Incidental Mutation 'R9233:Zmym4'
| ID |
700342 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zmym4
|
| Ensembl Gene |
ENSMUSG00000042446 |
| Gene Name |
zinc finger, MYM-type 4 |
| Synonyms |
Zfp262, 6330503C17Rik |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.586)
|
| Stock # |
R9233 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
4 |
| Chromosomal Location |
126755732-126861928 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 126776310 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Threonine
at position 1209
(M1209T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000101714
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106108]
|
| AlphaFold |
A2A791 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106108
AA Change: M1209T
PolyPhen 2
Score 0.989 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000101714
Gene: ENSMUSG00000042446
AA Change: M1209T
| Domain | Start | End | E-Value | Type |
|---|
|
TRASH
|
341 |
377 |
6.53e-4 |
SMART |
|
TRASH
|
389 |
429 |
7.22e-6 |
SMART |
|
TRASH
|
441 |
479 |
1.77e0 |
SMART |
|
TRASH
|
486 |
525 |
4.95e-4 |
SMART |
|
TRASH
|
531 |
569 |
1.05e-2 |
SMART |
|
TRASH
|
579 |
615 |
2.82e1 |
SMART |
|
low complexity region
|
640 |
649 |
N/A |
INTRINSIC |
|
TRASH
|
687 |
723 |
8.49e-3 |
SMART |
|
TRASH
|
729 |
764 |
1.14e-3 |
SMART |
|
TRASH
|
772 |
810 |
4.48e-2 |
SMART |
|
TRASH
|
816 |
851 |
2.06e-1 |
SMART |
|
low complexity region
|
974 |
993 |
N/A |
INTRINSIC |
|
low complexity region
|
1002 |
1021 |
N/A |
INTRINSIC |
|
Pfam:DUF3504
|
1357 |
1527 |
1.7e-68 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000120813
Gene: ENSMUSG00000042446
AA Change: M868T
| Domain | Start | End | E-Value | Type |
|---|
|
TRASH
|
90 |
126 |
6.53e-4 |
SMART |
|
TRASH
|
138 |
178 |
7.22e-6 |
SMART |
|
TRASH
|
190 |
228 |
1.77e0 |
SMART |
|
TRASH
|
235 |
274 |
3.05e-4 |
SMART |
|
low complexity region
|
300 |
309 |
N/A |
INTRINSIC |
|
TRASH
|
347 |
383 |
8.49e-3 |
SMART |
|
TRASH
|
389 |
424 |
1.14e-3 |
SMART |
|
TRASH
|
432 |
470 |
4.48e-2 |
SMART |
|
TRASH
|
476 |
511 |
2.06e-1 |
SMART |
|
low complexity region
|
634 |
653 |
N/A |
INTRINSIC |
|
low complexity region
|
662 |
681 |
N/A |
INTRINSIC |
|
Pfam:DUF3504
|
1017 |
1187 |
1.5e-68 |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 69 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca6 |
G |
T |
11: 110,082,496 (GRCm39) |
T1159K |
probably benign |
Het |
| Acap1 |
A |
G |
11: 69,775,484 (GRCm39) |
V479A |
probably benign |
Het |
| Actl11 |
A |
G |
9: 107,807,900 (GRCm39) |
E741G |
possibly damaging |
Het |
| Anp32b |
A |
T |
4: 46,463,909 (GRCm39) |
I103F |
probably damaging |
Het |
| Ap4m1 |
C |
T |
5: 138,176,653 (GRCm39) |
R418* |
probably null |
Het |
| Asic3 |
G |
A |
5: 24,618,837 (GRCm39) |
R43H |
probably damaging |
Het |
| Bsn |
A |
G |
9: 107,994,289 (GRCm39) |
V662A |
probably benign |
Het |
| Cacna1a |
C |
T |
8: 85,271,283 (GRCm39) |
R479C |
probably damaging |
Het |
| Chchd3 |
A |
T |
6: 32,780,845 (GRCm39) |
C214S |
probably damaging |
Het |
| Cspg4b |
A |
T |
13: 113,502,754 (GRCm39) |
Y100F |
|
Het |
| Dock9 |
T |
A |
14: 121,820,781 (GRCm39) |
T1538S |
probably benign |
Het |
| Dyrk1a |
A |
G |
16: 94,466,913 (GRCm39) |
M156V |
probably benign |
Het |
| Dzip1 |
T |
C |
14: 119,124,635 (GRCm39) |
Q546R |
probably benign |
Het |
| Eef2 |
T |
C |
10: 81,014,668 (GRCm39) |
V185A |
