Incidental Mutation 'R9220:Tnfrsf21'
ID 699432
Institutional Source Beutler Lab
Gene Symbol Tnfrsf21
Ensembl Gene ENSMUSG00000023915
Gene Name tumor necrosis factor receptor superfamily, member 21
Synonyms TR7, Death receptor 6, DR6
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.175) question?
Stock # R9220 (G1)
Quality Score 225.009
Status Not validated
Chromosome 17
Chromosomal Location 43327446-43400079 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43398801 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Glycine at position 636 (S636G)
Ref Sequence ENSEMBL: ENSMUSP00000024708 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024708]
AlphaFold Q9EPU5
Predicted Effect probably damaging
Transcript: ENSMUST00000024708
AA Change: S636G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000024708
Gene: ENSMUSG00000023915
AA Change: S636G

DomainStartEndE-ValueType
TNFR 50 88 1.58e1 SMART
TNFR 91 131 3.42e-3 SMART
TNFR 133 168 9.31e-5 SMART
TNFR 171 211 1.1e-1 SMART
transmembrane domain 351 370 N/A INTRINSIC
DEATH 393 498 1.41e-22 SMART
low complexity region 511 526 N/A INTRINSIC
low complexity region 562 575 N/A INTRINSIC
PDB:2DBH|A 576 655 5e-48 PDB
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired T cell differentiation and an enhanced Th2 response. Mice homozygous for a different knock-out allele show increased CD4+ T cell proliferation and Th2 cytokine production, and enhanced B cell proliferation, survival, and humoral responses. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acte1 G T 7: 143,434,902 (GRCm39) probably null Het
Afg3l2 T G 18: 67,562,266 (GRCm39) I270L probably benign Het
Akap6 A T 12: 53,187,232 (GRCm39) I1549F possibly damaging Het
Ank2 T C 3: 126,737,086 (GRCm39) T2933A unknown Het
Atp1a3 C A 7: 24,696,625 (GRCm39) E309* probably null Het
B4galt2 T C 4: 117,734,399 (GRCm39) Y250C probably damaging Het
Bcl2l13 C A 6: 120,847,735 (GRCm39) T129K possibly damaging Het
Bltp3b A T 10: 89,626,457 (GRCm39) T384S probably benign Het
Clp1 A T 2: 84,554,076 (GRCm39) H364Q probably damaging Het
Ddx27 T C 2: 166,871,433 (GRCm39) V510A probably benign Het
Dicer1 A G 12: 104,679,415 (GRCm39) C521R probably damaging Het
Dnah10 A T 5: 124,871,437 (GRCm39) I2486F probably benign Het
Eml1 C A 12: 108,480,702 (GRCm39) C389* probably null Het
Fabp6 C T 11: 43,489,572 (GRCm39) G23D probably benign Het
Fam3b A T 16: 97,302,111 (GRCm39) S38T probably benign Het
Fsd1l A T 4: 53,679,799 (GRCm39) K166* probably null Het
Galc A G 12: 98,220,523 (GRCm39) S115P probably damaging Het
Gpn1 G A 5: 31,664,884 (GRCm39) A303T probably benign Het
Grid2 A T 6: 63,885,888 (GRCm39) S95C probably damaging Het
Helz T A 11: 107,560,873 (GRCm39) S1312T probably benign Het
Matn2 T C 15: 34,410,325 (GRCm39) F506L possibly damaging Het
Mcemp1 A G 8: 3,717,512 (GRCm39) S148G probably benign Het
Minar1 T A 9: 89,484,398 (GRCm39) D333V probably damaging Het
Ndrg1 A G 15: 66,805,711 (GRCm39) probably null Het
Nlrp4a A T 7: 26,149,523 (GRCm39) N377Y probably damaging Het
Nox4 C T 7: 86,970,774 (GRCm39) T217I probably benign Het
Or7g21 T C 9: 19,033,193 (GRCm39) F311S possibly damaging Het
Or8b52 A T 9: 38,576,803 (GRCm39) Y112* probably null Het
Phf8-ps T C 17: 33,286,494 (GRCm39) I103V probably benign Het
Plekhd1 T A 12: 80,768,726 (GRCm39) F403Y possibly damaging Het
Plekhg1 T C 10: 3,913,805 (GRCm39) S1231P Het
Plekhg3 T A 12: 76,618,839 (GRCm39) M497K probably benign Het
Rpap1 T C 2: 119,604,669 (GRCm39) H413R probably damaging Het
Rragd A G 4: 32,995,924 (GRCm39) T90A probably damaging Het
Septin9 T C 11: 117,242,396 (GRCm39) M286T probably benign Het
Shpk GACCTTAGCCAGAAGGAGCCTTAGTTCATCAA GA 11: 73,113,996 (GRCm39) probably null Het
Slc22a2 T A 17: 12,838,757 (GRCm39) D528E probably benign Het
Slirp G A 12: 87,494,376 (GRCm39) R47K probably benign Het
Sncg T C 14: 34,096,474 (GRCm39) T22A possibly damaging Het
Unc80 T G 1: 66,546,534 (GRCm39) S535R probably damaging Het
Vmn1r149 A T 7: 22,137,378 (GRCm39) S93T probably benign Het
Vps13d A G 4: 144,783,058 (GRCm39) Y3957H Het
Wdr35 T A 12: 9,036,000 (GRCm39) V257E possibly damaging Het
Wscd1 A G 11: 71,662,750 (GRCm39) T264A probably benign Het
Zfp266 G A 9: 20,413,337 (GRCm39) Q108* probably null Het
Zfp62 T A 11: 49,106,075 (GRCm39) S55R probably benign Het
Other mutations in Tnfrsf21
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01406:Tnfrsf21 APN 17 43,348,837 (GRCm39) missense probably damaging 1.00
IGL01663:Tnfrsf21 APN 17 43,398,702 (GRCm39) missense probably benign 0.13
IGL01811:Tnfrsf21 APN 17 43,348,504 (GRCm39) missense probably benign
