Mutagenetix > Incidental Mutation

Incidental Mutation 'R9209:Vmn2r78'

698712

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r78

Ensembl Gene

ENSMUSG00000091962

Gene Name

vomeronasal 2, receptor 78

Synonyms

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R9209 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

86915300-86955177 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 86920223 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Valine at position 108 (D108V)

Ref Sequence

ENSEMBL: ENSMUSP00000126698 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170835]

AlphaFold

K7N6U5

Predicted Effect

probably benign
Transcript: ENSMUST00000170835
AA Change: D108V

PolyPhen 2 Score 0.080 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000126698
Gene: ENSMUSG00000091962
AA Change: D108V

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	75	464	5.9e-31	PFAM
Pfam:NCD3G	507	559	8.1e-21	PFAM
Pfam:7tm_3	592	827	1e-52	PFAM

Meta Mutation Damage Score

0.0846

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

96% (73/76)

Allele List at MGI

Other mutations in this stock

Total: 77 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2610021A01Rik	T	A	7: 41,626,413	N513K	possibly damaging	Het
Actl6a	T	A	3: 32,725,320	I399N	probably damaging	Het
Adamts5	A	G	16: 85,870,083	V507A	probably damaging	Het
Ap3d1	A	G	10: 80,719,084	V469A	probably benign	Het
Arhgef4	G	T	1: 34,725,160		probably null	Het
Arhgef4	A	T	1: 34,810,495	Q389L	probably benign	Het
Atad2	A	G	15: 58,116,798	V106A	possibly damaging	Het
Azin2	T	C	4: 128,947,548	E275G	probably damaging	Het
Bhlhe23	A	G	2: 180,776,350	S132P	probably damaging	Het
Capn12	A	G	7: 28,881,818	Y32C	probably damaging	Het
Celsr2	A	T	3: 108,414,033	S488T	probably benign	Het
Cenpx	A	G	11: 120,711,756	V27A	possibly damaging	Het
Clca2	G	A	3: 145,072,244	P760L	probably benign	Het
Clstn3	T	C	6: 124,431,612	S951G	probably benign	Het
Clybl	C	A	14: 122,384,258	P286Q	probably benign	Het
Cmya5	T	A	13: 93,090,358	M2741L	probably benign	Het
Cntnap2	G	A	6: 47,049,249	G944E	probably damaging	Het
Col8a1	A	C	16: 57,626,920	Y742*	probably null	Het
Crb1	T	C	1: 139,243,313	K780E	probably damaging	Het
Crygc	T	A	1: 65,073,217	Y66F	probably benign	Het
Cyp2b9	G	A	7: 26,173,579	G49E	possibly damaging	Het
D130043K22Rik	T	C	13: 24,857,107	S171P	possibly damaging	Het
Dhx36	T	C	3: 62,471,474	I890V	probably benign	Het
Dpp9	C	T	17: 56,205,765	G148S	probably damaging	Het
Eml6	G	T	11: 29,831,175	S619Y	probably damaging	Het
Enpp4	A	T	17: 44,101,361	L319*	probably null	Het
