Incidental Mutation 'R9256:Prb1b'
ID 701866
Institutional Source Beutler Lab
Gene Symbol Prb1b
Ensembl Gene ENSMUSG00000107874
Gene Name proline-rich protein BstNI subfamily 1B
Synonyms MP5, Prpmp5
MMRRC Submission
Accession Numbers
Essential gene? Probably non essential (E-score: 0.127) question?
Stock # R9256 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 132288553-132291706 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 132288972 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 284 (N284S)
Ref Sequence ENSEMBL: ENSMUSP00000047347 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048686]
AlphaFold E9PXN1
Predicted Effect unknown
Transcript: ENSMUST00000048686
AA Change: N284S
SMART Domains Protein: ENSMUSP00000047347
Gene: ENSMUSG00000107874
AA Change: N284S

DomainStartEndE-ValueType
Pfam:Pro-rich 1 136 2.2e-36 PFAM
Pfam:Pro-rich 84 169 6.1e-17 PFAM
Pfam:Pro-rich 131 182 2.5e-10 PFAM
Pfam:Pro-rich 171 228 4.7e-10 PFAM
Pfam:Pro-rich 222 290 1.1e-11 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.8%
Validation Efficiency 99% (70/71)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acsl1 A G 8: 46,945,930 (GRCm39) Y21C probably damaging Het
Adamts7 A T 9: 90,060,218 (GRCm39) I290F probably damaging Het
Adcy5 G A 16: 35,124,052 (GRCm39) V1244I probably damaging Het
Adnp A T 2: 168,025,945 (GRCm39) I450N probably damaging Het
AL732309.1 A T 2: 25,136,211 (GRCm39) M1K probably null Het
Alox15 C T 11: 70,236,370 (GRCm39) G510D possibly damaging Het
Arhgef16 C A 4: 154,363,502 (GRCm39) E685* probably null Het
Atp13a2 A G 4: 140,730,038 (GRCm39) E643G probably damaging Het
AW554918 C A 18: 25,423,061 (GRCm39) Q171K probably damaging Het
Bdkrb2 A G 12: 105,558,352 (GRCm39) T198A probably benign Het
C7 T C 15: 5,023,645 (GRCm39) E721G probably damaging Het
Cc2d2b T C 19: 40,797,848 (GRCm39) Y823H unknown Het
Cd74 T C 18: 60,944,366 (GRCm39) V192A probably benign Het
Cdc42bpg G A 19: 6,361,067 (GRCm39) A231T probably damaging Het
Cers6 G A 2: 68,777,706 (GRCm39) probably benign Het
Copg2 T C 6: 30,788,637 (GRCm39) I555M probably benign Het
Cracd T G 5: 76,988,757 (GRCm39) V36G unknown Het
Crnkl1 A G 2: 145,770,216 (GRCm39) V209A possibly damaging Het
Dock7 T C 4: 98,971,272 (GRCm39) T98A Het
Enpp5 T C 17: 44,396,414 (GRCm39) I442T probably benign Het
Fbxw19 T C 9: 109,310,641 (GRCm39) Y427C probably damaging Het
Fktn T C 4: 53,744,653 (GRCm39) V311A probably benign Het
Fyb1 T G 15: 6,674,358 (GRCm39) S665A possibly damaging Het
Igkv6-20 T C 6: 70,313,417 (GRCm39) Y16C probably benign Het
Ints10 A G 8: 69,261,129 (GRCm39) R370G possibly damaging Het
Iqub A T 6: 24,446,198 (GRCm39) I742N possibly damaging Het
Kcnn3 T C 3: 89,574,407 (GRCm39) Y640H probably damaging Het
Lrp2 A G 2: 69,341,303 (GRCm39) V959A probably benign Het
Marcksl1 A G 4: 129,408,816 (GRCm39) S132G probably benign Het
Mfsd4b3-ps T A 10: 39,824,010 (GRCm39) K83N probably damaging Het
Mib1 A G 18: 10,760,862 (GRCm39) E384G possibly damaging Het
Morn5 G T 2: 35,939,553 (GRCm39) G5W probably damaging Het
Mrpl46 A G 7: 78,432,671 (GRCm39) S36P probably benign Het
Mtif2 T C 11: 29,490,777 (GRCm39) F494L probably benign Het
Naalad2 T C 9: 18,274,534 (GRCm39) N336S probably benign Het
Nepro A G 16: 44,544,790 (GRCm39) N22S probably benign Het
Nos1 G C 5: 118,017,402 (GRCm39) R255P probably benign Het
Or10x4 C T 1: 174,219,109 (GRCm39) T158I probably benign Het
