Incidental Mutation 'R9226:Vmn2r108'
| ID |
699883 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r108
|
| Ensembl Gene |
ENSMUSG00000091805 |
| Gene Name |
vomeronasal 2, receptor 108 |
| Synonyms |
EG627805 |
| MMRRC Submission |
068960-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.073)
|
| Stock # |
R9226 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
20682635-20701498 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 20691330 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Histidine
at position 398
(N398H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130373
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167314]
|
| AlphaFold |
E9PYS0 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167314
AA Change: N398H
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: N398H
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
83 |
467 |
6e-33 |
PFAM |
|
Pfam:NCD3G
|
510 |
563 |
9.2e-22 |
PFAM |
|
Pfam:7tm_3
|
593 |
831 |
2.2e-51 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.6%
|
| Validation Efficiency |
100% (57/57) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 56 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310003L06Rik |
A |
T |
5: 88,118,518 (GRCm39) |
M1L |
probably benign |
Het |
| Adgrf4 |
C |
A |
17: 42,980,606 (GRCm39) |
A160S |
probably damaging |
Het |
| Adgrl1 |
T |
C |
8: 84,656,426 (GRCm39) |
V243A |
possibly damaging |
Het |
| Adgrl4 |
G |
T |
3: 151,198,064 (GRCm39) |
|
probably null |
Het |
| Alg8 |
A |
G |
7: 97,027,423 (GRCm39) |
Y97C |
probably damaging |
Het |
| Ankrd12 |
T |
A |
17: 66,292,754 (GRCm39) |
D893V |
probably damaging |
Het |
| Anxa6 |
T |
A |
11: 54,885,791 (GRCm39) |
T385S |
probably benign |
Het |
| Art4 |
A |
T |
6: 136,831,365 (GRCm39) |
C259S |
probably damaging |
Het |
| Ccer2 |
T |
C |
7: 28,456,561 (GRCm39) |
S102P |
possibly damaging |
Het |
| Cdhr3 |
A |
G |
12: 33,132,320 (GRCm39) |
F101S |
probably damaging |
Het |
| Ctdsp1 |
G |
T |
1: 74,434,735 (GRCm39) |
G260W |
probably damaging |
Het |
| Cyp24a1 |
T |
C |
2: 170,338,277 (GRCm39) |
Y89C |
probably damaging |
Het |
| Cyp2d34 |
T |
C |
15: 82,504,901 (GRCm39) |
D53G |
probably damaging |
Het |
| Dnah7a |
A |
C |
1: 53,560,326 (GRCm39) |
I2115S |
possibly damaging |
Het |
| Exoc4 |
T |
A |
6: 33,895,359 (GRCm39) |
I792N |
possibly damaging |
Het |
| Gm4353 |
A |
G |
7: 115,683,006 (GRCm39) |
F192L |
probably damaging |
Het |
| Hps4 |
G |
A |
5: 112,525,905 (GRCm39) |
S642N |
possibly damaging |
Het |
| Ift140 |
T |
C |
17: 25,317,839 (GRCm39) |
V1441A |
probably benign |
Het |
| Ighv1-49 |
A |
T |
12: 115,019,073 (GRCm39) |
C41S |
probably damaging |
Het |
| Lgalsl |
A |
T |
11: 20,779,306 (GRCm39) |
I113N |
possibly damaging |
Het |
| Lrp1b |
T |
C |
2: 41,401,460 (GRCm39) |
D398G |
|
Het |
| Lrrc4b |
A |
G |
7: 44,112,099 (GRCm39) |
H657R |
possibly damaging |
Het |
| Map2k2 |
T |
C |
10: 80,955,193 (GRCm39) |
V228A |
possibly damaging |
Het |
| Mdn1 |
A |
G |
4: 32,694,612 (GRCm39) |
I1112V |
probably benign |
Het |
| Mipep |
T |
A |
14: 61,068,692 (GRCm39) |
M488K |
possibly damaging |
Het |
| Myo15b |
A |
G |
11: 115,750,924 (GRCm39) |
T565A |
|
Het |
| Nfat5 |
T |
C |
8: 108,095,401 (GRCm39) |
L1214P |
probably damaging |
Het |
| Nphp3 |
A |
G |
9: 103,885,328 (GRCm39) |
T223A |
probably benign |
Het |
| Or10s1 |
A |
G |
9: 39,986,187 (GRCm39) |
I199V |
probably benign |
Het |
| Or52s19 |
A |
G |
7: 103,008,092 (GRCm39) |
M103T |
probably damaging |
Het |
| Pkn2 |
G |
A |
3: 142,499,709 (GRCm39) |
R939W |
probably damaging |
Het |
| Pla2g4c |
T |
C |
7: 13,059,671 (GRCm39) |
C3R |
possibly damaging |
Het |
| Plxnd1 |
A |
T |
6: 115,934,524 (GRCm39) |
I1803N |
probably damaging |
Het |
| Pygb |
C |
A |
2: 150,662,781 (GRCm39) |
H583N |
possibly damaging |
Het |
| Rbm20 |
A |
G |
19: 53,839,645 (GRCm39) |
D878G |
possibly damaging |
Het |
| Rdx |
C |
A |
9: 51,992,468 (GRCm39) |
Q414K |
probably benign |
Het |
| Scara3 |
T |
C |
14: 66,169,233 (GRCm39) |
E128G |
possibly damaging |
Het |
| Sel1l2 |
T |
C |
2: 140,097,222 (GRCm39) |
Y361C |
probably damaging |
Het |
| Sfmbt2 |
T |
C |
