Incidental Mutation 'R9244:Or6d12'
ID 701150
Institutional Source Beutler Lab
Gene Symbol Or6d12
Ensembl Gene ENSMUSG00000053251
Gene Name olfactory receptor family 6 subfamily D member 12
Synonyms Olfr212, GA_x54KRFPKN04-58149882-58150865, 4931403F16Rik, MOR119-4
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R9244 (G1)
Quality Score 225.009
Status Not validated
Chromosome 6
Chromosomal Location 116483477-116494926 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 116492782 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 15 (V15I)
Ref Sequence ENSEMBL: ENSMUSP00000075164 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075756] [ENSMUST00000218028] [ENSMUST00000220134]
AlphaFold Q7TS33
Predicted Effect probably benign
Transcript: ENSMUST00000075756
AA Change: V15I

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000075164
Gene: ENSMUSG00000053251
AA Change: V15I

DomainStartEndE-ValueType
Pfam:7tm_4 37 314 9.3e-44 PFAM
Pfam:7tm_1 47 296 2e-16 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000218028
AA Change: V15I

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
Predicted Effect probably benign
Transcript: ENSMUST00000220134
AA Change: V15I

PolyPhen 2 Score 0.025 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 A G 11: 9,241,577 (GRCm39) I1147V probably benign Het
Adcy10 A G 1: 165,370,679 (GRCm39) T653A probably benign Het
App A G 16: 84,759,629 (GRCm39) I656T probably damaging Het
Arnt T A 3: 95,397,879 (GRCm39) I574N possibly damaging Het
Cdc42 T C 4: 137,056,391 (GRCm39) T75A probably benign Het
Cdh23 C A 10: 60,249,442 (GRCm39) K822N possibly damaging Het
Chrnb3 T A 8: 27,884,594 (GRCm39) L444I unknown Het
Ctnnbl1 G T 2: 157,678,583 (GRCm39) K395N possibly damaging Het
Dmxl1 T A 18: 50,026,316 (GRCm39) I1808K probably benign Het
Dnajb8 C A 6: 88,199,884 (GRCm39) P140Q probably damaging Het
Dock5 G A 14: 67,996,563 (GRCm39) R1727W probably damaging Het
Dscam G A 16: 96,486,429 (GRCm39) T1082I possibly damaging Het
Eaf1 T C 14: 31,219,766 (GRCm39) probably benign Het
Elapor2 A G 5: 9,460,700 (GRCm39) Y207C probably damaging Het
Enpp3 T C 10: 24,654,689 (GRCm39) D663G probably damaging Het
Epha5 A G 5: 84,265,441 (GRCm39) V451A probably benign Het
Erap1 G A 13: 74,821,903 (GRCm39) probably null Het
Esco2 A G 14: 66,059,088 (GRCm39) W530R probably damaging Het
Fhip1b A G 7: 105,038,870 (GRCm39) V123A possibly damaging Het
Fhod3 T C 18: 25,248,922 (GRCm39) I1367T probably damaging Het
Fryl T C 5: 73,348,862 (GRCm39) probably benign Het
Get1 A G 16: 95,955,383 (GRCm39) T147A probably benign Het
Gm42669 A G 5: 107,656,370 (GRCm39) T295A possibly damaging Het
Harbi1 A G 2: 91,543,040 (GRCm39) N167S probably damaging Het
Hfm1 A C 5: 107,022,766 (GRCm39) N945K probably damaging Het
Hook3 A G 8: 26,561,084 (GRCm39) probably null Het
Htr1f G T 16: 64,746,857 (GRCm39) T145K probably benign Het
Igf2bp2 A C 16: 21,886,901 (GRCm39) S453A possibly damaging Het
Ipo4 A T 14: 55,871,799 (GRCm39) W116R probably damaging Het
Jak1 T C 4: 101,015,040 (GRCm39) H917R probably benign Het
Klrb1b A T 6: 128,792,245 (GRCm39) C189* probably null Het
