Mutagenetix > Incidental Mutation

Incidental Mutation 'R9224:Hydin'

699684

Institutional Source

Beutler Lab

Gene Symbol

Hydin

Ensembl Gene

ENSMUSG00000059854

Gene Name

HYDIN, axonemal central pair apparatus protein

Synonyms

hy-3, hyrh, hy3, 1700034M11Rik, 4930545D19Rik

Accession Numbers

Ncbi RefSeq: NM_172916; MGI: 2389007

Essential gene?

Probably essential (E-score: 0.784) question?

Stock #

R9224 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

110266977-110610253 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 110532884 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 2496 (I2496T)

Ref Sequence

ENSEMBL: ENSMUSP00000046204 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043141]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000043141
AA Change: I2496T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000046204
Gene: ENSMUSG00000059854
AA Change: I2496T

Domain	Start	End	E-Value	Type
Pfam:Motile_Sperm	246	325	5.6e-8	PFAM
Pfam:ASH	559	659	9.4e-17	PFAM
low complexity region	788	798	N/A	INTRINSIC
Pfam:PapD-like	848	906	1.2e-6	PFAM
low complexity region	998	1024	N/A	INTRINSIC
low complexity region	1279	1292	N/A	INTRINSIC
internal_repeat_6	1317	1549	5.96e-5	PROSPERO
internal_repeat_5	1355	1502	3.23e-5	PROSPERO
low complexity region	1574	1590	N/A	INTRINSIC
internal_repeat_4	1712	1940	5.14e-6	PROSPERO
coiled coil region	1947	1977	N/A	INTRINSIC
low complexity region	2009	2020	N/A	INTRINSIC
low complexity region	2034	2049	N/A	INTRINSIC
SCOP:d1eq1a_	2305	2403	3e-4	SMART
low complexity region	2404	2419	N/A	INTRINSIC
coiled coil region	2543	2588	N/A	INTRINSIC
low complexity region	2636	2656	N/A	INTRINSIC
internal_repeat_7	2772	3008	8.1e-5	PROSPERO
low complexity region	3660	3670	N/A	INTRINSIC
low complexity region	3919	3934	N/A	INTRINSIC
internal_repeat_5	4046	4190	3.23e-5	PROSPERO
internal_repeat_2	4106	4251	6.03e-7	PROSPERO
internal_repeat_4	4317	4532	5.14e-6	PROSPERO
internal_repeat_3	4403	4689	2.05e-6	PROSPERO
internal_repeat_2	4549	4697	6.03e-7	PROSPERO
low complexity region	4951	4964	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

MGI Phenotype

Strain: 1856913; 3801608
Lethality: D28-D42
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that may be involved in cilia motility. Mutations in this gene cause of autosomal recessive primary ciliary dyskinesia-5, a disorder characterized by the accumulation of cerebrospinal fluid within the ventricles of the brain. A duplicate copy of this gene has been found in humans on chromosome 1. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for a mutation in this gene develop hydrocephaly after birth. Symptoms develop after 3-5 days. Affected animals usually die before 2 months of age. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted(1) Gene trapped(3) Transgenic(1) Spontaneous(2)

