Incidental Mutation 'R9212:Wdr24'
ID 698965
Institutional Source Beutler Lab
Gene Symbol Wdr24
Ensembl Gene ENSMUSG00000025737
Gene Name WD repeat domain 24
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R9212 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 26042601-26047704 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 26043472 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 98 (V98A)
Ref Sequence ENSEMBL: ENSMUSP00000026833 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026832] [ENSMUST00000026833] [ENSMUST00000045692] [ENSMUST00000123582] [ENSMUST00000133595]
AlphaFold Q8CFJ9
Predicted Effect probably benign
Transcript: ENSMUST00000026832
SMART Domains Protein: ENSMUSP00000026832
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
JmjC 140 271 5.27e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000026833
AA Change: V98A

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000026833
Gene: ENSMUSG00000025737
AA Change: V98A

DomainStartEndE-ValueType
Blast:WD40 19 53 6e-8 BLAST
WD40 68 103 2.13e1 SMART
WD40 109 149 5.77e-5 SMART
WD40 152 192 4.48e-2 SMART
WD40 196 236 1.48e-11 SMART
WD40 244 282 1.66e0 SMART
WD40 286 327 2.48e0 SMART
low complexity region 605 623 N/A INTRINSIC
Blast:RING 743 780 2e-7 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000045692
SMART Domains Protein: ENSMUSP00000048562
Gene: ENSMUSG00000025738

DomainStartEndE-ValueType
low complexity region 49 65 N/A INTRINSIC
low complexity region 70 89 N/A INTRINSIC
Blast:FBOX 98 137 2e-14 BLAST
LRR 241 266 1.32e1 SMART
LRR 267 291 1.61e2 SMART
LRR 293 318 1.76e2 SMART
LRR 319 344 3.21e-4 SMART
LRR 345 370 7.67e-2 SMART
LRR 371 396 6.13e-1 SMART
LRR 421 446 3.52e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000123582
SMART Domains Protein: ENSMUSP00000119840
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
low complexity region 158 172 N/A INTRINSIC
low complexity region 194 208 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000133595
SMART Domains Protein: ENSMUSP00000122744
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
transmembrane domain 55 74 N/A INTRINSIC
JmjC 185 316 5.27e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000152434
SMART Domains Protein: ENSMUSP00000119378
Gene: ENSMUSG00000025736

