Incidental Mutation 'R9227:Kif1b'
| ID |
699916 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kif1b
|
| Ensembl Gene |
ENSMUSG00000063077 |
| Gene Name |
kinesin family member 1B |
| Synonyms |
N-3 kinesin, KIF1Bp130, KIF1Bp204, Kif1b beta, Kif1b alpha, D4Mil1e, A530096N05Rik |
| MMRRC Submission |
068984-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9227 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
149260776-149392150 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 149322357 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Arginine
at position 854
(M854R)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000030806
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000030806]
[ENSMUST00000055647]
[ENSMUST00000060537]
|
| AlphaFold |
Q60575 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000030806
AA Change: M854R
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000030806
Gene: ENSMUSG00000063077
AA Change: M854R
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
3 |
356 |
5.85e-176 |
SMART |
|
low complexity region
|
389 |
404 |
N/A |
INTRINSIC |
|
FHA
|
509 |
566 |
1.61e-4 |
SMART |
|
coiled coil region
|
626 |
660 |
N/A |
INTRINSIC |
|
coiled coil region
|
814 |
858 |
N/A |
INTRINSIC |
|
low complexity region
|
889 |
902 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055647
|
| SMART Domains |
Protein: ENSMUSP00000061472
Gene: ENSMUSG00000063077
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
3 |
356 |
5.85e-176 |
SMART |
|
low complexity region
|
389 |
404 |
N/A |
INTRINSIC |
|
FHA
|
509 |
566 |
1.61e-4 |
SMART |
|
coiled coil region
|
626 |
685 |
N/A |
INTRINSIC |
|
Pfam:KIF1B
|
799 |
846 |
9.7e-13 |
PFAM |
|
internal_repeat_1
|
901 |
933 |
7.01e-7 |
PROSPERO |
|
low complexity region
|
1165 |
1179 |
N/A |
INTRINSIC |
|
Pfam:DUF3694
|
1220 |
1368 |
1.1e-46 |
PFAM |
|
low complexity region
|
1444 |
1461 |
N/A |
INTRINSIC |
|
low complexity region
|
1479 |
1507 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1591 |
N/A |
INTRINSIC |
|
PH
|
1656 |
1755 |
1.02e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000060537
|
| SMART Domains |
Protein: ENSMUSP00000056754
Gene: ENSMUSG00000063077
| Domain | Start | End | E-Value | Type |
|---|
|
KISc
|
3 |
362 |
7.61e-175 |
SMART |
|
low complexity region
|
390 |
400 |
N/A |
INTRINSIC |
|
low complexity region
|
432 |
450 |
N/A |
INTRINSIC |
|
FHA
|
555 |
612 |
1.61e-4 |
SMART |
|
coiled coil region
|
672 |
731 |
N/A |
INTRINSIC |
|
Pfam:KIF1B
|
845 |
892 |
7.1e-15 |
PFAM |
|
internal_repeat_1
|
947 |
979 |
4.76e-7 |
PROSPERO |
|
low complexity region
|
1211 |
1225 |
N/A |
INTRINSIC |
|
Pfam:DUF3694
|
1266 |
1413 |
1.1e-40 |
PFAM |
|
low complexity region
|
1490 |
1507 |
N/A |
INTRINSIC |
|
low complexity region
|
1525 |
1553 |
N/A |
INTRINSIC |
|
low complexity region
|
1619 |
1637 |
N/A |
INTRINSIC |
|
PH
|
1702 |
1801 |
1.02e-14 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
| Validation Efficiency |
100% (79/79) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for a targeted null mutation exhibit reduced brain size, elevated pain threshold, and neonatal death from apnea. Heterozygotes exhibit impaired synaptic vesicle precursor transport and progressive muscle weakness. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 82 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adarb1 |
A |
T |
10: 77,157,626 (GRCm39) |
F274I |
probably damaging |
Het |
| Adprhl1 |
C |
T |
8: 13,271,974 (GRCm39) |
V1595I |
probably benign |
Het |
| Anxa6 |
A |
G |
11: 54,898,694 (GRCm39) |
V160A |
probably benign |
Het |
| Appl1 |
T |
C |
14: 26,645,692 (GRCm39) |
E706G |
unknown |
Het |
| Arhgap21 |
T |
C |
2: 20,860,469 (GRCm39) |
T1313A |
possibly damaging |
Het |
| Armc2 |
T |
C |
