Mutagenetix > Incidental Mutation

Incidental Mutation 'R9258:Aox1'

701981

Institutional Source

Beutler Lab

Gene Symbol

Aox1

Ensembl Gene

ENSMUSG00000063558

Gene Name

aldehyde oxidase 1

Synonyms

Aox-1, retinal oxidase, Aox-2, Aox2

MMRRC Submission

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R9258 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

58069090-58145572 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 58351515 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 701 (I701F)

Ref Sequence

ENSEMBL: ENSMUSP00000110006 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000114366]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000114366
AA Change: I701F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000110006
Gene: ENSMUSG00000079554
AA Change: I701F

Domain	Start	End	E-Value	Type
Pfam:Fer2	13	83	3.4e-9	PFAM
Pfam:Fer2_2	92	166	4.2e-30	PFAM
Pfam:FAD_binding_5	241	421	5.1e-46	PFAM
CO_deh_flav_C	428	532	1.4e-23	SMART
Ald_Xan_dh_C	604	707	4.64e-47	SMART
Pfam:Ald_Xan_dh_C2	717	1251	1.3e-178	PFAM
low complexity region	1257	1271	N/A	INTRINSIC
low complexity region	1285	1303	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 97 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb10	T	A	8: 124,709,347 (GRCm39)	Q69L	probably benign	Het
Abtb2	A	C	2: 103,546,410 (GRCm39)	Q930P	probably null	Het
Adam18	G	A	8: 25,158,574 (GRCm39)	T73I	probably benign	Het
Ankrd54	A	T	15: 78,946,996 (GRCm39)	M1K	probably null	Het
Anks1	T	C	17: 28,277,400 (GRCm39)	V1106A	probably damaging	Het
Arfgef3	C	T	10: 18,465,387 (GRCm39)	R2152H	probably damaging	Het
Arnt2	C	T	7: 84,010,798 (GRCm39)	G37E	probably damaging	Het
Arpp21	G	A	9: 111,953,956 (GRCm39)	T581M	probably benign	Het
Arvcf	A	G	16: 18,216,957 (GRCm39)	N428S	probably damaging	Het
C2cd3	A	G	7: 100,098,026 (GRCm39)	E1471G		Het
Cadm1	A	G	9: 47,710,730 (GRCm39)	K211R	probably benign	Het
Cdh6	A	G	15: 13,064,462 (GRCm39)	S143P	probably damaging	Het
Cep152	G	A	2: 125,421,356 (GRCm39)	Q1125*	probably null	Het
Cfap54	A	C	10: 92,770,960 (GRCm39)	S2095A	unknown	Het
Col12a1	T	C	9: 79,613,645 (GRCm39)	T67A	probably benign	Het
Col6a3	T	C	1: 90,700,703 (GRCm39)	N3216S	unknown	Het
Cpeb2	T	A	5: 43,391,455 (GRCm39)	L217Q		Het
Ctbp2	A	T	7: 132,597,021 (GRCm39)	N119K	probably damaging	Het
Des	G	T	1: 75,340,289 (GRCm39)	V399L	probably benign	Het
Dnah2	G	T	11: 69,368,079 (GRCm39)	H1753Q	probably damaging	Het
