Incidental Mutation 'R9228:Vmn2r69'
ID 700013
Institutional Source Beutler Lab
Gene Symbol Vmn2r69
Ensembl Gene ENSMUSG00000091006
Gene Name vomeronasal 2, receptor 69
Synonyms
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R9228 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 85055584-85064884 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 85064697 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 63 (I63T)
Ref Sequence ENSEMBL: ENSMUSP00000132726 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171213]
AlphaFold G3XA45
Predicted Effect probably benign
Transcript: ENSMUST00000171213
AA Change: I63T

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000132726
Gene: ENSMUSG00000091006
AA Change: I63T

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 465 1.3e-28 PFAM
Pfam:NCD3G 507 559 1.8e-20 PFAM
Pfam:7tm_3 592 827 3.2e-54 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (87/87)
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1810037I17Rik G A 3: 122,718,274 (GRCm39) A56T probably benign Het
4930438A08Rik A T 11: 58,178,296 (GRCm39) I119F Het
Abca12 A T 1: 71,332,599 (GRCm39) I1254N probably damaging Het
Abcb11 G T 2: 69,138,809 (GRCm39) Y157* probably null Het
Adcy7 G A 8: 89,044,675 (GRCm39) probably null Het
Adnp A G 2: 168,026,798 (GRCm39) Y166H probably damaging Het
Adprhl1 A G 8: 13,275,279 (GRCm39) V493A probably benign Het
Ahctf1 T C 1: 179,611,685 (GRCm39) T562A probably benign Het
Amotl1 T A 9: 14,504,320 (GRCm39) N296I possibly damaging Het
Ankar A G 1: 72,713,210 (GRCm39) V693A probably benign Het
Ankrd16 T C 2: 11,786,318 (GRCm39) V189A probably benign Het
Bmp1 A G 14: 70,757,338 (GRCm39) L47P probably benign Het
Cacna2d4 A G 6: 119,248,476 (GRCm39) D429G probably benign Het
Cadps2 T A 6: 23,688,927 (GRCm39) E127D probably benign Het
Cd109 A T 9: 78,577,042 (GRCm39) I580F possibly damaging Het
Cdrt4 T A 11: 62,842,124 (GRCm39) I2N unknown Het
Cep250 C T 2: 155,812,042 (GRCm39) A446V unknown Het
Chuk A T 19: 44,095,789 (GRCm39) W15R probably damaging Het
Cpvl C T 6: 53,951,779 (GRCm39) M1I probably null Het
Cyfip1 A G 7: 55,549,758 (GRCm39) M642V probably damaging Het
Dhh T A 15: 98,795,757 (GRCm39) R133* probably null Het
Dnmt3b G A 2: 153,507,980 (GRCm39) V212M probably benign Het
Dync2li1 A G 17: 84,957,137 (GRCm39) S301G probably benign Het
Epas1 A C 17: 87,133,990 (GRCm39) I500L possibly damaging Het
Ephb4 A T 5: 137,352,824 (GRCm39) I136F possibly damaging Het
Foxg1 T C 12: 49,431,320 (GRCm39) F18L unknown Het
Frem1 T C 4: 82,920,057 (GRCm39) E432G probably damaging Het
Gpld1 A T 13: 25,136,900 (GRCm39) S73C probably damaging Het
Hddc3 A G 7: 79,993,328 (GRCm39) I52V probably benign Het
Hmgcll1 A T 9: 75,991,732 (GRCm39) T252S probably damaging Het
Igsf10 G A 3: 59,243,843 (GRCm39) R164W probably damaging Het
Jph2 A G 2: 163,180,606 (GRCm39) V675A probably benign Het
Kifap3 T C 1: 163,689,666 (GRCm39) F550S probably benign Het
Klk15 C T 7: 43,587,790 (GRCm39) H73Y possibly damaging Het
