Incidental Mutation 'R9246:Robo1'
| ID |
701326 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Robo1
|
| Ensembl Gene |
ENSMUSG00000022883 |
| Gene Name |
roundabout guidance receptor 1 |
| Synonyms |
DUTT1 |
| MMRRC Submission |
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R9246 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
72105194-72842983 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 72769178 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 532
(D532E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000023600
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023600]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000023600
AA Change: D532E
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000023600
Gene: ENSMUSG00000022883
AA Change: D532E
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
41 |
115 |
3.15e-10 |
SMART |
|
IGc2
|
143 |
208 |
2.52e-9 |
SMART |
|
IGc2
|
235 |
298 |
3.85e-14 |
SMART |
|
IGv
|
328 |
391 |
3.71e-7 |
SMART |
|
IGc2
|
428 |
493 |
2.46e-12 |
SMART |
|
FN3
|
522 |
604 |
3.17e-13 |
SMART |
|
FN3
|
634 |
721 |
1.66e0 |
SMART |
|
FN3
|
736 |
822 |
4.28e-10 |
SMART |
|
low complexity region
|
1108 |
1125 |
N/A |
INTRINSIC |
|
low complexity region
|
1148 |
1157 |
N/A |
INTRINSIC |
|
low complexity region
|
1186 |
1197 |
N/A |
INTRINSIC |
|
low complexity region
|
1249 |
1269 |
N/A |
INTRINSIC |
|
low complexity region
|
1282 |
1298 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1380 |
N/A |
INTRINSIC |
|
low complexity region
|
1442 |
1449 |
N/A |
INTRINSIC |
|
low complexity region
|
1563 |
1576 |
N/A |
INTRINSIC |
|
low complexity region
|
1602 |
1611 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 98.9%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
PHENOTYPE: Mice homozygous for a reporter allele show altered axon guidance. Mice homozygous for a null allele die at birth showing aberrant axon pathfinding and cortical interneuron migration. Homozygotes for another null allele show neonatal death, aphagia, delayed lung maturation and bronchial hyperplasia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 70 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022A10Rik |
C |
T |
7: 27,279,961 (GRCm39) |
T314I |
probably benign |
Het |
| Abca7 |
G |
A |
10: 79,838,535 (GRCm39) |
S603N |
probably damaging |
Het |
| Abcc2 |
T |
C |
19: 43,786,882 (GRCm39) |
F168L |
probably benign |
Het |
| Abcc8 |
T |
C |
7: 45,774,289 (GRCm39) |
T764A |
probably benign |
Het |
| Acot4 |
A |
C |
12: 84,090,097 (GRCm39) |
I265L |
probably benign |
Het |
| Adrb2 |
C |
A |
18: 62,312,226 (GRCm39) |
A200S |
probably damaging |
Het |
| Atp2c2 |
G |
T |
8: 120,456,989 (GRCm39) |
R197L |
probably damaging |
Het |
| Bmpr1a |
T |
C |
14: 34,156,664 (GRCm39) |
T121A |
probably benign |
Het |
| Brwd1 |
A |
T |
16: 95,804,016 (GRCm39) |
S2051R |
probably benign |
Het |
| Card10 |
T |
C |
15: 78,673,036 (GRCm39) |
E547G |
possibly damaging |
Het |
| Cbln1 |
A |
T |
8: 88,197,048 (GRCm39) |
I139N |
probably damaging |
Het |
| Ccdc86 |
CCTCTGGCTGAGGTCCGGGAGACGGAAGGCTCAGTGGTGGACAGGGCGATCCGGGGCTCGTCTCTGGCTGAGGTCCGGGAGACGGAAGGCTCAGTGGTGGACAGGGCGATCCGGGGCTCGTCTCCGGCTGAGGTCCGGGAGACGGAAGGCTCAGTGGTGGACAGGGCGATCCGGGGCTCGTCTCCGGCTGAGGTCCGGGAGACGGAAGGCTCAGTGGTGGACAGGGCGATCCGGGGCTCGTCTCCGGCTGAGGTCCGGGAGACGGAAGGCTCAGTGGTGGA |