IGL01916:Tnfrsf21 APN 17 43,350,694 (GRCm39) missense probably benign 0.00
IGL01934:Tnfrsf21 APN 17 43,376,078 (GRCm39) missense probably benign 0.15
IGL02184:Tnfrsf21 APN 17 43,396,354 (GRCm39) missense probably benign 0.37
IGL02292:Tnfrsf21 APN 17 43,350,802 (GRCm39) missense probably benign
IGL02385:Tnfrsf21 APN 17 43,350,942 (GRCm39) missense probably damaging 1.00
IGL02710:Tnfrsf21 APN 17 43,398,820 (GRCm39) missense probably damaging 0.97
IGL03001:Tnfrsf21 APN 17 43,398,786 (GRCm39) missense probably damaging 0.99
IGL03003:Tnfrsf21 APN 17 43,350,834 (GRCm39) missense probably damaging 1.00
PIT4480001:Tnfrsf21 UTSW 17 43,348,802 (GRCm39) missense probably benign 0.00
R0007:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0046:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0088:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0091:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0102:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0102:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0103:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0105:Tnfrsf21 UTSW 17 43,351,082 (GRCm39) critical splice donor site probably null
R0105:Tnfrsf21 UTSW 17 43,351,082 (GRCm39) critical splice donor site probably null
R0206:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0211:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0240:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0243:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0308:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0363:Tnfrsf21 UTSW 17 43,348,768 (GRCm39) missense probably benign 0.01
R0456:Tnfrsf21 UTSW 17 43,348,982 (GRCm39) missense probably benign 0.01
R0522:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0523:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0525:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0528:Tnfrsf21 UTSW 17 43,348,505 (GRCm39) missense probably benign
R0543:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0549:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0550:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0699:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0724:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0734:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0847:Tnfrsf21 UTSW 17 43,349,104 (GRCm39) missense probably benign
R0880:Tnfrsf21 UTSW 17 43,348,733 (GRCm39) nonsense probably null
R1591:Tnfrsf21 UTSW 17 43,396,265 (GRCm39) missense probably benign 0.01
R2069:Tnfrsf21 UTSW 17 43,348,829 (GRCm39) missense possibly damaging 0.67
R2153:Tnfrsf21 UTSW 17 43,398,763 (GRCm39) missense probably damaging 1.00
R2323:Tnfrsf21 UTSW 17 43,396,420 (GRCm39) nonsense probably null
R3941:Tnfrsf21 UTSW 17 43,348,901 (GRCm39) missense probably damaging 1.00
R4438:Tnfrsf21 UTSW 17 43,398,733 (GRCm39) missense possibly damaging 0.49
R4509:Tnfrsf21 UTSW 17 43,396,279 (GRCm39) missense probably benign 0.00
R4510:Tnfrsf21 UTSW 17 43,375,910 (GRCm39) missense probably damaging 0.98
R4511:Tnfrsf21 UTSW 17 43,375,910 (GRCm39) missense probably damaging 0.98
R4708:Tnfrsf21 UTSW 17 43,349,123 (GRCm39) missense possibly damaging 0.66
R4721:Tnfrsf21 UTSW 17 43,396,395 (GRCm39) missense probably damaging 1.00
R4811:Tnfrsf21 UTSW 17 43,348,621 (GRCm39) missense probably benign 0.00
R5437:Tnfrsf21 UTSW 17 43,348,753 (GRCm39) missense possibly damaging 0.55
R5767:Tnfrsf21 UTSW 17 43,348,550 (GRCm39) missense probably damaging 0.98
R6057:Tnfrsf21 UTSW 17 43,350,606 (GRCm39) missense possibly damaging 0.86
R6392:Tnfrsf21 UTSW 17 43,327,979 (GRCm39) missense probably benign 0.00
R6860:Tnfrsf21 UTSW 17 43,327,957 (GRCm39) missense probably benign
R7253:Tnfrsf21 UTSW 17 43,348,558 (GRCm39) missense probably benign 0.00
R7288:Tnfrsf21 UTSW 17 43,348,709 (GRCm39) missense possibly damaging 0.86
R7643:Tnfrsf21 UTSW 17 43,348,807 (GRCm39) missense probably benign 0.00
R7937:Tnfrsf21 UTSW 17 43,348,816 (GRCm39) missense probably benign 0.01
R8098:Tnfrsf21 UTSW 17 43,350,790 (GRCm39) missense probably benign
R8495:Tnfrsf21 UTSW 17 43,349,128 (GRCm39) missense probably benign
R8865:Tnfrsf21 UTSW 17 43,396,372 (GRCm39) missense probably damaging 1.00
R8991:Tnfrsf21 UTSW 17 43,396,299 (GRCm39) missense probably benign 0.03
R9088:Tnfrsf21 UTSW 17 43,348,607 (GRCm39) missense probably damaging 1.00
R9150:Tnfrsf21 UTSW 17 43,398,691 (GRCm39) missense probably damaging 1.00
V3553:Tnfrsf21 UTSW 17 43,348,822 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AGGTTCAGAATGCCAGCAG -3'
(R):5'- GGCCATACACTCTGTTAAACAC -3'

Sequencing Primer
(F):5'- CCAGCAGCCCCTCATCTG -3'
(R):5'- TCTGTTAAACACATACATACACACC -3'
Posted On 2022-02-07