Incidental Mutation 'R9214:Muc21'
| ID |
699097 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Muc21
|
| Ensembl Gene |
ENSMUSG00000090588 |
| Gene Name |
mucin 21 |
| Synonyms |
epiglycanin, Gm9573 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.097)
|
| Stock # |
R9214 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
17 |
| Chromosomal Location |
35928815-35937529 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 35931838 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Cysteine
at position 783
(S783C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130987
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000164502]
[ENSMUST00000174521]
|
| AlphaFold |
F7C950 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000164502
AA Change: S783C
|
| SMART Domains |
Protein: ENSMUSP00000130987
Gene: ENSMUSG00000090588
AA Change: S783C
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
low complexity region
|
26 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
42 |
59 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
144 |
N/A |
INTRINSIC |
|
low complexity region
|
149 |
578 |
N/A |
INTRINSIC |
|
low complexity region
|
580 |
653 |
N/A |
INTRINSIC |
|
low complexity region
|
655 |
1179 |
N/A |
INTRINSIC |
|
low complexity region
|
1183 |
1373 |
N/A |
INTRINSIC |
|
low complexity region
|
1383 |
1436 |
N/A |
INTRINSIC |
|
low complexity region
|
1438 |
1479 |
N/A |
INTRINSIC |
|
Pfam:Epiglycanin_C
|
1518 |
1605 |
3.8e-22 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174521
|
| SMART Domains |
Protein: ENSMUSP00000134221
Gene: ENSMUSG00000090509
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:SFTA2
|
80 |
117 |
9.2e-18 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
100% (64/64) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 66 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930563M21Rik |
T |
C |
9: 55,890,653 (GRCm39) |
D352G |
probably benign |
Het |
| Abi1 |
A |
T |
2: 22,831,989 (GRCm39) |
Y447* |
probably null |
Het |
| Acot1 |
A |
G |
12: 84,064,189 (GRCm39) |
Y124C |
|
Het |
| Adgrf4 |
T |
C |
17: 42,978,704 (GRCm39) |
N213S |
possibly damaging |
Het |
| Alg9 |
T |
A |
9: 50,717,545 (GRCm39) |
Y443N |
probably damaging |
Het |
| Bhlhe22 |
A |
G |
3: 18,109,024 (GRCm39) |
T25A |
probably benign |
Het |
| Bpifa1 |
C |
A |
2: 153,985,789 (GRCm39) |
P35T |
unknown |
Het |
| Btbd16 |
T |
C |
7: 130,381,437 (GRCm39) |
|
probably null |
Het |
| Ccdc187 |
G |
T |
2: 26,183,409 (GRCm39) |
T197K |
probably benign |
Het |
| Cd209b |
A |
G |
8: 3,968,771 (GRCm39) |
V295A |
probably benign |
Het |
| Cdcp3 |
C |
T |
7: 130,824,481 (GRCm39) |
S192L |
possibly damaging |
Het |
| Clrn2 |
G |
T |
5: 45,617,518 (GRCm39) |
A130S |
probably benign |
Het |
| Cnrip1 |
A |
G |
11: 17,004,740 (GRCm39) |
T97A |
probably damaging |
Het |
| Col15a1 |
G |
C |
4: 47,288,200 (GRCm39) |
|
probably benign |
Het |
| Col6a5 |
T |
C |
9: 105,758,940 (GRCm39) |
T2089A |
possibly damaging |
Het |
| Cyfip1 |
T |
A |
7: 55,523,273 (GRCm39) |
|
probably null |
Het |
| Ddx1 |
A |
G |
12: 13,286,119 (GRCm39) |
S278P |
probably benign |
Het |
| Dnah12 |
A |
C |
14: 26,445,060 (GRCm39) |
E654D |
probably benign |
Het |
| Efcab7 |
T |
C |