10: 41,823,935 (GRCm39) |
Y511C |
probably damaging |
Het |
| Atp1a1 |
A |
T |
3: 101,499,750 (GRCm39) |
C111S |
probably damaging |
Het |
| Atp6v0d2 |
T |
A |
4: 19,878,374 (GRCm39) |
M300L |
probably benign |
Het |
| C1ra |
T |
C |
6: 124,493,739 (GRCm39) |
C164R |
probably damaging |
Het |
| Cacna1h |
T |
C |
17: 25,599,856 (GRCm39) |
Y1659C |
probably damaging |
Het |
| Catsperb |
T |
C |
12: 101,516,053 (GRCm39) |
I563T |
probably benign |
Het |
| Cblif |
G |
A |
19: 11,737,748 (GRCm39) |
W386* |
probably null |
Het |
| Cd180 |
TA |
TAA |
13: 102,841,514 (GRCm39) |
|
probably null |
Het |
| Cd55b |
A |
T |
1: 130,350,619 (GRCm39) |
L26* |
probably null |
Het |
| Cdc42bpa |
A |
G |
1: 179,933,638 (GRCm39) |
N759S |
probably benign |
Het |
| Cenpj |
C |
T |
14: 56,802,176 (GRCm39) |
E130K |
possibly damaging |
Het |
| Cep250 |
C |
T |
2: 155,812,042 (GRCm39) |
A446V |
unknown |
Het |
| Chd7 |
C |
T |
4: 8,805,272 (GRCm39) |
S777L |
probably benign |
Het |
| Chrm3 |
C |
A |
13: 9,928,479 (GRCm39) |
V186L |
probably benign |
Het |
| Clrn2 |
A |
G |
5: 45,621,283 (GRCm39) |
T226A |
probably damaging |
Het |
| Col3a1 |
C |
T |
1: 45,383,138 (GRCm39) |
P1071S |
unknown |
Het |
| Dytn |
A |
T |
1: 63,686,611 (GRCm39) |
V353D |
probably benign |
Het |
| Egfem1 |
G |
A |
3: 29,411,317 (GRCm39) |
E155K |
probably benign |
Het |
| Eif3m |
A |
T |
2: 104,831,705 (GRCm39) |
M285K |
probably damaging |
Het |
| Fam135b |
T |
C |
15: 71,335,856 (GRCm39) |
K446R |
probably benign |
Het |
| Fam186a |
T |
C |
15: 99,853,384 (GRCm39) |
T119A |
unknown |
Het |
| Frmd4a |
T |
C |
2: 4,612,844 (GRCm39) |
S1025P |
possibly damaging |
Het |
| Fubp3 |
A |
G |
2: 31,502,564 (GRCm39) |
H449R |
probably benign |
Het |
| Fyco1 |
A |
T |
9: 123,648,211 (GRCm39) |
I1241N |
probably damaging |
Het |
| Gabpb2 |
A |
T |
3: 95,111,998 (GRCm39) |
M77K |
probably damaging |
Het |
| Gfpt1 |
T |
A |
6: 87,027,906 (GRCm39) |
I4K |
probably damaging |
Het |
| Glis1 |
T |
C |
4: 107,425,327 (GRCm39) |
S313P |
probably benign |
Het |
| Golga4 |
T |
A |
9: 118,385,941 (GRCm39) |
M1021K |
possibly damaging |
Het |
| Grid2ip |
G |
A |
5: 143,359,194 (GRCm39) |
R270Q |
probably damaging |
Het |
| Hps4 |
G |
A |
5: 112,525,905 (GRCm39) |
S642N |
possibly damaging |
Het |
| Ifit1 |
A |
G |
19: 34,625,236 (GRCm39) |
E124G |
possibly damaging |
Het |
| Ifna14 |
T |
C |
4: 88,489,752 (GRCm39) |
D95G |
probably benign |
Het |
| Ilkap |
A |
C |
1: 91,314,937 (GRCm39) |
I142S |
probably benign |
Het |
| Inpp5e |
C |
T |
2: 26,288,616 (GRCm39) |
R588H |
probably damaging |
Het |
| Lcn6 |
A |
T |
2: 25,570,107 (GRCm39) |
K91M |
probably damaging |
Het |
| Lpin1 |
A |
T |
12: 16,588,483 (GRCm39) |
S902R |
unknown |
Het |
| Lrig1 |
C |
A |
6: 94,607,113 (GRCm39) |
C160F |
probably damaging |
Het |
| Mapk13 |
T |
C |
17: 28,994,532 (GRCm39) |
I141T |
probably damaging |
Het |
| Mapkapk3 |
A |
G |
9: 107,137,354 (GRCm39) |
L175P |
probably damaging |
Het |
| Micall2 |
A |
G |
5: 139,701,827 (GRCm39) |
V472A |
unknown |
Het |
| Mmp15 |
T |
C |
8: 96,092,959 (GRCm39) |
F113L |
probably benign |
Het |
| Msh2 |
T |
G |
17: 88,026,717 (GRCm39) |
S738A |
probably benign |
Het |
| Myb |
C |
T |
10: 21,030,612 (GRCm39) |
D62N |
probably benign |
Het |
| Myo1f |
T |
C |
17: 33,795,424 (GRCm39) |
V53A |
probably damaging |
Het |
| Ncf1 |
A |
T |
5: 134,250,718 (GRCm39) |
N367K |
probably benign |
Het |
| Nim1k |
C |
A |
13: 120,174,118 (GRCm39) |
V259F |
probably damaging |
Het |
| Nme8 |
T |
G |
13: 19,874,384 (GRCm39) |
I139L |
probably benign |
Het |
| Odam |
T |
C |
5: 88,034,457 (GRCm39) |
F46L |
probably benign |
Het |
| Ogfr |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
2: 180,237,059 (GRCm39) |
|
probably benign |
Het |
| Or7a42 |
G |
A |
10: 78,791,929 (GRCm39) |