Kplce C T 3: 92,775,951 (GRCm39) G244D probably benign Het
L1td1 T C 4: 98,625,932 (GRCm39) V643A possibly damaging Het
L3mbtl3 C T 10: 26,212,155 (GRCm39) M255I unknown Het
Layn T A 9: 50,968,837 (GRCm39) D302V probably damaging Het
Lpcat4 A G 2: 112,072,418 (GRCm39) I136V possibly damaging Het
Lrp1 T A 10: 127,382,807 (GRCm39) D3658V probably damaging Het
Metap1d T C 2: 71,352,900 (GRCm39) L243S possibly damaging Het
Midn T A 10: 79,990,275 (GRCm39) H315Q probably damaging Het
Mtrex A T 13: 113,050,888 (GRCm39) probably null Het
Myb C T 10: 21,030,612 (GRCm39) D62N probably benign Het
Myh2 T C 11: 67,077,522 (GRCm39) S886P probably benign Het
Nemf T C 12: 69,388,093 (GRCm39) I396V probably damaging Het
Nemp1 T G 10: 127,525,227 (GRCm39) V127G possibly damaging Het
Nkx3-1 C T 14: 69,428,227 (GRCm39) T25M possibly damaging Het
Nmral1 A C 16: 4,531,631 (GRCm39) L208R probably damaging Het
Nol6 A T 4: 41,116,422 (GRCm39) I989N probably benign Het
Or12e7 T A 2: 87,287,907 (GRCm39) C133S possibly damaging Het
Palld A T 8: 62,173,571 (GRCm39) S363T probably damaging Het
Pcdha11 A G 18: 37,144,512 (GRCm39) D201G probably damaging Het
Per2 A G 1: 91,366,081 (GRCm39) C339R probably damaging Het
Phactr4 T C 4: 132,097,874 (GRCm39) T455A possibly damaging Het
Phc2 T C 4: 128,617,062 (GRCm39) I445T probably damaging Het
Pmepa1 T C 2: 173,117,962 (GRCm39) T6A probably benign Het
Polr1a T C 6: 71,931,755 (GRCm39) F945L probably damaging Het
Ppp2r5e T A 12: 75,640,063 (GRCm39) K13* probably null Het
Ptafr T C 4: 132,306,613 (GRCm39) M1T probably null Het
Rbms1 G A 2: 60,610,087 (GRCm39) P208S probably benign Het
Scg3 T A 9: 75,558,955 (GRCm39) I419F probably damaging Het
Scn1a T C 2: 66,130,099 (GRCm39) T219A probably benign Het
Sec14l4 A G 11: 3,989,977 (GRCm39) D92G probably damaging Het
Senp3 G T 11: 69,569,085 (GRCm39) Q359K probably damaging Het
Sirt1 T C 10: 63,172,857 (GRCm39) D142G probably damaging Het
Skint2 T C 4: 112,483,039 (GRCm39) M148T possibly damaging Het
Slc30a10 T A 1: 185,187,391 (GRCm39) M44K probably damaging Het
Snai2 T A 16: 14,524,792 (GRCm39) D99E probably damaging Het
Spg7 A G 8: 123,807,408 (GRCm39) K395E possibly damaging Het
Sphk2 G A 7: 45,360,337 (GRCm39) H556Y possibly damaging Het
Supt6 A C 11: 78,116,612 (GRCm39) F637L probably benign Het
Tcam1 A G 11: 106,177,292 (GRCm39) N428S probably damaging Het
Tctn3 C T 19: 40,596,692 (GRCm39) R276K probably benign Het
Timm29 G A 9: 21,504,656 (GRCm39) R108H probably damaging Het
Tlr9 A T 9: 106,102,752 (GRCm39) E681V possibly damaging Het
Tmco1 C T 1: 167,136,132 (GRCm39) probably benign Het
Tns3 T C 11: 8,400,094 (GRCm39) K1169E probably damaging Het
Trim72 A C 7: 127,608,315 (GRCm39) D271A possibly damaging Het
Trpv4 A T 5: 114,772,622 (GRCm39) D369E probably benign Het
Ttn A G 2: 76,583,192 (GRCm39) L22567P probably damaging Het
Uimc1 G A 13: 55,223,652 (GRCm39) P207S probably damaging Het
Unc5d A T 8: 29,165,448 (GRCm39) V781E probably damaging Het
