Incidental Mutation 'R9251:Olfr801'
ID 701560
Institutional Source Beutler Lab
Gene Symbol Olfr801
Ensembl Gene ENSMUSG00000058513
Gene Name olfactory receptor 801
Synonyms GA_x6K02T2PULF-11349138-11348182, MOR110-10
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R9251 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 129666989-129673865 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 129670111 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 136 (N136I)
Ref Sequence ENSEMBL: ENSMUSP00000148943 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072063] [ENSMUST00000203424] [ENSMUST00000213294] [ENSMUST00000216067]
AlphaFold Q8VEU1
Predicted Effect possibly damaging
Transcript: ENSMUST00000072063
AA Change: N136I

PolyPhen 2 Score 0.613 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000071941
Gene: ENSMUSG00000058513
AA Change: N136I

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 1.2e-51 PFAM
Pfam:7tm_1 39 288 8.8e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203424
SMART Domains Protein: ENSMUSP00000145011
Gene: ENSMUSG00000058513

DomainStartEndE-ValueType
Pfam:7tm_4 1 96 5.9e-18 PFAM
Pfam:7tm_1 2 96 1.3e-17 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213294
AA Change: N136I

PolyPhen 2 Score 0.613 (Sensitivity: 0.87; Specificity: 0.91)
Predicted Effect possibly damaging
Transcript: ENSMUST00000216067
AA Change: N136I

