Incidental Mutation 'R9238:Or10j3'
ID 700568
Institutional Source Beutler Lab
Gene Symbol Or10j3
Ensembl Gene ENSMUSG00000046643
Gene Name olfactory receptor family 10 subfamily J member 3B
Synonyms Olfr1405-ps1, GA_x6K02T2R7CC-643715-642847, Olfr218, GA_x6K02SYWG4P-534-1100, MOR267-3, MOR267-3
MMRRC Submission 068987-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.136) question?
Stock # R9238 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 173030925-173031866 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 173031352 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 143 (I143T)
Ref Sequence ENSEMBL: ENSMUSP00000150815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057548] [ENSMUST00000215844] [ENSMUST00000216603]
AlphaFold E9PWV2
Predicted Effect probably benign
Transcript: ENSMUST00000057548
AA Change: I143T

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000053317
Gene: ENSMUSG00000046643
AA Change: I143T

DomainStartEndE-ValueType
Pfam:7tm_4 32 309 3.4e-58 PFAM
Pfam:7tm_1 42 291 2.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000215844
AA Change: I143T

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000216603
AA Change: I143T

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Meta Mutation Damage Score 0.0891 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agfg2 C A 5: 137,653,622 (GRCm39) V365F probably damaging Het
Atxn7 A T 14: 14,089,441 (GRCm38) N319I probably damaging Het
AY074887 C T 9: 54,858,087 (GRCm39) V13M unknown Het
Boc T C 16: 44,311,021 (GRCm39) T738A Het
C2cd5 A G 6: 143,027,127 (GRCm39) V126A possibly damaging Het
Cdk9 A T 2: 32,598,273 (GRCm39) L261Q possibly damaging Het
Chi3l1 T C 1: 134,115,685 (GRCm39) L231P probably damaging Het
Ckap5 T A 2: 91,399,027 (GRCm39) C604S probably null Het
Dop1a T C 9: 86,415,027 (GRCm39) V1923A probably benign Het
Dop1b T C 16: 93,546,018 (GRCm39) S230P probably benign Het
Eps15l1 T C 8: 73,095,274 (GRCm39) E892G probably damaging Het
Fasn T C 11: 120,705,871 (GRCm39) T1133A probably benign Het
Fktn G A 4: 53,734,854 (GRCm39) G125D probably benign Het
Fras1 A T 5: 96,832,220 (GRCm39) I1518F possibly damaging Het
Grid1 G A 14: 35,043,664 (GRCm39) D340N probably damaging Het
Herc2 T A 7: 55,813,508 (GRCm39) C2580S probably damaging Het
Ino80b T A 6: 83,102,314 (GRCm39) probably benign Het
Kdm2b T C 5: 123,009,889 (GRCm39) R1274G probably damaging Het
Lcn12 A G 2: 25,382,273 (GRCm39) I144T possibly damaging Het
Lrrc37 G T 11: 103,509,859 (GRCm39) P703Q unknown Het
Mroh5 T C 15: 73,663,586 (GRCm39) N158S probably benign Het
Mtpap G T 18: 4,396,439 (GRCm39) G577V probably damaging Het
Ncoa1 A G 12: 4,325,177 (GRCm39) V967A possibly damaging Het
Ndufa11 T C 17: 57,028,112 (GRCm39) Y61H probably benign Het
Nr2c2 T A 6: 92,144,530 (GRCm39) N602K probably damaging Het
Nubp1 C A 16: 10,231,604 (GRCm39) T85K probably benign Het
Oosp3 A G 19: 11,676,753 (GRCm39) I37M probably damaging Het
Optn A G 2: 5,057,951 (GRCm39) S73P probably damaging Het
Or2y15 A G 11: 49,350,529 (GRCm39) T8A probably benign Het