Dnajc6	T	C	4: 101,475,813 (GRCm39)	V562A	probably benign	Het
Dusp13b	T	C	14: 21,791,155 (GRCm39)	D99G	probably benign	Het
Ehd3	A	G	17: 74,127,561 (GRCm39)	I165V	probably benign	Het
Eme2	C	T	17: 25,112,053 (GRCm39)	V241M	probably damaging	Het
Eml5	A	G	12: 98,810,376 (GRCm39)	L860P	possibly damaging	Het
Eogt	T	A	6: 97,089,043 (GRCm39)	K521M	possibly damaging	Het
Epb41l5	T	C	1: 119,506,701 (GRCm39)	T489A	probably benign	Het
Fmo5	G	T	3: 97,558,802 (GRCm39)	V421L	probably benign	Het
Gabpa	C	T	16: 84,653,403 (GRCm39)	P268S	probably benign	Het
Gas2l3	G	T	10: 89,262,315 (GRCm39)	H136N	probably benign	Het
Gm5592	C	T	7: 40,938,407 (GRCm39)	A563V	possibly damaging	Het
Gpn3	A	T	5: 122,519,508 (GRCm39)	D205V	probably benign	Het
H13	T	C	2: 152,522,999 (GRCm39)	L104S	probably damaging	Het
H2-Q4	T	A	17: 35,599,105 (GRCm39)	V125E	probably benign	Het
Ifih1	A	G	2: 62,442,242 (GRCm39)	F374S	probably damaging	Het
Ildr2	A	G	1: 166,131,158 (GRCm39)	D338G	probably damaging	Het
Kmt2b	A	T	7: 30,281,893 (GRCm39)	N1162K	probably null	Het
Lmntd1	T	C	6: 145,359,256 (GRCm39)	D298G	probably damaging	Het
Lrrc32	T	A	7: 98,148,345 (GRCm39)	V375E	probably benign	Het
Lrrc37a	A	C	11: 103,393,022 (GRCm39)	I801R	probably benign	Het
Matcap1	A	G	8: 106,008,775 (GRCm39)	V414A	probably damaging	Het
Mgam	A	G	6: 40,657,121 (GRCm39)	E935G	probably benign	Het
Mms22l	A	T	4: 24,588,238 (GRCm39)	T917S	probably damaging	Het
Myo3a	A	T	2: 22,467,545 (GRCm39)	E1204D	possibly damaging	Het
Nav3	T	A	10: 109,550,243 (GRCm39)	E1829V	probably damaging	Het
Nccrp1	C	T	7: 28,245,632 (GRCm39)	G150D	probably damaging	Het
Nlrp4b	G	T	7: 10,444,087 (GRCm39)	W12L	probably damaging	Het
Nmb	T	C	7: 80,554,001 (GRCm39)	T71A	possibly damaging	Het
Ogfod2	T	A	5: 124,250,505 (GRCm39)	H35Q	probably benign	Het
Ola1	A	T	2: 72,929,732 (GRCm39)	S290R	probably damaging	Het
Or1e30	T	G	11: 73,678,281 (GRCm39)	N172K	probably benign	Het
Or4k47	A	T	2: 111,452,329 (GRCm39)	I30N	possibly damaging	Het
Or51v15-ps1	T	G	7: 103,278,543 (GRCm39)	Y208S	unknown	Het
Or52e2	C	A	7: 102,804,409 (GRCm39)	E182*	probably null	Het
Or5p68	T	G	7: 107,945,886 (GRCm39)	T101P	probably benign	Het
Or9i14	A	T	19: 13,792,099 (GRCm39)	L285*	probably null	Het
Pcsk9	T	C	4: 106,316,047 (GRCm39)	D132G	possibly damaging	Het
Pkhd1	A	T	1: 20,444,174 (GRCm39)	V2296E	probably damaging	Het
Prl2c5	A	T	13: 13,365,297 (GRCm39)	I151L	probably damaging	Het