4: 99,735,437 (GRCm39) |
S154P |
probably damaging |
Het |
| Emcn |
T |
C |
3: 137,047,029 (GRCm39) |
F10S |
probably damaging |
Het |
| Fhip2a |
A |
G |
19: 57,373,756 (GRCm39) |
H672R |
probably damaging |
Het |
| Flg2 |
G |
T |
3: 93,110,884 (GRCm39) |
A971S |
unknown |
Het |
| Gli2 |
A |
T |
1: 118,795,791 (GRCm39) |
H121Q |
probably damaging |
Het |
| Gm3633 |
A |
G |
14: 42,460,359 (GRCm39) |
|
probably benign |
Het |
| Golga2 |
T |
C |
2: 32,195,822 (GRCm39) |
L846P |
probably damaging |
Het |
| Golga7b |
A |
T |
19: 42,255,440 (GRCm39) |
I106F |
probably damaging |
Het |
| Hltf |
T |
C |
3: 20,140,280 (GRCm39) |
S460P |
probably benign |
Het |
| Hyal5 |
A |
G |
6: 24,876,403 (GRCm39) |
Y92C |
probably damaging |
Het |
| Kif19b |
G |
A |
5: 140,468,257 (GRCm39) |
R649Q |
probably benign |
Het |
| Mapk1 |
T |
A |
16: 16,853,549 (GRCm39) |
C84S |
probably benign |
Het |
| Marchf10 |
A |
G |
11: 105,281,100 (GRCm39) |
V395A |
probably benign |
Het |
| Meltf |
A |
G |
16: 31,697,763 (GRCm39) |
T7A |
probably benign |
Het |
| Mfhas1 |
T |
A |
8: 36,057,730 (GRCm39) |
V735D |
probably damaging |
Het |
| Mia2 |
G |
T |
12: 59,223,150 (GRCm39) |
R486L |
possibly damaging |
Het |
| Mmp20 |
T |
C |
9: 7,628,327 (GRCm39) |
L25P |
probably benign |
Het |
| Mprip |
C |
T |
11: 59,650,901 (GRCm39) |
T1535I |
possibly damaging |
Het |
| Mrpl9 |
T |
A |
3: 94,355,126 (GRCm39) |
S233T |
possibly damaging |
Het |
| Nckap5 |
A |
C |
1: 125,942,376 (GRCm39) |
V1576G |
probably benign |
Het |
| Ntng1 |
T |
C |
3: 109,841,921 (GRCm39) |
Y284C |
probably damaging |
Het |
| Numa1 |
T |
A |
7: 101,650,139 (GRCm39) |
V1290D |
probably damaging |
Het |
| Or52l1 |
T |
G |
7: 104,829,587 (GRCm39) |
Y326S |
probably benign |
Het |
| Pcdhgc4 |
A |
T |
18: 37,950,264 (GRCm39) |
D560V |
probably damaging |
Het |
| Pla2g1b |
A |
G |
5: 115,610,107 (GRCm39) |
K84E |
possibly damaging |
Het |
| Pramel16 |
T |
C |
4: 143,675,750 (GRCm39) |
I359V |
probably benign |
Het |
| Prrt4 |
C |
T |
6: 29,170,767 (GRCm39) |
A562T |
possibly damaging |
Het |
| Rab6a |
T |
C |
7: 100,275,786 (GRCm39) |
F33S |
probably damaging |
Het |
| Rgs11 |
A |
G |
17: 26,427,260 (GRCm39) |
Y397C |
probably damaging |
Het |
| Rnf43 |
A |
T |
11: 87,622,111 (GRCm39) |
H277L |
probably benign |
Het |
| Ryr1 |
A |
G |
7: 28,785,187 (GRCm39) |
S1842P |
possibly damaging |
Het |
| Slc25a34 |
C |
T |
4: 141,350,641 (GRCm39) |
A123T |
probably damaging |
Het |
| Smoc2 |
A |
G |
17: 14,556,839 (GRCm39) |
Y96C |
probably damaging |
Het |
| Sqle |
A |
G |
15: 59,194,765 (GRCm39) |
E267G |
probably benign |
Het |
| Sspo |
G |
A |
6: 48,440,869 (GRCm39) |
R1777H |
possibly damaging |
Het |
| Stx6 |
T |
A |
1: 155,067,210 (GRCm39) |
N133K |
probably benign |
Het |
| Taf7l2 |
T |
C |
10: 115,948,903 (GRCm39) |
T208A |
probably benign |
Het |
| Thoc5 |
A |
T |
11: 4,864,303 (GRCm39) |
Q320L |
probably benign |
Het |
| Tmc4 |
G |
C |
7: 3,670,497 (GRCm39) |
C531W |
probably damaging |
Het |
| Tmigd1 |
A |
G |
11: 76,801,031 (GRCm39) |
T173A |
probably damaging |
Het |
| Tpp2 |
A |
C |
1: 44,031,514 (GRCm39) |
M1111L |
probably benign |
Het |
| Ttc21a |
T |
C |
9: 119,772,941 (GRCm39) |
V206A |
probably benign |
Het |
| Ulk1 |
A |
T |
5: 110,936,663 (GRCm39) |