Or1e1f A T 11: 73,856,135 (GRCm39) I234F probably benign Het
Or2d36 T C 7: 106,747,387 (GRCm39) I288T probably damaging Het
Or8c16 T A 9: 38,130,498 (GRCm39) Y123* probably null Het
Or9r7 A G 10: 129,962,335 (GRCm39) V197A possibly damaging Het
Pcnx1 A T 12: 82,020,047 (GRCm39) N724Y Het
Pde8b G A 13: 95,164,204 (GRCm39) R669C probably damaging Het
Pkhd1l1 T A 15: 44,397,290 (GRCm39) probably null Het
Pls1 A G 9: 95,655,696 (GRCm39) V352A probably damaging Het
Prtg A T 9: 72,758,977 (GRCm39) I444F probably damaging Het
Ptprb A T 10: 116,219,776 (GRCm39) H1998L probably damaging Het
Qrich2 A T 11: 116,356,450 (GRCm39) V133D probably benign Het
Rab35 C A 5: 115,778,246 (GRCm39) R71S probably damaging Het
Scgb2b12 A G 7: 32,026,054 (GRCm39) L46P probably damaging Het
Sdha A T 13: 74,475,483 (GRCm39) probably benign Het
Sdr39u1 C A 14: 56,135,209 (GRCm39) V245F probably benign Het
Sgo2a T A 1: 58,058,772 (GRCm39) V1117E possibly damaging Het
Slc12a2 T C 18: 58,074,867 (GRCm39) S1154P probably damaging Het
Slc6a1 A T 6: 114,287,554 (GRCm39) Q441L possibly damaging Het
Smtnl2 A T 11: 72,293,835 (GRCm39) probably null Het
Sorbs2 T G 8: 46,248,774 (GRCm39) V675G probably benign Het
Tmco1 C T 1: 167,136,132 (GRCm39) probably benign Het
Tmem38b A T 4: 53,848,924 (GRCm39) I110F probably damaging Het
Ubqln1 A G 13: 58,325,721 (GRCm39) I573T probably damaging Het
Usp9y T C Y: 1,356,235 (GRCm39) I1155M possibly damaging Het
Vipr1 A G 9: 121,490,118 (GRCm39) I164V probably benign Het
Vps13b T G 15: 35,623,925 (GRCm39) S1281A possibly damaging Het
Vps13d A G 4: 144,882,374 (GRCm39) L1073P Het
Wipi1 C T 11: 109,473,952 (GRCm39) probably null Het
Zdhhc8 G A 16: 18,042,686 (GRCm39) P505S probably damaging Het
Zfp292 C T 4: 34,839,899 (GRCm39) V84I probably benign Het
Zfp712 T C 13: 67,188,791 (GRCm39) T579A probably benign Het
Zfp788 G A 7: 41,299,638 (GRCm39) R758Q probably benign Het
Other mutations in Prb1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01392:Prb1b APN 6 132,289,383 (GRCm39) missense unknown
IGL02259:Prb1b APN 6 132,289,637 (GRCm39) missense unknown
IGL02434:Prb1b APN 6 132,289,339 (GRCm39) missense unknown
IGL03238:Prb1b APN 6 132,289,308 (GRCm39) missense unknown
R0971:Prb1b UTSW 6 132,290,618 (GRCm39) missense unknown
R1900:Prb1b UTSW 6 132,291,661 (GRCm39) missense unknown
R3800:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R3951:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R3952:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R3981:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R4083:Prb1b UTSW 6 132,289,657 (GRCm39) missense unknown
R4348:Prb1b UTSW 6 132,290,624 (GRCm39) missense unknown
R4351:Prb1b UTSW 6 132,290,624 (GRCm39) missense unknown
R4352:Prb1b UTSW 6 132,290,624 (GRCm39) missense unknown
R4353:Prb1b UTSW 6 132,290,624 (GRCm39) missense unknown
R6190:Prb1b UTSW 6 132,289,692 (GRCm39) missense unknown
R7001:Prb1b UTSW 6 132,289,527 (GRCm39) missense unknown
R9023:Prb1b UTSW 6 132,289,174 (GRCm39) frame shift probably null
R9028:Prb1b UTSW 6 132,289,618 (GRCm39) missense unknown
R9193:Prb1b UTSW 6 132,288,996 (GRCm39) missense unknown
R9388:Prb1b UTSW 6 132,289,437 (GRCm39) missense unknown
R9644:Prb1b UTSW 6 132,289,218 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCTGTTAGAGCTTCACAGTTGAC -3'
(R):5'- TCTTCAGAGACCTCCTCAGC -3'

Sequencing Primer
(F):5'- TTAGAGCTTCACAGTTGACTGAGAG -3'
(R):5'- GAGACCTCCTCAGCCTGGAAAC -3'
Posted On 2022-03-25