D297N |
possibly damaging |
Het |
| Pcare |
A |
G |
17: 72,057,217 (GRCm39) |
L820P |
probably damaging |
Het |
| Pcdha9 |
A |
G |
18: 37,131,954 (GRCm39) |
E341G |
probably damaging |
Het |
| Pmepa1 |
T |
C |
2: 173,117,962 (GRCm39) |
T6A |
probably benign |
Het |
| Poglut1 |
A |
T |
16: 38,355,168 (GRCm39) |
D219E |
possibly damaging |
Het |
| Racgap1 |
A |
G |
15: 99,534,078 (GRCm39) |
S145P |
possibly damaging |
Het |
| Rasgef1a |
C |
T |
6: 118,066,110 (GRCm39) |
T441I |
possibly damaging |
Het |
| Rbm6 |
T |
C |
9: 107,664,498 (GRCm39) |
T844A |
probably benign |
Het |
| Rbmyf9 |
T |
G |
Y: 3,774,819 (GRCm39) |
D5E |
probably damaging |
Het |
| Rell1 |
T |
C |
5: 64,097,105 (GRCm39) |
|
probably benign |
Het |
| Ripk3 |
A |
G |
14: 56,023,303 (GRCm39) |
F134S |
probably benign |
Het |
| Rnf169 |
T |
C |
7: 99,574,699 (GRCm39) |
D632G |
possibly damaging |
Het |
| Sclt1 |
A |
T |
3: 41,665,631 (GRCm39) |
W146R |
probably benign |
Het |
| Setd5 |
T |
C |
6: 113,098,755 (GRCm39) |
F796S |
possibly damaging |
Het |
| Slc24a5 |
G |
T |
2: 124,922,568 (GRCm39) |
G110V |
probably damaging |
Het |
| Slc30a10 |
T |
A |
1: 185,187,391 (GRCm39) |
M44K |
probably damaging |
Het |
| Slc38a10 |
T |
A |
11: 119,996,781 (GRCm39) |
D772V |
probably benign |
Het |
| Thy1 |
C |
T |
9: 43,958,004 (GRCm39) |
T44I |
probably damaging |
Het |
| Tinagl1 |
G |
T |
4: 130,061,271 (GRCm39) |
S324Y |
probably benign |
Het |
| Tll2 |
T |
A |
19: 41,093,436 (GRCm39) |
Y477F |
probably benign |
Het |
| Tmco1 |
C |
T |
1: 167,136,132 (GRCm39) |
|
probably benign |
Het |
| Tmco6 |
T |
C |
18: 36,874,719 (GRCm39) |
L402P |
probably damaging |
Het |
| Tnrc18 |
G |
T |
5: 142,773,392 (GRCm39) |
A479D |
|
Het |
| Uba7 |
T |
C |
9: 107,853,001 (GRCm39) |
V12A |
possibly damaging |
Het |
| Usp5 |
T |
C |
6: 124,795,599 (GRCm39) |
D598G |
probably damaging |
Het |
| Vmn1r158 |
C |
T |
7: 22,489,469 (GRCm39) |
V247I |
probably benign |
Het |
| Vpreb1b |
A |
G |
16: 17,798,801 (GRCm39) |
N96D |
probably damaging |
Het |
| Zcchc17 |
A |
T |
4: 130,230,928 (GRCm39) |
M87K |
probably damaging |
Het |
|
| Other mutations in Kif1b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01311:Kif1b
|
APN |
4 |
149,305,059 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01943:Kif1b
|
APN |
4 |
149,299,362 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02240:Kif1b
|
APN |
4 |
149,330,871 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02414:Kif1b
|
APN |
4 |
149,283,771 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02490:Kif1b
|
APN |
4 |
149,288,665 (GRCm39) |
missense |
probably benign |
|
|
IGL02501:Kif1b
|
APN |
4 |
149,299,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02833:Kif1b
|
APN |
4 |
149,330,821 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02852:Kif1b
|
APN |
4 |
149,375,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02900:Kif1b
|
APN |
4 |
149,265,266 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03287:Kif1b
|
APN |
4 |
149,299,438 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL03412:Kif1b
|
APN |
4 |
149,359,396 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4305001:Kif1b
|
UTSW |
4 |
149,305,249 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0005:Kif1b
|
UTSW |
4 |
149,266,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Kif1b
|
UTSW |
4 |
149,348,058 (GRCm39) |
splice site |
probably benign |
|
|
R0044:Kif1b
|
UTSW |
4 |
149,348,058 (GRCm39) |
splice site |
probably benign |
|
|
R0129:Kif1b
|
UTSW |
4 |
149,345,658 (GRCm39) |
missense |
probably benign |
|
|
R0180:Kif1b
|
UTSW |
4 |
149,298,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0288:Kif1b
|
UTSW |
4 |
149,283,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0360:Kif1b
|
UTSW |
4 |
