Mutagenetix > Incidental Mutation

Incidental Mutation 'R9217:Or8c10'

699259

Institutional Source

Beutler Lab

Gene Symbol

Or8c10

Ensembl Gene

ENSMUSG00000049864

Gene Name

olfactory receptor family 8 subfamily C member 10

Synonyms

GA_x6K02T2PVTD-32060891-32061865, MOR170-8, MOR170-14, GA_x6K02T2MYUG-19447-18473, Olfr899, Olfr250

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

R9217 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

38278844-38279839 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 38279268 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 132 (Y132C)

Ref Sequence

ENSEMBL: ENSMUSP00000150432 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000052085] [ENSMUST00000216168]

AlphaFold

E9PV37

Predicted Effect

probably damaging
Transcript: ENSMUST00000052085
AA Change: Y142C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000051631
Gene: ENSMUSG00000049864
AA Change: Y142C

Domain	Start	End	E-Value	Type
Pfam:7tm_4	41	317	1.2e-46	PFAM
Pfam:7tm_1	51	300	3.7e-19	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000216168
AA Change: Y132C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 98.8%

Validation Efficiency

97% (59/61)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 60 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A730049H05Rik	T	C	6: 92,808,967 (GRCm39)	V98A	unknown	Het
Abca15	A	T	7: 119,987,439 (GRCm39)	M1242L	probably benign	Het
Abcb9	G	A	5: 124,214,090 (GRCm39)	R576C	possibly damaging	Het
Abl2	A	G	1: 156,452,902 (GRCm39)	S146G	probably damaging	Het
Aga	G	A	8: 53,966,627 (GRCm39)	G60S	probably damaging	Het
Amigo1	T	A	3: 108,095,944 (GRCm39)	V481D	probably damaging	Het
Ano5	C	A	7: 51,243,415 (GRCm39)	P846Q	probably damaging	Het
Ccdc62	C	A	5: 124,092,470 (GRCm39)	T485K	probably benign	Het
Cd177	A	T	7: 24,445,550 (GRCm39)	I631K	possibly damaging	Het
Chil6	T	A	3: 106,313,411 (GRCm39)		probably benign	Het
Clip1	A	G	5: 123,717,441 (GRCm39)	S1283P	probably damaging	Het
Cpt1a	G	A	19: 3,425,111 (GRCm39)	V493I	probably benign	Het
Dcbld1	T	A	10: 52,138,028 (GRCm39)	D97E	probably benign	Het
Decr1	G	A	4: 15,930,969 (GRCm39)	P121L	probably damaging	Het
Ehmt1	A	T	2: 24,729,578 (GRCm39)	L661Q	probably benign	Het
Eif2d	A	G	1: 131,085,972 (GRCm39)	M156V	possibly damaging	Het
Ermn	A	T	2: 57,938,010 (GRCm39)	I201K	probably damaging	Het
Etfbkmt	T	C	6: 149,045,663 (GRCm39)	C6R	probably benign	Het
Evx2	A	T	2: 74,488,109 (GRCm39)		probably null	Het
Fam222a	T	C	5: 114,748,905 (GRCm39)	S34P	probably benign	Het
Fmo6	A	T	1: 162,748,046 (GRCm39)	D339E	probably benign	Het
Fubp1	T	C	3: 151,923,873 (GRCm39)	S142P	probably benign	Het
Gm40460	ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG	ACCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAGCCACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAGGAACTACAGCCTCCCTTGCAGCCCCCACAG	7: 141,794,450 (GRCm39)		probably benign	Het
Gnb1	A	T	4: 155,625,033 (GRCm39)	Q75L	probably damaging	Het
Gucy2e	C	T	11: 69,126,778 (GRCm39)	A232T	possibly damaging	Het
Haspin	A	T	11: 73,026,936 (GRCm39)	C718S	probably benign	Het
Iqcd	C	T	5: 120,738,707 (GRCm39)	P175L	possibly damaging	Het
Jph1	T	A	1: 17,167,632 (GRCm39)	Q66L	probably benign	Het
Kank1	G	T	19: 25,386,944 (GRCm39)	D206Y	possibly damaging	Het
Klf14	T	C	6: 30,935,470 (GRCm39)	T55A	probably benign	Het
Lclat1	T	C	17: 73,494,879 (GRCm39)	M125T	probably damaging	Het
Lgr5	T	A	10: 115,423,349 (GRCm39)	Q17L	probably benign	Het
Lrmda	A	G	14: 22,648,361 (GRCm39)	I64V	unknown	Het
Lrrc15	A	G	16: 30,092,415 (GRCm39)	L308P	probably damaging	Het
Lyst	C	A	13: 13,871,245 (GRCm39)	Q2661K	probably benign	Het
Map3k21	T	A	8: 126,638,027 (GRCm39)	D204E	possibly damaging	Het
Msln	T	C	17: 25,970,125 (GRCm39)	I277V	probably benign	Het
Ndst4	C	T	3: 125,518,385 (GRCm39)	S354L	probably benign	Het
Nup153	G	A	13: 46,835,138 (GRCm39)	T1389M	probably damaging	Het
Plcd1	T	C	9: 118,901,723 (GRCm39)		probably null	Het
Plce1	C	T	19: 38,748,551 (GRCm39)	R1761C	probably damaging	Het
Prrc2b	T	C	2: 32,103,414 (GRCm39)	L964P	probably damaging	Het
Prss43	T	C	9: 110,656,564 (GRCm39)	S84P	possibly damaging	Het
Rffl	T	C	11: 82,703,633 (GRCm39)	T97A	possibly damaging	Het
Riok2	G	C	17: 17,598,057 (GRCm39)	G48A	possibly damaging	Het
Sec24a	A	G	11: 51,617,331 (GRCm39)	M488T	probably benign	Het
Setdb2	C	T	14: 59,646,881 (GRCm39)	D545N	possibly damaging	Het
Slc39a4	T	A	15: 76,498,126 (GRCm39)	H400L	possibly damaging	Het
St7	T	A	6: 17,846,271 (GRCm39)	F175I	probably damaging	Het
Syne1	T	A	10: 5,299,324 (GRCm39)	D977V	probably damaging	Het
Tenm4	C	T	7: 96,534,646 (GRCm39)	T1801I	probably damaging	Het
Terf1	C	T	1: 15,883,295 (GRCm39)	T136I	probably damaging	Het
Tnnt1	T	C	7: 4,513,381 (GRCm39)	S42G	probably benign	Het
Trappc8	A	G	18: 21,000,822 (GRCm39)	V287A	probably benign	Het
Ttc3	T	A	16: 94,230,467 (GRCm39)	I870K	possibly damaging	Het
Ttn	A	T	2: 76,574,389 (GRCm39)	N25501K	possibly damaging	Het
Unc13c	A	T	9: 73,485,715 (GRCm39)	W1662R	probably damaging	Het
Wdr47	T	A	3: 108,525,890 (GRCm39)	C138S	probably damaging	Het
Zfp458	A	G	13: 67,408,298 (GRCm39)	S6P	probably damaging	Het
Zfp668	A	C	7: 127,465,804 (GRCm39)	L460*	probably null	Het