Prl3d3	A	T	13: 27,344,931 (GRCm39)	D101V	possibly damaging	Het
Prrt1	A	G	17: 34,850,120 (GRCm39)	Y178C	probably damaging	Het
Rasal1	A	T	5: 120,793,155 (GRCm39)	I87F	possibly damaging	Het
Rpgrip1l	A	T	8: 91,987,614 (GRCm39)	Y814*	probably null	Het
Rpl3l	T	G	17: 24,951,447 (GRCm39)		probably null	Het
Rrbp1	C	A	2: 143,853,161 (GRCm39)		probably benign	Het
Ryr3	A	G	2: 112,483,364 (GRCm39)	S4158P	probably damaging	Het
Scube2	G	T	7: 109,398,515 (GRCm39)	S951Y	probably damaging	Het
Sec14l1	T	C	11: 117,041,002 (GRCm39)	V396A	probably benign	Het
Sh3gl1	T	A	17: 56,325,911 (GRCm39)	K173*	probably null	Het
Shank3	A	T	15: 89,388,521 (GRCm39)	E371V	probably damaging	Het
Slc25a24	A	G	3: 109,066,751 (GRCm39)	T302A	probably damaging	Het
Slc25a41	A	T	17: 57,348,580 (GRCm39)	H4Q	probably benign	Het
Slc45a1	A	T	4: 150,723,071 (GRCm39)	V271D	possibly damaging	Het
Smad6	A	T	9: 63,927,573 (GRCm39)	L245Q	probably damaging	Het
Smad7	C	A	18: 75,527,317 (GRCm39)	Q388K	probably damaging	Het
Snx29	G	T	16: 11,532,799 (GRCm39)	D348Y	possibly damaging	Het
Son	A	T	16: 91,474,570 (GRCm39)	H2418L	unknown	Het
Sppl3	G	A	5: 115,233,922 (GRCm39)	V331M	probably damaging	Het
St13	T	G	15: 81,272,569 (GRCm39)	T92P	probably benign	Het
St3gal4	A	G	9: 34,963,643 (GRCm39)	W222R	probably damaging	Het
Stk32a	T	A	18: 43,444,999 (GRCm39)	N264K	probably benign	Het
Stoml3	T	A	3: 53,405,397 (GRCm39)	I26N	possibly damaging	Het
Taf7	T	C	18: 37,776,021 (GRCm39)	E182G	probably damaging	Het
Tas2r138	A	G	6: 40,590,129 (GRCm39)	V39A	probably damaging	Het
Tbc1d12	A	G	19: 38,889,823 (GRCm39)	S418G	possibly damaging	Het
Tbr1	T	A	2: 61,642,723 (GRCm39)	C663S	probably benign	Het
Tmc5	A	T	7: 118,222,501 (GRCm39)	Y67F	probably benign	Het
Tnfsf4	A	C	1: 161,244,814 (GRCm39)	I168L	probably benign	Het
Trav5-1	T	G	14: 52,860,347 (GRCm39)	S51A	probably benign	Het
Trmt10c	A	T	16: 55,854,646 (GRCm39)	C330S	possibly damaging	Het
Trpm1	T	C	7: 63,884,713 (GRCm39)	M798T	probably benign	Het
Unc13d	AATGCCTCCCATGCC	AATGCCTCCCATGCCTCCCATGCC	11: 115,958,998 (GRCm39)		probably benign	Het
Unc13d	CATGCC	CATGCCTCCGATGCC	11: 115,959,007 (GRCm39)		probably benign	Het
Vmn1r199	A	G	13: 22,566,822 (GRCm39)	T39A	possibly damaging	Het
Vmn1r74	T	A	7: 11,580,999 (GRCm39)	C100S	possibly damaging	Het
Vmn2r77	T	A	7: 86,452,302 (GRCm39)	I494K	possibly damaging	Het
Wdr17	G	A	8: 55,112,654 (GRCm39)	Q816*	probably null	Het

