Incidental Mutation 'R9215:Vmn2r67'
| ID |
699125 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r67
|
| Ensembl Gene |
ENSMUSG00000095664 |
| Gene Name |
vomeronasal 2, receptor 67 |
| Synonyms |
EG620672 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.114)
|
| Stock # |
R9215 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
84785448-84805110 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 84802008 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Isoleucine
at position 98
(V98I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126007
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000168730]
|
| AlphaFold |
K7N6T2 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000168730
AA Change: V98I
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000126007
Gene: ENSMUSG00000095664
AA Change: V98I
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
464 |
2.1e-31 |
PFAM |
|
Pfam:NCD3G
|
507 |
559 |
4.8e-19 |
PFAM |
|
Pfam:7tm_3
|
590 |
827 |
1.4e-53 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (69/69) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Amigo3 |
G |
A |
9: 107,931,638 (GRCm39) |
A354T |
probably damaging |
Het |
| Ano1 |
A |
G |
7: 144,149,342 (GRCm39) |
S840P |
probably damaging |
Het |
| Arap1 |
A |
G |
7: 101,049,214 (GRCm39) |
Q923R |
probably benign |
Het |
| Blk |
T |
C |
14: 63,610,999 (GRCm39) |
M448V |
probably damaging |
Het |
| Calhm2 |
C |
A |
19: 47,121,305 (GRCm39) |
R288L |
possibly damaging |
Het |
| Card11 |
A |
T |
5: 140,866,154 (GRCm39) |
M913K |
possibly damaging |
Het |
| Carf |
A |
C |
1: 60,189,804 (GRCm39) |
E676D |
possibly damaging |
Het |
| Ccn5 |
T |
A |
2: 163,670,966 (GRCm39) |
C158S |
probably damaging |
Het |
| Ccr2 |
A |
G |
9: 123,906,023 (GRCm39) |
D101G |
probably damaging |
Het |
| Ckap2l |
T |
C |
2: 129,123,826 (GRCm39) |
R532G |
possibly damaging |
Het |
| Clec1a |
T |
C |
6: 129,412,134 (GRCm39) |
T112A |
possibly damaging |
Het |
| Clint1 |
T |
C |
11: 45,774,578 (GRCm39) |
V28A |
probably damaging |
Het |
| Col13a1 |
C |
A |
10: 61,685,990 (GRCm39) |
|
probably null |
Het |
| Cryz |
G |
T |
3: 154,324,446 (GRCm39) |
V216F |
probably benign |
Het |
| Cyp1a1 |
G |
A |
9: 57,609,456 (GRCm39) |
V386I |
probably benign |
Het |
| Cyp2c54 |
G |
A |
19: 40,035,950 (GRCm39) |
T320I |
possibly damaging |
Het |
| Dock7 |
G |
C |
4: 98,859,088 (GRCm39) |
N1431K |
unknown |
Het |
| Fam110c |
G |
T |
12: 31,123,863 (GRCm39) |
|
probably benign |
Het |
| Fbn2 |
A |
T |
18: 58,209,747 (GRCm39) |
C1045S |
probably damaging |
Het |
| Fbxo30 |
G |
A |
10: 11,167,243 (GRCm39) |
R655H |
probably damaging |
Het |
| Fhip1b |
A |
G |
7: 105,034,296 (GRCm39) |
L445P |
possibly damaging |
Het |
| Gbp2 |
T |
C |
3: 142,338,036 (GRCm39) |
|
probably null |
Het |
| Hmgcll1 |
A |
G |
9: 75,982,083 (GRCm39) |
D176G |
probably benign |
Het |
| Inafm1 |
A |
T |
7: 16,007,055 (GRCm39) |
I54N |
probably damaging |
Het |
| Ipo9 |
C |
G |
1: 135,347,033 (GRCm39) |
M152I |
probably benign |
Het |
| Khdrbs3 |
C |
T |
15: 68,964,798 (GRCm39) |
T333M |
probably damaging |
Het |
| Lefty2 |
A |
G |
1: 180,725,145 (GRCm39) |
T292A |
probably benign |
Het |
| Lgr5 |
T |
C |
10: 115,311,085 (GRCm39) |
E237G |
probably damaging |
Het |
| Lrig2 |
T |
A |