2: 10,442,860 (GRCm39) |
I179T |
probably benign |
Het |
| Sgsm2 |
C |
T |
11: 74,748,960 (GRCm39) |
V567M |
possibly damaging |
Het |
| Sirt4 |
G |
A |
5: 115,618,372 (GRCm39) |
T234M |
probably damaging |
Het |
| Stab1 |
T |
G |
14: 30,867,812 (GRCm39) |
K1653Q |
probably benign |
Het |
| Strn4 |
T |
C |
7: 16,559,722 (GRCm39) |
|
probably benign |
Het |
| Stxbp5l |
C |
A |
16: 37,076,206 (GRCm39) |
S280I |
probably damaging |
Het |
| Tex30 |
G |
A |
1: 44,126,133 (GRCm39) |
R199W |
probably damaging |
Het |
| Tjp3 |
A |
C |
10: 81,110,420 (GRCm39) |
F731V |
probably damaging |
Het |
| Tmco1 |
C |
T |
1: 167,136,132 (GRCm39) |
|
probably benign |
Het |
| Tmco3 |
A |
G |
8: 13,360,143 (GRCm39) |
|
probably null |
Het |
| Tmem94 |
C |
A |
11: 115,683,191 (GRCm39) |
A658E |
probably damaging |
Het |
| Tnxb |
T |
A |
17: 34,904,766 (GRCm39) |
L1177Q |
probably damaging |
Het |
| Trim28 |
G |
A |
7: 12,763,490 (GRCm39) |
A544T |
probably benign |
Het |
| Upf2 |
T |
A |
2: 6,051,845 (GRCm39) |
V1169D |
unknown |
Het |
| Usp20 |
C |
A |
2: 30,907,412 (GRCm39) |
A648D |
probably damaging |
Het |
| Whamm |
A |
T |
7: 81,243,655 (GRCm39) |
S626C |
probably damaging |
Het |
| Zbtb44 |
A |
G |
9: 30,975,524 (GRCm39) |
S385G |
possibly damaging |
Het |
| Zfp580 |
C |
T |
7: 5,056,137 (GRCm39) |
Q166* |
probably null |
Het |
|
| Other mutations in Vmn2r108 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00903:Vmn2r108
|
APN |
17 |
20,682,774 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01143:Vmn2r108
|
APN |
17 |
20,682,727 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01311:Vmn2r108
|
APN |
17 |
20,682,939 (GRCm39) |
nonsense |
probably null |
|
|
IGL01411:Vmn2r108
|
APN |
17 |
20,691,282 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01414:Vmn2r108
|
APN |
17 |
20,691,942 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01536:Vmn2r108
|
APN |
17 |
20,683,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01748:Vmn2r108
|
APN |
17 |
20,683,476 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01769:Vmn2r108
|
APN |
17 |
20,691,280 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02022:Vmn2r108
|
APN |
17 |
20,691,987 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
IGL02041:Vmn2r108
|
APN |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02049:Vmn2r108
|
APN |
17 |
20,691,608 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02344:Vmn2r108
|
APN |
17 |
20,689,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02939:Vmn2r108
|
APN |
17 |
20,691,545 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL03202:Vmn2r108
|
APN |
17 |
20,691,319 (GRCm39) |
nonsense |
probably null |
|
|
PIT4498001:Vmn2r108
|
UTSW |
17 |
20,683,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0112:Vmn2r108
|
UTSW |
17 |
20,691,897 (GRCm39) |
missense |
probably benign |
0.07 |
|
R0505:Vmn2r108
|
UTSW |
17 |
20,683,096 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0833:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
|
R0836:Vmn2r108
|
UTSW |
17 |
20,691,721 (GRCm39) |
missense |
probably benign |
|
|
R0943:Vmn2r108
|
UTSW |
17 |
20,691,397 (GRCm39) |
nonsense |
probably null |
|
|
R1411:Vmn2r108
|
UTSW |
17 |
20,683,107 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1442:Vmn2r108
|
UTSW |
17 |
20,692,623 (GRCm39) |
nonsense |
probably null |
|
|
R1587:Vmn2r108
|
UTSW |
17 |
20,692,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Vmn2r108
|
UTSW |
17 |
20,682,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1773:Vmn2r108
|
UTSW |
17 |
20,689,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2021:Vmn2r108
|
UTSW |
17 |
20,691,252 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2159:Vmn2r108
|
UTSW |
17 |
20,689,363 (GRCm39) |
missense |
probably benign |
0.41 |
|
R2224:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
|
R2226:Vmn2r108
|
UTSW |
17 |
20,701,295 (GRCm39) |
nonsense |
probably null |
|
|
R2517:Vmn2r108
|
UTSW |
17 |
20,692,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3710:Vmn2r108
|
UTSW |
17 |
20,682,932 (GRCm39) |
missense |
probably benign |
|
|
R4470:Vmn2r108
|
UTSW |
17 |
