Incidental Mutation 'R9224:Fyb2'
ID 699655
Institutional Source Beutler Lab
Gene Symbol Fyb2
Ensembl Gene ENSMUSG00000078612
Gene Name FYN binding protein 2
Synonyms 1700024P16Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.084) question?
Stock # R9224 (G1)
Quality Score 225.009
Status Not validated
Chromosome 4
Chromosomal Location 104770653-104874060 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 104853105 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 566 (W566R)
Ref Sequence ENSEMBL: ENSMUSP00000102415 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106803] [ENSMUST00000106804]
AlphaFold A2A995
Predicted Effect probably benign
Transcript: ENSMUST00000106803
AA Change: W566R

PolyPhen 2 Score 0.435 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000102415
Gene: ENSMUSG00000078612
AA Change: W566R

DomainStartEndE-ValueType
low complexity region 120 132 N/A INTRINSIC
low complexity region 340 349 N/A INTRINSIC
low complexity region 442 459 N/A INTRINSIC
low complexity region 537 549 N/A INTRINSIC
low complexity region 567 578 N/A INTRINSIC
low complexity region 682 697 N/A INTRINSIC
SH3 735 791 3.82e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000106804
AA Change: W502R

PolyPhen 2 Score 0.169 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000102416
Gene: ENSMUSG00000078612
AA Change: W502R

DomainStartEndE-ValueType
low complexity region 56 68 N/A INTRINSIC
low complexity region 276 285 N/A INTRINSIC
low complexity region 378 395 N/A INTRINSIC
low complexity region 473 485 N/A INTRINSIC
low complexity region 503 514 N/A INTRINSIC
low complexity region 618 633 N/A INTRINSIC
SH3 671 727 3.82e0 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 112 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810055G02Rik C T 19: 3,767,100 (GRCm39) S229L possibly damaging Het
Actc1 TGA T 2: 113,879,710 (GRCm39) probably null Het
Actl9 G A 17: 33,653,004 (GRCm39) A355T probably benign Het
Adamts8 A G 9: 30,854,188 (GRCm39) Q19R probably benign Het
Akr1c14 A T 13: 4,130,695 (GRCm39) Y216F possibly damaging Het
Alms1 T C 6: 85,598,770 (GRCm39) C1199R possibly damaging Het
Apc2 T C 10: 80,150,111 (GRCm39) S1722P probably damaging Het
Arid1a T C 4: 133,409,167 (GRCm39) E1395G unknown Het
Atp6v0e2 T C 6: 48,516,190 (GRCm39) V46A possibly damaging Het
Bcar3 A G 3: 122,319,091 (GRCm39) R743G probably damaging Het
Bhmt2 A G 13: 93,805,854 (GRCm39) V56A probably damaging Het
Bsn C A 9: 107,982,686 (GRCm39) R917L Het
Cabyr T G 18: 12,887,278 (GRCm39) V303G possibly damaging Het
Carmil1 A T 13: 24,292,512 (GRCm39) I429N probably damaging Het
Ccdc27 T C 4: 154,122,174 (GRCm39) N235D unknown Het
Ccdc61 T C 7: 18,637,746 (GRCm39) M37V probably benign Het
Cd40 A T 2: 164,898,716 (GRCm39) I48F unknown Het
Cdk13 A T 13: 17,941,071 (GRCm39) S664R probably damaging Het
Cel TTA TTATA 2: 28,449,441 (GRCm39) probably null Het
Cfap46 T A 7: 139,258,416 (GRCm39) R286* probably null Het
Ckap2 A C 8: 22,659,954 (GRCm39) I509S possibly damaging Het
Clptm1l A T 13: 73,752,344 (GRCm39) probably benign Het