Other mutations in this stock

Total: 112 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1810055G02Rik	C	T	19: 3,717,100	S229L	possibly damaging	Het
Actc1	TGA	T	2: 114,049,229		probably null	Het
Actl9	G	A	17: 33,434,030	A355T	probably benign	Het
Adamts8	A	G	9: 30,942,892	Q19R	probably benign	Het
Akr1c14	A	T	13: 4,080,695	Y216F	possibly damaging	Het
Alms1	T	C	6: 85,621,788	C1199R	possibly damaging	Het
Apc2	T	C	10: 80,314,277	S1722P	probably damaging	Het
Arid1a	T	C	4: 133,681,856	E1395G	unknown	Het
Atp6v0e2	T	C	6: 48,539,256	V46A	possibly damaging	Het
Bcar3	A	G	3: 122,525,442	R743G	probably damaging	Het
Bhmt2	A	G	13: 93,669,346	V56A	probably damaging	Het
Bsn	C	A	9: 108,105,487	R917L		Het
Cabyr	T	G	18: 12,754,221	V303G	possibly damaging	Het
Carmil1	A	T	13: 24,108,529	I429N	probably damaging	Het
Ccdc27	T	C	4: 154,037,717	N235D	unknown	Het
Ccdc61	T	C	7: 18,903,821	M37V	probably benign	Het
Cd40	A	T	2: 165,056,796	I48F	unknown	Het
Cdk13	A	T	13: 17,766,486	S664R	probably damaging	Het
Cel	TTA	TTATA	2: 28,559,429		probably null	Het
Cfap46	T	A	7: 139,678,500	R286*	probably null	Het
Ckap2	A	C	8: 22,169,938	I509S	possibly damaging	Het
Clptm1l	A	T	13: 73,604,225		probably benign	Het
Col11a1	T	G	3: 114,208,280	M1591R	unknown	Het
Col6a5	C	A	9: 105,937,395	A473S	unknown	Het
Cxcr2	T	A	1: 74,158,597	D83E	probably damaging	Het
Cyp2c39	G	A	19: 39,538,888	C226Y	probably benign	Het
Ddr1	A	C	17: 35,689,717	F352C	probably damaging	Het
Defb22	T	A	2: 152,485,801	T155S	unknown	Het
Dennd4c	G	T	4: 86,819,933	E935*	probably null	Het
Dst	A	C	1: 34,291,798	E4889D	probably damaging	Het
Emilin1	T	A	5: 30,917,479	C355S	probably damaging	Het
Enpp3	C	T	10: 24,774,818	V807I	probably benign	Het
Fcnb	T	A	2: 28,079,148	D179V	probably damaging	Het
Ficd	T	A	5: 113,737,135	D88E	probably benign	Het
Fndc3b	T	C	3: 27,470,301	K437E	possibly damaging	Het
Fyb2	T	A	4: 104,995,908	W566R	probably benign	Het
Gm11639	A	G	11: 104,770,975	Q1314R	probably benign	Het
Gm14403	A	G	2: 177,508,543	Q94R	probably benign	Het
Gm14548	T	C	7: 3,897,235	T123A	probably benign	Het
Gm32687	T	A	10: 81,879,032	I86N	probably benign	Het
Gpam	T	G	19: 55,087,475	D235A	probably damaging	Het
Gstt4	T	C	10: 75,815,212	E192G	probably damaging	Het
H2-Q6	T	G	17: 35,425,333	V97G	probably benign	Het
Hcn1	G	A	13: 117,925,718	G507S	unknown	Het
Jund	A	G	8: 70,699,215	D53G	probably damaging	Het
Kat6b	T	A	14: 21,669,963	M1461K	probably benign	Het
Lnx1	T	G	5: 74,606,149	K435Q	probably benign	Het
Lpcat1	C	A	13: 73,510,042	L316M	probably damaging	Het
Lrrtm3	ATTTT	ATTTTT	10: 64,089,256		probably null	Het
Ly6c1	T	A	15: 75,044,616	T126S	probably benign	Het
Macf1	A	G	4: 123,432,897	S4938P	probably damaging	Het
Map2k2	T	C	10: 81,118,174	V158A	possibly damaging	Het
Map3k4	A	G	17: 12,238,086	V1323A	probably damaging	Het
Map4k5	A	T	12: 69,892,693	V23E	possibly damaging	Het
Med30	T	G	15: 52,719,443	L92R	probably damaging	Het
Mroh8	C	T	2: 157,221,149	G851S	possibly damaging	Het