V758E |
possibly damaging |
Het |
| Vdr |
T |
A |
15: 97,767,600 (GRCm39) |
H130L |
probably benign |
Het |
| Vps13b |
A |
G |
15: 35,623,892 (GRCm39) |
T1270A |
probably damaging |
Het |
| Zc3h13 |
A |
G |
14: 75,560,991 (GRCm39) |
D527G |
unknown |
Het |
| Zfp512 |
C |
T |
5: 31,637,434 (GRCm39) |
R508W |
probably damaging |
Het |
| Zfp606 |
A |
G |
7: 12,215,026 (GRCm39) |
T85A |
unknown |
Het |
|
| Other mutations in Muc21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
BB009:Muc21
|
UTSW |
17 |
35,933,525 (GRCm39) |
intron |
probably benign |
|
|
FR4304:Muc21
|
UTSW |
17 |
35,933,013 (GRCm39) |
intron |
probably benign |
|
|
R0334:Muc21
|
UTSW |
17 |
35,933,614 (GRCm39) |
intron |
probably benign |
|
|
R0946:Muc21
|
UTSW |
17 |
35,929,105 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1117:Muc21
|
UTSW |
17 |
35,930,920 (GRCm39) |
intron |
probably benign |
|
|
R1345:Muc21
|
UTSW |
17 |
35,932,489 (GRCm39) |
intron |
probably benign |
|
|
R1697:Muc21
|
UTSW |
17 |
35,931,540 (GRCm39) |
intron |
probably benign |
|
|
R1750:Muc21
|
UTSW |
17 |
35,931,940 (GRCm39) |
intron |
probably benign |
|
|
R1756:Muc21
|
UTSW |
17 |
35,930,131 (GRCm39) |
intron |
probably benign |
|
|
R1946:Muc21
|
UTSW |
17 |
35,933,416 (GRCm39) |
intron |
probably benign |
|
|
R1978:Muc21
|
UTSW |
17 |
35,933,857 (GRCm39) |
intron |
probably benign |
|
|
R1991:Muc21
|
UTSW |
17 |
35,929,600 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1992:Muc21
|
UTSW |
17 |
35,929,600 (GRCm39) |
missense |
probably benign |
0.32 |
|
R2063:Muc21
|
UTSW |
17 |
35,932,297 (GRCm39) |
intron |
probably benign |
|
|
R2356:Muc21
|
UTSW |
17 |
35,932,563 (GRCm39) |
intron |
probably benign |
|
|
R2866:Muc21
|
UTSW |
17 |
35,930,599 (GRCm39) |
intron |
probably benign |
|
|
R3826:Muc21
|
UTSW |
17 |
35,932,504 (GRCm39) |
intron |
probably benign |
|
|
R4020:Muc21
|
UTSW |
17 |
35,930,953 (GRCm39) |
intron |
probably benign |
|
|
R4474:Muc21
|
UTSW |
17 |
35,931,496 (GRCm39) |
intron |
probably benign |
|
|
R4677:Muc21
|
UTSW |
17 |
35,930,599 (GRCm39) |
intron |
probably benign |
|
|
R4786:Muc21
|
UTSW |
17 |
35,930,221 (GRCm39) |
intron |
probably benign |
|
|
R5071:Muc21
|
UTSW |
17 |
35,931,444 (GRCm39) |
intron |
probably benign |
|
|
R5173:Muc21
|
UTSW |
17 |
35,931,633 (GRCm39) |
intron |
probably benign |
|
|
R5283:Muc21
|
UTSW |
17 |
35,932,224 (GRCm39) |
intron |
probably benign |
|
|
R5446:Muc21
|
UTSW |
17 |
35,933,395 (GRCm39) |
intron |
probably benign |
|
|
R5542:Muc21
|
UTSW |
17 |
35,933,395 (GRCm39) |
intron |
probably benign |
|
|
R5716:Muc21
|
UTSW |
17 |
35,931,675 (GRCm39) |
intron |
probably benign |
|
|
R5913:Muc21
|
UTSW |
17 |
35,934,123 (GRCm39) |
intron |
probably benign |
|
|
R6011:Muc21
|
UTSW |
17 |
35,933,074 (GRCm39) |
intron |
probably benign |
|
|
R6198:Muc21
|
UTSW |
17 |
35,931,808 (GRCm39) |
intron |
probably benign |
|
|
R6394:Muc21
|
UTSW |
17 |
35,931,058 (GRCm39) |
intron |
probably benign |
|
|
R6786:Muc21
|
UTSW |
17 |
35,934,057 (GRCm39) |
intron |
probably benign |
|
|
R6940:Muc21
|
UTSW |
17 |
35,934,118 (GRCm39) |
intron |
probably benign |
|
|
R7082:Muc21
|
UTSW |
17 |
35,932,093 (GRCm39) |
missense |
unknown |
|
|
R7103:Muc21
|
UTSW |
17 |