Col11a1 T G 3: 114,001,929 (GRCm39) M1591R unknown Het
Col6a5 C A 9: 105,814,594 (GRCm39) A473S unknown Het
Cxcr2 T A 1: 74,197,756 (GRCm39) D83E probably damaging Het
Cyp2c39 G A 19: 39,527,332 (GRCm39) C226Y probably benign Het
Ddr1 A C 17: 36,000,609 (GRCm39) F352C probably damaging Het
Defb22 T A 2: 152,327,721 (GRCm39) T155S unknown Het
Dennd4c G T 4: 86,738,170 (GRCm39) E935* probably null Het
Dst A C 1: 34,330,879 (GRCm39) E4889D probably damaging Het
Efcab3 A G 11: 104,661,801 (GRCm39) Q1314R probably benign Het
Emilin1 T A 5: 31,074,823 (GRCm39) C355S probably damaging Het
Enpp3 C T 10: 24,650,716 (GRCm39) V807I probably benign Het
Fcnb T A 2: 27,969,160 (GRCm39) D179V probably damaging Het
Ficd T A 5: 113,875,196 (GRCm39) D88E probably benign Het
Fndc3b T C 3: 27,524,450 (GRCm39) K437E possibly damaging Het
Gm14403 A G 2: 177,200,336 (GRCm39) Q94R probably benign Het
Gm32687 T A 10: 81,714,866 (GRCm39) I86N probably benign Het
Gpam T G 19: 55,075,907 (GRCm39) D235A probably damaging Het
Gstt4 T C 10: 75,651,046 (GRCm39) E192G probably damaging Het
H2-Q6 T G 17: 35,644,309 (GRCm39) V97G probably benign Het
Hcn1 G A 13: 118,062,254 (GRCm39) G507S unknown Het
Hydin T C 8: 111,259,516 (GRCm39) I2496T probably benign Het
Jund A G 8: 71,151,864 (GRCm39) D53G probably damaging Het
Kat6b T A 14: 21,720,031 (GRCm39) M1461K probably benign Het
Lnx1 T G 5: 74,766,810 (GRCm39) K435Q probably benign Het
Lpcat1 C A 13: 73,658,161 (GRCm39) L316M probably damaging Het
Lrrtm3 ATTTT ATTTTT 10: 63,925,035 (GRCm39) probably null Het
Ly6c1 T A 15: 74,916,465 (GRCm39) T126S probably benign Het
Macf1 A G 4: 123,326,690 (GRCm39) S4938P probably damaging Het
Map2k2 T C 10: 80,954,008 (GRCm39) V158A possibly damaging Het
Map3k4 A G 17: 12,456,973 (GRCm39) V1323A probably damaging Het
Map4k5 A T 12: 69,939,467 (GRCm39) V23E possibly damaging Het
Med30 T G 15: 52,582,839 (GRCm39) L92R probably damaging Het
Mroh8 C T 2: 157,063,069 (GRCm39) G851S possibly damaging Het
Msmb T A 14: 31,880,060 (GRCm39) C83* probably null Het
Mtif2 A T 11: 29,494,364 (GRCm39) R655S probably benign Het
Myo10 C T 15: 25,808,081 (GRCm39) S1901L probably benign Het
Myom2 A T 8: 15,178,804 (GRCm39) I1279F possibly damaging Het
Nat9 T C 11: 115,075,441 (GRCm39) I67V probably damaging Het
Ncam1 A G 9: 49,419,995 (GRCm39) S774P probably damaging Het
Ndufaf6 T C 4: 11,062,089 (GRCm39) T181A probably damaging Het
Nlrp4f T A 13: 65,332,829 (GRCm39) K110* probably null Het
Nlrp9b T C 7: 19,753,217 (GRCm39) S41P probably benign Het
Nlrp9b A G 7: 19,757,476 (GRCm39) T238A probably benign Het
Noxo1 A T 17: 24,919,305 (GRCm39) E342D probably benign Het
Nt5dc2 T C 14: 30,857,665 (GRCm39) M55T probably benign Het
Or1j14 A T 2: 36,417,838 (GRCm39) Q138L probably benign Het
Or2ag18 T C 7: 106,405,489 (GRCm39) Y60C probably damaging Het
Or2f1 T C 6: 42,721,904 (GRCm39) F311S probably benign Het
Or2h2c T C 17: 37,422,767 (GRCm39) T36A possibly damaging Het
Or5al6 T A 2: 85,976,220 (GRCm39) N286I probably damaging Het
Or6c210 C A 10: 129,496,007 (GRCm39) L111M probably damaging Het
