Incidental Mutation 'R9211:Tns1'
| ID |
698826 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tns1
|
| Ensembl Gene |
ENSMUSG00000055322 |
| Gene Name |
tensin 1 |
| Synonyms |
E030018G17Rik, 1110018I21Rik, E030037J05Rik, 1200014E20Rik, Tns |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.565)
|
| Stock # |
R9211 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
73949390-74163608 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 73956948 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 491
(L491P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000139844
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000169786]
[ENSMUST00000187584]
[ENSMUST00000187691]
[ENSMUST00000191104]
[ENSMUST00000212888]
|
| AlphaFold |
E9Q0S6 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000169786
AA Change: L1755P
PolyPhen 2
Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000127715
Gene: ENSMUSG00000055322
AA Change: L1755P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
33 |
N/A |
INTRINSIC |
|
C1
|
62 |
108 |
1.77e-2 |
SMART |
|
low complexity region
|
154 |
167 |
N/A |
INTRINSIC |
|
SCOP:d1d5ra2
|
176 |
348 |
3e-32 |
SMART |
|
PTEN_C2
|
350 |
477 |
1.12e-51 |
SMART |
|
low complexity region
|
822 |
833 |
N/A |
INTRINSIC |
|
low complexity region
|
905 |
922 |
N/A |
INTRINSIC |
|
low complexity region
|
1227 |
1239 |
N/A |
INTRINSIC |
|
low complexity region
|
1284 |
1300 |
N/A |
INTRINSIC |
|
low complexity region
|
1459 |
1470 |
N/A |
INTRINSIC |
|
low complexity region
|
1518 |
1530 |
N/A |
INTRINSIC |
|
SH2
|
1614 |
1716 |
6.85e-17 |
SMART |
|
PTB
|
1747 |
1888 |
1.69e-29 |
SMART |
|
| Predicted Effect |
|
| Predicted Effect |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000187584
AA Change: L1690P
PolyPhen 2
Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000140254
Gene: ENSMUSG00000055322
AA Change: L1690P
| Domain | Start | End | E-Value | Type |
|---|
|
C1
|
21 |
67 |
8.6e-5 |
SMART |
|
low complexity region
|
113 |
124 |
N/A |
INTRINSIC |
|
PTPc_DSPc
|
197 |
319 |
9.9e-6 |
SMART |
|
PTEN_C2
|
306 |
433 |
5.6e-56 |
SMART |
|
low complexity region
|
778 |
789 |
N/A |
INTRINSIC |
|
low complexity region
|
861 |
878 |
N/A |
INTRINSIC |
|
low complexity region
|
1162 |
1174 |
N/A |
INTRINSIC |
|
low complexity region
|
1219 |
1235 |
N/A |
INTRINSIC |
|
low complexity region
|
1394 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1453 |
1465 |
N/A |
INTRINSIC |
|
SH2
|
1549 |
1651 |
4.3e-19 |
SMART |
|
PTB
|
1682 |
1823 |
9e-32 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000187691
AA Change: L491P
PolyPhen 2
Score 0.631 (Sensitivity: 0.87; Specificity: 0.91)
|
| SMART Domains |
Protein: ENSMUSP00000139844
Gene: ENSMUSG00000055322
AA Change: L491P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
20 |
36 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
206 |
N/A |
INTRINSIC |
|
low complexity region
|
254 |
266 |
N/A |
INTRINSIC |
|
SH2
|
350 |
452 |
4.3e-19 |
SMART |
|
PTB
|
483 |
624 |
9e-32 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000191104
AA Change: L1734P
PolyPhen 2
Score 0.977 (Sensitivity: 0.76; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000140317
Gene: ENSMUSG00000055322
AA Change: L1734P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
33 |
N/A |
INTRINSIC |
|
C1
|
62 |
108 |
8.6e-5 |
SMART |
|
low complexity region
|
154 |
167 |
N/A |
INTRINSIC |
|
PTPc_DSPc
|
241 |
363 |
9.9e-6 |
SMART |
|
PTEN_C2
|
350 |
477 |
5.6e-56 |