CCTCTGGCTGAGGTCCGGGAGACGGAAGGCTCAGTGGTGGACAGGGCGATCCGGGGCTCGTCTCCGGCTGAGGTCCGGGAGACGGAAGGCTCAGTGGTGGACAGGGCGATCCGGGGCTCGTCTCCGGCTGAGGTCCGGGAGACGGAAGGCTCAGTGGTGGACAGGGCGATCCGGGGCTCGTCTCCGGCTGAGGTCCGGGAGACGGAAGGCTCAGTGGTGGA |
19: 10,926,162 (GRCm39) |
|
probably benign |
Het |
| Cdh16 |
C |
T |
8: 105,344,602 (GRCm39) |
D510N |
probably benign |
Het |
| Cdh2 |
G |
A |
18: 16,781,654 (GRCm39) |
Q146* |
probably null |
Het |
| Cdhr1 |
T |
G |
14: 36,801,654 (GRCm39) |
K763T |
possibly damaging |
Het |
| Cfl1 |
G |
C |
19: 5,543,634 (GRCm39) |
G204R |
probably damaging |
Het |
| Clcn6 |
A |
T |
4: 148,113,866 (GRCm39) |
V64E |
probably benign |
Het |
| Col4a4 |
G |
A |
1: 82,430,956 (GRCm39) |
P1649S |
unknown |
Het |
| Ctnna1 |
T |
A |
18: 35,356,562 (GRCm39) |
N410K |
probably benign |
Het |
| Dhx34 |
A |
G |
7: 15,937,162 (GRCm39) |
F845S |
probably damaging |
Het |
| Dnah7c |
T |
G |
1: 46,571,934 (GRCm39) |
N802K |
possibly damaging |
Het |
| Dnmt3a |
T |
C |
12: 3,949,204 (GRCm39) |
S492P |
probably damaging |
Het |
| Fhit |
C |
A |
14: 10,421,494 (GRCm38) |
|
probably null |
Het |
| Fzd2 |
A |
T |
11: 102,496,749 (GRCm39) |
I398F |
possibly damaging |
Het |
| Gm9195 |
A |
G |
14: 72,710,314 (GRCm39) |
S457P |
probably benign |
Het |
| Gnao1 |
A |
G |
8: 94,676,967 (GRCm39) |
K211E |
|
Het |
| Gzme |
T |
C |
14: 56,356,198 (GRCm39) |
D100G |
probably benign |
Het |
| Hook3 |
T |
C |
8: 26,562,319 (GRCm39) |
T249A |
probably benign |
Het |
| Hoxd4 |
G |
A |
2: 74,558,747 (GRCm39) |
C190Y |
possibly damaging |
Het |
| Hr |
T |
A |
14: 70,808,915 (GRCm39) |
V1097E |
probably damaging |
Het |
| Iqca1l |
T |
G |
5: 24,753,969 (GRCm39) |
E430A |
probably benign |
Het |
| Kdm3b |
A |
T |
18: 34,941,480 (GRCm39) |
K524* |
probably null |
Het |
| Kif18a |
A |
G |
2: 109,163,819 (GRCm39) |
T723A |
probably benign |
Het |
| Kif1a |
A |
G |
1: 93,005,501 (GRCm39) |
V91A |
probably damaging |
Het |
| Krtap19-2 |
AAAGCCTCCAAAGCCTCCATAGCCAGAGCCATATCCGAAGCCTCCA |
AAAGCCTCCA |
16: 88,670,859 (GRCm39) |
|
probably benign |
Het |
| Lama3 |
G |
A |
18: 12,710,959 (GRCm39) |
V1559M |
probably damaging |
Het |
| Maco1 |
A |
G |
4: 134,565,242 (GRCm39) |
V47A |
possibly damaging |
Het |
| Msto1 |
A |
T |
3: 88,819,411 (GRCm39) |
I160N |
probably damaging |
Het |
| Muc5ac |
C |
A |
7: 141,364,215 (GRCm39) |
Q2509K |
probably benign |
Het |
| Nicn1 |
C |
T |
9: 108,171,708 (GRCm39) |
R163C |
possibly damaging |
Het |
| Nos1 |
G |
C |
5: 118,017,402 (GRCm39) |
R255P |
probably benign |
Het |
| Nup98 |
C |
A |
7: 101,788,037 (GRCm39) |
R1011L |
probably benign |
Het |
| Or1ad8 |
T |
A |
11: 50,897,891 (GRCm39) |
F31I |
probably damaging |
Het |
| Or2ag2b |
C |
T |
7: 106,417,938 (GRCm39) |
T216I |
probably benign |
Het |
| Or52ad1 |
C |
T |
7: 102,995,908 (GRCm39) |
V76I |
probably damaging |
Het |
| Or7e170 |
T |
C |
9: 19,795,686 (GRCm39) |
|
probably benign |
Het |
| Or8k21 |
A |
T |
2: 86,145,222 (GRCm39) |
M136K |
probably damaging |
Het |
| Pik3c3 |
C |
A |
18: 30,466,364 (GRCm39) |
A805D |
probably damaging |
Het |
| Pnn |
A |
G |
12: 59,116,929 (GRCm39) |
Q167R |
probably damaging |