20,682,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4686:Vmn2r108
|
UTSW |
17 |
20,691,636 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4729:Vmn2r108
|
UTSW |
17 |
20,692,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4799:Vmn2r108
|
UTSW |
17 |
20,682,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4993:Vmn2r108
|
UTSW |
17 |
20,701,449 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5088:Vmn2r108
|
UTSW |
17 |
20,690,454 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R5213:Vmn2r108
|
UTSW |
17 |
20,691,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5289:Vmn2r108
|
UTSW |
17 |
20,691,866 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5290:Vmn2r108
|
UTSW |
17 |
20,691,665 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5713:Vmn2r108
|
UTSW |
17 |
20,691,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5753:Vmn2r108
|
UTSW |
17 |
20,683,179 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5792:Vmn2r108
|
UTSW |
17 |
20,683,398 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5798:Vmn2r108
|
UTSW |
17 |
20,692,545 (GRCm39) |
missense |
probably benign |
0.39 |
|
R5897:Vmn2r108
|
UTSW |
17 |
20,691,580 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6018:Vmn2r108
|
UTSW |
17 |
20,683,268 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6093:Vmn2r108
|
UTSW |
17 |
20,701,402 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6156:Vmn2r108
|
UTSW |
17 |
20,692,447 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6199:Vmn2r108
|
UTSW |
17 |
20,682,644 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6259:Vmn2r108
|
UTSW |
17 |
20,683,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6309:Vmn2r108
|
UTSW |
17 |
20,691,660 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6324:Vmn2r108
|
UTSW |
17 |
20,691,977 (GRCm39) |
nonsense |
probably null |
|
|
R6364:Vmn2r108
|
UTSW |
17 |
20,691,260 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6446:Vmn2r108
|
UTSW |
17 |
20,692,609 (GRCm39) |
nonsense |
probably null |
|
|
R6541:Vmn2r108
|
UTSW |
17 |
20,701,480 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7025:Vmn2r108
|
UTSW |
17 |
20,691,345 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7063:Vmn2r108
|
UTSW |
17 |
20,701,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7092:Vmn2r108
|
UTSW |
17 |
20,701,338 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7096:Vmn2r108
|
UTSW |
17 |
20,682,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7203:Vmn2r108
|
UTSW |
17 |
20,683,038 (GRCm39) |
missense |
probably benign |
0.12 |
|
R7458:Vmn2r108
|
UTSW |
17 |
20,692,532 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7619:Vmn2r108
|
UTSW |
17 |
20,692,457 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7841:Vmn2r108
|
UTSW |
17 |
20,690,305 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7944:Vmn2r108
|
UTSW |
17 |
20,691,890 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8048:Vmn2r108
|
UTSW |
17 |
20,691,762 (GRCm39) |
missense |
probably benign |
0.29 |
|
R8213:Vmn2r108
|
UTSW |
17 |
20,690,350 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8218:Vmn2r108
|
UTSW |
17 |
20,683,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8507:Vmn2r108
|
UTSW |
17 |
20,683,195 (GRCm39) |
nonsense |
probably null |
|
|
R8708:Vmn2r108
|
UTSW |
17 |
20,682,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8845:Vmn2r108
|
UTSW |
17 |
20,691,361 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9030:Vmn2r108
|
UTSW |
17 |
20,690,312 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9278:Vmn2r108
|
UTSW |
17 |
20,692,561 (GRCm39) |
missense |
probably benign |
0.11 |
|
X0022:Vmn2r108
|
UTSW |
17 |
20,691,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Vmn2r108
|
UTSW |
17 |
20,691,375 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Vmn2r108
|
UTSW |
17 |
20,691,219 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- CACTTCAAACTGCATTGACCTC -3'
(R):5'- ATGCTTGACTCATTCCATGGTAG -3'
Sequencing Primer
(F):5'- CTTCAAACTGCATTGACCTCTAAATG -3'
(R):5'- TCCATGGTAGCTTAATTTTTACACAC -3'
|
| Posted On |
2022-02-07 |
Incidental Mutation