Msmb	T	A	14: 32,158,103	C83*	probably null	Het
Mtif2	A	T	11: 29,544,364	R655S	probably benign	Het
Myo10	C	T	15: 25,807,995	S1901L	probably benign	Het
Myom2	A	T	8: 15,128,804	I1279F	possibly damaging	Het
Nat9	T	C	11: 115,184,615	I67V	probably damaging	Het
Ncam1	A	G	9: 49,508,695	S774P	probably damaging	Het
Ndufaf6	T	C	4: 11,062,089	T181A	probably damaging	Het
Nlrp4f	T	A	13: 65,185,015	K110*	probably null	Het
Nlrp9b	T	C	7: 20,019,292	S41P	probably benign	Het
Nlrp9b	A	G	7: 20,023,551	T238A	probably benign	Het
Noxo1	A	T	17: 24,700,331	E342D	probably benign	Het
Nt5dc2	T	C	14: 31,135,708	M55T	probably benign	Het
Olfr1040	T	A	2: 86,145,876	N286I	probably damaging	Het
Olfr342	A	T	2: 36,527,826	Q138L	probably benign	Het
Olfr453	T	C	6: 42,744,970	F311S	probably benign	Het
Olfr466	C	T	13: 65,152,389	T55I	probably damaging	Het
Olfr700	T	C	7: 106,806,282	Y60C	probably damaging	Het
Olfr782	T	A	10: 129,350,581	M6K	probably benign	Het
Olfr800	C	A	10: 129,660,138	L111M	probably damaging	Het
Olfr92	T	C	17: 37,111,875	T36A	possibly damaging	Het
P4ha2	C	T	11: 54,119,137	P240L	possibly damaging	Het
Pcdha11	T	A	18: 37,006,020	L234Q	probably damaging	Het
Pgm3	C	T	9: 86,556,362	A457T	probably benign	Het
Pkp4	T	C	2: 59,314,394	V533A	probably benign	Het
Plac8l1	T	C	18: 42,192,637	T68A	possibly damaging	Het
Pou2f3	A	T	9: 43,139,399	I222N	probably damaging	Het
Ppp1r14d	T	C	2: 119,229,741	D20G	probably benign	Het
Ppp1r37	C	A	7: 19,531,804	G679V	probably damaging	Het
Ppp6r2	T	A	15: 89,262,396	I199N	probably damaging	Het
Prune2	A	G	19: 17,120,029	T966A	probably damaging	Het
Ptdss2	T	C	7: 141,154,885	V375A	probably benign	Het
Rara	TGCCCCGC	TGCCCCGCCCCGC	11: 98,966,410		probably null	Het
Rin2	T	A	2: 145,878,902	C718*	probably null	Het
Rptor	C	T	11: 119,894,287	T1170I	probably benign	Het
Samd5	T	C	10: 9,674,515	Y150C	probably damaging	Het
Setd1b	T	C	5: 123,158,710	S1245P	unknown	Het
Sipa1l2	T	C	8: 125,491,977	E207G	probably damaging	Het
Slc29a1	C	A	17: 45,586,227	V378L	probably damaging	Het
Slc2a12	T	G	10: 22,665,362	I372S	possibly damaging	Het
Slc7a10	T	A	7: 35,195,214	Y99*	probably null	Het
Smco3	A	G	6: 136,831,519	V119A	probably damaging	Het
Sptlc3	C	T	2: 139,494,234	T10I	probably benign	Het
Sri	T	A	5: 8,063,323	W105R	probably damaging	Het
Stk35	T	C	2: 129,810,571	Y331H	probably damaging	Het
Tipin	T	C	9: 64,288,148	I12T	probably benign	Het
Tlr5	A	G	1: 182,975,128	T666A	probably benign	Het
Tmprss11g	C	A	5: 86,492,144	V222L	probably benign	Het
Tnfrsf11b	T	A	15: 54,252,160	Y347F	possibly damaging	Het
Traf6	A	G	2: 101,697,167	T421A	probably benign	Het
Trrap	T	A	5: 144,771,239	D30E	possibly damaging	Het
Ube2k	T	A	5: 65,594,504	Y162N	probably damaging	Het
Uck2	A	T	1: 167,237,602	V49E	probably damaging	Het
Vcam1	A	T	3: 116,110,943	Y718*	probably null	Het
Zan	T	C	5: 137,474,007	N159S	probably damaging	Het
Zfp438	A	G	18: 5,210,788	L750P	probably damaging	Het
Zfp54	A	T	17: 21,433,775	Y177F	probably benign	Het