Other mutations in Aox1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00336:Aox1	APN	1	58,098,203 (GRCm39)	missense	probably damaging	1.00
IGL01014:Aox1	APN	1	58,361,960 (GRCm39)	missense	possibly damaging	0.73
IGL01077:Aox1	APN	1	58,096,569 (GRCm39)	splice site	probably benign
IGL01288:Aox1	APN	1	58,333,566 (GRCm39)	missense	probably damaging	0.99
IGL01335:Aox1	APN	1	58,121,312 (GRCm39)	nonsense	probably null
IGL01383:Aox1	APN	1	58,333,464 (GRCm39)	missense	probably benign	0.09
IGL01410:Aox1	APN	1	58,145,184 (GRCm39)	splice site	probably null
IGL01684:Aox1	APN	1	58,116,740 (GRCm39)	splice site	probably null
IGL01727:Aox1	APN	1	58,112,387 (GRCm39)	nonsense	probably null
IGL01734:Aox1	APN	1	58,393,469 (GRCm39)	missense	possibly damaging	0.95
IGL01793:Aox1	APN	1	58,375,783 (GRCm39)	missense	possibly damaging	0.79
IGL01805:Aox1	APN	1	58,120,672 (GRCm39)	missense	possibly damaging	0.94
IGL01834:Aox1	APN	1	58,348,183 (GRCm39)	missense	possibly damaging	0.90
IGL01924:Aox1	APN	1	58,326,902 (GRCm39)	missense	possibly damaging	0.90
IGL01996:Aox1	APN	1	58,121,225 (GRCm39)	missense	probably benign	0.11
IGL02060:Aox1	APN	1	58,137,114 (GRCm39)	missense	possibly damaging	0.95
IGL02206:Aox1	APN	1	58,104,499 (GRCm39)	missense	probably benign	0.00
IGL02591:Aox1	APN	1	58,398,158 (GRCm39)	nonsense	probably null
IGL02645:Aox1	APN	1	58,373,883 (GRCm39)	missense	probably damaging	1.00
IGL02710:Aox1	APN	1	58,373,928 (GRCm39)	critical splice donor site	probably null
IGL02801:Aox1	APN	1	58,393,336 (GRCm39)	missense	probably damaging	1.00
IGL02839:Aox1	APN	1	58,107,943 (GRCm39)	missense	probably benign	0.05
IGL02975:Aox1	APN	1	58,107,550 (GRCm39)	missense	probably damaging	1.00
IGL02988:Aox1	APN	1	58,376,509 (GRCm39)	missense	probably benign
IGL03062:Aox1	APN	1	58,117,624 (GRCm39)	missense	probably benign	0.01
IGL03104:Aox1	APN	1	58,321,918 (GRCm39)	missense	probably benign
IGL03121:Aox1	APN	1	58,398,113 (GRCm39)	missense	probably damaging	1.00
IGL03191:Aox1	APN	1	58,398,228 (GRCm39)	missense	probably null	0.98
IGL03236:Aox1	APN	1	58,349,156 (GRCm39)	nonsense	probably null
IGL03286:Aox1	APN	1	58,088,543 (GRCm39)	missense	probably benign	0.19
IGL03335:Aox1	APN	1	58,115,319 (GRCm39)	missense	probably damaging	0.98
IGL03395:Aox1	APN	1	58,107,884 (GRCm39)	splice site	probably benign
IGL03409:Aox1	APN	1	58,393,588 (GRCm39)	missense	possibly damaging	0.91
PIT4362001:Aox1	UTSW	1	58,321,839 (GRCm39)	missense	probably damaging	1.00
R0035:Aox1	UTSW	1	58,393,581 (GRCm39)	missense	probably benign	0.00
R0035:Aox1	UTSW	1	58,393,581 (GRCm39)	missense	probably benign	0.00
R0048:Aox1	UTSW	1	58,112,371 (GRCm39)	missense	probably damaging	0.98
R0144:Aox1	UTSW	1	58,109,233 (GRCm39)	missense	probably benign	0.00
R0207:Aox1	UTSW	1	58,144,173 (GRCm39)	missense	possibly damaging	0.82
R0267:Aox1	UTSW	1	58,378,605 (GRCm39)	splice site	probably benign
R0357:Aox1	UTSW	1	58,131,675 (GRCm39)	missense	probably damaging	1.00
R0383:Aox1	UTSW	1	58,100,400 (GRCm39)	missense	probably benign	0.00
R0388:Aox1	UTSW	1	58,393,565 (GRCm39)	missense	probably damaging	1.00
R0399:Aox1	UTSW	1	58,108,008 (GRCm39)	splice site	probably null
R0409:Aox1	UTSW	1	58,375,783 (GRCm39)	missense	possibly damaging	0.90
