Incidental Mutation 'R9236:Cycs'
ID 700481
Institutional Source Beutler Lab
Gene Symbol Cycs
Ensembl Gene ENSMUSG00000063694
Gene Name cytochrome c, somatic
Synonyms
Accession Numbers
Essential gene? Not available question?
Stock # R9236 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 50539543-50543518 bp(-) (GRCm39)
Type of Mutation start gained
DNA Base Change (assembly) C to T at 50543507 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000124523 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000161401]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000161401
SMART Domains Protein: ENSMUSP00000124523
Gene: ENSMUSG00000063694

DomainStartEndE-ValueType
Pfam:Cytochrom_C 4 103 6.4e-16 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]
PHENOTYPE: Mice homozygous for a targeted mutation die at midgestation. By E8.5, homozygous null embryos exhibit a strikingly reduced size and are developmentally retarded. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 A G 17: 24,626,712 (GRCm39) T1514A probably benign Het
Abcb1b G A 5: 8,874,893 (GRCm39) probably null Het
Adam12 A C 7: 133,614,022 (GRCm39) L109R probably benign Het
Adgre1 T A 17: 57,709,782 (GRCm39) Y146* probably null Het
Ap5m1 G T 14: 49,311,064 (GRCm39) V45L probably benign Het
Bpifa5 A T 2: 154,006,150 (GRCm39) I113F probably damaging Het
Cacna1h A T 17: 25,600,424 (GRCm39) M1639K probably damaging Het
Celsr1 T C 15: 85,915,051 (GRCm39) E974G probably damaging Het
Cfap251 T C 5: 123,428,125 (GRCm39) C980R probably damaging Het
Cggbp1 C T 16: 64,676,318 (GRCm39) A128V probably benign Het
Col7a1 G T 9: 108,789,684 (GRCm39) R898L unknown Het
Cyp2c54 A T 19: 40,060,938 (GRCm39) Y68* probably null Het
Dock9 T C 14: 121,876,970 (GRCm39) D467G probably damaging Het
Eif2s1 A T 12: 78,921,343 (GRCm39) I83L probably benign Het
Eppk1 T A 15: 75,990,510 (GRCm39) R2124* probably null Het
Fkbp15 G C 4: 62,254,664 (GRCm39) L279V probably damaging Het
Fndc1 A G 17: 7,992,460 (GRCm39) V412A unknown Het
Gfap A G 11: 102,786,327 (GRCm39) I194T probably damaging Het
Gpatch2 C A 1: 186,965,977 (GRCm39) T350K probably benign Het
Hecw1 C T 13: 14,490,643 (GRCm39) G783D possibly damaging Het
Hipk1 A T 3: 103,671,789 (GRCm39) W437R probably damaging Het
Hps4 G A 5: 112,525,905 (GRCm39) S642N possibly damaging Het
Hr C T 14: 70,809,396 (GRCm39) P1136S probably damaging Het
Il1rl2 T A 1: 40,368,221 (GRCm39) N130K probably damaging Het
Kif13b A G 14: 64,982,383 (GRCm39) I532V probably benign Het
Klk15 C T 7: 43,587,790 (GRCm39) H73Y possibly damaging Het
Lrba T A 3: 86,261,066 (GRCm39) I1474K probably benign Het
Luc7l3 T C 11: 94,186,772 (GRCm39) E371G unknown Het
Myo5b T A 18: 74,853,934 (GRCm39) D1184E probably benign Het
N4bp2l2 A G 5: 150,585,479 (GRCm39) M167T probably benign Het
N4bp2l2 T C 5: 150,585,734 (GRCm39) H82R probably benign Het
Ndufaf1 T C 2: 119,490,712 (GRCm39) E118G possibly damaging Het
Nedd9 A T 13: 41,492,153 (GRCm39) V119E possibly damaging Het
Nlgn3 T C X: 100,352,390 (GRCm39) V179A probably damaging Het
Ntmt1 T A 2: 30,712,407 (GRCm39) L150Q probably damaging Het
Or5b99 G T 19: 12,976,763 (GRCm39) V138F probably damaging Het
Or7g21 A G 9: 19,033,206 (GRCm39) *315W probably null Het
Or8b40 A T 9: 38,027,496 (GRCm39) M140L possibly damaging Het
Or8h7 C T 2: 86,720,622 (GRCm39) S299N probably benign Het
Osbpl8 A G 10: 111,106,496 (GRCm39) N301S probably benign Het
Pgm5 A T 19: 24,839,003 (GRCm39) S51T probably benign Het
Pitx2 A G 3: 129,009,345 (GRCm39) K88R probably damaging Het
Pnma8b A T 7: 16,679,964 (GRCm39) D316V unknown Het
Pop1 C A 15: 34,499,558 (GRCm39) P41Q probably damaging Het
Rcor1 A C 12: 111,070,080 (GRCm39) K292N Het
Rps6kc1 C T 1: 190,532,200 (GRCm39) D601N probably damaging Het
Sema7a A T 9: 57,862,408 (GRCm39) I204F probably damaging Het
Slc29a4 T C 5: 142,698,702 (GRCm39) L121P probably damaging Het
Slc4a2 A G 5: 24,644,308 (GRCm39) T983A probably benign Het
Slc4a4 C T 5: 89,194,158 (GRCm39) R213* probably null Het
Tbc1d2 G A 4: 46,609,029 (GRCm39) T736I probably benign Het
Tmco1 C T 1: 167,136,132 (GRCm39) probably benign Het
Trim28 G A 7: 12,763,490 (GRCm39) A544T probably benign Het
Trip12 A C 1: 84,703,550 (GRCm39) L1895R probably damaging Het
Ttc41 A T 10: 86,612,594 (GRCm39) Y1289F probably damaging Het
Vmn1r70 G A 7: 10,368,016 (GRCm39) C168Y probably damaging Het
Vtcn1 C A 3: 100,795,533 (GRCm39) R167S probably benign Het
Zfp369 G A 13: 65,445,010 (GRCm39) V718I probably benign Het
Zfp608 T C 18: 55,032,354 (GRCm39) T529A probably benign Het
Zfp936 A G 7: 42,836,922 (GRCm39) N46D probably benign Het
Zfp974 A G 7: 27,610,342 (GRCm39) V461A possibly damaging Het
Zgrf1 A G 3: 127,378,312 (GRCm39) N1024S probably benign Het
Other mutations in Cycs
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00975:Cycs APN 6 50,542,347 (GRCm39) missense probably benign 0.01
R1854:Cycs UTSW 6 50,542,309 (GRCm39) missense possibly damaging 0.85
R6622:Cycs UTSW 6 50,543,443 (GRCm39) start gained probably benign
R7331:Cycs UTSW 6 50,542,532 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GGGCGAGTTCCTTCTAGAAC -3'
(R):5'- TCGTAAGTGTCGGGCAAACG -3'

Sequencing Primer
(F):5'- TGCCACAGTTCTGCATGG -3'
(R):5'- GCAAACGAGGCCTCTGAAG -3'
Posted On 2022-02-07