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (57/57)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aass T C 6: 23,075,767 (GRCm39) D790G probably damaging Het
Abcb4 C T 5: 9,005,591 (GRCm39) P1158L probably damaging Het
Actn3 T C 19: 4,914,565 (GRCm39) D521G probably benign Het
Adhfe1 A T 1: 9,637,036 (GRCm39) D396V possibly damaging Het
Arhgap28 A G 17: 68,162,430 (GRCm39) M639T probably benign Het
Asb18 T C 1: 89,880,447 (GRCm39) T453A probably benign Het
Asxl3 T C 18: 22,655,389 (GRCm39) I1133T probably benign Het
C2cd4b G A 9: 67,667,028 (GRCm39) R8H probably damaging Het
Ccdc91 A G 6: 147,508,398 (GRCm39) I375V unknown Het
Cdh24 T A 14: 54,878,679 (GRCm39) probably benign Het
Cfap57 T A 4: 118,436,649 (GRCm39) I916F possibly damaging Het
Cfap65 G A 1: 74,959,567 (GRCm39) T861I probably benign Het
Chd1 T G 17: 15,950,767 (GRCm39) S153A possibly damaging Het
Cit A T 5: 116,013,952 (GRCm39) I222F possibly damaging Het
Clip1 T A 5: 123,721,399 (GRCm39) K1165N probably damaging Het
Cln6 A G 9: 62,757,973 (GRCm39) H244R probably damaging Het
Col19a1 A T 1: 24,500,555 (GRCm39) probably null Het
Dhx57 T G 17: 80,576,338 (GRCm39) D584A probably damaging Het
Dnah14 G A 1: 181,628,852 (GRCm39) V4123M possibly damaging Het
Fam193a T C 5: 34,597,481 (GRCm39) V94A probably benign Het
Fzd6 A G 15: 38,898,289 (GRCm39) H543R probably damaging Het
Gad2 T A 2: 22,571,399 (GRCm39) C446S probably damaging Het
Gm29106 A G 1: 118,127,270 (GRCm39) R321G probably damaging Het
Gon4l T C 3: 88,803,730 (GRCm39) V1447A probably benign Het
Hus1b A C 13: 31,130,858 (GRCm39) I267S possibly damaging Het
Kifap3 C T 1: 163,610,600 (GRCm39) L27F probably damaging Het
Lancl2 A C 6: 57,714,673 (GRCm39) I431L probably benign Het
Ltbp2 G A 12: 84,839,824 (GRCm39) P1069S probably damaging Het
Mrgprb2 A T 7: 48,202,392 (GRCm39) V111D possibly damaging Het
Mta3 A T 17: 84,015,846 (GRCm39) N16I probably damaging Het
Npepps G T 11: 97,129,047 (GRCm39) A379E probably damaging Het
Nppc G T 1: 86,597,619 (GRCm39) Q50K possibly damaging Het
Or2a51 T A 6: 43,178,756 (GRCm39) Y59* probably null Het
Or5p54 C A 7: 107,554,017 (GRCm39) H56Q probably benign Het
Orc2 A G 1: 58,515,695 (GRCm39) L271P probably damaging Het
Papolg T C 11: 23,823,817 (GRCm39) T334A probably benign Het
Pikfyve T C 1: 65,291,719 (GRCm39) S1313P probably damaging Het
Ppp2r3d T C 9: 101,063,175 (GRCm39) T154A probably benign Het
Ptprz1 A G 6: 23,050,493 (GRCm39) M2254V probably damaging Het
Rabgap1 T C 2: 37,377,152 (GRCm39) V328A probably damaging Het
Rnf17 T C 14: 56,761,785 (GRCm39) V1616A probably damaging Het
Rph3a T A 5: 121,086,005 (GRCm39) H477L possibly damaging Het
Rttn T C 18: 89,064,286 (GRCm39) probably null Het
Ryr2 A C 13: 11,844,560 (GRCm39) I392S probably damaging Het
Sbsn A G 7: 30,452,427 (GRCm39) N481D probably benign Het
Sf3a3 G A 4: 124,621,921 (GRCm39) E354K possibly damaging Het
Slc15a2 A C 16: 36,602,053 (GRCm39) Y81* probably null Het
Slc5a2 C A 7: 127,867,939 (GRCm39) Q202K probably damaging Het
Spata31h1 T C 10: 82,118,979 (GRCm39) N4677S possibly damaging Het
Stxbp2 G C 8: 3,686,220 (GRCm39) K313N Het
Tbc1d2b A T 9: 90,087,183 (GRCm39) L932Q possibly damaging Het
Trim24 A T 6: 37,896,335 (GRCm39) Q264L probably benign Het
Tubgcp3 A G 8: 12,691,200 (GRCm39) V446A possibly damaging Het
Unc93b1 G A 19: 3,993,557 (GRCm39) R333Q probably damaging Het
Wdr62 G A 7: 29,942,563 (GRCm39) S1015L probably damaging Het
Zfp280d A G 9: 72,269,789 (GRCm39) *975W probably null Het
