Incidental Mutation 'R9226:Zfp580'
ID 699853
Institutional Source Beutler Lab
Gene Symbol Zfp580
Ensembl Gene ENSMUSG00000055633
Gene Name zinc finger protein 580
Synonyms 1500015O20Rik
MMRRC Submission 068960-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R9226 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 5054537-5056722 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to T at 5056137 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Stop codon at position 166 (Q166*)
Ref Sequence ENSEMBL: ENSMUSP00000147223 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045543] [ENSMUST00000069324] [ENSMUST00000108571] [ENSMUST00000207215] [ENSMUST00000207974] [ENSMUST00000208042] [ENSMUST00000208161] [ENSMUST00000208570] [ENSMUST00000208728]
AlphaFold Q9DB38
Predicted Effect probably benign
Transcript: ENSMUST00000045543
SMART Domains Protein: ENSMUSP00000041033
Gene: ENSMUSG00000035228

DomainStartEndE-ValueType
coiled coil region 62 101 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000069324
AA Change: Q108*
SMART Domains Protein: ENSMUSP00000065861
Gene: ENSMUSG00000055633
AA Change: Q108*

DomainStartEndE-ValueType
low complexity region 2 30 N/A INTRINSIC
ZnF_C2H2 92 114 3.39e-3 SMART
ZnF_C2H2 120 142 1.18e-2 SMART
ZnF_C2H2 150 172 1.04e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108571
SMART Domains Protein: ENSMUSP00000104211
Gene: ENSMUSG00000035228