Lrrn2 A G 1: 132,865,058 (GRCm39) Y41C probably damaging Het
Lrrn2 T C 1: 132,865,237 (GRCm39) S101P probably damaging Het
Mcmdc2 C T 1: 9,985,835 (GRCm39) T127I probably damaging Het
Mtch1 C A 17: 29,566,626 (GRCm39) A46S unknown Het
Ndufb5 C A 3: 32,795,906 (GRCm39) Q33K probably null Het
Nufip2 T C 11: 77,583,475 (GRCm39) V463A probably damaging Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,237,059 (GRCm39) probably benign Het
Or2r3 T A 6: 42,448,537 (GRCm39) I192F possibly damaging Het
Or5p62 A G 7: 107,771,852 (GRCm39) I33T probably benign Het
Or8j3c A T 2: 86,253,423 (GRCm39) V199E probably damaging Het
Pira13 T C 7: 3,825,226 (GRCm39) D472G unknown Het
Ppip5k1 A C 2: 121,164,932 (GRCm39) S972A probably benign Het
Prl8a2 A T 13: 27,534,982 (GRCm39) M86L probably benign Het
Prorsd1 T C 11: 29,463,271 (GRCm39) I164V probably benign Het
Ptgs1 A G 2: 36,130,724 (GRCm39) T208A probably damaging Het
Ptpn3 A T 4: 57,254,915 (GRCm39) probably null Het
Reln T C 5: 22,120,151 (GRCm39) R2834G probably damaging Het
Shc4 G T 2: 125,497,589 (GRCm39) Y373* probably null Het
Skor1 A T 9: 63,049,524 (GRCm39) probably null Het
Slc9a4 T C 1: 40,658,249 (GRCm39) S591P probably damaging Het
Stat2 A G 10: 128,118,634 (GRCm39) E389G possibly damaging Het
Trav14n-3 C A 14: 53,608,004 (GRCm39) D111E probably damaging Het
Unc5c A G 3: 141,533,370 (GRCm39) S873G probably benign Het
Vmn1r210 T C 13: 23,012,089 (GRCm39) I66V probably benign Het
Vmn2r117 T A 17: 23,696,589 (GRCm39) I273F probably damaging Het
Vmn2r95 T A 17: 18,672,189 (GRCm39) M714K possibly damaging Het
Zfp235 A G 7: 23,839,919 (GRCm39) T113A probably benign Het
Zranb1 T G 7: 132,585,640 (GRCm39) L696R probably damaging Het
Other mutations in Or6d12
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1477:Or6d12 UTSW 6 116,493,626 (GRCm39) missense probably damaging 1.00
R1912:Or6d12 UTSW 6 116,492,950 (GRCm39) missense probably benign 0.00
R4035:Or6d12 UTSW 6 116,493,590 (GRCm39) missense possibly damaging 0.94
R4654:Or6d12 UTSW 6 116,493,409 (GRCm39) missense probably damaging 1.00
R5284:Or6d12 UTSW 6 116,493,513 (GRCm39) nonsense probably null
R5772:Or6d12 UTSW 6 116,492,912 (GRCm39) missense possibly damaging 0.70
R6882:Or6d12 UTSW 6 116,493,395 (GRCm39) missense probably benign 0.00
R6944:Or6d12 UTSW 6 116,492,791 (GRCm39) missense possibly damaging 0.95
R7078:Or6d12 UTSW 6 116,493,632 (GRCm39) missense probably damaging 1.00
R7099:Or6d12 UTSW 6 116,493,721 (GRCm39) makesense probably null
R7205:Or6d12 UTSW 6 116,492,936 (GRCm39) missense probably damaging 1.00
R7556:Or6d12 UTSW 6 116,493,697 (GRCm39) nonsense probably null
R8155:Or6d12 UTSW 6 116,492,813 (GRCm39) missense probably benign 0.16
R8530:Or6d12 UTSW 6 116,493,530 (GRCm39) missense probably damaging 1.00
R9158:Or6d12 UTSW 6 116,492,791 (GRCm39) missense possibly damaging 0.95
R9205:Or6d12 UTSW 6 116,493,315 (GRCm39) missense probably benign 0.00
R9425:Or6d12 UTSW 6 116,493,574 (GRCm39) missense possibly damaging 0.94
RF016:Or6d12 UTSW 6 116,493,004 (GRCm39) missense probably benign 0.03
Predicted Primers
Posted On 2022-03-25