Incidental Mutation 'R9212:Or2a51'
ID 698937
Institutional Source Beutler Lab
Gene Symbol Or2a51
Ensembl Gene ENSMUSG00000048693
Gene Name olfactory receptor family 2 subfamily A member 51
Synonyms MOR261-5, GA_x6K02T2P3E9-4356476-4355535, Olfr435
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.137) question?
Stock # R9212 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 43178580-43179521 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 43178756 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 59 (Y59*)
Ref Sequence ENSEMBL: ENSMUSP00000150935 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058118] [ENSMUST00000215565]
AlphaFold Q8VFS3
Predicted Effect probably null
Transcript: ENSMUST00000058118
AA Change: Y59*
SMART Domains Protein: ENSMUSP00000058912
Gene: ENSMUSG00000048693
AA Change: Y59*

DomainStartEndE-ValueType
Pfam:7tm_4 30 307 3e-61 PFAM
Pfam:7tm_1 40 289 4.3e-30 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215565
AA Change: Y59*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (57/57)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T C 6: 23,075,767 (GRCm39) D790G probably damaging Het
Abcb4 C T 5: 9,005,591 (GRCm39) P1158L probably damaging Het
Actn3 T C 19: 4,914,565 (GRCm39) D521G probably benign Het
Adhfe1 A T 1: 9,637,036 (GRCm39) D396V possibly damaging Het
Arhgap28 A G 17: 68,162,430 (GRCm39) M639T probably benign Het
Asb18 T C 1: 89,880,447 (GRCm39) T453A probably benign Het
Asxl3 T C 18: 22,655,389 (GRCm39) I1133T probably benign Het
C2cd4b G A 9: 67,667,028 (GRCm39) R8H probably damaging Het
Ccdc91 A G 6: 147,508,398 (GRCm39) I375V unknown Het
Cdh24 T A 14: 54,878,679 (GRCm39) probably benign Het
Cfap57 T A 4: 118,436,649 (GRCm39) I916F possibly damaging Het
Cfap65 G A 1: 74,959,567 (GRCm39) T861I probably benign Het
Chd1 T G 17: 15,950,767 (GRCm39) S153A possibly damaging Het
Cit A T 5: 116,013,952 (GRCm39) I222F possibly damaging Het
Clip1 T A 5: 123,721,399 (GRCm39) K1165N probably damaging Het
Cln6 A G 9: 62,757,973 (GRCm39) H244R probably damaging Het
Col19a1 A T 1: 24,500,555 (GRCm39) probably null Het
Dhx57 T G 17: 80,576,338 (GRCm39) D584A probably damaging Het
Dnah14 G A 1: 181,628,852 (GRCm39) V4123M possibly damaging Het
Fam193a T C 5: 34,597,481 (GRCm39) V94A probably benign Het
Fzd6 A G 15: 38,898,289 (GRCm39) H543R probably damaging Het
Gad2 T A 2: 22,571,399 (GRCm39) C446S probably damaging Het
Gm29106 A G 1: 118,127,270 (GRCm39) R321G probably damaging Het
Gon4l T C 3: 88,803,730 (GRCm39) V1447A probably benign Het
Hus1b A C 13: 31,130,858 (GRCm39) I267S possibly damaging Het
Kifap3 C T 1: 163,610,600 (GRCm39) L27F probably damaging Het
Lancl2 A C 6: 57,714,673 (GRCm39) I431L probably benign Het
Ltbp2 G A 12: 84,839,824 (GRCm39) P1069S probably damaging Het
Mrgprb2 A T 7: 48,202,392 (GRCm39) V111D possibly damaging Het
Mta3 A T 17: 84,015,846 (GRCm39) N16I probably damaging Het
Npepps G T 11: 97,129,047 (GRCm39) A379E probably damaging Het
Nppc G T 1: 86,597,619 (GRCm39) Q50K possibly damaging Het
Or5p54 C A 7: 107,554,017 (GRCm39) H56Q probably benign Het
Orc2 A G 1: 58,515,695 (GRCm39) L271P probably damaging Het
Papolg T C 11: 23,823,817 (GRCm39) T334A probably benign Het
Pikfyve T C 1: 65,291,719 (GRCm39) S1313P probably damaging Het
Ppp2r3d T C 9: 101,063,175 (GRCm39) T154A probably benign Het
Ptprz1 A G 6: 23,050,493 (GRCm39) M2254V probably damaging Het
Rabgap1 T C 2: 37,377,152 (GRCm39) V328A probably damaging Het
Rnf17 T C 14: 56,761,785 (GRCm39) V1616A probably damaging Het
Rph3a T A 5: 121,086,005 (GRCm39) H477L possibly damaging Het
Rttn T C 18: 89,064,286 (GRCm39) probably null Het
Ryr2 A C 13: 11,844,560 (GRCm39) I392S probably damaging Het
Sbsn A G 7: 30,452,427 (GRCm39) N481D probably benign Het
Sf3a3 G A 4: 124,621,921 (GRCm39) E354K possibly damaging Het
Slc15a2 A C 16: 36,602,053 (GRCm39) Y81* probably null Het
Slc5a2 C A 7: 127,867,939 (GRCm39) Q202K probably damaging Het
Spata31h1 T C 10: 82,118,979 (GRCm39) N4677S possibly damaging Het
Stxbp2 G C 8: 3,686,220 (GRCm39) K313N Het
Tbc1d2b A T 9: 90,087,183 (GRCm39) L932Q possibly damaging Het
Trim24 A T 6: 37,896,335 (GRCm39) Q264L probably benign Het
Tubgcp3 A G 8: 12,691,200 (GRCm39) V446A possibly damaging Het
Unc93b1 G A 19: 3,993,557 (GRCm39) R333Q probably damaging Het
Wdr24 T C 17: 26,043,472 (GRCm39) V98A probably benign Het
Wdr62 G A 7: 29,942,563 (GRCm39) S1015L probably damaging Het
Zfp280d A G 9: 72,269,789 (GRCm39) *975W probably null Het
Zfp317 A T 9: 19,558,442 (GRCm39) K219* probably null Het
Zfp974 A G 7: 27,610,052 (GRCm39) S558P possibly damaging Het
Zfp986 A G 4: 145,625,798 (GRCm39) K153E probably benign Het
Other mutations in Or2a51
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02817:Or2a51 APN 6 43,178,993 (GRCm39) missense probably benign 0.01
IGL03385:Or2a51 APN 6 43,178,914 (GRCm39) missense probably benign 0.20
R0455:Or2a51 UTSW 6 43,179,006 (GRCm39) missense probably benign
R1977:Or2a51 UTSW 6 43,178,914 (GRCm39) missense possibly damaging 0.93
R2152:Or2a51 UTSW 6 43,179,003 (GRCm39) missense probably benign
R3821:Or2a51 UTSW 6 43,178,604 (GRCm39) missense probably benign 0.26
R7041:Or2a51 UTSW 6 43,178,837 (GRCm39) missense probably benign 0.05
R9533:Or2a51 UTSW 6 43,178,991 (GRCm39) missense probably benign 0.35
R9743:Or2a51 UTSW 6 43,179,229 (GRCm39) missense probably benign 0.44
Predicted Primers PCR Primer
(F):5'- TGGATGCCCACACTGAAATG -3'
(R):5'- ACCACAAGGAGGACACATTCTG -3'

Sequencing Primer
(F):5'- CCAAAAACATCTGACTTGGGG -3'
(R):5'- CTGTGCTCCCAAATGTCAAAAATAGG -3'
Posted On 2022-02-07