Upk3bl C T 5: 136,086,076 (GRCm39) P4L unknown Het
Vmn1r201 A G 13: 22,659,670 (GRCm39) N295D probably benign Het
Zfyve28 T C 5: 34,374,788 (GRCm39) T409A probably benign Het
Other mutations in Vmn2r69
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01019:Vmn2r69 APN 7 85,055,739 (GRCm39) missense probably benign
IGL01457:Vmn2r69 APN 7 85,055,836 (GRCm39) missense possibly damaging 0.87
IGL01760:Vmn2r69 APN 7 85,056,072 (GRCm39) missense possibly damaging 0.90
IGL01834:Vmn2r69 APN 7 85,061,576 (GRCm39) missense probably damaging 1.00
IGL02001:Vmn2r69 APN 7 85,056,434 (GRCm39) missense probably benign 0.05
IGL02057:Vmn2r69 APN 7 85,060,990 (GRCm39) missense possibly damaging 0.93
IGL02289:Vmn2r69 APN 7 85,056,054 (GRCm39) missense probably damaging 1.00
IGL02472:Vmn2r69 APN 7 85,058,960 (GRCm39) missense probably benign 0.01
IGL02478:Vmn2r69 APN 7 85,055,889 (GRCm39) missense probably damaging 1.00
IGL02554:Vmn2r69 APN 7 85,059,014 (GRCm39) missense probably damaging 1.00
IGL02723:Vmn2r69 APN 7 85,059,416 (GRCm39) missense probably damaging 1.00
R0526:Vmn2r69 UTSW 7 85,060,711 (GRCm39) missense probably damaging 1.00
R0560:Vmn2r69 UTSW 7 85,058,922 (GRCm39) critical splice donor site probably null
R0909:Vmn2r69 UTSW 7 85,055,873 (GRCm39) missense probably benign 0.00
R0976:Vmn2r69 UTSW 7 85,056,108 (GRCm39) missense probably damaging 1.00
R1158:Vmn2r69 UTSW 7 85,059,058 (GRCm39) splice site probably benign
R1459:Vmn2r69 UTSW 7 85,055,908 (GRCm39) nonsense probably null
R1482:Vmn2r69 UTSW 7 85,056,082 (GRCm39) missense probably damaging 1.00
R1917:Vmn2r69 UTSW 7 85,060,891 (GRCm39) missense probably damaging 1.00
R2016:Vmn2r69 UTSW 7 85,056,493 (GRCm39) missense probably damaging 0.98
R2108:Vmn2r69 UTSW 7 85,059,404 (GRCm39) missense probably benign
R2571:Vmn2r69 UTSW 7 85,064,764 (GRCm39) missense probably benign
R2910:Vmn2r69 UTSW 7 85,055,918 (GRCm39) missense probably damaging 1.00
R2920:Vmn2r69 UTSW 7 85,060,973 (GRCm39) missense probably benign 0.08
R3708:Vmn2r69 UTSW 7 85,061,029 (GRCm39) missense probably damaging 0.98
R3710:Vmn2r69 UTSW 7 85,055,601 (GRCm39) missense probably benign
R4757:Vmn2r69 UTSW 7 85,061,575 (GRCm39) missense probably damaging 0.99
R4823:Vmn2r69 UTSW 7 85,060,508 (GRCm39) missense probably benign 0.21
R4870:Vmn2r69 UTSW 7 85,060,793 (GRCm39) missense possibly damaging 0.93
R4918:Vmn2r69 UTSW 7 85,055,967 (GRCm39) missense probably benign 0.06
R5022:Vmn2r69 UTSW 7 85,060,367 (GRCm39) missense possibly damaging 0.72
R5174:Vmn2r69 UTSW 7 85,064,739 (GRCm39) missense possibly damaging 0.92
R5200:Vmn2r69 UTSW 7 85,055,717 (GRCm39) missense probably damaging 1.00
R5278:Vmn2r69 UTSW 7 85,060,991 (GRCm39) missense probably benign 0.02
R5643:Vmn2r69 UTSW 7 85,056,404 (GRCm39) missense probably damaging 0.98
R5996:Vmn2r69 UTSW 7 85,061,117 (GRCm39) splice site probably null
R6083:Vmn2r69 UTSW 7 85,055,711 (GRCm39) missense probably damaging 1.00