Het |
| Pogk |
G |
T |
1: 166,226,380 (GRCm39) |
H590Q |
probably damaging |
Het |
| Prkcd |
A |
G |
14: 30,327,432 (GRCm39) |
L251P |
probably damaging |
Het |
| Prrc1 |
T |
A |
18: 57,496,208 (GRCm39) |
V53E |
probably benign |
Het |
| Ripor1 |
T |
C |
8: 106,345,522 (GRCm39) |
F856S |
unknown |
Het |
| Rnf31 |
G |
A |
14: 55,833,698 (GRCm39) |
A569T |
probably benign |
Het |
| Sh2d6 |
T |
A |
6: 72,497,594 (GRCm39) |
K3* |
probably null |
Het |
| Slc22a27 |
T |
C |
19: 7,874,209 (GRCm39) |
T289A |
probably benign |
Het |
| Speg |
T |
C |
1: 75,361,498 (GRCm39) |
S171P |
probably damaging |
Het |
| Stag1 |
T |
A |
9: 100,770,329 (GRCm39) |
F622I |
probably benign |
Het |
| Stxbp1 |
T |
C |
2: 32,679,586 (GRCm39) |
D589G |
possibly damaging |
Het |
| Syne1 |
T |
C |
10: 5,255,706 (GRCm39) |
I2391M |
probably benign |
Het |
| Sytl2 |
A |
G |
7: 90,007,384 (GRCm39) |
M49V |
probably benign |
Het |
| Tmem185b |
T |
C |
1: 119,454,368 (GRCm39) |
V43A |
probably damaging |
Het |
| Trappc8 |
A |
T |
18: 20,993,590 (GRCm39) |
M499K |
possibly damaging |
Het |
| Vmn1r172 |
T |
A |
7: 23,359,593 (GRCm39) |
S159R |
possibly damaging |
Het |
| Vmn1r62 |
A |
G |
7: 5,678,628 (GRCm39) |
Y103C |
probably damaging |
Het |
| Vmn1r65 |
C |
T |
7: 6,011,769 (GRCm39) |
C155Y |
possibly damaging |
Het |
| Vmn2r112 |
G |
A |
17: 22,824,088 (GRCm39) |
V448I |
probably benign |
Het |
| Zfp592 |
A |
T |
7: 80,691,529 (GRCm39) |
D1236V |
probably benign |
Het |
| Zfp827 |
T |
C |
8: 79,803,132 (GRCm39) |
V568A |
possibly damaging |
Het |
| Zscan4-ps3 |
A |
T |
7: 11,346,320 (GRCm39) |
I147F |
probably damaging |
Het |
|
| Other mutations in Robo1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01766:Robo1
|
APN |
16 |
72,801,553 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01937:Robo1
|
APN |
16 |
72,759,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01945:Robo1
|
APN |
16 |
72,759,114 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02151:Robo1
|
APN |
16 |
72,786,504 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02232:Robo1
|
APN |
16 |
72,768,872 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
IGL02282:Robo1
|
APN |
16 |
72,539,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02590:Robo1
|
APN |
16 |
72,840,020 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL02874:Robo1
|
APN |
16 |
72,809,806 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02974:Robo1
|
APN |
16 |
72,803,750 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL03233:Robo1
|
APN |
16 |
72,767,081 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4378001:Robo1
|
UTSW |
16 |
72,801,423 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0079:Robo1
|
UTSW |
16 |
72,730,230 (GRCm39) |
splice site |
probably benign |
|
|
R0254:Robo1
|
UTSW |
16 |
72,461,058 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0366:Robo1
|
UTSW |
16 |
72,539,133 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R0410:Robo1
|
UTSW |
16 |
72,768,872 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R0511:Robo1
|
UTSW |
16 |
72,810,013 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0563:Robo1
|
UTSW |
16 |
72,769,174 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0637:Robo1