probably benign |
Het |
| Etv4 |
A |
C |
11: 101,662,532 (GRCm39) |
V314G |
probably damaging |
Het |
| F5 |
T |
A |
1: 164,047,020 (GRCm39) |
I2160N |
probably damaging |
Het |
| Fbp2 |
A |
T |
13: 62,989,622 (GRCm39) |
V228E |
possibly damaging |
Het |
| Fcgbpl1 |
A |
G |
7: 27,839,519 (GRCm39) |
Y444C |
possibly damaging |
Het |
| Fhip2a |
T |
A |
19: 57,369,098 (GRCm39) |
F360L |
probably damaging |
Het |
| Gcc1 |
A |
G |
6: 28,418,710 (GRCm39) |
L541P |
probably damaging |
Het |
| Gemin4 |
A |
G |
11: 76,103,942 (GRCm39) |
I273T |
possibly damaging |
Het |
| Gm32742 |
T |
C |
9: 51,056,387 (GRCm39) |
K1193E |
possibly damaging |
Het |
| Gmps |
C |
T |
3: 63,924,133 (GRCm39) |
P687L |
probably damaging |
Het |
| Gpr162 |
A |
G |
6: 124,836,014 (GRCm39) |
L462P |
possibly damaging |
Het |
| Hps4 |
G |
A |
5: 112,525,905 (GRCm39) |
S642N |
possibly damaging |
Het |
| Hspa12b |
T |
C |
2: 130,976,036 (GRCm39) |
Y13H |
probably damaging |
Het |
| Kcnh8 |
A |
C |
17: 53,285,168 (GRCm39) |
E1046A |
probably damaging |
Het |
| Kcnk12 |
T |
A |
17: 88,053,538 (GRCm39) |
T375S |
probably benign |
Het |
| Kdm4a |
A |
G |
4: 118,004,193 (GRCm39) |
|
probably null |
Het |
| Klhl5 |
G |
T |
5: 65,300,673 (GRCm39) |
V219L |
possibly damaging |
Het |
| Kpna1 |
A |
T |
16: 35,853,793 (GRCm39) |
E474D |
probably damaging |
Het |
| Lama5 |
A |
T |
2: 179,840,502 (GRCm39) |
Y632* |
probably null |
Het |
| Lias |
A |
G |
5: 65,551,331 (GRCm39) |
N88S |
probably benign |
Het |
| Mei1 |
C |
T |
15: 81,973,752 (GRCm39) |
R80C |
|
Het |
| Mical2 |
T |
G |
7: 111,981,399 (GRCm39) |
S458A |
probably benign |
Het |
| Mrps33 |
A |
G |
6: 39,782,447 (GRCm39) |
S25P |
probably benign |
Het |
| Mttp |
T |
A |
3: 137,822,280 (GRCm39) |
D169V |
probably damaging |
Het |
| Npdc1 |
A |
G |
2: 25,296,329 (GRCm39) |
E72G |
probably damaging |
Het |
| Nsrp1 |
G |
A |
11: 76,937,036 (GRCm39) |
R387W |
probably benign |
Het |
| Pcnx4 |
A |
G |
12: 72,603,587 (GRCm39) |
T503A |
possibly damaging |
Het |
| Peg10 |
CCACATCAGGATCCACATCAGGATGCACATCAGCATCAGGATCCCCATCAGGATGCACATCAGGATCCACATCAGGATGCACATCAG |
CCACATCAGGATCCACATCAGGATGCACATCAG |
6: 4,756,398 (GRCm39) |
|
probably benign |
Het |
| Pigu |
C |
T |
2: 155,178,610 (GRCm39) |
V83I |
possibly damaging |
Het |
| Ppcs |
G |
A |
4: 119,279,397 (GRCm39) |
R52* |
probably null |
Het |
| Rbm33 |
A |
G |
5: 28,544,239 (GRCm39) |
E165G |
probably benign |
Het |
| Rnf5 |
A |
T |
17: 34,822,326 (GRCm39) |
V41E |
possibly damaging |
Het |
| Ror2 |
T |
C |
13: 53,265,590 (GRCm39) |
T501A |
probably benign |
Het |
| Rps17 |
T |
G |
7: 80,993,497 (GRCm39) |
M105L |
probably benign |
Het |
| Ryr2 |
A |
T |
13: 11,610,772 (GRCm39) |
M4018K |
possibly damaging |
Het |
| Scarf1 |
A |
G |
11: 75,416,720 (GRCm39) |
M721V |
probably benign |
Het |
| Scgb1b30 |
A |
G |
7: 33,799,184 (GRCm39) |
T39A |
probably damaging |
Het |
| Selenoo |
T |
C |
15: 88,984,044 (GRCm39) |
V620A |
probably damaging |
Het |
| Slfn8 |
A |
C |
11: 82,894,422 (GRCm39) |
I739R |
probably damaging |
Het |
| Smc6 |
A |
G |
12: 11,359,291 (GRCm39) |
T972A |
probably benign |
Het |
| Spred1 |
G |
A |
2: 117,002,644 (GRCm39) |
R221H |
unknown |
Het |
| Stag1 |
T |
A |
9: 100,812,024 (GRCm39) |
M834K |
probably benign |
Het |
| Taf1a |
T |
C |
1: 183,181,878 (GRCm39) |
I177T |
possibly damaging |
Het |
| Tcam1 |
G |
A |
11: 106,175,018 (GRCm39) |
D158N |