Esyt1	T	C	10: 128,525,487	S113G	probably benign	Het
Fat1	A	G	8: 44,951,754	D514G	possibly damaging	Het
Fbxo16	G	A	14: 65,287,145	R38Q	probably damaging	Het
Fchsd1	A	T	18: 37,959,653	M668K	unknown	Het
Gpr149	C	T	3: 62,603,672	S302N	probably benign	Het
Gsap	A	G	5: 21,228,066	K258E	probably benign	Het
Helq	C	A	5: 100,791,352	V443F	probably benign	Het
Helq	T	A	5: 100,791,353	K442N	probably damaging	Het
Ighv1-37	T	C	12: 114,896,503	E29G	possibly damaging	Het
Ighv1-9	C	A	12: 114,584,000	M1I	probably null	Het
Itga6	T	G	2: 71,841,133	F743V	probably benign	Het
Lpin1	C	A	12: 16,538,547	D881Y		Het
Lypd8	T	A	11: 58,382,814	C40S	possibly damaging	Het
Macf1	C	T	4: 123,432,434	R5092Q	probably damaging	Het
Mcm7	A	G	5: 138,168,331		probably null	Het
Micall2	G	A	5: 139,710,415	T831I	unknown	Het
Myo18b	A	T	5: 112,875,061	M155K	unknown	Het
Nckap5	T	A	1: 125,940,191	H201L	unknown	Het
Ndst2	A	T	14: 20,729,172	D333E	possibly damaging	Het
Nlgn1	A	G	3: 25,912,640		probably null	Het
Nup188	T	G	2: 30,342,385	Y1483D	probably benign	Het
Olfr1214	A	C	2: 88,987,713	L163*	probably null	Het
Olfr490	T	A	7: 108,286,319	Y269F	probably benign	Het
Olfr503	A	C	7: 108,545,457	I311L	probably benign	Het
Olfr629	T	A	7: 103,741,112	S43C	probably benign	Het
Olfr952	T	A	9: 39,426,339	H244L	probably damaging	Het
Peg3	A	C	7: 6,708,227	I1332S	possibly damaging	Het
Piezo2	T	C	18: 63,021,301	K2469R	probably damaging	Het
Pik3cg	T	C	12: 32,197,313	M804V	probably damaging	Het
Polq	A	T	16: 37,048,649	I794F	possibly damaging	Het
Rasgef1b	A	G	5: 99,222,332	V437A	probably benign	Het
Rdm1	T	A	11: 101,628,031	D21E	probably benign	Het
Ripk4	G	T	16: 97,750,111	Q219K	possibly damaging	Het
Ropn1l	T	C	15: 31,441,325	I217V		Het
Sdf2	T	C	11: 78,246,032	S13P	unknown	Het
Selenbp1	A	G	3: 94,939,768	T202A	probably benign	Het
Slfn5	T	C	11: 82,960,107	F410S	possibly damaging	Het
Srrm2	A	G	17: 23,820,906	T2175A	probably benign	Het
St6galnac3	T	C	3: 153,411,723	Y121C	possibly damaging	Het
Stat1	A	G	1: 52,145,178	N417S	probably benign	Het
Tead1	T	C	7: 112,876,171	F276L	probably damaging	Het
Teddm3	A	T	16: 21,152,987	S277R	probably benign	Het
Tmc2	A	G	2: 130,261,397		probably null	Het
Tmem156	G	A	5: 65,073,784	L248F	probably damaging	Het
Tnn	T	C	1: 160,126,416	S590G	probably benign	Het
Trmt44	A	G	5: 35,574,078		probably null	Het
Upp2	T	A	2: 58,778,010	Y238*	probably null	Het
Usp32	T	C	11: 85,040,012	T531A	probably damaging	Het
Wdfy3	G	T	5: 101,930,964	A824E	probably benign	Het
Xylt1	T	C	7: 117,656,647	V814A	probably benign	Het
Zfy1	C	T	Y: 732,990	R281H	unknown	Het