R0465:Aox1	UTSW	1	58,101,366 (GRCm39)	missense	probably damaging	1.00
R0480:Aox1	UTSW	1	58,082,810 (GRCm39)	splice site	probably benign
R0547:Aox1	UTSW	1	58,349,201 (GRCm39)	missense	probably damaging	0.96
R0630:Aox1	UTSW	1	58,376,480 (GRCm39)	splice site	probably benign
R0726:Aox1	UTSW	1	58,373,941 (GRCm39)	splice site	probably benign
R0734:Aox1	UTSW	1	58,344,500 (GRCm39)	missense	probably benign	0.22
R0831:Aox1	UTSW	1	58,378,842 (GRCm39)	missense	probably benign	0.28
R0961:Aox1	UTSW	1	58,349,230 (GRCm39)	missense	probably benign	0.00
R1005:Aox1	UTSW	1	58,104,511 (GRCm39)	missense	probably benign	0.00
R1404:Aox1	UTSW	1	58,385,371 (GRCm39)	splice site	probably benign
R1507:Aox1	UTSW	1	58,143,610 (GRCm39)	missense	probably benign	0.01
R1512:Aox1	UTSW	1	58,346,510 (GRCm39)	missense	probably benign	0.00
R1573:Aox1	UTSW	1	58,348,186 (GRCm39)	missense	probably benign	0.00
R1592:Aox1	UTSW	1	58,339,853 (GRCm39)	missense	probably benign	0.00
R1597:Aox1	UTSW	1	58,086,326 (GRCm39)	missense	probably damaging	1.00
R1693:Aox1	UTSW	1	58,124,701 (GRCm39)	missense	probably damaging	1.00
R1709:Aox1	UTSW	1	58,116,633 (GRCm39)	missense	probably benign
R1747:Aox1	UTSW	1	58,378,751 (GRCm39)	missense	probably benign	0.01
R1768:Aox1	UTSW	1	58,393,354 (GRCm39)	missense	probably benign	0.00
R1809:Aox1	UTSW	1	58,333,484 (GRCm39)	missense	probably benign
R1823:Aox1	UTSW	1	58,351,518 (GRCm39)	missense	probably benign	0.02
R1834:Aox1	UTSW	1	58,348,150 (GRCm39)	missense	probably benign	0.08
R1835:Aox1	UTSW	1	58,348,150 (GRCm39)	missense	probably benign	0.08
R1836:Aox1	UTSW	1	58,348,150 (GRCm39)	missense	probably benign	0.08
R1869:Aox1	UTSW	1	58,115,262 (GRCm39)	missense	probably damaging	1.00
R1870:Aox1	UTSW	1	58,115,262 (GRCm39)	missense	probably damaging	1.00
R1898:Aox1	UTSW	1	58,117,601 (GRCm39)	missense	probably damaging	1.00
R1908:Aox1	UTSW	1	58,141,783 (GRCm39)	missense	probably damaging	1.00
R2002:Aox1	UTSW	1	58,086,300 (GRCm39)	missense	possibly damaging	0.69
R2062:Aox1	UTSW	1	58,098,351 (GRCm39)	splice site	probably null
R2065:Aox1	UTSW	1	58,098,351 (GRCm39)	splice site	probably null
R2219:Aox1	UTSW	1	58,388,289 (GRCm39)	splice site	probably null
R2220:Aox1	UTSW	1	58,388,289 (GRCm39)	splice site	probably null
R2265:Aox1	UTSW	1	58,120,679 (GRCm39)	missense	probably damaging	0.99
R2508:Aox1	UTSW	1	58,382,832 (GRCm39)	missense	probably benign	0.38
R2942:Aox1	UTSW	1	58,376,540 (GRCm39)	missense	probably benign	0.03
R2967:Aox1	UTSW	1	58,361,993 (GRCm39)	missense	probably damaging	0.96
R3082:Aox1	UTSW	1	58,322,759 (GRCm39)	splice site	probably benign
R3161:Aox1	UTSW	1	58,343,597 (GRCm39)	missense	possibly damaging	0.91
R3408:Aox1	UTSW	1	58,382,827 (GRCm39)	missense	probably benign	0.32
R3713:Aox1	UTSW	1	58,095,374 (GRCm39)	missense	probably benign	0.01
R3778:Aox1	UTSW	1	58,092,862 (GRCm39)	missense	possibly damaging	0.89
R3803:Aox1	UTSW	1	58,329,058 (GRCm39)	splice site	probably null
R3894:Aox1	UTSW	1	58,373,837 (GRCm39)	critical splice acceptor site	probably null
R4198:Aox1	UTSW	1	58,124,766 (GRCm39)	missense	probably benign
R4214:Aox1	UTSW	1	58,346,603 (GRCm39)	critical splice donor site	probably null
R4249:Aox1	UTSW	1	58,338,978 (GRCm39)	missense	probably benign	0.01
R4296:Aox1	UTSW	1	58,096,559 (GRCm39)	splice site	probably null