Other mutations in Hydin

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00338:Hydin	APN	8	110569802	missense	possibly damaging	0.69
IGL00432:Hydin	APN	8	110601252	missense	probably damaging	0.98
IGL01025:Hydin	APN	8	110326401	missense	probably benign	0.38
IGL01140:Hydin	APN	8	110398062	missense	probably benign	0.14
IGL01317:Hydin	APN	8	110326446	missense	probably damaging	0.98
IGL01473:Hydin	APN	8	110312160	missense	probably benign	0.08
IGL01473:Hydin	APN	8	110354953	missense	probably damaging	1.00
IGL01610:Hydin	APN	8	110557713	missense	probably benign	0.00
IGL01685:Hydin	APN	8	110355033	nonsense	probably null
IGL01734:Hydin	APN	8	110490789	nonsense	probably null
IGL01743:Hydin	APN	8	110592776	missense	possibly damaging	0.94
IGL01829:Hydin	APN	8	110589522	missense	possibly damaging	0.68
IGL01919:Hydin	APN	8	110519174	missense	possibly damaging	0.89
IGL01946:Hydin	APN	8	110490718	missense	possibly damaging	0.91
IGL01983:Hydin	APN	8	110514895	missense	probably benign	0.02
IGL02122:Hydin	APN	8	110494415	missense	possibly damaging	0.86
IGL02140:Hydin	APN	8	110566938	missense	probably benign
IGL02158:Hydin	APN	8	110609966	missense	possibly damaging	0.89
IGL02167:Hydin	APN	8	110418423	missense	possibly damaging	0.96
IGL02171:Hydin	APN	8	110451958	nonsense	probably null
IGL02185:Hydin	APN	8	110506476	missense	possibly damaging	0.86
IGL02517:Hydin	APN	8	110566972	missense	probably benign	0.01
IGL02639:Hydin	APN	8	110538449	missense	probably benign	0.01
IGL02644:Hydin	APN	8	110538468	missense	probably damaging	1.00
IGL02652:Hydin	APN	8	110589522	missense	possibly damaging	0.68
IGL02658:Hydin	APN	8	110413276	missense	possibly damaging	0.86
IGL02706:Hydin	APN	8	110410566	missense	probably damaging	0.99
IGL02892:Hydin	APN	8	110598959	missense	possibly damaging	0.89
IGL02947:Hydin	APN	8	110418462	missense	probably damaging	0.96
IGL03136:Hydin	APN	8	110418524	missense	probably benign	0.22
IGL03248:Hydin	APN	8	110595289	missense	probably damaging	0.97
IGL03251:Hydin	APN	8	110490596	missense	probably damaging	1.00
IGL03350:Hydin	APN	8	110312224	missense	possibly damaging	0.86
IGL03366:Hydin	APN	8	110267363	missense	unknown
IGL03404:Hydin	APN	8	110569777	missense	probably benign	0.06
Franz_joseph	UTSW	8	110601318	missense	probably damaging	1.00
jahreszeiten	UTSW	8	110569359	missense	probably damaging	1.00
maria	UTSW	8	110509127	splice site	probably benign
schoepfung	UTSW	8	110600245	missense	possibly damaging	0.68
surprise	UTSW	8	110528016	missense	probably benign
teresa	UTSW	8	110609671	missense	possibly damaging	0.79
BB001:Hydin	UTSW	8	110418471	missense	possibly damaging	0.93
BB004:Hydin	UTSW	8	110580844	missense	possibly damaging	0.89
BB011:Hydin	UTSW	8	110418471	missense	possibly damaging	0.93
BB014:Hydin	UTSW	8	110580844	missense	possibly damaging	0.89
P0005:Hydin	UTSW	8	110494289	critical splice acceptor site	probably null
R0099:Hydin	UTSW	8	110589561	missense	probably damaging	1.00
R0125:Hydin	UTSW	8	110462531	missense	probably benign	0.12
R0157:Hydin	UTSW	8	110300010	missense	possibly damaging	0.86
R0241:Hydin	UTSW	8	110398023	missense	probably benign	0.04
R0241:Hydin	UTSW	8	110398023	missense	probably benign	0.04
R0255:Hydin	UTSW	8	110565018	missense	probably benign	0.00
R0352:Hydin	UTSW	8	110569901	critical splice donor site	probably null
R0379:Hydin	UTSW	8	110509127	splice site	probably benign
R0468:Hydin	UTSW	8	110413223	missense	possibly damaging	0.96
R0477:Hydin	UTSW	8	110418498	missense	probably damaging	1.00