Other mutations in Vmn2r78

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01302:Vmn2r78	APN	7	86915361	missense	unknown
IGL01473:Vmn2r78	APN	7	86920312	missense	possibly damaging	0.61
IGL01767:Vmn2r78	APN	7	86954435	missense	probably benign	0.28
IGL02322:Vmn2r78	APN	7	86921479	missense	probably damaging	0.96
IGL02537:Vmn2r78	APN	7	86954288	missense	probably damaging	0.99
IGL03297:Vmn2r78	APN	7	86920761	nonsense	probably null
ANU74:Vmn2r78	UTSW	7	86921065	missense	possibly damaging	0.62
R0035:Vmn2r78	UTSW	7	86920205	missense	probably benign	0.22
R0081:Vmn2r78	UTSW	7	86923027	missense	probably benign	0.35
R0401:Vmn2r78	UTSW	7	86921311	missense	probably benign	0.04
R0751:Vmn2r78	UTSW	7	86954380	missense	possibly damaging	0.77
R1341:Vmn2r78	UTSW	7	86922269	missense	possibly damaging	0.71
R1386:Vmn2r78	UTSW	7	86915407	missense	unknown
R1526:Vmn2r78	UTSW	7	86922257	splice site	probably null
R1712:Vmn2r78	UTSW	7	86954924	missense	probably damaging	1.00
R1739:Vmn2r78	UTSW	7	86920789	missense	probably benign
R1812:Vmn2r78	UTSW	7	86920787	missense	probably benign	0.38
R2011:Vmn2r78	UTSW	7	86955079	missense	possibly damaging	0.52
R2144:Vmn2r78	UTSW	7	86954482	missense	probably damaging	1.00
R2197:Vmn2r78	UTSW	7	86921327	missense	probably damaging	0.96
R2291:Vmn2r78	UTSW	7	86920154	missense	probably damaging	1.00
R2409:Vmn2r78	UTSW	7	86920745	splice site	probably benign
R3023:Vmn2r78	UTSW	7	86954966	missense	probably damaging	1.00
R4486:Vmn2r78	UTSW	7	86920751	critical splice acceptor site	probably null
R4512:Vmn2r78	UTSW	7	86920244	missense	probably benign	0.00
R4515:Vmn2r78	UTSW	7	86954258	missense	probably damaging	0.99
R4544:Vmn2r78	UTSW	7	86921191	missense	probably benign
R4546:Vmn2r78	UTSW	7	86954603	missense	probably damaging	1.00
R4872:Vmn2r78	UTSW	7	86954708	missense	possibly damaging	0.87
R4928:Vmn2r78	UTSW	7	86954627	missense	probably damaging	1.00
R5101:Vmn2r78	UTSW	7	86922355	missense	probably damaging	1.00
R5265:Vmn2r78	UTSW	7	86920124	missense	probably damaging	1.00
R5328:Vmn2r78	UTSW	7	86921030	missense	probably damaging	0.98
R5442:Vmn2r78	UTSW	7	86920122	missense	possibly damaging	0.95
R5567:Vmn2r78	UTSW	7	86921529	missense	probably benign	0.17
R5572:Vmn2r78	UTSW	7	86915512	missense	probably benign	0.01
R5636:Vmn2r78	UTSW	7	86954429	missense	probably damaging	0.99
R5901:Vmn2r78	UTSW	7	86954588	missense	probably damaging	1.00
R5977:Vmn2r78	UTSW	7	86920333	missense	possibly damaging	0.74
R5977:Vmn2r78	UTSW	7	86954907	missense	probably benign	0.00
R6276:Vmn2r78	UTSW	7	86921110	missense	probably benign	0.00
R6386:Vmn2r78	UTSW	7	86922337	nonsense	probably null
R6724:Vmn2r78	UTSW	7	86954258	missense	probably damaging	0.99
R6852:Vmn2r78	UTSW	7	86954603	missense	probably damaging	1.00
R6896:Vmn2r78	UTSW	7	86922350	missense	probably benign	0.10
R7385:Vmn2r78	UTSW	7	86922425	missense	probably benign	0.18
R7578:Vmn2r78	UTSW	7	86954344	nonsense	probably null
R7680:Vmn2r78	UTSW	7	86954941	missense	probably damaging	1.00
R7748:Vmn2r78	UTSW	7	86921135	missense	probably benign	0.00
R7852:Vmn2r78	UTSW	7	86920170	nonsense	probably null
R8031:Vmn2r78	UTSW	7	86954867	missense	probably damaging	1.00
R8070:Vmn2r78	UTSW	7	86922487	missense	probably benign	0.01
R8085:Vmn2r78	UTSW	7	86954790	missense	probably benign	0.00
R8163:Vmn2r78	UTSW	7	86954452	missense	probably damaging	1.00
R8501:Vmn2r78	UTSW	7	86920886	missense	probably damaging	0.99
R8749:Vmn2r78	UTSW	7	86954305	missense	possibly damaging	0.81
RF018:Vmn2r78	UTSW	7	86954431	nonsense	probably null
Z1177:Vmn2r78	UTSW	7	86921207	missense	probably benign	0.44
Z1177:Vmn2r78	UTSW	7	86954774	missense	probably benign	0.02

Predicted Primers

PCR Primer
(F):5'- CTGTGTCAACATATGAATGGGTCAC -3'
(R):5'- AAATGTAACCCTCTCTGACTTACC -3'

Sequencing Primer
(F):5'- AAAAATCTTTGCTTAACCCACAATG -3'
(R):5'- ACCTCTGGAGTTTGGGAGAAGTAC -3'

Posted On

2022-02-07