Or6c6 T A 10: 129,186,450 (GRCm39) M6K probably benign Het
Or9s18 C T 13: 65,300,203 (GRCm39) T55I probably damaging Het
P4ha2 C T 11: 54,009,963 (GRCm39) P240L possibly damaging Het
Pcdha11 T A 18: 37,139,073 (GRCm39) L234Q probably damaging Het
Pgm3 C T 9: 86,438,415 (GRCm39) A457T probably benign Het
Pira12 T C 7: 3,900,234 (GRCm39) T123A probably benign Het
Pkp4 T C 2: 59,144,738 (GRCm39) V533A probably benign Het
Plac8l1 T C 18: 42,325,702 (GRCm39) T68A possibly damaging Het
Pou2f3 A T 9: 43,050,694 (GRCm39) I222N probably damaging Het
Ppp1r14d T C 2: 119,060,222 (GRCm39) D20G probably benign Het
Ppp1r37 C A 7: 19,265,729 (GRCm39) G679V probably damaging Het
Ppp6r2 T A 15: 89,146,599 (GRCm39) I199N probably damaging Het
Prune2 A G 19: 17,097,393 (GRCm39) T966A probably damaging Het
Ptdss2 T C 7: 140,734,798 (GRCm39) V375A probably benign Het
Rara TGCCCCGC TGCCCCGCCCCGC 11: 98,857,236 (GRCm39) probably null Het
Rin2 T A 2: 145,720,822 (GRCm39) C718* probably null Het
Rptor C T 11: 119,785,113 (GRCm39) T1170I probably benign Het
Samd5 T C 10: 9,550,259 (GRCm39) Y150C probably damaging Het
Setd1b T C 5: 123,296,773 (GRCm39) S1245P unknown Het
Sipa1l2 T C 8: 126,218,716 (GRCm39) E207G probably damaging Het
Slc29a1 C A 17: 45,897,153 (GRCm39) V378L probably damaging Het
Slc2a12 T G 10: 22,541,261 (GRCm39) I372S possibly damaging Het
Slc7a10 T A 7: 34,894,639 (GRCm39) Y99* probably null Het
Smco3 A G 6: 136,808,517 (GRCm39) V119A probably damaging Het
Sptlc3 C T 2: 139,336,154 (GRCm39) T10I probably benign Het
Sri T A 5: 8,113,323 (GRCm39) W105R probably damaging Het
Stk35 T C 2: 129,652,491 (GRCm39) Y331H probably damaging Het
Tipin T C 9: 64,195,430 (GRCm39) I12T probably benign Het
Tlr5 A G 1: 182,802,693 (GRCm39) T666A probably benign Het
Tmprss11g C A 5: 86,640,003 (GRCm39) V222L probably benign Het
Tnfrsf11b T A 15: 54,115,556 (GRCm39) Y347F possibly damaging Het
Traf6 A G 2: 101,527,512 (GRCm39) T421A probably benign Het
Trrap T A 5: 144,708,049 (GRCm39) D30E possibly damaging Het
Ube2k T A 5: 65,751,847 (GRCm39) Y162N probably damaging Het
Uck2 A T 1: 167,065,171 (GRCm39) V49E probably damaging Het
Vcam1 A T 3: 115,904,592 (GRCm39) Y718* probably null Het
Zan T C 5: 137,472,269 (GRCm39) N159S probably damaging Het
Zfp438 A G 18: 5,210,788 (GRCm39) L750P probably damaging Het
Zfp54 A T 17: 21,654,037 (GRCm39) Y177F probably benign Het
Other mutations in Fyb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00664:Fyb2 APN 4 104,872,913 (GRCm39) missense probably damaging 1.00
IGL01155:Fyb2 APN 4 104,856,583 (GRCm39) missense probably benign 0.00
IGL01632:Fyb2 APN 4 104,853,008 (GRCm39) missense probably benign
IGL01746:Fyb2 APN 4 104,802,404 (GRCm39) missense probably benign 0.01
IGL02381:Fyb2 APN 4 104,805,863 (GRCm39) splice site probably benign
IGL02590:Fyb2 APN 4 104,836,250 (GRCm39) missense probably damaging 1.00
IGL02885:Fyb2 APN 4 104,861,118 (GRCm39) missense probably damaging 0.99
IGL03114:Fyb2 APN 4 104,852,975 (GRCm39) missense probably damaging 0.97