R0479:Hydin	UTSW	8	110599088	missense	probably damaging	1.00
R0539:Hydin	UTSW	8	110523072	missense	probably benign
R0550:Hydin	UTSW	8	110587775	missense	probably benign	0.01
R0571:Hydin	UTSW	8	110514103	splice site	probably null
R0606:Hydin	UTSW	8	110549798	splice site	probably benign
R0789:Hydin	UTSW	8	110566971	missense	possibly damaging	0.53
R0849:Hydin	UTSW	8	110598984	missense	probably damaging	1.00
R0946:Hydin	UTSW	8	110531053	missense	probably benign	0.25
R1201:Hydin	UTSW	8	110569855	missense	probably benign	0.01
R1375:Hydin	UTSW	8	110506222	critical splice donor site	probably null
R1385:Hydin	UTSW	8	110523204	missense	probably benign	0.40
R1411:Hydin	UTSW	8	110575031	missense	probably benign	0.04
R1437:Hydin	UTSW	8	110581985	nonsense	probably null
R1447:Hydin	UTSW	8	110523166	missense	probably damaging	1.00
R1448:Hydin	UTSW	8	110446585	missense	probably benign	0.27
R1466:Hydin	UTSW	8	110532953	missense	possibly damaging	0.47
R1466:Hydin	UTSW	8	110532953	missense	possibly damaging	0.47
R1523:Hydin	UTSW	8	110533271	missense	probably benign	0.05
R1544:Hydin	UTSW	8	110574854	missense	probably benign	0.30
R1581:Hydin	UTSW	8	110410460	missense	probably benign
R1584:Hydin	UTSW	8	110580815	missense	probably benign	0.27
R1598:Hydin	UTSW	8	110410674	missense	possibly damaging	0.96
R1633:Hydin	UTSW	8	110506982	missense	probably benign	0.10
R1777:Hydin	UTSW	8	110589571	missense	probably benign	0.14
R1817:Hydin	UTSW	8	110532827	missense	probably benign	0.00
R1828:Hydin	UTSW	8	110510894	missense	probably benign	0.03
R1837:Hydin	UTSW	8	110569625	missense	probably benign	0.20
R1848:Hydin	UTSW	8	110569808	missense	probably benign	0.19
R1869:Hydin	UTSW	8	110500705	missense	possibly damaging	0.94
R1909:Hydin	UTSW	8	110587772	missense	probably damaging	1.00
R1928:Hydin	UTSW	8	110502947	missense	possibly damaging	0.93
R1950:Hydin	UTSW	8	110609987	missense	possibly damaging	0.64
R2095:Hydin	UTSW	8	110462657	missense	probably damaging	0.96
R2172:Hydin	UTSW	8	110582049	missense	probably benign	0.42
R2217:Hydin	UTSW	8	110418506	missense	probably benign
R2248:Hydin	UTSW	8	110578203	missense	probably benign	0.09
R2272:Hydin	UTSW	8	110309132	missense	probably benign	0.01
R2294:Hydin	UTSW	8	110299959	missense	probably damaging	0.99
R2315:Hydin	UTSW	8	110398044	missense	probably benign	0.01
R2330:Hydin	UTSW	8	110565009	missense	probably benign	0.01
R2374:Hydin	UTSW	8	110565148	missense	probably damaging	1.00
R2446:Hydin	UTSW	8	110587715	missense	possibly damaging	0.82
R2484:Hydin	UTSW	8	110513115	missense	possibly damaging	0.76
R2698:Hydin	UTSW	8	110609929	missense	possibly damaging	0.70
R2843:Hydin	UTSW	8	110519114	missense	probably benign
R2844:Hydin	UTSW	8	110519114	missense	probably benign
R2846:Hydin	UTSW	8	110519114	missense	probably benign
R2882:Hydin	UTSW	8	110566923	missense	possibly damaging	0.92
R2937:Hydin	UTSW	8	110404295	missense	possibly damaging	0.88
R3031:Hydin	UTSW	8	110603216	missense	possibly damaging	0.83
R3038:Hydin	UTSW	8	110582689	missense	probably damaging	1.00
R3121:Hydin	UTSW	8	110506506	missense	probably benign
R3157:Hydin	UTSW	8	110267373	missense	unknown
R3547:Hydin	UTSW	8	110582067	missense	possibly damaging	0.85
R3696:Hydin	UTSW	8	110603279	missense	probably damaging	1.00
R3850:Hydin	UTSW	8	110563929	missense	probably damaging	0.99
R3896:Hydin	UTSW	8	110509079	missense	possibly damaging	0.93
R3983:Hydin	UTSW	8	110392325	missense	probably damaging	1.00
R4031:Hydin	UTSW	8	110610047	missense	probably benign	0.30