3: 104,398,324 (GRCm39) |
E268D |
probably benign |
Het |
| Mbtd1 |
T |
A |
11: 93,834,628 (GRCm39) |
L602Q |
possibly damaging |
Het |
| Mtbp |
T |
C |
15: 55,484,035 (GRCm39) |
V828A |
possibly damaging |
Het |
| Ncapd3 |
C |
A |
9: 26,975,386 (GRCm39) |
Q812K |
possibly damaging |
Het |
| Nlrx1 |
T |
C |
9: 44,165,325 (GRCm39) |
K857R |
probably benign |
Het |
| Or2b28 |
C |
T |
13: 21,532,004 (GRCm39) |
A302V |
probably damaging |
Het |
| Or4d6 |
A |
T |
19: 12,086,016 (GRCm39) |
M72K |
probably damaging |
Het |
| Or4k1 |
T |
C |
14: 50,377,829 (GRCm39) |
Y89C |
probably benign |
Het |
| Or8b1c |
C |
T |
9: 38,384,694 (GRCm39) |
S217F |
probably damaging |
Het |
| P4ha2 |
T |
C |
11: 54,017,226 (GRCm39) |
F456L |
probably benign |
Het |
| Pakap |
T |
A |
4: 57,709,595 (GRCm39) |
V180E |
probably damaging |
Het |
| Pard3b |
A |
G |
1: 62,203,344 (GRCm39) |
D424G |
probably damaging |
Het |
| Pecam1 |
A |
G |
11: 106,579,797 (GRCm39) |
S422P |
probably damaging |
Het |
| Pias2 |
T |
A |
18: 77,216,677 (GRCm39) |
V296E |
probably damaging |
Het |
| Plekha5 |
T |
A |
6: 140,501,733 (GRCm39) |
S640R |
possibly damaging |
Het |
| Prdx2 |
A |
G |
8: 85,697,932 (GRCm39) |
K92E |
possibly damaging |
Het |
| Prl7c1 |
C |
T |
13: 27,960,204 (GRCm39) |
E113K |
probably benign |
Het |
| Pxylp1 |
A |
T |
9: 96,707,111 (GRCm39) |
V357D |
possibly damaging |
Het |
| Rbm12b2 |
T |
C |
4: 12,095,471 (GRCm39) |
F777L |
probably damaging |
Het |
| Rbm4b |
G |
T |
19: 4,812,268 (GRCm39) |
V226F |
possibly damaging |
Het |
| Rel |
T |
C |
11: 23,698,870 (GRCm39) |
D139G |
probably benign |
Het |
| Rnf214 |
C |
T |
9: 45,816,129 (GRCm39) |
D28N |
probably benign |
Het |
| Slc26a5 |
A |
G |
5: 22,042,285 (GRCm39) |
S224P |
possibly damaging |
Het |
| Slc39a6 |
C |
T |
18: 24,732,323 (GRCm39) |
A322T |
probably benign |
Het |
| Slc47a1 |
T |
C |
11: 61,262,647 (GRCm39) |
I81V |
probably benign |
Het |
| Smad5 |
T |
A |
13: 56,880,815 (GRCm39) |
C310S |
probably damaging |
Het |
| Sparcl1 |
T |
C |
5: 104,240,701 (GRCm39) |
D241G |
probably benign |
Het |
| Spata16 |
C |
T |
3: 26,721,994 (GRCm39) |
Q172* |
probably null |
Het |
| Spata31d1d |
G |
T |
13: 59,875,823 (GRCm39) |
Q571K |
probably benign |
Het |
| Speer1e |
A |
T |
5: 11,236,449 (GRCm39) |
I161F |
possibly damaging |
Het |
| Sspo |
G |
A |
6: 48,440,869 (GRCm39) |
R1777H |
possibly damaging |
Het |
| Stt3b |
A |
T |
9: 115,085,223 (GRCm39) |
F381I |
probably damaging |
Het |
| Tjp1 |
T |
C |
7: 64,962,595 (GRCm39) |
Y1194C |
probably benign |
Het |
| Tmem132b |
T |
C |
5: 125,864,180 (GRCm39) |
I762T |
probably damaging |
Het |
| Tnxb |
A |
G |
17: 34,891,564 (GRCm39) |
T636A |
unknown |
Het |
| Trat1 |
T |
A |
16: 48,574,637 (GRCm39) |
R54* |
probably null |
Het |
| Tubb4a |
A |
T |
17: 57,387,769 (GRCm39) |
V419E |
probably damaging |
Het |
| Txn2 |
A |
T |
15: 77,803,965 (GRCm39) |
W84R |
unknown |
Het |
| Uggt2 |
A |
G |
14: 119,279,006 (GRCm39) |
Y834H |
probably damaging |
Het |
| Upp2 |
T |
C |
2: 58,670,065 (GRCm39) |
L257P |
probably damaging |
Het |
| Zfp354c |
T |
C |
11: 50,706,666 (GRCm39) |
I136M |
probably benign |
Het |
|
| Other mutations in Vmn2r67 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00096:Vmn2r67
|
APN |
7 |