149,347,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0383:Kif1b
|
UTSW |
4 |
149,286,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0398:Kif1b
|
UTSW |
4 |
149,288,688 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R0403:Kif1b
|
UTSW |
4 |
149,266,424 (GRCm39) |
nonsense |
probably null |
|
|
R0445:Kif1b
|
UTSW |
4 |
149,272,466 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1466:Kif1b
|
UTSW |
4 |
149,307,709 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1466:Kif1b
|
UTSW |
4 |
149,307,709 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1681:Kif1b
|
UTSW |
4 |
149,279,958 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1728:Kif1b
|
UTSW |
4 |
149,272,179 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1840:Kif1b
|
UTSW |
4 |
149,272,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1874:Kif1b
|
UTSW |
4 |
149,272,089 (GRCm39) |
missense |
probably benign |
|
|
R1915:Kif1b
|
UTSW |
4 |
149,351,673 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2106:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2124:Kif1b
|
UTSW |
4 |
149,306,753 (GRCm39) |
missense |
probably benign |
0.08 |
|
R2126:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2127:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2128:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2129:Kif1b
|
UTSW |
4 |
149,272,097 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2146:Kif1b
|
UTSW |
4 |
149,268,766 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2255:Kif1b
|
UTSW |
4 |
149,359,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2392:Kif1b
|
UTSW |
4 |
149,305,077 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R2883:Kif1b
|
UTSW |
4 |
149,322,105 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2981:Kif1b
|
UTSW |
4 |
149,304,998 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3038:Kif1b
|
UTSW |
4 |
149,297,790 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3616:Kif1b
|
UTSW |
4 |
149,346,740 (GRCm39) |
splice site |
probably benign |
|
|
R3935:Kif1b
|
UTSW |
4 |
149,321,617 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4347:Kif1b
|
UTSW |
4 |
149,331,691 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4423:Kif1b
|
UTSW |
4 |
149,298,562 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4637:Kif1b
|
UTSW |
4 |
149,283,768 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4745:Kif1b
|
UTSW |
4 |
149,322,339 (GRCm39) |
nonsense |
probably null |
|
|
R4807:Kif1b
|
UTSW |
4 |
149,332,378 (GRCm39) |
intron |
probably benign |
|
|
R5618:Kif1b
|
UTSW |
4 |
149,354,346 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5644:Kif1b
|
UTSW |
4 |
149,322,939 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5683:Kif1b
|
UTSW |
4 |
149,306,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5696:Kif1b
|
UTSW |
4 |
149,358,306 (GRCm39) |
splice site |
probably null |
|
|
R6022:Kif1b
|
UTSW |
4 |
149,282,989 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6048:Kif1b
|
UTSW |
4 |
149,348,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6137:Kif1b
|
UTSW |
4 |
149,322,883 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R6139:Kif1b
|
UTSW |
4 |
149,321,989 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R6171:Kif1b
|
UTSW |
4 |
149,342,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6250:Kif1b
|
UTSW |
4 |