DomainStartEndE-ValueType
Pfam:CCDC106 117 337 1.4e-100 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000207215
Predicted Effect probably benign
Transcript: ENSMUST00000207974
Predicted Effect probably benign
Transcript: ENSMUST00000208042
Predicted Effect probably benign
Transcript: ENSMUST00000208161
Predicted Effect probably null
Transcript: ENSMUST00000208570
AA Change: Q166*
Predicted Effect probably benign
Transcript: ENSMUST00000208728
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 100% (57/57)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310003L06Rik A T 5: 88,118,518 (GRCm39) M1L probably benign Het
Adgrf4 C A 17: 42,980,606 (GRCm39) A160S probably damaging Het
Adgrl1 T C 8: 84,656,426 (GRCm39) V243A possibly damaging Het
Adgrl4 G T 3: 151,198,064 (GRCm39) probably null Het
Alg8 A G 7: 97,027,423 (GRCm39) Y97C probably damaging Het
Ankrd12 T A 17: 66,292,754 (GRCm39) D893V probably damaging Het
Anxa6 T A 11: 54,885,791 (GRCm39) T385S probably benign Het
Art4 A T 6: 136,831,365 (GRCm39) C259S probably damaging Het
Ccer2 T C 7: 28,456,561 (GRCm39) S102P possibly damaging Het
Cdhr3 A G 12: 33,132,320 (GRCm39) F101S probably damaging Het
Ctdsp1 G T 1: 74,434,735 (GRCm39) G260W probably damaging Het
Cyp24a1 T C 2: 170,338,277 (GRCm39) Y89C probably damaging Het
Cyp2d34 T C 15: 82,504,901 (GRCm39) D53G probably damaging Het
Dnah7a A C 1: 53,560,326 (GRCm39) I2115S possibly damaging Het
Exoc4 T A 6: 33,895,359 (GRCm39) I792N possibly damaging Het
Gm4353 A G 7: 115,683,006 (GRCm39) F192L probably damaging Het
Hps4 G A 5: 112,525,905 (GRCm39) S642N possibly damaging Het
Ift140 T C 17: 25,317,839 (GRCm39) V1441A probably benign Het
Ighv1-49 A T 12: 115,019,073 (GRCm39) C41S probably damaging Het
Lgalsl A T 11: 20,779,306 (GRCm39) I113N possibly damaging Het
Lrp1b T C 2: 41,401,460 (GRCm39) D398G Het
Lrrc4b A G 7: 44,112,099 (GRCm39) H657R possibly damaging Het
Map2k2 T C 10: 80,955,193 (GRCm39) V228A possibly damaging Het
Mdn1 A G 4: 32,694,612 (GRCm39) I1112V probably benign Het
Mipep T A 14: 61,068,692 (GRCm39) M488K possibly damaging Het
Myo15b A G 11: 115,750,924 (GRCm39) T565A Het
Nfat5 T C 8: 108,095,401 (GRCm39) L1214P probably damaging Het
Nphp3 A G 9: 103,885,328 (GRCm39) T223A probably benign Het
Or10s1 A G 9: 39,986,187 (GRCm39) I199V probably benign Het
Or52s19 A G 7: 103,008,092 (GRCm39) M103T probably damaging Het
Pkn2 G A 3: 142,499,709 (GRCm39) R939W probably damaging Het
Pla2g4c T C 7: 13,059,671 (GRCm39) C3R possibly damaging Het
Plxnd1 A T 6: 115,934,524 (GRCm39) I1803N probably damaging Het
Pygb C A 2: 150,662,781 (GRCm39) H583N possibly damaging Het
Rbm20 A G 19: 53,839,645 (GRCm39) D878G possibly damaging Het
Rdx C A 9: 51,992,468 (GRCm39) Q414K probably benign Het
Scara3 T C 14: 66,169,233 (GRCm39) E128G possibly damaging Het
Sel1l2 T C 2: 140,097,222 (GRCm39) Y361C probably damaging Het
Sfmbt2 T C 2: 10,442,860 (GRCm39) I179T probably benign Het
Sgsm2 C T 11: 74,748,960 (GRCm39) V567M possibly damaging Het
Sirt4 G A 5: 115,618,372 (GRCm39) T234M probably damaging Het
Stab1 T G 14: 30,867,812 (GRCm39) K1653Q probably benign Het
Strn4 T C 7: 16,559,722 (GRCm39) probably benign Het
Stxbp5l C A 16: 37,076,206 (GRCm39) S280I probably damaging Het
Tex30 G A 1: 44,126,133 (GRCm39) R199W probably damaging Het
Tjp3 A C 10: 81,110,420 (GRCm39) F731V probably damaging Het
Tmco1 C T 1: 167,136,132 (GRCm39) probably benign Het
Tmco3 A G 8: 13,360,143 (GRCm39) probably null Het
Tmem94 C A 11: 115,683,191 (GRCm39) A658E probably damaging Het
Tnxb T A 17: 34,904,766 (GRCm39) L1177Q probably damaging Het
Trim28 G A 7: 12,763,490 (GRCm39) A544T probably benign Het
Upf2 T A 2: 6,051,845 (GRCm39) V1169D unknown Het
Usp20 C A 2: 30,907,412 (GRCm39) A648D probably damaging Het
Vmn2r108 T G 17: 20,691,330 (GRCm39) N398H probably benign Het
Whamm A T 7: 81,243,655 (GRCm39) S626C probably damaging Het
Zbtb44 A G 9: 30,975,524 (GRCm39) S385G possibly damaging Het
Other mutations in Zfp580
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01154:Zfp580 APN 7 5,056,267 (GRCm39) missense possibly damaging 0.64
R1580:Zfp580 UTSW 7 5,056,284 (GRCm39) missense probably damaging 1.00
R2120:Zfp580 UTSW 7 5,056,008 (GRCm39) missense probably damaging 0.99
R2167:Zfp580 UTSW 7 5,056,063 (GRCm39) missense possibly damaging 0.79
R5793:Zfp580 UTSW 7 5,055,891 (GRCm39) intron probably benign
R8192:Zfp580 UTSW 7 5,056,114 (GRCm39) missense probably benign 0.41
R8872:Zfp580 UTSW 7 5,056,216 (GRCm39) missense possibly damaging 0.93
R9178:Zfp580 UTSW 7 5,056,152 (GRCm39) missense possibly damaging 0.70
Predicted Primers PCR Primer
(F):5'- TGGCAGGGAGTGGTATCATC -3'
(R):5'- GGCAGTAACCTCAGGAGAAC -3'

Sequencing Primer
(F):5'- TTTTCCCAAGGCGGAAGG -3'
(R):5'- AGGGCTGAGCTCAGTGCAG -3'
Posted On 2022-02-07