Incidental Mutation 'R9239:Or6b3'
ID 700617
Institutional Source Beutler Lab
Gene Symbol Or6b3
Ensembl Gene ENSMUSG00000042849
Gene Name olfactory receptor family 6 subfamily B member 3
Synonyms MOR103-2, GA_x6K02T2R7CC-81245243-81246181, Olfr1414
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R9239 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 92438770-92446237 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 92439454 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 99 (T99A)
Ref Sequence ENSEMBL: ENSMUSP00000054752 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062353] [ENSMUST00000189174]
AlphaFold Q8VGU5
Predicted Effect probably benign
Transcript: ENSMUST00000062353
AA Change: T99A

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000054752
Gene: ENSMUSG00000042849
AA Change: T99A

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 4.7e-52 PFAM
Pfam:7tm_1 41 290 5.7e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000189174
AA Change: T99A

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000140956
Gene: ENSMUSG00000042849
AA Change: T99A

DomainStartEndE-ValueType
low complexity region 23 40 N/A INTRINSIC
Pfam:7tm_1 41 290 4.2e-25 PFAM
Pfam:7tm_4 139 283 4.3e-42 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.5%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot8 A G 2: 164,646,608 (GRCm39) probably null Het
Aldh1l2 A G 10: 83,342,496 (GRCm39) F438S probably damaging Het
Alk T A 17: 72,256,864 (GRCm39) N665I probably benign Het
Anxa4 T A 6: 86,734,812 (GRCm39) T59S probably benign Het
B3gnt8 ACCCC ACCC 7: 25,327,676 (GRCm39) probably null Het
Cabs1 G A 5: 88,127,385 (GRCm39) R12Q probably benign Het
Cep152 A G 2: 125,425,830 (GRCm39) V845A probably benign Het
Dipk1a T C 5: 108,059,572 (GRCm39) E127G possibly damaging Het
Dsg1a T A 18: 20,473,750 (GRCm39) V941E probably damaging Het
Fbxo11 G T 17: 88,316,522 (GRCm39) H284N Het
Fubp1 A G 3: 151,923,486 (GRCm39) E98G probably damaging Het
Fyco1 A G 9: 123,626,637 (GRCm39) I1358T probably damaging Het
Ginm1 T C 10: 7,649,825 (GRCm39) N156S possibly damaging Het
Gm3739 T C 14: 18,505,221 (GRCm39) Y101C probably damaging Het
Ide T C 19: 37,307,898 (GRCm39) N38S Het
Itgb4 T C 11: 115,898,130 (GRCm39) V1644A probably damaging Het
Itpka A G 2: 119,580,023 (GRCm39) D254G probably damaging Het
Kat7 T A 11: 95,197,020 (GRCm39) R6S probably benign Het
Klhl40 A T 9: 121,607,637 (GRCm39) T266S probably benign Het
Lratd1 A G 12: 14,200,185 (GRCm39) W181R probably damaging Het
Mmaa T C 8: 79,995,856 (GRCm39) D289G probably damaging Het
Muc5ac A T 7: 141,353,954 (GRCm39) D851V probably damaging Het
Or1e29 A G 11: 73,667,346 (GRCm39) V269A probably benign Het
Or52n4 G T 7: 104,293,746 (GRCm39) H278N probably damaging Het
Pcdh17 T G 14: 84,770,649 (GRCm39) I1042M probably benign Het
Pipox A G 11: 77,774,765 (GRCm39) I106T probably benign Het
Ppcs C T 4: 119,276,235 (GRCm39) V290M possibly damaging Het
Rnasel T A 1: 153,630,097 (GRCm39) N204K probably damaging Het
Runx1 A G 16: 92,402,935 (GRCm39) Y336H probably damaging Het
Sell A G 1: 163,893,176 (GRCm39) I131V possibly damaging Het
Serpina3f A G 12: 104,184,710 (GRCm39) R285G possibly damaging Het
Slc25a2 A T 18: 37,771,169 (GRCm39) M120K possibly damaging Het
Slc47a1 A T 11: 61,250,344 (GRCm39) probably null Het
Slc4a11 C T 2: 130,533,664 (GRCm39) A100T probably damaging Het
Spats2l A G 1: 57,871,257 (GRCm39) probably benign Het
Spopfm1 T A 3: 94,173,871 (GRCm39) V289E probably benign Het
Taf1b T A 12: 24,606,015 (GRCm39) L431H probably damaging Het
Tectb CT C 19: 55,181,094 (GRCm39) probably null Het
Thsd7b G A 1: 130,087,453 (GRCm39) probably null Het
Tmtc4 A G 14: 123,165,078 (GRCm39) Y594H possibly damaging Het
Trim33 T C 3: 103,237,453 (GRCm39) F599L probably benign Het
Vcl A G 14: 21,072,092 (GRCm39) D819G probably damaging Het
Vmn1r43 G A 6: 89,846,877 (GRCm39) T203M probably damaging Het
Vmn2r1 G T 3: 64,011,959 (GRCm39) V607L probably damaging Het
Other mutations in Or6b3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01415:Or6b3 APN 1 92,438,974 (GRCm39) missense probably damaging 1.00
IGL01951:Or6b3 APN 1 92,438,853 (GRCm39) missense probably null 0.00
IGL02748:Or6b3 APN 1 92,439,189 (GRCm39) missense probably damaging 1.00
R1451:Or6b3 UTSW 1 92,439,517 (GRCm39) missense possibly damaging 0.78
R1926:Or6b3 UTSW 1 92,439,330 (GRCm39) missense probably damaging 0.98
R1978:Or6b3 UTSW 1 92,439,499 (GRCm39) missense probably damaging 1.00
R2507:Or6b3 UTSW 1 92,439,100 (GRCm39) missense probably damaging 1.00
R4820:Or6b3 UTSW 1 92,438,812 (GRCm39) makesense probably null
R7205:Or6b3 UTSW 1 92,439,573 (GRCm39) missense probably benign 0.04
R7258:Or6b3 UTSW 1 92,438,898 (GRCm39) missense possibly damaging 0.67
R7366:Or6b3 UTSW 1 92,439,400 (GRCm39) missense possibly damaging 0.88
R7467:Or6b3 UTSW 1 92,439,570 (GRCm39) missense possibly damaging 0.79
R9119:Or6b3 UTSW 1 92,438,904 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TTCAAGACATTGGAGCCACAG -3'
(R):5'- AGAACCTGGCCATCATCCTC -3'

Sequencing Primer
(F):5'- AGTAGACCTTAATCACAGAGATGC -3'
(R):5'- ATCCTCACTGTCTGGAGCAG -3'
Posted On 2022-02-07