R4562:Aox1	UTSW	1	58,098,215 (GRCm39)	missense	probably damaging	0.99
R4666:Aox1	UTSW	1	58,343,756 (GRCm39)	nonsense	probably null
R4668:Aox1	UTSW	1	58,373,853 (GRCm39)	missense	possibly damaging	0.63
R4703:Aox1	UTSW	1	58,398,116 (GRCm39)	missense	possibly damaging	0.78
R4758:Aox1	UTSW	1	58,371,741 (GRCm39)	missense	probably benign	0.00
R4858:Aox1	UTSW	1	58,143,640 (GRCm39)	missense	probably benign
R4862:Aox1	UTSW	1	58,134,316 (GRCm39)	missense	probably damaging	0.98
R4890:Aox1	UTSW	1	58,373,862 (GRCm39)	missense	probably benign	0.11
R4900:Aox1	UTSW	1	58,344,544 (GRCm39)	missense	probably benign
R4924:Aox1	UTSW	1	58,344,503 (GRCm39)	missense	probably damaging	1.00
R4970:Aox1	UTSW	1	58,349,254 (GRCm39)	splice site	probably null
R5048:Aox1	UTSW	1	58,098,641 (GRCm39)	splice site	probably benign
R5112:Aox1	UTSW	1	58,349,254 (GRCm39)	splice site	probably null
R5127:Aox1	UTSW	1	58,069,185 (GRCm39)	missense	probably benign	0.00
R5139:Aox1	UTSW	1	58,100,456 (GRCm39)	missense	probably benign	0.03
R5157:Aox1	UTSW	1	58,109,222 (GRCm39)	missense	probably damaging	1.00
R5168:Aox1	UTSW	1	58,088,561 (GRCm39)	missense	probably damaging	1.00
R5186:Aox1	UTSW	1	58,107,529 (GRCm39)	missense	probably damaging	1.00
R5235:Aox1	UTSW	1	58,096,714 (GRCm39)	missense	possibly damaging	0.77
R5289:Aox1	UTSW	1	58,131,717 (GRCm39)	missense	probably damaging	0.99
R5466:Aox1	UTSW	1	58,080,619 (GRCm39)	missense	probably damaging	1.00
R5540:Aox1	UTSW	1	58,143,569 (GRCm39)	missense	probably benign	0.03
R5615:Aox1	UTSW	1	58,136,125 (GRCm39)	missense	probably benign
R5652:Aox1	UTSW	1	58,134,356 (GRCm39)	missense	probably damaging	1.00
R5920:Aox1	UTSW	1	58,088,631 (GRCm39)	missense	probably damaging	1.00
R5987:Aox1	UTSW	1	58,346,518 (GRCm39)	missense	probably benign	0.00
R6008:Aox1	UTSW	1	58,116,672 (GRCm39)	missense	probably damaging	1.00
R6073:Aox1	UTSW	1	58,143,668 (GRCm39)	critical splice donor site	probably null
R6215:Aox1	UTSW	1	58,124,620 (GRCm39)	missense	probably benign
R6239:Aox1	UTSW	1	58,344,550 (GRCm39)	critical splice donor site	probably null
R6273:Aox1	UTSW	1	58,378,831 (GRCm39)	missense	probably benign	0.00
R6291:Aox1	UTSW	1	58,369,965 (GRCm39)	missense	probably damaging	0.98
R6334:Aox1	UTSW	1	58,346,566 (GRCm39)	nonsense	probably null
R6403:Aox1	UTSW	1	58,107,594 (GRCm39)	missense	probably damaging	1.00
R6440:Aox1	UTSW	1	58,133,631 (GRCm39)	missense	probably damaging	1.00
R6601:Aox1	UTSW	1	58,102,665 (GRCm39)	missense	probably damaging	1.00
R6608:Aox1	UTSW	1	58,096,705 (GRCm39)	missense	probably benign	0.40
R6752:Aox1	UTSW	1	58,086,398 (GRCm39)	missense	probably benign	0.00
R6764:Aox1	UTSW	1	58,389,441 (GRCm39)	missense	probably damaging	0.97
R6766:Aox1	UTSW	1	58,388,227 (GRCm39)	missense	possibly damaging	0.95
R6789:Aox1	UTSW	1	58,343,644 (GRCm39)	missense	probably benign	0.01
R6804:Aox1	UTSW	1	58,343,757 (GRCm39)	missense	probably benign	0.04
R6989:Aox1	UTSW	1	58,124,611 (GRCm39)	missense	probably damaging	1.00
R7007:Aox1	UTSW	1	58,370,051 (GRCm39)	missense	probably damaging	1.00
R7015:Aox1	UTSW	1	58,321,917 (GRCm39)	missense	probably benign	0.00
R7042:Aox1	UTSW	1	58,141,759 (GRCm39)	missense	probably damaging	0.99
R7055:Aox1	UTSW	1	58,338,927 (GRCm39)	missense	probably benign	0.08