SMART |
|
low complexity region
|
822 |
833 |
N/A |
INTRINSIC |
|
low complexity region
|
905 |
922 |
N/A |
INTRINSIC |
|
low complexity region
|
1206 |
1218 |
N/A |
INTRINSIC |
|
low complexity region
|
1263 |
1279 |
N/A |
INTRINSIC |
|
low complexity region
|
1438 |
1449 |
N/A |
INTRINSIC |
|
low complexity region
|
1497 |
1509 |
N/A |
INTRINSIC |
|
SH2
|
1593 |
1695 |
4.3e-19 |
SMART |
|
PTB
|
1726 |
1867 |
9e-32 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000212888
AA Change: L1747P
PolyPhen 2
Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
99% (86/87) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced female fertility, and develop kidney cysts and progressive kidney degeneration that may lead to death from renal failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3110009E18Rik |
G |
T |
1: 120,099,161 (GRCm39) |
D85Y |
possibly damaging |
Het |
| Accs |
T |
C |
2: 93,668,614 (GRCm39) |
R315G |
probably damaging |
Het |
| Adam3 |
A |
C |
8: 25,177,910 (GRCm39) |
W668G |
probably benign |
Het |
| Adgrb2 |
T |
A |
4: 129,886,199 (GRCm39) |
V113E |
probably benign |
Het |
| Anapc4 |
C |
T |
5: 53,007,994 (GRCm39) |
T391I |
possibly damaging |
Het |
| Angpt2 |
C |
T |
8: 18,748,078 (GRCm39) |
G394D |
probably benign |
Het |
| Ankrd31 |
C |
G |
13: 97,029,551 (GRCm39) |
L1662V |
possibly damaging |
Het |
| Ankrd36 |
A |
G |
11: 5,612,370 (GRCm39) |
D1234G |
possibly damaging |
Het |
| Ankrd6 |
C |
T |
4: 32,806,580 (GRCm39) |
V558M |
probably damaging |
Het |
| Ankrd61 |
T |
A |
5: 143,828,358 (GRCm39) |
M206L |
probably benign |
Het |
| Arhgap33 |
C |
T |
7: 30,223,023 (GRCm39) |
G970R |
possibly damaging |
Het |
| Atf7 |
A |
G |
15: 102,437,117 (GRCm39) |
V115A |
unknown |
Het |
| Atp2c2 |
A |
T |
8: 120,446,032 (GRCm39) |
R65S |
probably benign |
Het |
| Atp8b5 |
T |
A |
4: 43,367,960 (GRCm39) |
M861K |
probably damaging |
Het |
| Bmi1 |
T |
C |
2: 18,689,152 (GRCm39) |
S279P |
probably benign |
Het |
| Bptf |
T |
G |
11: 106,946,124 (GRCm39) |
S2372R |
probably damaging |
Het |
| Cacnb2 |
A |
T |
2: 14,879,308 (GRCm39) |
I15L |
unknown |
Het |
| Card11 |
A |
G |
5: 140,869,375 (GRCm39) |
M807T |
probably benign |
Het |
| Ccdc175 |
A |
T |
12: 72,153,458 (GRCm39) |
D704E |
probably damaging |
Het |
| Cd300ld |
T |
A |
11: 114,878,386 (GRCm39) |
Y42F |
probably damaging |
Het |
| Cdh1 |
A |
T |
8: 107,390,962 (GRCm39) |
T693S |
probably benign |
Het |
| Clca4b |
T |
C |
3: 144,638,214 (GRCm39) |
Y16C |
possibly damaging |
Het |
| Col4a4 |
A |
G |
1: 82,506,501 (GRCm39) |
I273T |
unknown |
Het |
| Coro2b |
C |
A |
9: 62,427,662 (GRCm39) |
V9L |
probably benign |
Het |
| Crnkl1 |
T |
C |
2: 145,774,773 (GRCm39) |
D55G |
probably damaging |
Het |
| Dcps |
T |
A |
9: 35,035,872 (GRCm39) |
N338I |
probably damaging |
Het |
| Dusp2 |
A |
T |
2: 127,179,311 (GRCm39) |
H222L |
probably benign |
Het |
| Dync1li1 |
C |
A |
9: 114,518,012 (GRCm39) |
Y21* |
probably null |
Het |
| Efhb |
T |
G |
17: 53,756,507 (GRCm39) |
Q381H |
probably damaging |
Het |
| Elac2 |
A |
T |
11: 64,869,864 (GRCm39) |
|
probably benign |
Het |
| Etaa1 |
A |
G |
11: 17,896,053 (GRCm39) |
V688A |
possibly damaging |
Het |
| Fam120c |
C |
T |
X: 150,127,495 (GRCm39) |
H84Y |
probably benign |
Het |
| Fbxl7 |
T |
A |
15: 26,789,616 (GRCm39) |
N37I |
probably damaging |
Het |
| Fndc3b |
A |
T |
3: 27,523,086 (GRCm39) |
W498R |
probably damaging |
Het |
| Galc |
G |
A |
12: 98,173,699 (GRCm39) |
A621V |
probably benign |
Het |
| Gch1 |