R4072:Hydin	UTSW	8	110505256	missense	possibly damaging	0.68
R4095:Hydin	UTSW	8	110541547	missense	probably damaging	0.98
R4176:Hydin	UTSW	8	110593820	missense	probably benign	0.00
R4213:Hydin	UTSW	8	110456507	missense	possibly damaging	0.91
R4412:Hydin	UTSW	8	110415736	missense	probably damaging	0.99
R4471:Hydin	UTSW	8	110587132	missense	probably damaging	1.00
R4474:Hydin	UTSW	8	110563865	missense	probably benign	0.11
R4495:Hydin	UTSW	8	110595402	missense	probably damaging	0.99
R4508:Hydin	UTSW	8	110519254	missense	possibly damaging	0.91
R4578:Hydin	UTSW	8	110267339	missense	unknown
R4583:Hydin	UTSW	8	110595225	missense	probably benign	0.36
R4600:Hydin	UTSW	8	110566950	missense	probably benign	0.04
R4681:Hydin	UTSW	8	110506471	missense	possibly damaging	0.85
R4685:Hydin	UTSW	8	110462522	missense	probably damaging	0.99
R4689:Hydin	UTSW	8	110595414	missense	probably benign	0.18
R4735:Hydin	UTSW	8	110555632	critical splice donor site	probably null
R4736:Hydin	UTSW	8	110523208	missense	probably benign	0.02
R4740:Hydin	UTSW	8	110446439	missense	probably benign	0.06
R4771:Hydin	UTSW	8	110532883	missense	probably benign
R4777:Hydin	UTSW	8	110410464	missense	probably damaging	0.98
R4859:Hydin	UTSW	8	110506494	missense	possibly damaging	0.93
R4911:Hydin	UTSW	8	110595438	missense	probably benign	0.01
R4964:Hydin	UTSW	8	110490673	missense	possibly damaging	0.86
R4965:Hydin	UTSW	8	110398095	missense	probably benign
R4989:Hydin	UTSW	8	110563922	missense	possibly damaging	0.84
R4995:Hydin	UTSW	8	110569642	missense	probably damaging	0.97
R5059:Hydin	UTSW	8	110505769	missense	probably damaging	0.96
R5071:Hydin	UTSW	8	110538473	missense	probably benign	0.03
R5073:Hydin	UTSW	8	110538473	missense	probably benign	0.03
R5092:Hydin	UTSW	8	110582668	missense	probably benign	0.16
R5156:Hydin	UTSW	8	110609701	missense	probably benign	0.00
R5166:Hydin	UTSW	8	110523142	missense	possibly damaging	0.89
R5189:Hydin	UTSW	8	110413211	critical splice acceptor site	probably null
R5243:Hydin	UTSW	8	110505748	missense	possibly damaging	0.92
R5244:Hydin	UTSW	8	110532819	missense	possibly damaging	0.77
R5256:Hydin	UTSW	8	110587223	missense	possibly damaging	0.92
R5266:Hydin	UTSW	8	110334784	missense	possibly damaging	0.87
R5283:Hydin	UTSW	8	110451980	missense	possibly damaging	0.96
R5343:Hydin	UTSW	8	110485419	missense	probably benign	0.40
R5359:Hydin	UTSW	8	110538372	missense	probably benign	0.00
R5390:Hydin	UTSW	8	110595467	missense	probably benign
R5394:Hydin	UTSW	8	110539842	splice site	probably null
R5441:Hydin	UTSW	8	110565109	missense	possibly damaging	0.72
R5461:Hydin	UTSW	8	110519231	missense	probably damaging	0.96
R5662:Hydin	UTSW	8	110580709	missense	probably benign	0.02
R5695:Hydin	UTSW	8	110535283	missense	probably benign	0.35
R5732:Hydin	UTSW	8	110452058	missense	probably benign	0.03
R5774:Hydin	UTSW	8	110571915	nonsense	probably null
R5780:Hydin	UTSW	8	110586080	missense	probably damaging	1.00
R5787:Hydin	UTSW	8	110326353	missense	probably damaging	0.99
R5802:Hydin	UTSW	8	110452060	missense	possibly damaging	0.86
R5841:Hydin	UTSW	8	110533214	missense	possibly damaging	0.76
R5856:Hydin	UTSW	8	110541842	missense	probably damaging	0.99
R5893:Hydin	UTSW	8	110490676	missense	probably benign	0.12
R5963:Hydin	UTSW	8	110494294	missense	possibly damaging	0.93
R6008:Hydin	UTSW	8	110599085	missense	probably benign	0.02
R6019:Hydin	UTSW	8	110566620	missense	probably benign
R6038:Hydin	UTSW	8	110599031	missense	probably benign	0.16