35,932,432 (GRCm39) |
missense |
unknown |
|
|
R7110:Muc21
|
UTSW |
17 |
35,933,510 (GRCm39) |
intron |
probably benign |
|
|
R7139:Muc21
|
UTSW |
17 |
35,933,525 (GRCm39) |
intron |
probably benign |
|
|
R7165:Muc21
|
UTSW |
17 |
35,932,870 (GRCm39) |
missense |
unknown |
|
|
R7200:Muc21
|
UTSW |
17 |
35,933,525 (GRCm39) |
intron |
probably benign |
|
|
R7204:Muc21
|
UTSW |
17 |
35,932,105 (GRCm39) |
intron |
probably benign |
|
|
R7289:Muc21
|
UTSW |
17 |
35,929,761 (GRCm39) |
missense |
unknown |
|
|
R7290:Muc21
|
UTSW |
17 |
35,929,761 (GRCm39) |
missense |
unknown |
|
|
R7295:Muc21
|
UTSW |
17 |
35,929,761 (GRCm39) |
missense |
unknown |
|
|
R7319:Muc21
|
UTSW |
17 |
35,932,935 (GRCm39) |
intron |
probably benign |
|
|
R7462:Muc21
|
UTSW |
17 |
35,931,568 (GRCm39) |
missense |
unknown |
|
|
R7529:Muc21
|
UTSW |
17 |
35,930,123 (GRCm39) |
missense |
unknown |
|
|
R7718:Muc21
|
UTSW |
17 |
35,933,728 (GRCm39) |
missense |
unknown |
|
|
R7762:Muc21
|
UTSW |
17 |
35,932,977 (GRCm39) |
missense |
unknown |
|
|
R7788:Muc21
|
UTSW |
17 |
35,929,798 (GRCm39) |
missense |
unknown |
|
|
R7798:Muc21
|
UTSW |
17 |
35,932,146 (GRCm39) |
missense |
unknown |
|
|
R7831:Muc21
|
UTSW |
17 |
35,929,651 (GRCm39) |
missense |
unknown |
|
|
R7896:Muc21
|
UTSW |
17 |
35,930,917 (GRCm39) |
missense |
unknown |
|
|
R7899:Muc21
|
UTSW |
17 |
35,931,493 (GRCm39) |
intron |
probably benign |
|
|
R7932:Muc21
|
UTSW |
17 |
35,933,525 (GRCm39) |
intron |
probably benign |
|
|
R8025:Muc21
|
UTSW |
17 |
35,931,879 (GRCm39) |
intron |
probably benign |
|
|
R8077:Muc21
|
UTSW |
17 |
35,930,628 (GRCm39) |
intron |
probably benign |
|
|
R8090:Muc21
|
UTSW |
17 |
35,932,617 (GRCm39) |
missense |
unknown |
|
|
R8169:Muc21
|
UTSW |
17 |
35,932,072 (GRCm39) |
missense |
unknown |
|
|
R8184:Muc21
|
UTSW |
17 |
35,933,722 (GRCm39) |
missense |
unknown |
|
|
R8209:Muc21
|
UTSW |
17 |
35,930,599 (GRCm39) |
intron |
probably benign |
|
|
R8226:Muc21
|
UTSW |
17 |
35,930,599 (GRCm39) |
intron |
probably benign |
|
|
R8464:Muc21
|
UTSW |
17 |
35,933,098 (GRCm39) |
intron |
probably benign |
|
|
R8670:Muc21
|
UTSW |
17 |
35,932,540 (GRCm39) |
missense |
unknown |
|
|
R8783:Muc21
|
UTSW |
17 |
35,930,875 (GRCm39) |
missense |
unknown |
|
|
R8856:Muc21
|
UTSW |
17 |
35,931,865 (GRCm39) |
missense |
unknown |
|
|
R9155:Muc21
|
UTSW |
17 |
35,932,131 (GRCm39) |
missense |
unknown |
|
|
R9353:Muc21
|
UTSW |
17 |
35,930,545 (GRCm39) |
missense |
unknown |
|
|
R9618:Muc21
|
UTSW |
17 |
35,932,935 (GRCm39) |
intron |
probably benign |
|
|
R9621:Muc21
|
UTSW |
17 |
35,932,720 (GRCm39) |
missense |
unknown |
|
|
R9679:Muc21
|
UTSW |
17 |
35,930,491 (GRCm39) |
missense |
unknown |
|
|
RF025:Muc21
|
UTSW |
17 |
35,933,771 (GRCm39) |
intron |
probably benign |
|
|
Z1176:Muc21
|
UTSW |
17 |
35,932,137 (GRCm39) |
missense |
unknown |
|
|
Z1177:Muc21
|
UTSW |
17 |
35,931,951 (GRCm39) |
missense |
unknown |
|
|
Z1177:Muc21
|
UTSW |
17 |
35,931,817 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGAGGCAGTGCTGGATTCAG -3'
(R):5'- TCTGCCTCAGGATCTATGCC -3'
Sequencing Primer
(F):5'- CAGTGCTGGATTCAGTGGTG -3'
(R):5'- CAGCTCTGCCTCAGGATCTG -3'
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| Posted On |
2022-02-07 |
Incidental Mutation