|
UTSW |
16 |
72,798,839 (GRCm39) |
missense |
probably benign |
0.29 |
|
R1239:Robo1
|
UTSW |
16 |
72,821,430 (GRCm39) |
splice site |
probably null |
|
|
R1773:Robo1
|
UTSW |
16 |
72,801,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1777:Robo1
|
UTSW |
16 |
72,801,555 (GRCm39) |
missense |
probably benign |
|
|
R1901:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1902:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1903:Robo1
|
UTSW |
16 |
72,757,092 (GRCm39) |
missense |
probably null |
1.00 |
|
R1996:Robo1
|
UTSW |
16 |
72,767,067 (GRCm39) |
missense |
probably benign |
0.40 |
|
R2040:Robo1
|
UTSW |
16 |
72,730,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2266:Robo1
|
UTSW |
16 |
72,775,660 (GRCm39) |
missense |
probably benign |
|
|
R2269:Robo1
|
UTSW |
16 |
72,775,660 (GRCm39) |
missense |
probably benign |
|
|
R2433:Robo1
|
UTSW |
16 |
72,767,127 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3084:Robo1
|
UTSW |
16 |
72,801,625 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3085:Robo1
|
UTSW |
16 |
72,798,898 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3150:Robo1
|
UTSW |
16 |
72,767,157 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R3418:Robo1
|
UTSW |
16 |
72,832,805 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3610:Robo1
|
UTSW |
16 |
72,780,658 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3940:Robo1
|
UTSW |
16 |
72,806,631 (GRCm39) |
missense |
probably benign |
|
|
R3953:Robo1
|
UTSW |
16 |
72,821,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4692:Robo1
|
UTSW |
16 |
72,757,090 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Robo1
|
UTSW |
16 |
72,768,931 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4814:Robo1
|
UTSW |
16 |
72,768,923 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4884:Robo1
|
UTSW |
16 |
72,701,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Robo1
|
UTSW |
16 |
72,776,756 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5150:Robo1
|
UTSW |
16 |
72,769,192 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5183:Robo1
|
UTSW |
16 |
72,539,038 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5360:Robo1
|
UTSW |
16 |
72,732,665 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5629:Robo1
|
UTSW |
16 |
72,780,598 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5804:Robo1
|
UTSW |
16 |
72,840,077 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6107:Robo1
|
UTSW |
16 |
72,780,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6127:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6128:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6129:Robo1
|
UTSW |
16 |
72,809,956 (GRCm39) |
missense |
probably benign |
|
|
R6191:Robo1
|
UTSW |
16 |
72,730,696 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6357:Robo1
|
UTSW |
16 |
72,767,190 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6408:Robo1
|
UTSW |
16 |
72,768,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6516:Robo1
|
UTSW |
16 |
72,821,241 (GRCm39) |
missense |
probably benign |
0.14 |
|
R6600:Robo1
|
UTSW |
16 |
72,786,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6802:Robo1
|
UTSW |
16 |
72,730,201 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7105:Robo1