84,801,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01346:Vmn2r67
|
APN |
7 |
84,786,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01373:Vmn2r67
|
APN |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01674:Vmn2r67
|
APN |
7 |
84,785,651 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01978:Vmn2r67
|
APN |
7 |
84,800,649 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02013:Vmn2r67
|
APN |
7 |
84,800,863 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02115:Vmn2r67
|
APN |
7 |
84,800,787 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02250:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
|
IGL02252:Vmn2r67
|
APN |
7 |
84,805,008 (GRCm39) |
missense |
probably benign |
|
|
IGL02328:Vmn2r67
|
APN |
7 |
84,799,898 (GRCm39) |
missense |
probably benign |
0.41 |
|
IGL02740:Vmn2r67
|
APN |
7 |
84,785,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02940:Vmn2r67
|
APN |
7 |
84,785,951 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL03237:Vmn2r67
|
APN |
7 |
84,799,118 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Vmn2r67
|
UTSW |
7 |
84,799,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1029:Vmn2r67
|
UTSW |
7 |
84,785,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1193:Vmn2r67
|
UTSW |
7 |
84,800,653 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1282:Vmn2r67
|
UTSW |
7 |
84,785,932 (GRCm39) |
missense |
probably benign |
|
|
R1416:Vmn2r67
|
UTSW |
7 |
84,800,824 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1429:Vmn2r67
|
UTSW |
7 |
84,802,031 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1462:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1970:Vmn2r67
|
UTSW |
7 |
84,801,013 (GRCm39) |
missense |
probably benign |
|
|
R2229:Vmn2r67
|
UTSW |
7 |
84,801,250 (GRCm39) |
missense |
probably benign |
0.21 |
|
R2246:Vmn2r67
|
UTSW |
7 |
84,785,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2262:Vmn2r67
|
UTSW |
7 |
84,786,182 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2398:Vmn2r67
|
UTSW |
7 |
84,785,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4249:Vmn2r67
|
UTSW |
7 |
84,799,722 (GRCm39) |
splice site |
probably null |
|
|
R4666:Vmn2r67
|
UTSW |
7 |
84,799,831 (GRCm39) |
missense |
probably benign |
|
|
R4669:Vmn2r67
|
UTSW |
7 |
84,799,732 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4966:Vmn2r67
|
UTSW |
7 |
84,785,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5264:Vmn2r67
|
UTSW |
7 |
84,801,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5296:Vmn2r67
|
UTSW |
7 |
84,786,230 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5327:Vmn2r67
|
UTSW |
7 |
84,785,698 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5401:Vmn2r67
|
UTSW |
7 |
84,785,765 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Vmn2r67
|
UTSW |
7 |
84,801,023 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5574:Vmn2r67
|
UTSW |
7 |
84,801,099 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5643:Vmn2r67
|
UTSW |
7 |
84,799,151 (GRCm39) |
nonsense |
probably null |
|
|
R5914:Vmn2r67
|
UTSW |
7 |
84,801,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Vmn2r67
|
UTSW |
7 |
84,799,768 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6291:Vmn2r67
|
UTSW |
7 |
84,799,142 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6309:Vmn2r67