IGL03189:Fyb2 APN 4 104,872,939 (GRCm39) missense probably damaging 1.00
IGL03231:Fyb2 APN 4 104,843,460 (GRCm39) nonsense probably null
R0076:Fyb2 UTSW 4 104,802,661 (GRCm39) missense possibly damaging 0.46
R0662:Fyb2 UTSW 4 104,852,895 (GRCm39) missense possibly damaging 0.46
R0723:Fyb2 UTSW 4 104,873,063 (GRCm39) missense probably benign 0.00
R1216:Fyb2 UTSW 4 104,852,903 (GRCm39) missense possibly damaging 0.86
R1672:Fyb2 UTSW 4 104,808,059 (GRCm39) missense probably benign 0.10
R1710:Fyb2 UTSW 4 104,861,113 (GRCm39) missense probably damaging 1.00
R1900:Fyb2 UTSW 4 104,802,652 (GRCm39) missense probably benign 0.06
R1965:Fyb2 UTSW 4 104,770,846 (GRCm39) missense probably benign 0.00
R2106:Fyb2 UTSW 4 104,802,769 (GRCm39) missense probably benign 0.01
R5191:Fyb2 UTSW 4 104,852,994 (GRCm39) missense possibly damaging 0.88
R5236:Fyb2 UTSW 4 104,805,957 (GRCm39) missense probably benign 0.00
R5277:Fyb2 UTSW 4 104,872,876 (GRCm39) missense probably damaging 1.00
R5502:Fyb2 UTSW 4 104,802,521 (GRCm39) missense probably damaging 1.00
R5769:Fyb2 UTSW 4 104,872,841 (GRCm39) missense probably damaging 1.00
R5769:Fyb2 UTSW 4 104,870,518 (GRCm39) missense probably damaging 1.00
R6167:Fyb2 UTSW 4 104,802,661 (GRCm39) missense possibly damaging 0.46
R6169:Fyb2 UTSW 4 104,857,713 (GRCm39) missense probably benign 0.16
R6371:Fyb2 UTSW 4 104,852,975 (GRCm39) missense probably damaging 0.97
R6582:Fyb2 UTSW 4 104,802,739 (GRCm39) missense probably benign 0.00
R6713:Fyb2 UTSW 4 104,847,432 (GRCm39) missense probably benign 0.16
R6719:Fyb2 UTSW 4 104,867,656 (GRCm39) missense probably benign 0.07
R7484:Fyb2 UTSW 4 104,870,499 (GRCm39) missense probably benign 0.01
R7534:Fyb2 UTSW 4 104,856,545 (GRCm39) nonsense probably null
R7590:Fyb2 UTSW 4 104,802,443 (GRCm39) missense probably benign 0.01
R7699:Fyb2 UTSW 4 104,867,651 (GRCm39) missense probably benign 0.07
R7700:Fyb2 UTSW 4 104,867,651 (GRCm39) missense probably benign 0.07
R8041:Fyb2 UTSW 4 104,857,681 (GRCm39) missense possibly damaging 0.82
R8298:Fyb2 UTSW 4 104,806,028 (GRCm39) missense probably damaging 0.99
R8300:Fyb2 UTSW 4 104,857,689 (GRCm39) missense probably damaging 1.00
R8755:Fyb2 UTSW 4 104,861,086 (GRCm39) missense unknown
R8817:Fyb2 UTSW 4 104,802,652 (GRCm39) missense probably benign 0.06
R8873:Fyb2 UTSW 4 104,856,538 (GRCm39) missense probably damaging 1.00
R8914:Fyb2 UTSW 4 104,857,700 (GRCm39) missense probably benign 0.09
R9434:Fyb2 UTSW 4 104,847,534 (GRCm39) missense probably damaging 0.99
R9512:Fyb2 UTSW 4 104,853,100 (GRCm39) missense probably benign 0.00
R9589:Fyb2 UTSW 4 104,872,833 (GRCm39) missense probably damaging 1.00
R9634:Fyb2 UTSW 4 104,856,579 (GRCm39) nonsense probably null
R9758:Fyb2 UTSW 4 104,802,961 (GRCm39) missense probably benign 0.01
X0018:Fyb2 UTSW 4 104,802,407 (GRCm39) missense probably benign 0.04
Z1176:Fyb2 UTSW 4 104,770,857 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TTGCCCTTACAGGTGGGTAC -3'
(R):5'- CTATTCCGGCCTCTAAGTGCAG -3'

Sequencing Primer
(F):5'- CCTTACAGGTGGGTACGTGGAG -3'
(R):5'- TCTAAGTGCAGGCCTTGGGAC -3'
Posted On 2022-02-07