R6038:Hydin	UTSW	8	110599031	missense	probably benign	0.16
R6133:Hydin	UTSW	8	110601276	missense	probably benign	0.00
R6135:Hydin	UTSW	8	110462660	missense	possibly damaging	0.85
R6157:Hydin	UTSW	8	110528016	missense	probably benign
R6209:Hydin	UTSW	8	110593802	missense	probably benign	0.05
R6238:Hydin	UTSW	8	110392111	splice site	probably null
R6293:Hydin	UTSW	8	110597911	missense	possibly damaging	0.83
R6340:Hydin	UTSW	8	110354942	splice site	probably null
R6349:Hydin	UTSW	8	110418459	nonsense	probably null
R6357:Hydin	UTSW	8	110541657	missense	possibly damaging	0.86
R6385:Hydin	UTSW	8	110312224	missense	possibly damaging	0.86
R6396:Hydin	UTSW	8	110506889	missense	probably damaging	0.96
R6466:Hydin	UTSW	8	110506968	missense	possibly damaging	0.85
R6648:Hydin	UTSW	8	110525667	splice site	probably null
R6671:Hydin	UTSW	8	110601318	missense	probably damaging	1.00
R6695:Hydin	UTSW	8	110326460	missense	probably benign	0.05
R6800:Hydin	UTSW	8	110597971	missense	probably benign	0.09
R6841:Hydin	UTSW	8	110538375	missense	probably benign	0.09
R6867:Hydin	UTSW	8	110539802	missense	probably benign	0.08
R6889:Hydin	UTSW	8	110532856	missense	possibly damaging	0.79
R6895:Hydin	UTSW	8	110312251	missense	probably benign	0.00
R6940:Hydin	UTSW	8	110490611	missense	probably damaging	1.00
R6951:Hydin	UTSW	8	110398125	missense	probably benign
R6980:Hydin	UTSW	8	110413284	missense	possibly damaging	0.91
R6981:Hydin	UTSW	8	110531072	missense	possibly damaging	0.89
R7061:Hydin	UTSW	8	110603288	missense	possibly damaging	0.90
R7085:Hydin	UTSW	8	110603330	missense	probably benign	0.03
R7086:Hydin	UTSW	8	110600245	missense	possibly damaging	0.68
R7110:Hydin	UTSW	8	110354951	critical splice acceptor site	probably null
R7158:Hydin	UTSW	8	110609671	missense	possibly damaging	0.79
R7163:Hydin	UTSW	8	110603336	missense	probably benign	0.25
R7209:Hydin	UTSW	8	110489792	nonsense	probably null
R7244:Hydin	UTSW	8	110549675	missense	probably damaging	0.98
R7347:Hydin	UTSW	8	110600362	missense	probably benign	0.06
R7349:Hydin	UTSW	8	110398171	splice site	probably null
R7359:Hydin	UTSW	8	110506101	missense	probably damaging	0.98
R7365:Hydin	UTSW	8	110557662	missense	probably damaging	0.99
R7365:Hydin	UTSW	8	110601273	missense	probably damaging	1.00
R7436:Hydin	UTSW	8	110583914	missense	probably damaging	0.96
R7528:Hydin	UTSW	8	110380572	nonsense	probably null
R7544:Hydin	UTSW	8	110589525	missense	probably benign	0.35
R7625:Hydin	UTSW	8	110541844	missense	probably benign	0.01
R7713:Hydin	UTSW	8	110593812	missense	possibly damaging	0.69
R7763:Hydin	UTSW	8	110505843	missense	possibly damaging	0.92
R7771:Hydin	UTSW	8	110565085	missense	probably damaging	0.97
R7794:Hydin	UTSW	8	110509083	missense	probably damaging	1.00
R7833:Hydin	UTSW	8	110589460	missense	probably damaging	0.99
R7894:Hydin	UTSW	8	110513010	missense	possibly damaging	0.88
R7899:Hydin	UTSW	8	110587748	missense	probably benign	0.00
R7908:Hydin	UTSW	8	110510867	missense	probably benign	0.01
R7912:Hydin	UTSW	8	110555607	missense	possibly damaging	0.68
R7919:Hydin	UTSW	8	110267339	missense	unknown
R7924:Hydin	UTSW	8	110418471	missense	possibly damaging	0.93
R7927:Hydin	UTSW	8	110580844	missense	possibly damaging	0.89
R7970:Hydin	UTSW	8	110309091	missense	probably damaging	0.99
R7993:Hydin	UTSW	8	110579632	missense	probably benign
R8011:Hydin	UTSW	8	110583909	missense	probably damaging	1.00
R8041:Hydin	UTSW	8	110574994	missense	probably benign	0.02
