Incidental Mutation 'R0761:Lrrc34'
ID 70078
Institutional Source Beutler Lab
Gene Symbol Lrrc34
Ensembl Gene ENSMUSG00000027702
Gene Name leucine rich repeat containing 34
Synonyms Spata34, 1700007J06Rik
MMRRC Submission 038941-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R0761 (G1)
Quality Score 216
Status Validated
Chromosome 3
Chromosomal Location 30678416-30701967 bp(-) (GRCm39)
Type of Mutation splice site (6 bp from exon)
DNA Base Change (assembly) A to G at 30685425 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000029252 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029252]
AlphaFold Q9DAM1
Predicted Effect probably null
Transcript: ENSMUST00000029252
SMART Domains Protein: ENSMUSP00000029252
Gene: ENSMUSG00000027702

DomainStartEndE-ValueType
LRR 73 100 2.23e2 SMART
LRR 101 128 6.92e-1 SMART
LRR 129 156 1.78e0 SMART
LRR 157 184 1.67e-2 SMART
Blast:LRR 216 242 2e-9 BLAST
LRR 244 271 2.57e-3 SMART
LRR 272 299 5.59e-4 SMART
LRR 301 328 4.16e0 SMART
LRR 329 356 1.66e2 SMART
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 94.7%
Validation Efficiency 100% (51/51)
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik T C 10: 78,903,833 (GRCm39) Y133C probably benign Het
Adcy5 G A 16: 35,091,195 (GRCm39) probably benign Het
Asb17 A G 3: 153,550,052 (GRCm39) K28R probably damaging Het
Bbs10 G T 10: 111,135,244 (GRCm39) C119F probably damaging Het
Camk2g G A 14: 20,816,280 (GRCm39) Q119* probably null Het
Cdh18 A T 15: 23,226,838 (GRCm39) I46L possibly damaging Het
Cimip2a T C 2: 25,110,135 (GRCm39) probably benign Het
Clmn T A 12: 104,747,817 (GRCm39) N577Y probably damaging Het
Col1a2 G A 6: 4,518,822 (GRCm39) probably benign Het
Crocc T C 4: 140,774,387 (GRCm39) E63G probably benign Het
Crocc T C 4: 140,757,087 (GRCm39) T965A probably benign Het
Cryzl2 A G 1: 157,293,294 (GRCm39) I132V probably benign Het
Csgalnact2 T C 6: 118,103,073 (GRCm39) probably benign Het
Ctr9 T C 7: 110,645,479 (GRCm39) S569P probably damaging Het
Cul3 A G 1: 80,255,203 (GRCm39) probably benign Het
Dcp2 G A 18: 44,543,300 (GRCm39) S286N probably benign Het
Dgkz C T 2: 91,775,696 (GRCm39) R189H probably benign Het
Dst A G 1: 34,221,848 (GRCm39) T2551A probably benign Het
Kcna4 T A 2: 107,126,417 (GRCm39) S384T probably benign Het
Klhl17 T C 4: 156,317,204 (GRCm39) probably null Het
Kmt2e C A 5: 23,708,032 (GRCm39) S1865* probably null Het
L3mbtl1 G A 2: 162,807,967 (GRCm39) R534H probably damaging Het
Lmnb2 A T 10: 80,742,088 (GRCm39) M1K probably null Het
Lrp1b T C 2: 41,075,947 (GRCm39) D1784G probably damaging Het
Megf10 C A 18: 57,421,048 (GRCm39) Y895* probably null Het
Mesd G T 7: 83,544,951 (GRCm39) A143S probably damaging Het
Mfap3l G T 8: 61,124,615 (GRCm39) V286L possibly damaging Het
Mroh2a G A 1: 88,171,672 (GRCm39) R770Q probably damaging Het
Nek1 T A 8: 61,542,489 (GRCm39) D717E probably benign Het
Nudt12 A T 17: 59,318,064 (GRCm39) D60E probably benign Het
Nup205 C T 6: 35,173,363 (GRCm39) probably benign Het
Or11g27 T C 14: 50,771,159 (GRCm39) S97P possibly damaging Het
Or2j3 A T 17: 38,616,282 (GRCm39) H23Q probably benign Het
Or4a75 T C 2: 89,448,179 (GRCm39) D119G probably damaging Het
