Incidental Mutation 'R9238:Lcn12'
ID 700570
Institutional Source Beutler Lab
Gene Symbol Lcn12
Ensembl Gene ENSMUSG00000026943
Gene Name lipocalin 12
Synonyms 9230102M18Rik
MMRRC Submission 068987-MU
Accession Numbers
Essential gene? Not available question?
Stock # R9238 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 25380857-25383923 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 25382273 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 144 (I144T)
Ref Sequence ENSEMBL: ENSMUSP00000028312 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028312] [ENSMUST00000114245]
AlphaFold Q6JVL5
Predicted Effect possibly damaging
Transcript: ENSMUST00000028312
AA Change: I144T

PolyPhen 2 Score 0.618 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000028312
Gene: ENSMUSG00000026943
AA Change: I144T

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
Pfam:Lipocalin 40 185 2.2e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000114245
AA Change: I108T

PolyPhen 2 Score 0.444 (Sensitivity: 0.89; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000109883
Gene: ENSMUSG00000026943
AA Change: I108T

DomainStartEndE-ValueType
Pfam:Lipocalin 4 149 2.9e-23 PFAM
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Members of the lipocalin family, such as LCN12, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agfg2 C A 5: 137,653,622 (GRCm39) V365F probably damaging Het
Atxn7 A T 14: 14,089,441 (GRCm38) N319I probably damaging Het
AY074887 C T 9: 54,858,087 (GRCm39) V13M unknown Het
Boc T C 16: 44,311,021 (GRCm39) T738A Het
C2cd5 A G 6: 143,027,127 (GRCm39) V126A possibly damaging Het
Cdk9 A T 2: 32,598,273 (GRCm39) L261Q possibly damaging Het
Chi3l1 T C 1: 134,115,685 (GRCm39) L231P probably damaging Het
Ckap5 T A 2: 91,399,027 (GRCm39) C604S probably null Het
Dop1a T C 9: 86,415,027 (GRCm39) V1923A probably benign Het
Dop1b T C 16: 93,546,018 (GRCm39) S230P probably benign Het
Eps15l1 T C 8: 73,095,274 (GRCm39) E892G probably damaging Het
Fasn T C 11: 120,705,871 (GRCm39) T1133A probably benign Het
Fktn G A 4: 53,734,854 (GRCm39) G125D probably benign Het
Fras1 A T 5: 96,832,220 (GRCm39) I1518F possibly damaging Het
Grid1 G A 14: 35,043,664 (GRCm39) D340N probably damaging Het
Herc2 T A 7: 55,813,508 (GRCm39) C2580S probably damaging Het
Ino80b T A 6: 83,102,314 (GRCm39) probably benign Het
Kdm2b T C 5: 123,009,889 (GRCm39) R1274G probably damaging Het
Lrrc37 G T 11: 103,509,859 (GRCm39) P703Q unknown Het
Mroh5 T C 15: 73,663,586 (GRCm39) N158S probably benign Het
Mtpap G T 18: 4,396,439 (GRCm39) G577V probably damaging Het
Ncoa1 A G 12: 4,325,177 (GRCm39) V967A possibly damaging Het
Ndufa11 T C 17: 57,028,112 (GRCm39) Y61H probably benign Het
Nr2c2 T A 6: 92,144,530 (GRCm39) N602K probably damaging Het
Nubp1 C A 16: 10,231,604 (GRCm39) T85K probably benign Het
Oosp3 A G 19: 11,676,753 (GRCm39) I37M probably damaging Het
Optn A G 2: 5,057,951 (GRCm39) S73P probably damaging Het
Or10j3 T C 1: 173,031,352 (GRCm39) I143T probably benign Het
Or2y15 A G 11: 49,350,529 (GRCm39) T8A probably benign Het
Osmr T G 15: 6,846,086 (GRCm39) I779L possibly damaging Het
Pcdh20 T C 14: 88,706,190 (GRCm39) D370G probably benign Het
Pgap1 A G 1: 54,550,570 (GRCm39) S571P probably benign Het
Pgbd5 A G 8: 125,106,930 (GRCm39) I204T probably damaging Het
Pkhd1 A G 1: 20,604,799 (GRCm39) I1172T possibly damaging Het
Plch1 T A 3: 63,606,412 (GRCm39) H1164L possibly damaging Het
Pramel39-ps G T 5: 94,451,001 (GRCm39) P375H probably damaging Het
Rab38 T A 7: 88,099,954 (GRCm39) F156L possibly damaging Het
Rtl1 T C 12: 109,561,017 (GRCm39) E274G possibly damaging Het
Serpinb9 A G 13: 33,199,479 (GRCm39) D258G probably benign Het
Slc26a11 T C 11: 119,265,733 (GRCm39) probably null Het
Slco1a7 G T 6: 141,686,153 (GRCm39) T229K probably damaging Het
Stard9 C A 2: 120,528,447 (GRCm39) T1568N probably damaging Het
Ston2 T C 12: 91,615,461 (GRCm39) T316A probably benign Het
Tacc1 A T 8: 25,672,634 (GRCm39) M198K probably benign Het
Tspan33 T C 6: 29,710,652 (GRCm39) F76S probably damaging Het
Tspyl5 T C 15: 33,687,082 (GRCm39) I288V possibly damaging Het
Vmn2r50 G A 7: 9,781,503 (GRCm39) S414F probably benign Het
Zfp141 G A 7: 42,125,111 (GRCm39) R454* probably null Het
Zscan22 T A 7: 12,641,075 (GRCm39) C440S probably damaging Het
Zscan4-ps2 A T 7: 11,251,339 (GRCm39) Q153L probably damaging Het
Other mutations in Lcn12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00903:Lcn12 APN 2 25,383,332 (GRCm39) missense possibly damaging 0.93
IGL03114:Lcn12 APN 2 25,383,274 (GRCm39) missense probably benign 0.40
R1738:Lcn12 UTSW 2 25,383,263 (GRCm39) missense probably damaging 1.00
R4687:Lcn12 UTSW 2 25,383,333 (GRCm39) missense probably benign 0.02
R5782:Lcn12 UTSW 2 25,383,769 (GRCm39) missense probably damaging 1.00
R8347:Lcn12 UTSW 2 25,382,045 (GRCm39) missense possibly damaging 0.89
Z1177:Lcn12 UTSW 2 25,382,253 (GRCm39) missense probably benign 0.12
Predicted Primers PCR Primer
(F):5'- CTGGTCAGGCAGATGAACTTG -3'
(R):5'- GGCAATTCACCAGGGACAACAG -3'

Sequencing Primer
(F):5'- CAGGCAGATGAACTTGTCTATTGTC -3'
(R):5'- TTCACCAGGGACAACAGAGGTG -3'
Posted On 2022-02-07