PolyPhen 2 Score 0.613 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 100% (59/59)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap31 G T 16: 38,602,856 N949K probably benign Het
Arv1 T A 8: 124,725,323 I76N probably damaging Het
Cfap44 G A 16: 44,408,913 A189T probably damaging Het
Ch25h T C 19: 34,474,369 Y253C probably damaging Het
Cnot11 T C 1: 39,542,506 M376T probably damaging Het
Cnot7 T C 8: 40,511,581 probably benign Het
Dnah17 G A 11: 118,121,792 S481F probably benign Het
Dnah2 C T 11: 69,515,793 R541Q probably damaging Het
Dnah7a C T 1: 53,582,512 M1151I probably damaging Het
Dpf2 T C 19: 5,907,138 D19G probably damaging Het
Eefsec A T 6: 88,355,592 M212K probably damaging Het
Elp6 G A 9: 110,305,598 V12I unknown Het
Enox1 G A 14: 77,615,557 probably null Het
Epha1 G T 6: 42,364,843 N424K probably damaging Het
Fam171a1 T C 2: 3,225,488 S553P probably benign Het
Fbxw21 A G 9: 109,145,619 S278P probably damaging Het
Gm45861 T C 8: 27,542,561 probably null Het
Gm4846 T A 1: 166,483,738 R517S probably benign Het
Gnrhr A G 5: 86,197,362 L155P possibly damaging Het
Igfn1 C T 1: 135,966,671 probably benign Het
Ik T A 18: 36,747,442 probably null Het
Insrr A T 3: 87,810,084 Q763L probably benign Het
Klf5 G T 14: 99,301,388 C79F possibly damaging Het
Lrrcc1 A T 3: 14,558,394 R760S probably damaging Het
Map3k7 T A 4: 32,002,080 probably benign Het
Mapkbp1 C T 2: 120,023,190 A1159V probably benign Het
Mgst3 C T 1: 167,378,291 probably null Het
Mtch2 T A 2: 90,849,636 F71I probably damaging Het
Myo1e A G 9: 70,368,794 I764V probably benign Het
Myo3b T A 2: 70,258,081 L896* probably null Het
Ndufs5 T G 4: 123,712,835 E103A probably benign Het
Nfe2l1 G A 11: 96,819,595 P603S probably damaging Het
Olfr954 A T 9: 39,462,372 M311L probably benign Het
Piezo1 T C 8: 122,492,615 N1093S Het
Pitpnb G A 5: 111,385,524 R258H probably benign Het
Pla2g4d T C 2: 120,268,897 E708G possibly damaging Het
Plppr4 T A 3: 117,321,959 T750S probably benign Het
Prrg4 T G 2: 104,845,054 E68A probably damaging Het
Rcan2 C T 17: 44,017,810 T90M possibly damaging Het
Rlbp1 T C 7: 79,377,345 E189G probably damaging Het
Satb1 A G 17: 51,805,265 F107S probably damaging Het
Sdc3 A T 4: 130,821,202 probably benign Het
Slc22a3 A T 17: 12,507,206 V40D probably damaging Het
Slc35d1 A G 4: 103,190,830 probably null Het
Slfn1 T C 11: 83,121,295 F79S probably damaging Het
Snrpg G T 6: 86,376,575 V46L probably benign Het
Tbl1xr1 G A 3: 22,210,405 C508Y probably benign Het
Thada A T 17: 84,231,136 D1481E probably benign Het
Tnfsf8 A G 4: 63,860,980 V27A probably benign Het
Tns1 T C 1: 73,991,696 H300R probably damaging Het
Ttc13 C A 8: 124,675,253 G589V probably benign Het
Ttc28 A G 5: 110,892,832 I29V possibly damaging Het
Tubb4a T A 17: 57,080,778 N416I possibly damaging Het
Ubr4 T A 4: 139,450,325 I1884N Het
Usp16 A G 16: 87,469,752 K175E probably benign Het
Usp24 A G 4: 106,360,518 I479M probably benign Het
Utrn T C 10: 12,636,787 T2313A probably benign Het
Ythdc2 T C 18: 44,841,375 V368A probably benign Het
Zfp628 T C 7: 4,920,881 S701P probably damaging Het
Other mutations in Olfr801
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00948:Olfr801 APN 10 129669887 missense probably damaging 1.00
IGL02400:Olfr801 APN 10 129669883 missense probably damaging 0.99
IGL02721:Olfr801 APN 10 129670123 missense probably benign 0.08
IGL03107:Olfr801 APN 10 129669940 missense probably benign 0.00
R0114:Olfr801 UTSW 10 129669598 missense probably benign
R0140:Olfr801 UTSW 10 129669688 missense probably damaging 1.00
R0652:Olfr801 UTSW 10 129670379 missense probably benign 0.08
R1375:Olfr801 UTSW 10 129670372 missense probably null 0.97
R1449:Olfr801 UTSW 10 129670369 missense probably damaging 0.99
R2026:Olfr801 UTSW 10 129670465 missense probably damaging 1.00
R2241:Olfr801 UTSW 10 129669895 missense probably damaging 1.00
R2516:Olfr801 UTSW 10 129670286 missense probably damaging 1.00
R2869:Olfr801 UTSW 10 129669759 nonsense probably null
R2869:Olfr801 UTSW 10 129669759 nonsense probably null
R2870:Olfr801 UTSW 10 129669759 nonsense probably null
R2870:Olfr801 UTSW 10 129669759 nonsense probably null
R2873:Olfr801 UTSW 10 129669759 nonsense probably null
R6562:Olfr801 UTSW 10 129670139 missense probably damaging 1.00
R8362:Olfr801 UTSW 10 129670231 missense possibly damaging 0.88
R8503:Olfr801 UTSW 10 129669643 missense probably damaging 0.99
R8867:Olfr801 UTSW 10 129669759 nonsense probably null
Z1177:Olfr801 UTSW 10 129669794 missense probably benign 0.39
Predicted Primers PCR Primer
(F):5'- TGTCATGAGAGCTATGACAAAAGC -3'
(R):5'- CACAACTGCCTGTATTCCACG -3'

Sequencing Primer
(F):5'- GCCATCAATTCCATGAAATGTGTGTC -3'
(R):5'- ATTCCACGGTTCTTGATGAGC -3'
Posted On 2022-03-25