149,298,100 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6423:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6424:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6425:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6443:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6460:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6462:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6463:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6469:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6470:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6471:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6472:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6504:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6536:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6537:Kif1b
|
UTSW |
4 |
149,277,053 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6668:Kif1b
|
UTSW |
4 |
149,297,864 (GRCm39) |
missense |
probably benign |
0.09 |
|
R6698:Kif1b
|
UTSW |
4 |
149,359,413 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7065:Kif1b
|
UTSW |
4 |
149,286,982 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R7222:Kif1b
|
UTSW |
4 |
149,309,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7342:Kif1b
|
UTSW |
4 |
149,298,547 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7720:Kif1b
|
UTSW |
4 |
149,266,812 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7744:Kif1b
|
UTSW |
4 |
149,321,532 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7797:Kif1b
|
UTSW |
4 |
149,321,844 (GRCm39) |
missense |
probably benign |
|
|
R7829:Kif1b
|
UTSW |
4 |
149,305,447 (GRCm39) |
splice site |
probably null |
|
|
R7869:Kif1b
|
UTSW |
4 |
149,268,833 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7878:Kif1b
|
UTSW |
4 |
149,299,454 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7980:Kif1b
|
UTSW |
4 |
149,354,378 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8047:Kif1b
|
UTSW |
4 |
149,299,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8237:Kif1b
|
UTSW |
4 |
149,275,642 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8243:Kif1b
|
UTSW |
4 |
149,288,724 (GRCm39) |
missense |
probably benign |
|
|
R8252:Kif1b
|
UTSW |
4 |
149,358,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8342:Kif1b
|
UTSW |
4 |
149,306,805 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8460:Kif1b
|
UTSW |
4 |
149,272,077 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R8462:Kif1b
|
UTSW |
4 |
149,266,797 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8496:Kif1b
|
UTSW |
4 |
149,277,068 (GRCm39) |
nonsense |
probably null |
|
|
R8687:Kif1b
|
UTSW |
4 |
149,345,620 (GRCm39) |
nonsense |
probably null |
|
|
R8694:Kif1b
|
UTSW |
4 |
149,305,024 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8842:Kif1b
|
UTSW |
4 |
149,338,196 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8883:Kif1b
|
UTSW |
4 |
149,361,342 (GRCm39) |
missense |
probably benign |
|
|
R8971:Kif1b
|
UTSW |
4 |
149,332,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8994:Kif1b
|
UTSW |
4 |
149,279,939 (GRCm39) |
missense |
|
|
|
R9002:Kif1b
|
UTSW |
4 |
149,275,712 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9231:Kif1b
|
UTSW |
4 |
149,275,652 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9450:Kif1b
|
UTSW |
4 |
149,322,467 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9478:Kif1b
|
UTSW |
4 |
149,345,616 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9571:Kif1b
|
UTSW |
4 |
149,305,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9644:Kif1b
|
UTSW |
4 |
149,375,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF008:Kif1b
|
UTSW |
4 |
149,336,195 (GRCm39) |
splice site |
probably null |
|
|
X0009:Kif1b
|
UTSW |
4 |
149,331,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0062:Kif1b
|
UTSW |
4 |
149,359,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Kif1b
|
UTSW |
4 |
149,350,755 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAAGCTGGATCCCCGTTCATC -3'
(R):5'- AATGAGCGAGACTCTTGGAG -3'
Sequencing Primer
(F):5'- TTCATCAGCTGGGAAACGC -3'
(R):5'- CAGGGATGTCTGGGACACTG -3'
|
| Posted On |
2022-02-07 |
Incidental Mutation