Zfp317 A T 9: 19,558,442 (GRCm39) K219* probably null Het
Zfp974 A G 7: 27,610,052 (GRCm39) S558P possibly damaging Het
Zfp986 A G 4: 145,625,798 (GRCm39) K153E probably benign Het
Other mutations in Wdr24
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00942:Wdr24 APN 17 26,045,595 (GRCm39) missense probably benign 0.20
IGL01700:Wdr24 APN 17 26,044,802 (GRCm39) missense probably damaging 1.00
IGL01763:Wdr24 APN 17 26,045,164 (GRCm39) missense probably benign 0.20
IGL02567:Wdr24 APN 17 26,043,322 (GRCm39) missense probably damaging 0.99
IGL03100:Wdr24 APN 17 26,044,681 (GRCm39) missense possibly damaging 0.47
R0012:Wdr24 UTSW 17 26,046,087 (GRCm39) missense probably benign
R0799:Wdr24 UTSW 17 26,045,102 (GRCm39) missense probably damaging 1.00
R1015:Wdr24 UTSW 17 26,047,212 (GRCm39) missense probably benign 0.12
R1276:Wdr24 UTSW 17 26,046,441 (GRCm39) missense probably benign 0.02
R1297:Wdr24 UTSW 17 26,046,322 (GRCm39) missense possibly damaging 0.90
R1934:Wdr24 UTSW 17 26,043,240 (GRCm39) missense possibly damaging 0.89
R2030:Wdr24 UTSW 17 26,045,017 (GRCm39) missense probably benign 0.38
R2069:Wdr24 UTSW 17 26,045,256 (GRCm39) missense probably damaging 1.00
R2508:Wdr24 UTSW 17 26,043,273 (GRCm39) missense possibly damaging 0.52
R4601:Wdr24 UTSW 17 26,047,181 (GRCm39) splice site probably null
R4604:Wdr24 UTSW 17 26,047,479 (GRCm39) missense probably damaging 1.00
R4894:Wdr24 UTSW 17 26,045,101 (GRCm39) missense probably damaging 1.00
R5068:Wdr24 UTSW 17 26,044,753 (GRCm39) missense possibly damaging 0.77
R5088:Wdr24 UTSW 17 26,047,181 (GRCm39) splice site probably null
R5104:Wdr24 UTSW 17 26,043,565 (GRCm39) missense probably damaging 1.00
R5498:Wdr24 UTSW 17 26,043,535 (GRCm39) missense probably damaging 1.00
R5719:Wdr24 UTSW 17 26,047,314 (GRCm39) critical splice donor site probably null
R5892:Wdr24 UTSW 17 26,046,960 (GRCm39) missense probably benign 0.00
R5975:Wdr24 UTSW 17 26,046,102 (GRCm39) missense probably benign 0.37
R6084:Wdr24 UTSW 17 26,043,504 (GRCm39) missense probably damaging 0.99
R6106:Wdr24 UTSW 17 26,043,579 (GRCm39) missense probably benign
R6114:Wdr24 UTSW 17 26,043,579 (GRCm39) missense probably benign
R6116:Wdr24 UTSW 17 26,043,579 (GRCm39) missense probably benign
R6165:Wdr24 UTSW 17 26,045,395 (GRCm39) missense probably benign 0.18
R6175:Wdr24 UTSW 17 26,045,552 (GRCm39) missense probably damaging 1.00
R6331:Wdr24 UTSW 17 26,044,650 (GRCm39) missense possibly damaging 0.61
R6548:Wdr24 UTSW 17 26,046,899 (GRCm39) missense probably damaging 0.99
R6984:Wdr24 UTSW 17 26,047,209 (GRCm39) missense possibly damaging 0.93
R7485:Wdr24 UTSW 17 26,045,101 (GRCm39) missense probably damaging 1.00
R7583:Wdr24 UTSW 17 26,044,804 (GRCm39) missense probably null 1.00
R7770:Wdr24 UTSW 17 26,046,070 (GRCm39) missense probably benign 0.04
R8086:Wdr24 UTSW 17 26,045,101 (GRCm39) missense probably damaging 1.00
R8164:Wdr24 UTSW 17 26,044,923 (GRCm39) splice site probably null
R9210:Wdr24 UTSW 17 26,043,472 (GRCm39) missense probably benign 0.00
R9567:Wdr24 UTSW 17 26,043,190 (GRCm39) missense probably damaging 0.98
R9667:Wdr24 UTSW 17 26,046,301 (GRCm39) missense possibly damaging 0.55
X0022:Wdr24 UTSW 17 26,043,246 (GRCm39) missense probably damaging 0.99
Z1177:Wdr24 UTSW 17 26,044,661 (GRCm39) missense probably benign 0.29
Predicted Primers PCR Primer
(F):5'- AACCATGCACTGCCATCTGG -3'
(R):5'- CTTCCTTCGGAGGTCAAAGC -3'

Sequencing Primer
(F):5'- GCGCCAGCTAATGCCATCAG -3'
(R):5'- TTCGGAGGTCAAAGCACTTC -3'
Posted On 2022-02-07