R7089:Aox1	UTSW	1	58,375,808 (GRCm39)	missense	probably benign	0.01
R7157:Aox1	UTSW	1	58,322,651 (GRCm39)	missense	probably benign	0.00
R7303:Aox1	UTSW	1	58,373,924 (GRCm39)	nonsense	probably null
R7426:Aox1	UTSW	1	58,329,142 (GRCm39)	nonsense	probably null
R7442:Aox1	UTSW	1	58,121,172 (GRCm39)	missense	probably damaging	1.00
R7506:Aox1	UTSW	1	58,088,562 (GRCm39)	missense	probably damaging	1.00
R7563:Aox1	UTSW	1	58,086,304 (GRCm39)	missense	probably benign	0.32
R7589:Aox1	UTSW	1	58,080,643 (GRCm39)	missense	probably damaging	1.00
R7735:Aox1	UTSW	1	58,107,451 (GRCm39)	missense	probably benign	0.01
R7762:Aox1	UTSW	1	58,388,263 (GRCm39)	missense	probably damaging	1.00
R7814:Aox1	UTSW	1	58,124,626 (GRCm39)	missense	probably benign
R7876:Aox1	UTSW	1	58,101,330 (GRCm39)	nonsense	probably null
R7899:Aox1	UTSW	1	58,320,396 (GRCm39)	splice site	probably null
R7905:Aox1	UTSW	1	58,143,557 (GRCm39)	missense	possibly damaging	0.72
R7908:Aox1	UTSW	1	58,145,227 (GRCm39)	missense	possibly damaging	0.68
R7942:Aox1	UTSW	1	58,376,590 (GRCm39)	missense	probably damaging	1.00
R7975:Aox1	UTSW	1	58,348,187 (GRCm39)	missense	probably benign	0.02
R8029:Aox1	UTSW	1	58,382,827 (GRCm39)	missense	probably benign	0.32
R8032:Aox1	UTSW	1	58,389,442 (GRCm39)	missense	probably benign	0.01
R8116:Aox1	UTSW	1	58,115,283 (GRCm39)	missense	probably damaging	1.00
R8147:Aox1	UTSW	1	58,339,821 (GRCm39)	missense	probably benign	0.02
R8165:Aox1	UTSW	1	58,348,088 (GRCm39)	missense	probably benign	0.08
R8179:Aox1	UTSW	1	58,137,117 (GRCm39)	missense	probably damaging	1.00
R8264:Aox1	UTSW	1	58,092,873 (GRCm39)	missense	possibly damaging	0.92
R8284:Aox1	UTSW	1	58,115,250 (GRCm39)	missense	probably damaging	1.00
R8326:Aox1	UTSW	1	58,335,046 (GRCm39)	missense	probably benign
R8415:Aox1	UTSW	1	58,080,638 (GRCm39)	missense	probably damaging	1.00
R8770:Aox1	UTSW	1	58,378,763 (GRCm39)	missense	probably benign	0.10
R8946:Aox1	UTSW	1	58,145,227 (GRCm39)	missense	possibly damaging	0.68
R8973:Aox1	UTSW	1	58,329,113 (GRCm39)	missense	probably benign	0.34
R8988:Aox1	UTSW	1	58,088,625 (GRCm39)	missense	possibly damaging	0.48
R9015:Aox1	UTSW	1	58,382,851 (GRCm39)	missense	probably damaging	1.00
R9097:Aox1	UTSW	1	58,326,887 (GRCm39)	missense	possibly damaging	0.82
R9101:Aox1	UTSW	1	58,371,796 (GRCm39)	missense	probably benign	0.03
R9108:Aox1	UTSW	1	58,321,851 (GRCm39)	missense	probably damaging	1.00
R9180:Aox1	UTSW	1	58,378,777 (GRCm39)	nonsense	probably null
R9293:Aox1	UTSW	1	58,361,953 (GRCm39)	missense	possibly damaging	0.86
R9296:Aox1	UTSW	1	58,124,612 (GRCm39)	missense	probably damaging	1.00
R9382:Aox1	UTSW	1	58,104,501 (GRCm39)	missense	possibly damaging	0.48
R9461:Aox1	UTSW	1	58,116,736 (GRCm39)	critical splice donor site	probably null
R9519:Aox1	UTSW	1	58,373,926 (GRCm39)	missense	probably damaging	0.98
R9581:Aox1	UTSW	1	58,370,055 (GRCm39)	critical splice donor site	probably null
Z1088:Aox1	UTSW	1	58,120,701 (GRCm39)	missense	probably benign	0.01
Z1177:Aox1	UTSW	1	58,393,556 (GRCm39)	missense	possibly damaging	0.69

Predicted Primers

PCR Primer
(F):5'- CACTATTACGGTGTGGAGAGTG -3'
(R):5'- ATGATGATGCTCTCGACCTCAC -3'

Sequencing Primer
(F):5'- GGTTTACAGAGCAAGCCCTGTTAC -3'
(R):5'- CCACATGTATGTCTATGTGCCAGG -3'

Posted On

2022-03-25