A |
T |
14: 47,426,519 (GRCm39) |
I69N |
probably damaging |
Het |
| Gdpd4 |
T |
C |
7: 97,615,466 (GRCm39) |
V97A |
possibly damaging |
Het |
| Hirip3 |
C |
T |
7: 126,463,567 (GRCm39) |
R485* |
probably null |
Het |
| Hmgcs2 |
C |
T |
3: 98,204,748 (GRCm39) |
T302I |
possibly damaging |
Het |
| Ing5 |
A |
T |
1: 93,740,409 (GRCm39) |
K137I |
possibly damaging |
Het |
| Kcnh8 |
T |
A |
17: 53,146,236 (GRCm39) |
Y375N |
probably damaging |
Het |
| Kdm3a |
C |
A |
6: 71,573,674 (GRCm39) |
W963L |
probably benign |
Het |
| Klra17 |
T |
G |
6: 129,842,651 (GRCm39) |
I216L |
possibly damaging |
Het |
| Kmt2e |
A |
G |
5: 23,669,770 (GRCm39) |
K86E |
possibly damaging |
Het |
| Krt42 |
T |
C |
11: 100,155,867 (GRCm39) |
N293S |
possibly damaging |
Het |
| Lrrc8d |
T |
A |
5: 105,960,216 (GRCm39) |
W209R |
probably damaging |
Het |
| Mettl23 |
C |
T |
11: 116,734,469 (GRCm39) |
P13S |
unknown |
Het |
| Ncln |
T |
C |
10: 81,323,527 (GRCm39) |
Y540C |
probably damaging |
Het |
| Neb |
C |
G |
2: 52,135,360 (GRCm39) |
G3250A |
probably damaging |
Het |
| Nebl |
A |
G |
2: 17,393,501 (GRCm39) |
|
probably null |
Het |
| Nqo2 |
A |
T |
13: 34,156,399 (GRCm39) |
T38S |
probably benign |
Het |
| Obscn |
A |
T |
11: 59,026,693 (GRCm39) |
I170N |
probably benign |
Het |
| Or2bd2 |
G |
T |
7: 6,443,417 (GRCm39) |
G173W |
probably damaging |
Het |
| Or4c100 |
A |
G |
2: 88,356,170 (GRCm39) |
D81G |
probably benign |
Het |
| Or5af2 |
A |
T |
11: 58,708,709 (GRCm39) |
N292Y |
probably damaging |
Het |
| Or5p6 |
C |
T |
7: 107,630,798 (GRCm39) |
V251I |
probably damaging |
Het |
| Or7g28 |
T |
A |
9: 19,271,824 (GRCm39) |
I276F |
possibly damaging |
Het |
| Or8k38 |
A |
T |
2: 86,488,024 (GRCm39) |
Y259* |
probably null |
Het |
| Pacs1 |
A |
T |
19: 5,189,057 (GRCm39) |
V775E |
probably damaging |
Het |
| Pheta2 |
A |
T |
15: 82,225,227 (GRCm39) |
|
probably benign |
Het |
| Pmfbp1 |
T |
C |
8: 110,262,445 (GRCm39) |
I713T |
probably benign |
Het |
| Pnma8b |
A |
G |
7: 16,679,589 (GRCm39) |
D191G |
unknown |
Het |
| Polr1a |
T |
C |
6: 71,943,521 (GRCm39) |
I1252T |
probably damaging |
Het |
| Prss16 |
A |
T |
13: 22,192,754 (GRCm39) |
M110K |
probably benign |
Het |
| Pygo2 |
T |
C |
3: 89,338,038 (GRCm39) |
|
probably null |
Het |
| Rab5b |
C |
A |
10: 128,519,063 (GRCm39) |
|
probably null |
Het |
| Reln |
G |
T |
5: 22,549,200 (GRCm39) |
Y69* |
probably null |
Het |
| Rgs12 |
T |
A |
5: 35,123,165 (GRCm39) |
M316K |
probably damaging |
Het |
| Rmi2 |
T |
C |
16: 10,657,743 (GRCm39) |
C118R |
possibly damaging |
Het |
| Rnf223 |
T |
A |
4: 156,216,834 (GRCm39) |
C70S |
probably damaging |
Het |
| Rxrb |
T |
A |
17: 34,255,626 (GRCm39) |
F371Y |
probably damaging |
Het |
| Smurf2 |
T |
A |
11: 106,759,463 (GRCm39) |
S78C |
probably damaging |
Het |
| Sorbs1 |
A |
T |
19: 40,332,798 (GRCm39) |
|
probably null |
Het |
| Spag17 |
C |
T |
3: 100,032,614 (GRCm39) |
|
probably benign |
Het |
| Spidr |
T |
C |
16: 15,871,319 (GRCm39) |
H217R |
probably benign |
Het |
| Tiam2 |
T |
G |
17: 3,498,729 (GRCm39) |
V835G |
possibly damaging |
Het |
| Tm2d2 |
C |
T |
8: 25,510,548 (GRCm39) |
R136* |
probably null |
Het |
| Tnks |
C |
T |
8: 35,316,489 (GRCm39) |
D877N |
probably damaging |
Het |
| Trps1 |
A |
G |
15: 50,694,840 (GRCm39) |
I485T |
probably damaging |
Het |
| Tubgcp5 |
A |
G |
7: 55,456,331 (GRCm39) |
S308G |
probably benign |
Het |
| Ugt8a |
T |
C |
3: 125,661,130 (GRCm39) |
H454R |
probably damaging |
Het |
| Usp32 |
G |
T |