|
UTSW |
7 |
84,801,124 (GRCm39) |
missense |
probably benign |
|
|
R6442:Vmn2r67
|
UTSW |
7 |
84,805,046 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6665:Vmn2r67
|
UTSW |
7 |
84,785,900 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6701:Vmn2r67
|
UTSW |
7 |
84,802,023 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6848:Vmn2r67
|
UTSW |
7 |
84,801,840 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6852:Vmn2r67
|
UTSW |
7 |
84,801,361 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6991:Vmn2r67
|
UTSW |
7 |
84,804,953 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R7143:Vmn2r67
|
UTSW |
7 |
84,801,846 (GRCm39) |
missense |
probably benign |
|
|
R7197:Vmn2r67
|
UTSW |
7 |
84,785,774 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7393:Vmn2r67
|
UTSW |
7 |
84,805,086 (GRCm39) |
missense |
probably null |
0.87 |
|
R7420:Vmn2r67
|
UTSW |
7 |
84,785,944 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7622:Vmn2r67
|
UTSW |
7 |
84,785,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7664:Vmn2r67
|
UTSW |
7 |
84,805,019 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7665:Vmn2r67
|
UTSW |
7 |
84,801,196 (GRCm39) |
nonsense |
probably null |
|
|
R7896:Vmn2r67
|
UTSW |
7 |
84,785,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7913:Vmn2r67
|
UTSW |
7 |
84,801,036 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8026:Vmn2r67
|
UTSW |
7 |
84,785,924 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8114:Vmn2r67
|
UTSW |
7 |
84,805,097 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8317:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8363:Vmn2r67
|
UTSW |
7 |
84,804,969 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8421:Vmn2r67
|
UTSW |
7 |
84,785,893 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8444:Vmn2r67
|
UTSW |
7 |
84,785,854 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8751:Vmn2r67
|
UTSW |
7 |
84,801,450 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8810:Vmn2r67
|
UTSW |
7 |
84,786,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8811:Vmn2r67
|
UTSW |
7 |
84,799,895 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9342:Vmn2r67
|
UTSW |
7 |
84,785,788 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9433:Vmn2r67
|
UTSW |
7 |
84,804,917 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9453:Vmn2r67
|
UTSW |
7 |
84,800,697 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9471:Vmn2r67
|
UTSW |
7 |
84,799,723 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9526:Vmn2r67
|
UTSW |
7 |
84,785,834 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9538:Vmn2r67
|
UTSW |
7 |
84,801,327 (GRCm39) |
missense |
|
|
|
R9544:Vmn2r67
|
UTSW |
7 |
84,786,317 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9574:Vmn2r67
|
UTSW |
7 |
84,786,017 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9599:Vmn2r67
|
UTSW |
7 |
84,804,941 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9768:Vmn2r67
|
UTSW |
7 |
84,802,037 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCTCAGGAATGCTATACATGAAC -3'
(R):5'- CCCTTTTCTGTCAGTTAAAACCAGTAC -3'
Sequencing Primer
(F):5'- AGGAATGCTATACATGAACATGAATG -3'
(R):5'- TCTGTCAGTTAAAACCAGTACATAAC -3'
|
| Posted On |
2022-02-07 |
Incidental Mutation