Incidental Mutation 'R9237:Mcrip1'
ID 700548
Institutional Source Beutler Lab
Gene Symbol Mcrip1
Ensembl Gene ENSMUSG00000061111
Gene Name MAPK regulated corepressor interacting protein 1
Synonyms Fam195b, BC003940
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.100) question?
Stock # R9237 (G1)
Quality Score 225.009
Status Not validated
Chromosome 11
Chromosomal Location 120433714-120440553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 120435542 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Leucine at position 31 (P31L)
Ref Sequence ENSEMBL: ENSMUSP00000034913 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034913]
AlphaFold Q3UGS4
Predicted Effect probably damaging
Transcript: ENSMUST00000034913
AA Change: P31L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000034913
Gene: ENSMUSG00000061111
AA Change: P31L

DomainStartEndE-ValueType
Pfam:FAM195 4 94 3.3e-26 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A T 1: 71,318,557 (GRCm39) N1815K probably damaging Het
Acat1 C A 9: 53,494,816 (GRCm39) A359S probably damaging Het
Actn1 T C 12: 80,240,470 (GRCm39) N206D possibly damaging Het
Adgrf4 T A 17: 42,980,782 (GRCm39) H101L probably benign Het
Ager T A 17: 34,816,869 (GRCm39) M1K probably null Het
Akap12 T C 10: 4,307,231 (GRCm39) I1452T probably benign Het
Arap3 G A 18: 38,112,934 (GRCm39) A1092V possibly damaging Het
Bnip5 T C 17: 29,123,522 (GRCm39) E392G probably benign Het
C8b A G 4: 104,650,481 (GRCm39) T430A probably benign Het
Dars2 G A 1: 160,873,025 (GRCm39) R455W probably damaging Het
Erbb4 T G 1: 68,081,601 (GRCm39) Q1144H possibly damaging Het
Exoc2 G A 13: 31,048,858 (GRCm39) H732Y probably benign Het
Fhad1 T A 4: 141,632,483 (GRCm39) M1219L probably benign Het
Fktn G A 4: 53,734,854 (GRCm39) G125D probably benign Het
Gna15 T C 10: 81,359,683 (GRCm39) K36E possibly damaging Het
Gpr156 C T 16: 37,825,648 (GRCm39) Q622* probably null Het
Grip1 C T 10: 119,911,310 (GRCm39) S1091L probably benign Het
H4c12 A G 13: 21,934,534 (GRCm39) S48P probably damaging Het
Helt A G 8: 46,745,536 (GRCm39) F154L probably benign Het
Ide T C 19: 37,307,898 (GRCm39) N38S Het
Ighg2b A T 12: 113,270,217 (GRCm39) V267E Het
Map3k10 C T 7: 27,357,842 (GRCm39) W645* probably null Het
Mttp T C 3: 137,810,444 (GRCm39) E657G probably benign Het
Myom1 C T 17: 71,408,051 (GRCm39) T1195I probably damaging Het
Myom2 T C 8: 15,152,591 (GRCm39) V646A possibly damaging Het
Nlrc3 A T 16: 3,783,073 (GRCm39) M128K probably benign Het
Nr2f6 A C 8: 71,831,073 (GRCm39) C112W probably damaging Het
Or5af1 A T 11: 58,722,057 (GRCm39) I26F possibly damaging Het
Or5m13b T A 2: 85,754,267 (GRCm39) Y218* probably null Het
P2rx3 T C 2: 84,853,896 (GRCm39) N139S probably benign Het
Pcdha11 T A 18: 37,145,260 (GRCm39) N450K probably damaging Het
Phb1 T C 11: 95,566,034 (GRCm39) I106T possibly damaging Het
Phyhipl C A 10: 70,406,720 (GRCm39) R78L possibly damaging Het
Pmfbp1 A G 8: 110,246,932 (GRCm39) D268G probably damaging Het
Pramel39-ps G T 5: 94,451,001 (GRCm39) P375H probably damaging Het
Rcbtb2 C A 14: 73,411,936 (GRCm39) H408Q probably damaging Het
Sptbn1 A T 11: 30,096,803 (GRCm39) V271E probably damaging Het
Sptlc3 T A 2: 139,408,605 (GRCm39) V240E probably benign Het
Stat4 A G 1: 52,146,073 (GRCm39) N742S probably benign Het
Tas2r118 T A 6: 23,969,617 (GRCm39) Y148F probably benign Het
Trmt5 G T 12: 73,331,568 (GRCm39) Q163K probably benign Het
Ube2d1 T A 10: 71,097,925 (GRCm39) I37F probably damaging Het
Vmn1r43 G A 6: 89,846,877 (GRCm39) T203M probably damaging Het
Vps13b C T 15: 35,841,479 (GRCm39) P2503L probably damaging Het
Other mutations in Mcrip1
AlleleSourceChrCoordTypePredicted EffectPPH Score
devonian UTSW 11 120,435,505 (GRCm39) critical splice donor site probably null
R0184:Mcrip1 UTSW 11 120,435,710 (GRCm39) start codon destroyed probably null 0.00
R2289:Mcrip1 UTSW 11 120,435,530 (GRCm39) missense probably damaging 1.00
R2304:Mcrip1 UTSW 11 120,435,519 (GRCm39) missense probably damaging 1.00
R7185:Mcrip1 UTSW 11 120,435,505 (GRCm39) critical splice donor site probably null
R8811:Mcrip1 UTSW 11 120,435,605 (GRCm39) missense probably damaging 1.00
R9142:Mcrip1 UTSW 11 120,435,542 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GAAGACCATCTCCCAGATCCTG -3'
(R):5'- TGGACATCCCAGCAATGACC -3'

Sequencing Primer
(F):5'- TGCGTTGTCACCCCAATG -3'
(R):5'- TCCCAGCAATGACCAGGTG -3'
Posted On 2022-02-07