Or5w19 C T 2: 87,698,880 (GRCm39) P182S possibly damaging Het
Pacs2 T A 12: 113,023,688 (GRCm39) probably benign Het
Pcdha9 T A 18: 37,133,016 (GRCm39) L695* probably null Het
Pira12 A T 7: 3,896,978 (GRCm39) probably null Het
Pkd1l1 A G 11: 8,804,375 (GRCm39) S1739P probably damaging Het
Polr1e C A 4: 45,027,392 (GRCm39) D207E probably damaging Het
Polr3f T A 2: 144,376,327 (GRCm39) V142E probably damaging Het
Psma6 T A 12: 55,459,127 (GRCm39) W170R possibly damaging Het
Rev3l T C 10: 39,750,191 (GRCm39) Y3114H probably benign Het
Rps6ka5 C T 12: 100,537,141 (GRCm39) A530T probably damaging Het
Simc1 T C 13: 54,674,387 (GRCm39) Y912H probably damaging Het
Tnfrsf1b T C 4: 144,942,670 (GRCm39) D371G possibly damaging Het
Trank1 T C 9: 111,195,681 (GRCm39) V1235A probably damaging Het
Ttn T C 2: 76,577,102 (GRCm39) E24597G probably damaging Het
Ubr2 G A 17: 47,294,242 (GRCm39) P297L probably damaging Het
Unc5d A T 8: 29,186,560 (GRCm39) probably null Het
Xpo4 A G 14: 57,850,840 (GRCm39) F355L probably damaging Het
Other mutations in Lrrc34
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02502:Lrrc34 APN 3 30,699,394 (GRCm39) missense probably benign 0.12
IGL02738:Lrrc34 APN 3 30,685,441 (GRCm39) missense possibly damaging 0.82
IGL02985:Lrrc34 APN 3 30,690,444 (GRCm39) missense probably benign 0.32
IGL02999:Lrrc34 APN 3 30,688,782 (GRCm39) missense probably damaging 0.99
R0367:Lrrc34 UTSW 3 30,684,142 (GRCm39) missense probably benign 0.08
R1426:Lrrc34 UTSW 3 30,697,728 (GRCm39) unclassified probably benign
R1980:Lrrc34 UTSW 3 30,696,890 (GRCm39) missense probably benign 0.33
R2215:Lrrc34 UTSW 3 30,697,678 (GRCm39) missense probably benign 0.03
R2414:Lrrc34 UTSW 3 30,688,711 (GRCm39) missense probably benign 0.00
R4379:Lrrc34 UTSW 3 30,685,524 (GRCm39) missense probably damaging 1.00
R5214:Lrrc34 UTSW 3 30,690,397 (GRCm39) nonsense probably null
R5418:Lrrc34 UTSW 3 30,696,923 (GRCm39) missense possibly damaging 0.85
R5662:Lrrc34 UTSW 3 30,685,473 (GRCm39) missense probably benign 0.03
R6736:Lrrc34 UTSW 3 30,679,008 (GRCm39) missense probably benign 0.03
R6809:Lrrc34 UTSW 3 30,688,749 (GRCm39) missense possibly damaging 0.80
R6941:Lrrc34 UTSW 3 30,678,969 (GRCm39) missense probably benign 0.01
R7017:Lrrc34 UTSW 3 30,699,465 (GRCm39) critical splice acceptor site probably null
R7080:Lrrc34 UTSW 3 30,688,705 (GRCm39) missense probably damaging 0.96
R7139:Lrrc34 UTSW 3 30,679,036 (GRCm39) missense probably benign 0.22
R7191:Lrrc34 UTSW 3 30,679,027 (GRCm39) missense possibly damaging 0.61
R7398:Lrrc34 UTSW 3 30,697,491 (GRCm39) missense probably damaging 1.00
R7662:Lrrc34 UTSW 3 30,697,452 (GRCm39) missense probably benign 0.16
R7707:Lrrc34 UTSW 3 30,679,041 (GRCm39) missense probably benign 0.00
R7945:Lrrc34 UTSW 3 30,696,886 (GRCm39) critical splice donor site probably null
R8799:Lrrc34 UTSW 3 30,678,979 (GRCm39) missense probably benign 0.06
R9764:Lrrc34 UTSW 3 30,697,467 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- catctcaccagcccGCTTATGAAC -3'
(R):5'- ACTTGATTGGCAGCCAGATGGGAG -3'

Sequencing Primer
(F):5'- gttcacagcacacactaagg -3'
(R):5'- CATCCTTGGAAGTTGAGCAAAC -3'
Posted On 2013-09-30