|
UTSW |
16 |
72,539,049 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7189:Robo1
|
UTSW |
16 |
72,757,039 (GRCm39) |
nonsense |
probably null |
|
|
R7290:Robo1
|
UTSW |
16 |
72,801,408 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7296:Robo1
|
UTSW |
16 |
72,786,519 (GRCm39) |
nonsense |
probably null |
|
|
R7576:Robo1
|
UTSW |
16 |
72,767,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7605:Robo1
|
UTSW |
16 |
72,821,189 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7607:Robo1
|
UTSW |
16 |
72,360,626 (GRCm39) |
missense |
|
|
|
R7634:Robo1
|
UTSW |
16 |
72,839,866 (GRCm39) |
splice site |
probably null |
|
|
R7636:Robo1
|
UTSW |
16 |
72,360,615 (GRCm39) |
missense |
|
|
|
R7857:Robo1
|
UTSW |
16 |
72,767,099 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7966:Robo1
|
UTSW |
16 |
72,780,760 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R7997:Robo1
|
UTSW |
16 |
72,701,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8101:Robo1
|
UTSW |
16 |
72,775,469 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8191:Robo1
|
UTSW |
16 |
72,730,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8218:Robo1
|
UTSW |
16 |
72,786,678 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R8228:Robo1
|
UTSW |
16 |
72,809,768 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8292:Robo1
|
UTSW |
16 |
72,769,420 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R8298:Robo1
|
UTSW |
16 |
72,769,020 (GRCm39) |
intron |
probably benign |
|
|
R8332:Robo1
|
UTSW |
16 |
72,775,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8402:Robo1
|
UTSW |
16 |
72,821,385 (GRCm39) |
missense |
probably benign |
0.16 |
|
R8492:Robo1
|
UTSW |
16 |
72,809,911 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8730:Robo1
|
UTSW |
16 |
72,786,495 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8774:Robo1
|
UTSW |
16 |
72,832,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8774-TAIL:Robo1
|
UTSW |
16 |
72,832,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8776:Robo1
|
UTSW |
16 |
72,821,141 (GRCm39) |
nonsense |
probably null |
|
|
R8776-TAIL:Robo1
|
UTSW |
16 |
72,821,141 (GRCm39) |
nonsense |
probably null |
|
|
R8905:Robo1
|
UTSW |
16 |
72,539,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8913:Robo1
|
UTSW |
16 |
72,701,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9003:Robo1
|
UTSW |
16 |
72,539,002 (GRCm39) |
splice site |
probably benign |
|
|
R9451:Robo1
|
UTSW |
16 |
72,803,718 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9509:Robo1
|
UTSW |
16 |
72,759,167 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9652:Robo1
|
UTSW |
16 |
72,821,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9653:Robo1
|
UTSW |
16 |
72,821,330 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9749:Robo1
|
UTSW |
16 |
72,105,257 (GRCm39) |
start gained |
probably benign |
|
|
Z1176:Robo1
|
UTSW |
16 |
72,774,688 (GRCm39) |
missense |
probably benign |
0.16 |
|
| Predicted Primers |
PCR Primer
(F):5'- CGAAGTCCAGGGTAAATTCATACG -3'
(R):5'- AGCTGCTACCAGATGCATGG -3'
Sequencing Primer
(F):5'- AAAGCCAATGTCCTGGTCTC -3'
(R):5'- TGCATGTACCCCTTTGTG -3'
|
| Posted On |
2022-03-25 |
Incidental Mutation