probably benign |
Het |
| Tcirg1 |
G |
T |
19: 3,952,543 (GRCm39) |
T275K |
probably damaging |
Het |
| Tmco1 |
C |
T |
1: 167,136,132 (GRCm39) |
|
probably benign |
Het |
| Tor1b |
A |
C |
2: 30,844,015 (GRCm39) |
I151L |
probably benign |
Het |
| Trappc12 |
T |
A |
12: 28,772,414 (GRCm39) |
Q471L |
possibly damaging |
Het |
| Trim28 |
G |
A |
7: 12,763,490 (GRCm39) |
A544T |
probably benign |
Het |
| Ugt2a2 |
G |
A |
5: 87,613,272 (GRCm39) |
P288S |
probably damaging |
Het |
| Vmn1r157 |
T |
C |
7: 22,461,381 (GRCm39) |
L87P |
probably damaging |
Het |
| Vmn1r188 |
A |
G |
13: 22,272,399 (GRCm39) |
R118G |
probably benign |
Het |
| Vps13d |
G |
A |
4: 144,879,344 (GRCm39) |
T1493I |
|
Het |
| Xrra1 |
T |
G |
7: 99,516,574 (GRCm39) |
M6R |
probably benign |
Het |
| Zfp142 |
T |
C |
1: 74,610,288 (GRCm39) |
E1169G |
probably benign |
Het |
| Zfp738 |
G |
T |
13: 67,819,017 (GRCm39) |
R325S |
possibly damaging |
Het |
|
| Other mutations in Zmym4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00537:Zmym4
|
APN |
4 |
126,783,851 (GRCm39) |
missense |
probably benign |
|
|
IGL00845:Zmym4
|
APN |
4 |
126,794,406 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL01122:Zmym4
|
APN |
4 |
126,758,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01374:Zmym4
|
APN |
4 |
126,762,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01564:Zmym4
|
APN |
4 |
126,805,073 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02014:Zmym4
|
APN |
4 |
126,794,462 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02187:Zmym4
|
APN |
4 |
126,764,066 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02887:Zmym4
|
APN |
4 |
126,842,268 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03371:Zmym4
|
APN |
4 |
126,808,881 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL03400:Zmym4
|
APN |
4 |
126,816,920 (GRCm39) |
missense |
probably benign |
0.12 |
|
arriba
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
|
foreclosed
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Foreshortened
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
levantese
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
|
terminated
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
BB004:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
|
BB014:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
|
R0149:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0361:Zmym4
|
UTSW |
4 |
126,804,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0423:Zmym4
|
UTSW |
4 |
126,776,112 (GRCm39) |
splice site |
probably benign |
|
|
R0532:Zmym4
|
UTSW |
4 |
126,792,194 (GRCm39) |
nonsense |
probably null |
|
|
R0745:Zmym4
|
UTSW |
4 |
126,796,496 (GRCm39) |
splice site |
probably benign |
|
|
R1183:Zmym4
|
UTSW |
4 |
126,819,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1401:Zmym4
|
UTSW |
4 |
126,804,962 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1446:Zmym4
|
UTSW |
4 |
126,776,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1491:Zmym4
|
UTSW |
4 |
126,776,105 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R1566:Zmym4
|
UTSW |
4 |
126,804,940 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1962:Zmym4
|
UTSW |
4 |
126,796,463 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R2398:Zmym4
|
UTSW |
4 |
126,816,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2930:Zmym4
|
UTSW |
4 |