11: 84,913,559 (GRCm39) |
T924K |
probably damaging |
Het |
| Vmn2r91 |
A |
T |
17: 18,356,819 (GRCm39) |
K829* |
probably null |
Het |
| Zfc3h1 |
T |
C |
10: 115,248,328 (GRCm39) |
F1146L |
possibly damaging |
Het |
| Zfp729a |
G |
T |
13: 67,767,820 (GRCm39) |
A803E |
probably benign |
Het |
| Zfp990 |
A |
G |
4: 145,264,171 (GRCm39) |
T390A |
probably damaging |
Het |
|
| Other mutations in Tns1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00954:Tns1
|
APN |
1 |
73,964,128 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01288:Tns1
|
APN |
1 |
73,992,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01536:Tns1
|
APN |
1 |
73,958,807 (GRCm39) |
splice site |
probably benign |
|
|
IGL01568:Tns1
|
APN |
1 |
73,992,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01683:Tns1
|
APN |
1 |
73,992,428 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02267:Tns1
|
APN |
1 |
74,031,290 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02597:Tns1
|
APN |
1 |
74,025,032 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02819:Tns1
|
APN |
1 |
73,976,407 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03370:Tns1
|
APN |
1 |
74,025,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0087:Tns1
|
UTSW |
1 |
73,956,076 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0207:Tns1
|
UTSW |
1 |
73,976,477 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0411:Tns1
|
UTSW |
1 |
73,964,920 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0543:Tns1
|
UTSW |
1 |
73,991,856 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0552:Tns1
|
UTSW |
1 |
73,959,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0720:Tns1
|
UTSW |
1 |
73,964,740 (GRCm39) |
missense |
probably benign |
0.03 |
|
R0828:Tns1
|
UTSW |
1 |
73,958,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1034:Tns1
|
UTSW |
1 |
73,981,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1061:Tns1
|
UTSW |
1 |
73,956,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1819:Tns1
|
UTSW |
1 |
73,955,635 (GRCm39) |
splice site |
probably benign |
|
|
R1826:Tns1
|
UTSW |
1 |
73,992,793 (GRCm39) |
start codon destroyed |
probably null |
0.91 |
|
R2208:Tns1
|
UTSW |
1 |
74,118,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3723:Tns1
|
UTSW |
1 |
73,964,099 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4079:Tns1
|
UTSW |
1 |
74,034,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4111:Tns1
|
UTSW |
1 |
73,981,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4155:Tns1
|
UTSW |
1 |
73,953,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4156:Tns1
|
UTSW |
1 |
73,953,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4157:Tns1
|
UTSW |
1 |
73,953,790 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4274:Tns1
|
UTSW |
1 |
73,967,257 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4426:Tns1
|
UTSW |
1 |
74,024,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4649:Tns1
|
UTSW |
1 |
73,992,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4742:Tns1
|
UTSW |
1 |
74,163,449 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4869:Tns1
|
UTSW |
1 |
73,991,774 (GRCm39) |
missense |
probably benign |
|
|
R4961:Tns1
|
UTSW |
1 |
73,975,074 (GRCm39) |
missense |
probably benign |
0.35 |
|
R5025:Tns1
|
UTSW |
1 |
73,964,641 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5035:Tns1
|
UTSW |
1 |
73,992,979 (GRCm39) |
start gained |
probably benign |
|
|
R5062:Tns1
|
UTSW |
1 |
73,992,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5080:Tns1
