
C |
A |
9: 110,408,033 (GRCm38) |
|
probably null |
Het |
| Rcbtb2 |
C |
T |
14: 73,177,060 (GRCm38) |
S437L |
probably damaging |
Het |
| Rxfp4 |
T |
A |
3: 88,652,083 (GRCm38) |
R354* |
probably null |
Het |
| Serpinb5 |
A |
G |
1: 106,876,123 (GRCm38) |
T180A |
probably damaging |
Het |
| Slc7a14 |
T |
A |
3: 31,227,210 (GRCm38) |
D317V |
probably damaging |
Het |
| Slco5a1 |
A |
G |
1: 12,989,578 (GRCm38) |
|
probably null |
Het |
| Snx14 |
T |
A |
9: 88,383,779 (GRCm38) |
T768S |
probably benign |
Het |
| Sorbs1 |
T |
A |
19: 40,365,018 (GRCm38) |
|
probably benign |
Het |
| Stambp |
C |
T |
6: 83,551,972 (GRCm38) |
A364T |
probably damaging |
Het |
| Tgm3 |
T |
A |
2: 130,023,698 (GRCm38) |
I6N |
possibly damaging |
Het |
| Tmem106b |
A |
T |
6: 13,082,431 (GRCm38) |
T202S |
probably damaging |
Het |
| Tnfsf8 |
A |
G |
4: 63,834,213 (GRCm38) |
V205A |
probably benign |
Het |
| Treml2 |
A |
T |
17: 48,307,894 (GRCm38) |
R136* |
probably null |
Het |
| Trim46 |
T |
C |
3: 89,235,159 (GRCm38) |
T674A |
possibly damaging |
Het |
| Trmt13 |
T |
A |
3: 116,582,707 (GRCm38) |
Y345F |
possibly damaging |
Het |
| Tspyl4 |
A |
G |
10: 34,297,572 (GRCm38) |
H20R |
probably benign |
Het |
| Uvssa |
T |
C |
5: 33,414,075 (GRCm38) |
|
probably null |
Het |
| Vmn1r192 |
A |
T |
13: 22,187,231 (GRCm38) |
F273Y |
probably damaging |
Het |
| Vmn2r45 |
A |
T |
7: 8,483,299 (GRCm38) |
I330N |
probably damaging |
Het |
| Zfp40 |
A |
G |
17: 23,175,577 (GRCm38) |
F679L |
probably damaging |
Het |
|
| Other mutations in Mslnl |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01621:Mslnl
|
APN |
17 |
25,743,667 (GRCm38) |
unclassified |
probably benign |
|
|
IGL01629:Mslnl
|
APN |
17 |
25,744,775 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL02084:Mslnl
|
APN |
17 |
25,746,151 (GRCm38) |
missense |
probably benign |
0.07 |
|
IGL02408:Mslnl
|
APN |
17 |
25,747,998 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
IGL02726:Mslnl
|
APN |
17 |
25,744,103 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL03387:Mslnl
|
APN |
17 |
25,744,077 (GRCm38) |
missense |
probably benign |
0.06 |
|
R0561:Mslnl
|
UTSW |
17 |
25,743,203 (GRCm38) |
nonsense |
probably null |
|
|
R0881:Mslnl
|
UTSW |
17 |
25,742,965 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R1295:Mslnl
|
UTSW |
17 |
25,743,240 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1296:Mslnl
|
UTSW |
17 |
25,743,240 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1582:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1629:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1630:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1631:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1632:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1794:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1850:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1866:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1876:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1914:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2166:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2241:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2243:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2247:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2282:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2284:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2852:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2867:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2867:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2877:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2878:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2919:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2920:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3026:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3405:Mslnl
|
UTSW |
17 |
25,746,181 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3406:Mslnl
|
UTSW |
17 |
25,746,181 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3411:Mslnl
|
UTSW |
17 |
25,744,517 (GRCm38) |
missense |
probably benign |
0.05 |
|
R3434:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3546:Mslnl
|
UTSW |
17 |
25,744,969 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R3612:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3729:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3730:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3802:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3804:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3894:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R3895:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4454:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4455:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4456:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4457:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4561:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4562:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4564:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4600:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4601:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4610:Mslnl
|
UTSW |
17 |
25,742,934 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R4704:Mslnl
|
UTSW |
17 |
25,738,978 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R5155:Mslnl
|
UTSW |
17 |
25,738,968 (GRCm38) |
nonsense |
probably null |
|
|
R5257:Mslnl
|
UTSW |
17 |
25,746,165 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5456:Mslnl
|
UTSW |
17 |
25,743,159 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5645:Mslnl
|
UTSW |
17 |
25,737,842 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R6007:Mslnl
|
UTSW |
17 |
25,746,775 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6083:Mslnl
|
UTSW |
17 |
25,737,902 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R6142:Mslnl
|
UTSW |
17 |
25,744,557 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6761:Mslnl
|
UTSW |
17 |
25,746,073 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7058:Mslnl
|
UTSW |
17 |
25,743,212 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7156:Mslnl
|
UTSW |
17 |
25,743,210 (GRCm38) |
missense |
probably benign |
0.20 |
|
R7467:Mslnl
|
UTSW |
17 |
25,736,921 (GRCm38) |
start codon destroyed |
probably benign |
0.33 |
|
R7687:Mslnl
|
UTSW |
17 |
25,743,183 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R7807:Mslnl
|
UTSW |
17 |
25,746,777 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8682:Mslnl
|
UTSW |
17 |
25,746,988 (GRCm38) |
missense |
probably benign |
|
|
R8735:Mslnl
|
UTSW |
17 |
25,745,088 (GRCm38) |
missense |
probably benign |
0.09 |
|
R8742:Mslnl
|
UTSW |
17 |
25,745,073 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9264:Mslnl
|
UTSW |
17 |
25,742,532 (GRCm38) |
intron |
probably benign |
|
|
RF007:Mslnl
|
UTSW |
17 |
25,743,228 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGCATGCCTTCTGCTGAG -3'
(R):5'- AATGAAGGCCCGGCAGTTAG -3'
Sequencing Primer
(F):5'- ACAGACAGTAACCTGCTG -3'
(R):5'- CACCTGGCTCAGACTAAGGAG -3'
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| Posted On |
2022-02-07 |
Incidental Mutation