126,819,316 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3891:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3892:Zmym4
|
UTSW |
4 |
126,798,269 (GRCm39) |
missense |
probably benign |
0.04 |
|
R4659:Zmym4
|
UTSW |
4 |
126,842,221 (GRCm39) |
splice site |
probably null |
|
|
R4702:Zmym4
|
UTSW |
4 |
126,816,958 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5160:Zmym4
|
UTSW |
4 |
126,763,977 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5614:Zmym4
|
UTSW |
4 |
126,804,729 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5773:Zmym4
|
UTSW |
4 |
126,799,163 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R6450:Zmym4
|
UTSW |
4 |
126,789,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6741:Zmym4
|
UTSW |
4 |
126,808,878 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7023:Zmym4
|
UTSW |
4 |
126,762,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7315:Zmym4
|
UTSW |
4 |
126,776,385 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7468:Zmym4
|
UTSW |
4 |
126,776,029 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7546:Zmym4
|
UTSW |
4 |
126,757,961 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7609:Zmym4
|
UTSW |
4 |
126,819,588 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7764:Zmym4
|
UTSW |
4 |
126,819,409 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7897:Zmym4
|
UTSW |
4 |
126,783,332 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R7918:Zmym4
|
UTSW |
4 |
126,804,797 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7927:Zmym4
|
UTSW |
4 |
126,799,170 (GRCm39) |
missense |
probably benign |
0.42 |
|
R8129:Zmym4
|
UTSW |
4 |
126,808,956 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8240:Zmym4
|
UTSW |
4 |
126,798,188 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8248:Zmym4
|
UTSW |
4 |
126,799,162 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R8261:Zmym4
|
UTSW |
4 |
126,798,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8313:Zmym4
|
UTSW |
4 |
126,804,762 (GRCm39) |
missense |
probably benign |
0.19 |
|
R8353:Zmym4
|
UTSW |
4 |
126,800,905 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R8747:Zmym4
|
UTSW |
4 |
126,787,198 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8787:Zmym4
|
UTSW |
4 |
126,816,953 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8795:Zmym4
|
UTSW |
4 |
126,799,819 (GRCm39) |
missense |
probably benign |
0.35 |
|
R8948:Zmym4
|
UTSW |
4 |
126,758,060 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9218:Zmym4
|
UTSW |
4 |
126,809,415 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9286:Zmym4
|
UTSW |
4 |
126,783,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9468:Zmym4
|
UTSW |
4 |
126,800,993 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9542:Zmym4
|
UTSW |
4 |
126,799,164 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9756:Zmym4
|
UTSW |
4 |
126,771,502 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9776:Zmym4
|
UTSW |
4 |
126,804,942 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
U24488:Zmym4
|
UTSW |
4 |
126,819,453 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
Z1177:Zmym4
|
UTSW |
4 |
126,801,005 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGGGACTGTATAAAACCAAGCTC -3'
(R):5'- CAGCCCTGAATTCTGAATCTTTATG -3'
Sequencing Primer
(F):5'- GGACTGTATAAAACCAAGCTCTAATC -3'
(R):5'- ATTCTCACAGGGGAGGAA -3'
|
| Posted On |
2022-02-07 |
Incidental Mutation