Osmr T G 15: 6,846,086 (GRCm39) I779L possibly damaging Het
Pcdh20 T C 14: 88,706,190 (GRCm39) D370G probably benign Het
Pgap1 A G 1: 54,550,570 (GRCm39) S571P probably benign Het
Pgbd5 A G 8: 125,106,930 (GRCm39) I204T probably damaging Het
Pkhd1 A G 1: 20,604,799 (GRCm39) I1172T possibly damaging Het
Plch1 T A 3: 63,606,412 (GRCm39) H1164L possibly damaging Het
Pramel39-ps G T 5: 94,451,001 (GRCm39) P375H probably damaging Het
Rab38 T A 7: 88,099,954 (GRCm39) F156L possibly damaging Het
Rtl1 T C 12: 109,561,017 (GRCm39) E274G possibly damaging Het
Serpinb9 A G 13: 33,199,479 (GRCm39) D258G probably benign Het
Slc26a11 T C 11: 119,265,733 (GRCm39) probably null Het
Slco1a7 G T 6: 141,686,153 (GRCm39) T229K probably damaging Het
Stard9 C A 2: 120,528,447 (GRCm39) T1568N probably damaging Het
Ston2 T C 12: 91,615,461 (GRCm39) T316A probably benign Het
Tacc1 A T 8: 25,672,634 (GRCm39) M198K probably benign Het
Tspan33 T C 6: 29,710,652 (GRCm39) F76S probably damaging Het
Tspyl5 T C 15: 33,687,082 (GRCm39) I288V possibly damaging Het
Vmn2r50 G A 7: 9,781,503 (GRCm39) S414F probably benign Het
Zfp141 G A 7: 42,125,111 (GRCm39) R454* probably null Het
Zscan22 T A 7: 12,641,075 (GRCm39) C440S probably damaging Het
Zscan4-ps2 A T 7: 11,251,339 (GRCm39) Q153L probably damaging Het
Other mutations in Or10j3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03404:Or10j3 APN 1 173,031,766 (GRCm39) missense probably benign 0.08
R0265:Or10j3 UTSW 1 173,031,484 (GRCm39) missense probably benign 0.10
R1388:Or10j3 UTSW 1 173,031,445 (GRCm39) missense probably benign 0.01
R1463:Or10j3 UTSW 1 173,030,934 (GRCm39) missense probably benign
R1547:Or10j3 UTSW 1 173,031,239 (GRCm39) nonsense probably null
R1698:Or10j3 UTSW 1 173,030,938 (GRCm39) missense probably damaging 1.00
R1892:Or10j3 UTSW 1 173,031,795 (GRCm39) missense probably damaging 1.00
R4773:Or10j3 UTSW 1 173,031,796 (GRCm39) missense probably damaging 1.00
R4939:Or10j3 UTSW 1 173,031,030 (GRCm39) missense possibly damaging 0.95
R5473:Or10j3 UTSW 1 173,031,732 (GRCm39) missense probably benign 0.02
R6149:Or10j3 UTSW 1 173,031,582 (GRCm39) missense probably benign 0.15
R6582:Or10j3 UTSW 1 173,031,847 (GRCm39) missense probably benign 0.00
R7151:Or10j3 UTSW 1 173,031,633 (GRCm39) missense probably damaging 1.00
R8120:Or10j3 UTSW 1 173,031,502 (GRCm39) missense probably benign 0.31
R8510:Or10j3 UTSW 1 173,031,411 (GRCm39) missense probably damaging 0.96
R8967:Or10j3 UTSW 1 173,031,039 (GRCm39) missense probably benign 0.14
R9292:Or10j3 UTSW 1 173,031,099 (GRCm39) missense probably damaging 1.00
R9358:Or10j3 UTSW 1 173,031,741 (GRCm39) missense probably damaging 1.00
R9517:Or10j3 UTSW 1 173,031,346 (GRCm39) missense possibly damaging 0.80
R9624:Or10j3 UTSW 1 173,031,672 (GRCm39) missense probably benign 0.30
Z1176:Or10j3 UTSW 1 173,031,364 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TTATTCCACGAATGCTAGCTGG -3'
(R):5'- TGGGTAACACAAGGACACAC -3'

Sequencing Primer
(F):5'- GAATGCTAGCTGGCCTCCTTAATC -3'
(R):5'- ACACACGCTGACAATAAAGTTG -3'
Posted On 2022-02-07