R6140:Vmn2r69 UTSW 7 85,060,657 (GRCm39) missense probably damaging 0.99
R6306:Vmn2r69 UTSW 7 85,064,799 (GRCm39) missense probably benign 0.04
R6330:Vmn2r69 UTSW 7 85,060,835 (GRCm39) missense probably benign
R6380:Vmn2r69 UTSW 7 85,061,067 (GRCm39) missense probably benign
R6466:Vmn2r69 UTSW 7 85,056,378 (GRCm39) missense probably benign 0.01
R6542:Vmn2r69 UTSW 7 85,060,413 (GRCm39) nonsense probably null
R6583:Vmn2r69 UTSW 7 85,059,017 (GRCm39) missense probably benign
R6623:Vmn2r69 UTSW 7 85,056,309 (GRCm39) missense possibly damaging 0.84
R6709:Vmn2r69 UTSW 7 85,061,069 (GRCm39) missense probably benign 0.03
R6732:Vmn2r69 UTSW 7 85,060,351 (GRCm39) missense probably benign 0.00
R6741:Vmn2r69 UTSW 7 85,061,724 (GRCm39) missense probably benign 0.01
R7070:Vmn2r69 UTSW 7 85,060,688 (GRCm39) missense probably damaging 0.98
R7234:Vmn2r69 UTSW 7 85,056,315 (GRCm39) missense probably benign 0.22
R7323:Vmn2r69 UTSW 7 85,060,972 (GRCm39) missense possibly damaging 0.95
R7427:Vmn2r69 UTSW 7 85,060,467 (GRCm39) missense probably benign 0.28
R7428:Vmn2r69 UTSW 7 85,060,467 (GRCm39) missense probably benign 0.28
R7453:Vmn2r69 UTSW 7 85,060,768 (GRCm39) frame shift probably null
R7532:Vmn2r69 UTSW 7 85,059,622 (GRCm39) missense probably benign 0.36
R7556:Vmn2r69 UTSW 7 85,060,768 (GRCm39) frame shift probably null
R7562:Vmn2r69 UTSW 7 85,056,420 (GRCm39) missense probably benign
R7592:Vmn2r69 UTSW 7 85,060,768 (GRCm39) frame shift probably null
R7708:Vmn2r69 UTSW 7 85,061,755 (GRCm39) missense possibly damaging 0.87
R7803:Vmn2r69 UTSW 7 85,056,324 (GRCm39) missense probably benign 0.00
R7960:Vmn2r69 UTSW 7 85,055,973 (GRCm39) missense probably benign
R7966:Vmn2r69 UTSW 7 85,060,762 (GRCm39) missense possibly damaging 0.81
R8071:Vmn2r69 UTSW 7 85,055,713 (GRCm39) nonsense probably null
R8237:Vmn2r69 UTSW 7 85,060,340 (GRCm39) missense probably benign 0.02
R8347:Vmn2r69 UTSW 7 85,064,838 (GRCm39) missense probably benign 0.00
R8737:Vmn2r69 UTSW 7 85,055,783 (GRCm39) missense probably damaging 1.00
R8795:Vmn2r69 UTSW 7 85,064,883 (GRCm39) start codon destroyed probably null 0.94
R8831:Vmn2r69 UTSW 7 85,059,018 (GRCm39) nonsense probably null
R8856:Vmn2r69 UTSW 7 85,061,663 (GRCm39) missense probably benign 0.00
R8998:Vmn2r69 UTSW 7 85,060,307 (GRCm39) missense probably benign 0.33
R8999:Vmn2r69 UTSW 7 85,060,307 (GRCm39) missense probably benign 0.33
R9161:Vmn2r69 UTSW 7 85,056,177 (GRCm39) missense possibly damaging 0.88
R9494:Vmn2r69 UTSW 7 85,060,768 (GRCm39) missense probably damaging 1.00
R9494:Vmn2r69 UTSW 7 85,056,084 (GRCm39) missense probably benign 0.08
R9541:Vmn2r69 UTSW 7 85,056,209 (GRCm39) missense probably benign
R9620:Vmn2r69 UTSW 7 85,061,504 (GRCm39) missense probably benign 0.10
Z1176:Vmn2r69 UTSW 7 85,055,696 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATGGTCAATACATGGGGTCATTC -3'
(R):5'- ATCTCTGTCATCTGGTTTCTGAAG -3'

Sequencing Primer
(F):5'- TGGGGTCATTCATTTAGTATCTACC -3'
(R):5'- TGTCATCTGGTTTCTGAAGATTAAAC -3'
Posted On 2022-02-07