Other mutations in Or8c10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01595:Or8c10	APN	9	38,279,346 (GRCm39)	missense	probably benign	0.01
IGL02073:Or8c10	APN	9	38,279,603 (GRCm39)	missense	probably damaging	1.00
IGL02499:Or8c10	APN	9	38,278,977 (GRCm39)	missense	probably benign	0.12
IGL03011:Or8c10	APN	9	38,279,364 (GRCm39)	missense	possibly damaging	0.89
R0313:Or8c10	UTSW	9	38,279,600 (GRCm39)	missense	probably damaging	1.00
R1457:Or8c10	UTSW	9	38,279,492 (GRCm39)	missense	probably benign	0.01
R1546:Or8c10	UTSW	9	38,278,844 (GRCm39)	start codon destroyed	probably benign
R1665:Or8c10	UTSW	9	38,278,862 (GRCm39)	missense	probably benign
R1718:Or8c10	UTSW	9	38,278,890 (GRCm39)	missense	probably benign	0.00
R1861:Or8c10	UTSW	9	38,278,902 (GRCm39)	missense	probably benign	0.08
R1900:Or8c10	UTSW	9	38,279,360 (GRCm39)	missense	probably benign	0.05
R2363:Or8c10	UTSW	9	38,279,394 (GRCm39)	missense	probably damaging	1.00
R4270:Or8c10	UTSW	9	38,278,997 (GRCm39)	missense	probably damaging	1.00
R5058:Or8c10	UTSW	9	38,279,220 (GRCm39)	missense	probably damaging	1.00
R5083:Or8c10	UTSW	9	38,279,358 (GRCm39)	missense	possibly damaging	0.87
R5422:Or8c10	UTSW	9	38,279,270 (GRCm39)	missense	probably benign	0.05
R5630:Or8c10	UTSW	9	38,279,402 (GRCm39)	missense	probably damaging	1.00
R6559:Or8c10	UTSW	9	38,279,052 (GRCm39)	missense	probably damaging	1.00
R8313:Or8c10	UTSW	9	38,279,346 (GRCm39)	missense	probably damaging	0.97
R8869:Or8c10	UTSW	9	38,279,142 (GRCm39)	missense	possibly damaging	0.69
R9163:Or8c10	UTSW	9	38,279,378 (GRCm39)	missense	probably damaging	1.00
R9331:Or8c10	UTSW	9	38,279,003 (GRCm39)	missense	probably benign	0.01
R9419:Or8c10	UTSW	9	38,279,162 (GRCm39)	missense	probably damaging	1.00
R9491:Or8c10	UTSW	9	38,278,971 (GRCm39)	missense	possibly damaging	0.94
R9631:Or8c10	UTSW	9	38,279,714 (GRCm39)	missense	possibly damaging	0.58
R9643:Or8c10	UTSW	9	38,278,912 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGAATTCTCATCTGCACACACC -3'
(R):5'- TGACTGCTACCACAGGAGAG -3'

Sequencing Primer
(F):5'- TTCTCATCTGCACACACCAATGTAC -3'
(R):5'- TGCTACCACAGGAGAGCTCAAG -3'

Posted On

2022-02-07