R8080:Hydin	UTSW	8	110535231	missense	probably benign	0.32
R8081:Hydin	UTSW	8	110365469	missense	possibly damaging	0.93
R8095:Hydin	UTSW	8	110569359	missense	probably damaging	1.00
R8157:Hydin	UTSW	8	110452036	missense	probably benign	0.33
R8186:Hydin	UTSW	8	110609645	missense	probably benign	0.14
R8205:Hydin	UTSW	8	110592638	missense	possibly damaging	0.57
R8263:Hydin	UTSW	8	110452073	missense	probably benign	0.00
R8288:Hydin	UTSW	8	110507029	missense	probably damaging	0.96
R8298:Hydin	UTSW	8	110600383	missense	probably damaging	1.00
R8309:Hydin	UTSW	8	110607902	missense	probably benign	0.18
R8348:Hydin	UTSW	8	110603246	missense	possibly damaging	0.68
R8356:Hydin	UTSW	8	110533124	missense	possibly damaging	0.67
R8406:Hydin	UTSW	8	110609911	missense	possibly damaging	0.94
R8415:Hydin	UTSW	8	110451994	missense	probably damaging	1.00
R8417:Hydin	UTSW	8	110569392	missense	probably benign	0.28
R8432:Hydin	UTSW	8	110597951	missense	probably benign	0.02
R8437:Hydin	UTSW	8	110462735	missense	probably damaging	0.96
R8463:Hydin	UTSW	8	110510921	missense	probably benign	0.22
R8508:Hydin	UTSW	8	110582018	missense	probably benign	0.00
R8510:Hydin	UTSW	8	110506570	missense	probably damaging	1.00
R8560:Hydin	UTSW	8	110538474	missense	probably benign	0.09
R8682:Hydin	UTSW	8	110309166	missense	probably damaging	0.96
R8697:Hydin	UTSW	8	110532883	missense	probably benign
R8857:Hydin	UTSW	8	110571955	critical splice donor site	probably null
R8866:Hydin	UTSW	8	110582147	missense	possibly damaging	0.89
R8878:Hydin	UTSW	8	110309088	missense	probably benign	0.12
R8897:Hydin	UTSW	8	110589480	missense	probably benign
R8987:Hydin	UTSW	8	110513134	nonsense	probably null
R9072:Hydin	UTSW	8	110267451	critical splice donor site	probably null
R9073:Hydin	UTSW	8	110267451	critical splice donor site	probably null
R9102:Hydin	UTSW	8	110508914	missense	probably benign	0.33
R9255:Hydin	UTSW	8	110535340	missense	probably benign	0.23
R9257:Hydin	UTSW	8	110575016	missense	probably damaging	0.99
R9261:Hydin	UTSW	8	110267415	missense	unknown
R9273:Hydin	UTSW	8	110506948	missense	probably damaging	0.98
R9376:Hydin	UTSW	8	110398063	missense	possibly damaging	0.70
R9380:Hydin	UTSW	8	110563872	missense	probably benign	0.07
R9386:Hydin	UTSW	8	110587730	missense	probably benign
R9406:Hydin	UTSW	8	110587780	missense	probably null	0.96
R9492:Hydin	UTSW	8	110600245	missense	possibly damaging	0.68
R9513:Hydin	UTSW	8	110595482	missense	probably damaging	0.99
R9562:Hydin	UTSW	8	110586154	missense	probably benign	0.11
R9664:Hydin	UTSW	8	110494333	missense	probably benign	0.01
R9733:Hydin	UTSW	8	110535379	missense	probably benign
R9753:Hydin	UTSW	8	110490766	missense	possibly damaging	0.85
X0063:Hydin	UTSW	8	110551319	missense	probably damaging	1.00
Z1088:Hydin	UTSW	8	110299973	missense	probably benign	0.12
Z1088:Hydin	UTSW	8	110586048	missense	probably benign	0.00
Z1088:Hydin	UTSW	8	110592791	frame shift	probably null
Z1176:Hydin	UTSW	8	110541600	missense	possibly damaging	0.65
Z1177:Hydin	UTSW	8	110380610	missense	probably damaging	1.00
Z1177:Hydin	UTSW	8	110450232	missense	possibly damaging	0.47
Z1177:Hydin	UTSW	8	110587142	frame shift	probably null
Z1177:Hydin	UTSW	8	110609989	missense	probably benign	0.10
Z1188:Hydin	UTSW	8	110415787	missense	probably benign	0.40

Predicted Primers

PCR Primer
(F):5'- TTTAGCTTGCTGCAGTTGCC -3'
(R):5'- ACACCTTCGAAGTCTGGAGAC -3'

Sequencing Primer
(F):5'- CTTGCTGCAGTTGCCAAGATAG -3'
(R):5'- AGGGCCTTCAGCTTCTCCAG -3'

Posted On

2022-02-07