|
UTSW |
1 |
73,992,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5213:Tns1
|
UTSW |
1 |
73,992,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Tns1
|
UTSW |
1 |
74,034,585 (GRCm39) |
intron |
probably benign |
|
|
R5368:Tns1
|
UTSW |
1 |
73,980,176 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5391:Tns1
|
UTSW |
1 |
74,029,568 (GRCm39) |
splice site |
probably null |
|
|
R5587:Tns1
|
UTSW |
1 |
73,959,755 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5735:Tns1
|
UTSW |
1 |
73,967,138 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5855:Tns1
|
UTSW |
1 |
73,957,192 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5999:Tns1
|
UTSW |
1 |
73,967,256 (GRCm39) |
nonsense |
probably null |
|
|
R6122:Tns1
|
UTSW |
1 |
73,991,578 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6148:Tns1
|
UTSW |
1 |
73,992,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6457:Tns1
|
UTSW |
1 |
73,957,209 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6525:Tns1
|
UTSW |
1 |
73,992,629 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6712:Tns1
|
UTSW |
1 |
74,118,460 (GRCm39) |
nonsense |
probably null |
|
|
R6773:Tns1
|
UTSW |
1 |
73,958,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6825:Tns1
|
UTSW |
1 |
74,041,482 (GRCm39) |
nonsense |
probably null |
|
|
R7085:Tns1
|
UTSW |
1 |
73,964,621 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7128:Tns1
|
UTSW |
1 |
74,034,463 (GRCm39) |
missense |
|
|
|
R7209:Tns1
|
UTSW |
1 |
73,993,074 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7348:Tns1
|
UTSW |
1 |
73,956,076 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7570:Tns1
|
UTSW |
1 |
73,992,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7670:Tns1
|
UTSW |
1 |
73,991,636 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7769:Tns1
|
UTSW |
1 |
73,992,530 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7833:Tns1
|
UTSW |
1 |
74,130,490 (GRCm39) |
intron |
probably benign |
|
|
R8052:Tns1
|
UTSW |
1 |
73,992,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8225:Tns1
|
UTSW |
1 |
74,025,046 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8244:Tns1
|
UTSW |
1 |
73,976,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8321:Tns1
|
UTSW |
1 |
74,024,939 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8344:Tns1
|
UTSW |
1 |
74,024,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8378:Tns1
|
UTSW |
1 |
73,976,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8434:Tns1
|
UTSW |
1 |
73,964,765 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8773:Tns1
|
UTSW |
1 |
73,976,407 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9251:Tns1
|
UTSW |
1 |
74,030,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9315:Tns1
|
UTSW |
1 |
73,980,141 (GRCm39) |
missense |
|
|
|
R9411:Tns1
|
UTSW |
1 |
73,992,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9592:Tns1
|
UTSW |
1 |
74,029,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9658:Tns1
|
UTSW |
1 |
73,981,183 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9658:Tns1
|
UTSW |
1 |
73,981,182 (GRCm39) |
missense |
probably benign |
0.14 |
|
Z1177:Tns1
|
UTSW |
1 |
74,041,466 (GRCm39) |
missense |
probably benign |
0.12 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGGTAGGCAAGGCTTACTTTC -3'
(R):5'- AACCACTGACCTGCTGAAGC -3'
Sequencing Primer
(F):5'- CAAGGCTTACTTTCTTTGATTGTCAG -3'
(R):5'- TGAGATAGGACTGGTGCCC -3'
|
| Posted On |
2022-02-07 |
Incidental Mutation